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The map label for this gene is aroD

Identifier: 15605625

GI number: 15605625

Start: 9001

End: 9660

Strand: Direct

Name: aroD

Synonym: aq_021

Alternate gene names: 15605625

Gene position: 9001-9660 (Clockwise)

Preceding gene: 15605624

Following gene: 15605633

Centisome position: 0.58

GC content: 42.42

Gene sequence:

>660_bases
ATGCTCATCGCCGTTCCCCTTGATGATACAAACTTTTCCGAAAACTTAAAAAAGGCTAAGGAAAAGGGTGCGGATATTGT
AGAACTCCGTGTGGACCAGTTCTCAGACACTTCCTTAAATTACGTAAAGGAAAAACTGGAAGAAGTACATTCGCAAGGTT
TGAAAACGATACTGACTATACGCTCTCCCGAGGAGGGAGGAAGGGAAGTTAAAAACAGGGAAGAGCTCTTTGAAGAACTT
TCTCCCCTCAGCGATTACACGGATATAGAACTCTCTTCCAGAGGGCTTTTGGTAAAACTTTACAATATAACGAAAGAAGC
GGGAAAAAAGTTGATAATCTCCTACCACAACTTTGAGCTCACACCCCCTAACTGGATAATAAGGGAAGTTTTAAGGGAGG
GATACAGGTACGGAGGAATACCGAAGATAGCGGTAAAGGCAAACTCCTACGAAGATGTTGCAAGGCTTTTATGTATTTCC
AGACAGGTTGAGGGAGAAAAGATATTAATTTCCATGGGTGATTACGGAAAGATTTCAAGGCTCGCGGGATACGTTTTTGG
GTCCGTAATAACCTACTGCTCCTTAGAAAAGGCTTTCGCTCCTGGTCAAATTCCTTTAGAAGAGATGGTTGAGCTCAGAA
AGAAGTTCTACAGGCTTTAA

Upstream 100 bases:

>100_bases
CCCTCTCCAAAACAAAGAGGTGGGTTGTAGTAAAGATACTCCAGAGGGCCAGAAGACCTGAGGAAGAAATACAAAAACAA
CAGGAAGGACAAGAACAGTA

Downstream 100 bases:

>100_bases
ATTAAACTCCTCTGAAGTAATTCTCCTAACTCCGGAAATCTTTCAATAAAGAAGAAGTAGAACATATTTGCGGAAAAGTG
GGCAAAGGCTGGAGCGATTA

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MLIAVPLDDTNFSENLKKAKEKGADIVELRVDQFSDTSLNYVKEKLEEVHSQGLKTILTIRSPEEGGREVKNREELFEEL
SPLSDYTDIELSSRGLLVKLYNITKEAGKKLIISYHNFELTPPNWIIREVLREGYRYGGIPKIAVKANSYEDVARLLCIS
RQVEGEKILISMGDYGKISRLAGYVFGSVITYCSLEKAFAPGQIPLEEMVELRKKFYRL

Sequences:

>Translated_219_residues
MLIAVPLDDTNFSENLKKAKEKGADIVELRVDQFSDTSLNYVKEKLEEVHSQGLKTILTIRSPEEGGREVKNREELFEEL
SPLSDYTDIELSSRGLLVKLYNITKEAGKKLIISYHNFELTPPNWIIREVLREGYRYGGIPKIAVKANSYEDVARLLCIS
RQVEGEKILISMGDYGKISRLAGYVFGSVITYCSLEKAFAPGQIPLEEMVELRKKFYRL
>Mature_219_residues
MLIAVPLDDTNFSENLKKAKEKGADIVELRVDQFSDTSLNYVKEKLEEVHSQGLKTILTIRSPEEGGREVKNREELFEEL
SPLSDYTDIELSSRGLLVKLYNITKEAGKKLIISYHNFELTPPNWIIREVLREGYRYGGIPKIAVKANSYEDVARLLCIS
RQVEGEKILISMGDYGKISRLAGYVFGSVITYCSLEKAFAPGQIPLEEMVELRKKFYRL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=207, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_AQUAE (O66440)

Other databases:

- EMBL:   AE000657
- PIR:   E70301
- RefSeq:   NP_212999.1
- PDB:   2EGZ
- PDB:   2YSW
- PDBsum:   2EGZ
- PDBsum:   2YSW
- ProteinModelPortal:   O66440
- SMR:   O66440
- GeneID:   1192637
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_021
- NMPDR:   fig|224324.1.peg.14
- HOGENOM:   HBG732926
- OMA:   IAKLAVM
- PhylomeDB:   O66440
- ProtClustDB:   CLSK2748236
- BioCyc:   AAEO224324:AQ_021-MONOMER
- BRENDA:   4.2.1.10
- HAMAP:   MF_00214
- InterPro:   IPR018508
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 24971; Mature: 24971

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 116-116 ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIAVPLDDTNFSENLKKAKEKGADIVELRVDQFSDTSLNYVKEKLEEVHSQGLKTILTI
CEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHEEEEE
RSPEEGGREVKNREELFEELSPLSDYTDIELSSRGLLVKLYNITKEAGKKLIISYHNFEL
ECCCCCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEHHHHHHHCCCEEEEEECCEEE
TPPNWIIREVLREGYRYGGIPKIAVKANSYEDVARLLCISRQVEGEKILISMGDYGKISR
CCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHH
LAGYVFGSVITYCSLEKAFAPGQIPLEEMVELRKKFYRL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLIAVPLDDTNFSENLKKAKEKGADIVELRVDQFSDTSLNYVKEKLEEVHSQGLKTILTI
CEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHEEEEE
RSPEEGGREVKNREELFEELSPLSDYTDIELSSRGLLVKLYNITKEAGKKLIISYHNFEL
ECCCCCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEHHHHHHHCCCEEEEEECCEEE
TPPNWIIREVLREGYRYGGIPKIAVKANSYEDVARLLCISRQVEGEKILISMGDYGKISR
CCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHH
LAGYVFGSVITYCSLEKAFAPGQIPLEEMVELRKKFYRL
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320