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The map label for this gene is cobW [H]

Identifier: 15605722

GI number: 15605722

Start: 89543

End: 90421

Strand: Direct

Name: cobW [H]

Synonym: aq_147

Alternate gene names: 15605722

Gene position: 89543-90421 (Clockwise)

Preceding gene: 15605721

Following gene: 15605723

Centisome position: 5.77

GC content: 43.34

Gene sequence:

>879_bases
ATGATTTCAGCGTTTGTTGTTACGGGATTTCTCGGAAGCGGTAAGACGAGTCTGATAATAAACTCCGTAAAGGAGCACCT
TAAAGATAAAAAGGTCGCGATAGTTGTAAACGAGTTCGGAGAGGTAGGAGTAGACGGAAAGATACTTAAAAACGTTTACT
CCGAAGTTCTGGAGCTTTCCGAAGGCTGTATTTGTTGCAAACTGAGTGCGGAATTTGAGAGTTCGGTCCGGAGGCTCATT
CAGGACTACAACCCGGAAGTTCTTATCGTAGAGACCTCCGGCGTAGCGGAGCCGTTTCCCATAGTGTTCAGTTTAAAGAC
TCTAGGGCTCTTCGTGGACGGAGTTATATGCGTTATTGACTCTAAAAACTTTCCGAAGTACAAAGAGGACGACACCGCAA
AGTACCAGCTCGCAACCTCAAACGTAGTCGTTTTAAACAAGACAGATTTAGTTTCAAAGGAAGAGCTGGAGAAAGTAAAG
GAAGAAGTGAAAAAGATAAAGGAAAAGTACAAAGTGGTGAACATGTTCTCCCCGGAAGAGAAGGAAAGCTTTTACAAAAT
TTACGAAGCTACTTATGGAAAAGTTCCAGCGGAAGTATTCAAAGGTGTCGGAAAACCCGTAGAGCTAAAGGAACACCTTC
ACTTTCACTCCCATGACAGCAGAAAGGAAGAAGTTGTAACCTTTGACAGAGAACTTACGGAAGAAGAACTCGTGAACTTC
CTGAAAAACCTGCCAAAGGAAGTTATACGTGCAAAGGGAATTGTTAAGTTAAAGGACTACCCCTTTCCCGTATTCGTCCA
CTACGTCTTCGGAGATTACGACTACGGAATGCCCGCGGAAAATTACGAAGGAGAGTCTTTCTTGGTTCTAATAAGATGA

Upstream 100 bases:

>100_bases
CTCCCAACCCTAAAAAGTGCAAAACGGGAACTAAAGAGTGCCTTTACTTTCCTGAGCCCGATTACGTTCTGGAAAAGGCA
ATACCTTATATTAAAGACTT

Downstream 100 bases:

>100_bases
TTGATGTAAGGAAGTACATAGACAACGCAGCCCTGAAACCTCACCTCTCTGAAAAAGAAATCGAAGAATTCGTCCTAAAG
TCTGAAGAACTCGGGATTTA

Product: cobalamin synthesis related protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MISAFVVTGFLGSGKTSLIINSVKEHLKDKKVAIVVNEFGEVGVDGKILKNVYSEVLELSEGCICCKLSAEFESSVRRLI
QDYNPEVLIVETSGVAEPFPIVFSLKTLGLFVDGVICVIDSKNFPKYKEDDTAKYQLATSNVVVLNKTDLVSKEELEKVK
EEVKKIKEKYKVVNMFSPEEKESFYKIYEATYGKVPAEVFKGVGKPVELKEHLHFHSHDSRKEEVVTFDRELTEEELVNF
LKNLPKEVIRAKGIVKLKDYPFPVFVHYVFGDYDYGMPAENYEGESFLVLIR

Sequences:

>Translated_292_residues
MISAFVVTGFLGSGKTSLIINSVKEHLKDKKVAIVVNEFGEVGVDGKILKNVYSEVLELSEGCICCKLSAEFESSVRRLI
QDYNPEVLIVETSGVAEPFPIVFSLKTLGLFVDGVICVIDSKNFPKYKEDDTAKYQLATSNVVVLNKTDLVSKEELEKVK
EEVKKIKEKYKVVNMFSPEEKESFYKIYEATYGKVPAEVFKGVGKPVELKEHLHFHSHDSRKEEVVTFDRELTEEELVNF
LKNLPKEVIRAKGIVKLKDYPFPVFVHYVFGDYDYGMPAENYEGESFLVLIR
>Mature_292_residues
MISAFVVTGFLGSGKTSLIINSVKEHLKDKKVAIVVNEFGEVGVDGKILKNVYSEVLELSEGCICCKLSAEFESSVRRLI
QDYNPEVLIVETSGVAEPFPIVFSLKTLGLFVDGVICVIDSKNFPKYKEDDTAKYQLATSNVVVLNKTDLVSKEELEKVK
EEVKKIKEKYKVVNMFSPEEKESFYKIYEATYGKVPAEVFKGVGKPVELKEHLHFHSHDSRKEEVVTFDRELTEEELVNF
LKNLPKEVIRAKGIVKLKDYPFPVFVHYVFGDYDYGMPAENYEGESFLVLIR

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI223941779, Length=291, Percent_Identity=28.8659793814433, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI33469141, Length=306, Percent_Identity=28.7581699346405, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI126722884, Length=306, Percent_Identity=28.7581699346405, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI148727351, Length=306, Percent_Identity=28.4313725490196, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI146231952, Length=301, Percent_Identity=27.906976744186, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI223941776, Length=296, Percent_Identity=28.7162162162162, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI119120938, Length=286, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788499, Length=171, Percent_Identity=28.0701754385965, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082430, Length=315, Percent_Identity=27.3015873015873, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=207, Percent_Identity=28.9855072463768, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 33160; Mature: 33160

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISAFVVTGFLGSGKTSLIINSVKEHLKDKKVAIVVNEFGEVGVDGKILKNVYSEVLELS
CCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHC
EGCICCKLSAEFESSVRRLIQDYNPEVLIVETSGVAEPFPIVFSLKTLGLFVDGVICVID
CCCEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEHHHHHHHHHCCEEEEEE
SKNFPKYKEDDTAKYQLATSNVVVLNKTDLVSKEELEKVKEEVKKIKEKYKVVNMFSPEE
CCCCCCCCCCCCCEEEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
KESFYKIYEATYGKVPAEVFKGVGKPVELKEHLHFHSHDSRKEEVVTFDRELTEEELVNF
HHHHHHHHHHHCCCCCHHHHHCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHH
LKNLPKEVIRAKGIVKLKDYPFPVFVHYVFGDYDYGMPAENYEGESFLVLIR
HHHHHHHHHHHCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MISAFVVTGFLGSGKTSLIINSVKEHLKDKKVAIVVNEFGEVGVDGKILKNVYSEVLELS
CCCEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHC
EGCICCKLSAEFESSVRRLIQDYNPEVLIVETSGVAEPFPIVFSLKTLGLFVDGVICVID
CCCEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEHHHHHHHHHCCEEEEEE
SKNFPKYKEDDTAKYQLATSNVVVLNKTDLVSKEELEKVKEEVKKIKEKYKVVNMFSPEE
CCCCCCCCCCCCCEEEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
KESFYKIYEATYGKVPAEVFKGVGKPVELKEHLHFHSHDSRKEEVVTFDRELTEEELVNF
HHHHHHHHHHHCCCCCHHHHHCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHH
LKNLPKEVIRAKGIVKLKDYPFPVFVHYVFGDYDYGMPAENYEGESFLVLIR
HHHHHHHHHHHCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]