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The map label for this gene is moeA1 [H]

Identifier: 15605633

GI number: 15605633

Start: 17053

End: 18261

Strand: Direct

Name: moeA1 [H]

Synonym: aq_030

Alternate gene names: 15605633

Gene position: 17053-18261 (Clockwise)

Preceding gene: 15605625

Following gene: 15605634

Centisome position: 1.1

GC content: 48.3

Gene sequence:

>1209_bases
ATGAAAAATTTGACACCCTTGGAAGAAGCCCTGAAGATCGTCTTGGAGAACGTAAAACCTCTGGAAAGTGAAAGGGTTTT
TATACACGAAGCTCTCGGAAGGGTTTTAGCGGAAGACGTAGTTTCCGATACGGATAAACCCTTGTTTGACAACTCCGCCA
TGGACGGGTATGCGGTGCGCTGGGAGGATATAAAGGAAGTGCCCGCCAAGTTAAAGGTAATAGGTGAGTACGCAGCGGGA
ACCGGGGAAAACTTAAAAGTGGAAAAGGGAACCGCGGTAAAGATATTCACGGGAGCTCCAATACCAGAGGGTGCGGATAC
GGTGGTACCCGTGGAGTATACGGAAACTCAGGACGGATACGTAATCGTTAAGAAGAGTTTCAAACAGGGAGCAAACGTAA
GGAGAAGGGGCGAAGACGTAAAAAAAGGAGAAGTGGTAATACCTAAAGGAAAGGAGATAAGACCTTATGAAATGGGAATG
CTCGCTTCAGTAAACAGGGCTGTGGTGAGTGTTTACAGAAAACCGCACGTGGGAATACTCTCCACGGGAGATGAGATACT
GGACGTGTGTGAAGAACAAACCAAACCTTCGCAGATAAGGACTTCTAACAACTACACCGTTTACGGGCAGGTTTTACAGG
CGGGAGGTATTCCTCACAACCTCGGCATAGCCCCCGACGAGCCTCAAAAACTGAAGGAAATTATGAGGAGTATACACAAG
TACGACATCTTCATAACCACGGGCGGTGTGTCCATGGGCGAAAAAGACTACGTCCAGTACCTCGTGGAAGACTTAGGTAT
AGACGTAAAGTTTCACAAACTCAGGATTAAACCGGCCAAACCCGTCCTTTTCGGCGTTTACGGAGAGAATAAACTCTTCT
TCGGACTTCCCGGAAATCCCGTCTCAGCAGCCGTAGCCTTTGACCTTCTCGTTTACCCTGCCATAAAAGCCATGCAAGGG
CACAGGGAAGTGTTTAAACAAAAGGTAACCGCTATCCTTGAGGGCGATTACAGGAGGAAGAACGCGGACAGGAGGGAGTT
CGCAAGGTGCAGGGTGTGGTTTGAGAACGGAAGGTACCACTGCGAACCTTATCCAAAACAGGACAGCCATATGCTCACCT
CCCTTGTTAACTCAAACGCCTACATGGTAGTTTACGAAGGCGTGAACGAGCTGAAGAAGGGGCAGGAGGTGGAAGTTATA
CTTTTCTAA

Upstream 100 bases:

>100_bases
TTGAAAAATGGTTTTTAAAGTTTCTAACTCTCTTTCTATAATCTTTGAGTACATCCTATTTAAAATTTAATTTTAGATTT
TTTCAGGAGGTAAAAAAATC

Downstream 100 bases:

>100_bases
GGGAGGGCAAAAGATGAATAAAAACGTATTTCTCGTTTTAGCCATTTTAGTTTTCTTCGGTGTCTTAATAACCTCCCCTT
TCGAAGGGAACGTCAACAAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKNLTPLEEALKIVLENVKPLESERVFIHEALGRVLAEDVVSDTDKPLFDNSAMDGYAVRWEDIKEVPAKLKVIGEYAAG
TGENLKVEKGTAVKIFTGAPIPEGADTVVPVEYTETQDGYVIVKKSFKQGANVRRRGEDVKKGEVVIPKGKEIRPYEMGM
LASVNRAVVSVYRKPHVGILSTGDEILDVCEEQTKPSQIRTSNNYTVYGQVLQAGGIPHNLGIAPDEPQKLKEIMRSIHK
YDIFITTGGVSMGEKDYVQYLVEDLGIDVKFHKLRIKPAKPVLFGVYGENKLFFGLPGNPVSAAVAFDLLVYPAIKAMQG
HREVFKQKVTAILEGDYRRKNADRREFARCRVWFENGRYHCEPYPKQDSHMLTSLVNSNAYMVVYEGVNELKKGQEVEVI
LF

Sequences:

>Translated_402_residues
MKNLTPLEEALKIVLENVKPLESERVFIHEALGRVLAEDVVSDTDKPLFDNSAMDGYAVRWEDIKEVPAKLKVIGEYAAG
TGENLKVEKGTAVKIFTGAPIPEGADTVVPVEYTETQDGYVIVKKSFKQGANVRRRGEDVKKGEVVIPKGKEIRPYEMGM
LASVNRAVVSVYRKPHVGILSTGDEILDVCEEQTKPSQIRTSNNYTVYGQVLQAGGIPHNLGIAPDEPQKLKEIMRSIHK
YDIFITTGGVSMGEKDYVQYLVEDLGIDVKFHKLRIKPAKPVLFGVYGENKLFFGLPGNPVSAAVAFDLLVYPAIKAMQG
HREVFKQKVTAILEGDYRRKNADRREFARCRVWFENGRYHCEPYPKQDSHMLTSLVNSNAYMVVYEGVNELKKGQEVEVI
LF
>Mature_402_residues
MKNLTPLEEALKIVLENVKPLESERVFIHEALGRVLAEDVVSDTDKPLFDNSAMDGYAVRWEDIKEVPAKLKVIGEYAAG
TGENLKVEKGTAVKIFTGAPIPEGADTVVPVEYTETQDGYVIVKKSFKQGANVRRRGEDVKKGEVVIPKGKEIRPYEMGM
LASVNRAVVSVYRKPHVGILSTGDEILDVCEEQTKPSQIRTSNNYTVYGQVLQAGGIPHNLGIAPDEPQKLKEIMRSIHK
YDIFITTGGVSMGEKDYVQYLVEDLGIDVKFHKLRIKPAKPVLFGVYGENKLFFGLPGNPVSAAVAFDLLVYPAIKAMQG
HREVFKQKVTAILEGDYRRKNADRREFARCRVWFENGRYHCEPYPKQDSHMLTSLVNSNAYMVVYEGVNELKKGQEVEVI
LF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=421, Percent_Identity=36.5795724465558, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI10880983, Length=421, Percent_Identity=36.5795724465558, Blast_Score=222, Evalue=4e-58,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=37.7604166666667, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=34.5345345345345, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562606, Length=346, Percent_Identity=23.4104046242775, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136978, Length=392, Percent_Identity=31.1224489795918, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24638841, Length=392, Percent_Identity=31.1224489795918, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45037; Mature: 45037

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTPLEEALKIVLENVKPLESERVFIHEALGRVLAEDVVSDTDKPLFDNSAMDGYAVR
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
WEDIKEVPAKLKVIGEYAAGTGENLKVEKGTAVKIFTGAPIPEGADTVVPVEYTETQDGY
HHHHHHCCHHHEEEEHHHCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCE
VIVKKSFKQGANVRRRGEDVKKGEVVIPKGKEIRPYEMGMLASVNRAVVSVYRKPHVGIL
EEEEECHHCCCCHHHCCCCCCCCCEECCCCCCCCCHHCCHHHHHHHHHHHHHCCCCCEEE
STGDEILDVCEEQTKPSQIRTSNNYTVYGQVLQAGGIPHNLGIAPDEPQKLKEIMRSIHK
ECCHHHHHHHHHCCCCCCEECCCCEEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
YDIFITTGGVSMGEKDYVQYLVEDLGIDVKFHKLRIKPAKPVLFGVYGENKLFFGLPGNP
EEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEECCCEEEEECCCCC
VSAAVAFDLLVYPAIKAMQGHREVFKQKVTAILEGDYRRKNADRREFARCRVWFENGRYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHEEEEEECCEEE
CEPYPKQDSHMLTSLVNSNAYMVVYEGVNELKKGQEVEVILF
CCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHCCCCEEEEEC
>Mature Secondary Structure
MKNLTPLEEALKIVLENVKPLESERVFIHEALGRVLAEDVVSDTDKPLFDNSAMDGYAVR
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
WEDIKEVPAKLKVIGEYAAGTGENLKVEKGTAVKIFTGAPIPEGADTVVPVEYTETQDGY
HHHHHHCCHHHEEEEHHHCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCE
VIVKKSFKQGANVRRRGEDVKKGEVVIPKGKEIRPYEMGMLASVNRAVVSVYRKPHVGIL
EEEEECHHCCCCHHHCCCCCCCCCEECCCCCCCCCHHCCHHHHHHHHHHHHHCCCCCEEE
STGDEILDVCEEQTKPSQIRTSNNYTVYGQVLQAGGIPHNLGIAPDEPQKLKEIMRSIHK
ECCHHHHHHHHHCCCCCCEECCCCEEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
YDIFITTGGVSMGEKDYVQYLVEDLGIDVKFHKLRIKPAKPVLFGVYGENKLFFGLPGNP
EEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEECCCEEEEECCCCC
VSAAVAFDLLVYPAIKAMQGHREVFKQKVTAILEGDYRRKNADRREFARCRVWFENGRYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHEEEEEECCEEE
CEPYPKQDSHMLTSLVNSNAYMVVYEGVNELKKGQEVEVILF
CCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]