Click here to switch to the map view.

The map label for this gene is ntrC4 [H]

Identifier: 15605734

GI number: 15605734

Start: 99015

End: 100343

Strand: Direct

Name: ntrC4 [H]

Synonym: aq_164

Alternate gene names: 15605734

Gene position: 99015-100343 (Clockwise)

Preceding gene: 15605733

Following gene: 15605736

Centisome position: 6.38

GC content: 41.91

Gene sequence:

>1329_bases
ATGAAGCGTGTTCTCGTTGTGGACGACGAAGAAAGTATTACTTCTTCTCTCTCCGCAATCCTTGAAGAAGAAGGATACCA
TCCAGATACGGCAAAGACGTTAAGGGAAGCGGAAAAGAAGATAAAGGAACTGTTCTTTCCCGTTATAGTCCTTGACGTTT
GGATGCCCGACGGGGACGGTGTAAACTTTATAGATTTCATAAAAGAAAACTCTCCCGACAGCGTTGTCATAGTAATCACG
GGACACGGGAGCGTGGACACAGCGGTAAAAGCGATAAAAAAGGGAGCTTACGAGTTCTTGGAAAAACCTTTTTCCGTTGA
GAGATTTCTTCTTACGATAAAACACGCCTTTGAGGAGTACTCAAAGAAAGCCCCGCCTCAGGAGGAAATAGAGTTTGTAG
GGGAACACCCGAAAATTCTGGAGATAAAGAGGCTTATACCCAAAATAGCGAAGAGCAAAGCTCCTGTCCTTATAACAGGA
GAAAGCGGAACGGGAAAGGAAATAGTAGCGAGGTTAATACACAGGTACTCGGGAAGAAAGGGAGCTTTTGTAGACCTGAA
CTGTGCTTCAATTCCTCAGGAACTGGCGGAAAGTGAACTCTTTGGACACGAAAAGGGAGCCTTCACTGGAGCACTTACGA
GAAAGAAGGGAAAATTAGAACTCGCCGATCAGGGAACCCTCTTTCTGGACGAGGTGGGAGAGCTTGACCAAAGGGTTCAG
GCAAAACTCTTGAGGGTTCTGGAGACGGGAAGTTTTACAAGACTCGGAGGAAATCAAAAAATAGAAGTGGACATAAGGGT
AATATCCGCAACGAATAAAAATCTGGAAGAAGAAATCAAGAAAGGAAACTTCAGGGAAGATCTTTACTACAGACTTTCTG
TATTTCAAATATACCTCCCGCCACTCAGGGAAAGGGGAAAGGATGTTATCCTCCTCGCGGAGTACTTTCTAAAGAAGTTC
GCAAAAGAGTATAAAAAGAACTGCTTTGAACTTTCCGAAGAGACGAAGGAATACTTAATGAAACAGGAGTGGAAAGGAAA
CGTAAGGGAATTAAAGAACTTAATAGAGAGGGCTGTTATTTTATGCGAAGGTGAAGTCATAAAACCTGAAGATCTGGGAC
TGAAGGAGAAAAGCTGGAGGGACTTATCTTACCTTCTTAAGATAAAAGAGCTAAAAGAAGCAAAAAAGGAATTTGAGAAG
ATATTTATCGAGGAAAAGTTAAGGGAGTACGATTACGACCTGAAAAGAACCGCGGAAGAAATAGGTATAGATCTTTCAAA
CTTGTACAGAAAAATAAAAAGTTTAAACATAAGAGTCAAAAGTTCATAA

Upstream 100 bases:

>100_bases
TTGAAATAGAACCGAATGTAATACATCCTATCTACAGAAAGCCTCTGAAGGAGTTTAAGCCCGAAAATACACTGAAACCT
TTCTGCTGTATCTTAAAAGT

Downstream 100 bases:

>100_bases
GAATAGACACTATACTCACGACCGCTGTTTCCGTCCTCAGGGTGTATGGCTCTAAAAGAACGGATTTAAATCCTTTTTCC
CTCAGTATTTGACTTTCCCT

Product: NtrC family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKRVLVVDDEESITSSLSAILEEEGYHPDTAKTLREAEKKIKELFFPVIVLDVWMPDGDGVNFIDFIKENSPDSVVIVIT
GHGSVDTAVKAIKKGAYEFLEKPFSVERFLLTIKHAFEEYSKKAPPQEEIEFVGEHPKILEIKRLIPKIAKSKAPVLITG
ESGTGKEIVARLIHRYSGRKGAFVDLNCASIPQELAESELFGHEKGAFTGALTRKKGKLELADQGTLFLDEVGELDQRVQ
AKLLRVLETGSFTRLGGNQKIEVDIRVISATNKNLEEEIKKGNFREDLYYRLSVFQIYLPPLRERGKDVILLAEYFLKKF
AKEYKKNCFELSEETKEYLMKQEWKGNVRELKNLIERAVILCEGEVIKPEDLGLKEKSWRDLSYLLKIKELKEAKKEFEK
IFIEEKLREYDYDLKRTAEEIGIDLSNLYRKIKSLNIRVKSS

Sequences:

>Translated_442_residues
MKRVLVVDDEESITSSLSAILEEEGYHPDTAKTLREAEKKIKELFFPVIVLDVWMPDGDGVNFIDFIKENSPDSVVIVIT
GHGSVDTAVKAIKKGAYEFLEKPFSVERFLLTIKHAFEEYSKKAPPQEEIEFVGEHPKILEIKRLIPKIAKSKAPVLITG
ESGTGKEIVARLIHRYSGRKGAFVDLNCASIPQELAESELFGHEKGAFTGALTRKKGKLELADQGTLFLDEVGELDQRVQ
AKLLRVLETGSFTRLGGNQKIEVDIRVISATNKNLEEEIKKGNFREDLYYRLSVFQIYLPPLRERGKDVILLAEYFLKKF
AKEYKKNCFELSEETKEYLMKQEWKGNVRELKNLIERAVILCEGEVIKPEDLGLKEKSWRDLSYLLKIKELKEAKKEFEK
IFIEEKLREYDYDLKRTAEEIGIDLSNLYRKIKSLNIRVKSS
>Mature_442_residues
MKRVLVVDDEESITSSLSAILEEEGYHPDTAKTLREAEKKIKELFFPVIVLDVWMPDGDGVNFIDFIKENSPDSVVIVIT
GHGSVDTAVKAIKKGAYEFLEKPFSVERFLLTIKHAFEEYSKKAPPQEEIEFVGEHPKILEIKRLIPKIAKSKAPVLITG
ESGTGKEIVARLIHRYSGRKGAFVDLNCASIPQELAESELFGHEKGAFTGALTRKKGKLELADQGTLFLDEVGELDQRVQ
AKLLRVLETGSFTRLGGNQKIEVDIRVISATNKNLEEEIKKGNFREDLYYRLSVFQIYLPPLRERGKDVILLAEYFLKKF
AKEYKKNCFELSEETKEYLMKQEWKGNVRELKNLIERAVILCEGEVIKPEDLGLKEKSWRDLSYLLKIKELKEAKKEFEK
IFIEEKLREYDYDLKRTAEEIGIDLSNLYRKIKSLNIRVKSS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=39.2935982339956, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=37.1794871794872, Blast_Score=311, Evalue=6e-86,
Organism=Escherichia coli, GI1790437, Length=437, Percent_Identity=39.1304347826087, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1788905, Length=428, Percent_Identity=35.0467289719626, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789233, Length=348, Percent_Identity=43.6781609195402, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI87082152, Length=320, Percent_Identity=41.5625, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1789087, Length=239, Percent_Identity=49.3723849372385, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082117, Length=307, Percent_Identity=42.3452768729642, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1786524, Length=407, Percent_Identity=33.9066339066339, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI87081872, Length=316, Percent_Identity=39.2405063291139, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1787583, Length=306, Percent_Identity=39.2156862745098, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1789828, Length=245, Percent_Identity=35.9183673469388, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081858, Length=356, Percent_Identity=26.685393258427, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786599, Length=125, Percent_Identity=31.2, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790552, Length=122, Percent_Identity=25.4098360655738, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786911, Length=136, Percent_Identity=30.8823529411765, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50742; Mature: 50742

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVLVVDDEESITSSLSAILEEEGYHPDTAKTLREAEKKIKELFFPVIVLDVWMPDGDG
CCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
VNFIDFIKENSPDSVVIVITGHGSVDTAVKAIKKGAYEFLEKPFSVERFLLTIKHAFEEY
CCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SKKAPPQEEIEFVGEHPKILEIKRLIPKIAKSKAPVLITGESGTGKEIVARLIHRYSGRK
HHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCC
GAFVDLNCASIPQELAESELFGHEKGAFTGALTRKKGKLELADQGTLFLDEVGELDQRVQ
CCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHH
AKLLRVLETGSFTRLGGNQKIEVDIRVISATNKNLEEEIKKGNFREDLYYRLSVFQIYLP
HHHHHHHHCCCEEECCCCCEEEEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
PLRERGKDVILLAEYFLKKFAKEYKKNCFELSEETKEYLMKQEWKGNVRELKNLIERAVI
CHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LCEGEVIKPEDLGLKEKSWRDLSYLLKIKELKEAKKEFEKIFIEEKLREYDYDLKRTAEE
HCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IGIDLSNLYRKIKSLNIRVKSS
HCCCHHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MKRVLVVDDEESITSSLSAILEEEGYHPDTAKTLREAEKKIKELFFPVIVLDVWMPDGDG
CCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
VNFIDFIKENSPDSVVIVITGHGSVDTAVKAIKKGAYEFLEKPFSVERFLLTIKHAFEEY
CCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SKKAPPQEEIEFVGEHPKILEIKRLIPKIAKSKAPVLITGESGTGKEIVARLIHRYSGRK
HHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCC
GAFVDLNCASIPQELAESELFGHEKGAFTGALTRKKGKLELADQGTLFLDEVGELDQRVQ
CCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHH
AKLLRVLETGSFTRLGGNQKIEVDIRVISATNKNLEEEIKKGNFREDLYYRLSVFQIYLP
HHHHHHHHCCCEEECCCCCEEEEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
PLRERGKDVILLAEYFLKKFAKEYKKNCFELSEETKEYLMKQEWKGNVRELKNLIERAVI
CHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LCEGEVIKPEDLGLKEKSWRDLSYLLKIKELKEAKKEFEKIFIEEKLREYDYDLKRTAEE
HCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IGIDLSNLYRKIKSLNIRVKSS
HCCCHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]