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The map label for this gene is secY

Identifier: 11499486

GI number: 11499486

Start: 1712876

End: 1714357

Strand: Reverse

Name: secY

Synonym: AF1902

Alternate gene names: 11499486

Gene position: 1714357-1712876 (Counterclockwise)

Preceding gene: 11499487

Following gene: 11499485

Centisome position: 78.7

GC content: 49.19

Gene sequence:

>1482_bases
TTGGACTCCGTGATAAGAGCCTTACAACCTTATTTTGAGCGCATACCCAGTGTAGAGAGGCCAAAGGGACATGTCCACTT
CAGGGAGAAATTTGGATGGACTGCGGCAATACTCCTTCTCTACTTTATCCTGTCCAATGTTCCCGTTTTTGGCCTCTCTC
CTGAGTCAATAGATATATTTGCTGCCTACAGAGCCCTTTTTGCTGGTTCTACGGGCTCAATAATTGCCCTCGGTATAGGG
CCGATTGTTACTGCCTCAATCATCCTTCAGCTGCTGGTTGGTGCCGGCATAATAAAACTTGATTTGACAAATCCAGAAGA
CAGGGCAGCTTATCAGGACTTCCAGCGCTTCCTTGTTTTTGTGATGATTGCAGTTGAAGCTATACCGCAGATTGCCGGAG
GGCTTTTAAAGCCCGATTTAAACCTTGCAGCCCAGCTTGGCGTCTCTCCGGGCATAATTTCATTCCTCATATTCATTCAG
CTCTTCATCGGTGGAGTTTTGATAGTATATATGGATGAGGTTGTTTCAAAGTGGGGCATTGGCAGCGGTGTCTCGCTCTT
CATCCTCGCTGGAATCGCTCAGTCCATTGTGGTTGGCCTATTCAACTGGGTCATTCCACCGAACTCAGCAATGCCAGCAG
GTATAATCCCAAGGTGGATCTGGATAGCCCAGAACTATCCGCTCGACCAGCTTTTCACAGGGAGCGGGCTGGCTTTCCTG
CTGATCCAGGGTGGCATTCTTGCTCTGATTACCACTGCTGCAATAATCCTGCTTGTTGTCTTCTTTGAGGGAACGAGGGT
TGAAATTCCTCTGGCTCATGCAGTTGCAAGAGGTGCGAGGGGTAGATTTCCAATAAAGCTCATTTACGCCAGCGTTTTGC
CAATGATTTTCGTTAGAGCACTGCAGGCCAACGTCGTGGCCTTAGGTCAGGTTCTTCACGCGAGGGGAGTGACGATTTTC
GGAGAGTTTGTTAACGGAAAGGCAGTAAGCGGTCTGATGTTCTTCCTCCAACCCGTCAGCAGCCCCTACGACTGGATCCC
CTCGCTCGTTAAATCACAGGGAGCAGCCTTTGCGGCAATTCCGGACTGGATGATTTACCTTCATTTGCTGATTGACGCCC
TTATTTTGGTTGTTGGCGGTATAATCTTTGCATGGTTCTGGGTTGAGACGAGCGGAATGGATGCAAGGACTGTAGCATCT
CAGATTGCCAAGTCTGGAATGCAGGTTCCGGGCTTCAGGAAGTCCCCACAGGTCCTTGAGAGAGTGCTTTCGAGGTACAT
CCCGAAGGTTACAATCCTTGGTGGTGCGATAATTGGCATTCTGACGCTTGTAGCCAACATGCTTGGAACAATTGGTAATG
TGAGTGGAACAGGACTTTTACTTGCTGTGAGCATTGCCTACAGATTCTACGAGGATCTGGCCAAGGAACAGCTCACTGAG
ATGCATCCGCTCATCAGAAGGATGCTCGGTGAAGAAGCATGA

Upstream 100 bases:

>100_bases
GGAAAATGGAGGTTAAAGTCTTTGAGGCAACGCCCAAGGCTGTCGAGAAGATTGAGGCTGCTGGAGGTAAGGTAGTGGCT
GAGTAAAGGGGTTGATCGAA

Downstream 100 bases:

>100_bases
AGGCGGTAATTTCAAGGTTCATAATGGTTCTTGGAGCTTTATTTTTCATTGGCATACTCTTCAGCAGGGAGTTCAGGCTG
GAGCTTGGACAGATTGTAGA

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MDSVIRALQPYFERIPSVERPKGHVHFREKFGWTAAILLLYFILSNVPVFGLSPESIDIFAAYRALFAGSTGSIIALGIG
PIVTASIILQLLVGAGIIKLDLTNPEDRAAYQDFQRFLVFVMIAVEAIPQIAGGLLKPDLNLAAQLGVSPGIISFLIFIQ
LFIGGVLIVYMDEVVSKWGIGSGVSLFILAGIAQSIVVGLFNWVIPPNSAMPAGIIPRWIWIAQNYPLDQLFTGSGLAFL
LIQGGILALITTAAIILLVVFFEGTRVEIPLAHAVARGARGRFPIKLIYASVLPMIFVRALQANVVALGQVLHARGVTIF
GEFVNGKAVSGLMFFLQPVSSPYDWIPSLVKSQGAAFAAIPDWMIYLHLLIDALILVVGGIIFAWFWVETSGMDARTVAS
QIAKSGMQVPGFRKSPQVLERVLSRYIPKVTILGGAIIGILTLVANMLGTIGNVSGTGLLLAVSIAYRFYEDLAKEQLTE
MHPLIRRMLGEEA

Sequences:

>Translated_493_residues
MDSVIRALQPYFERIPSVERPKGHVHFREKFGWTAAILLLYFILSNVPVFGLSPESIDIFAAYRALFAGSTGSIIALGIG
PIVTASIILQLLVGAGIIKLDLTNPEDRAAYQDFQRFLVFVMIAVEAIPQIAGGLLKPDLNLAAQLGVSPGIISFLIFIQ
LFIGGVLIVYMDEVVSKWGIGSGVSLFILAGIAQSIVVGLFNWVIPPNSAMPAGIIPRWIWIAQNYPLDQLFTGSGLAFL
LIQGGILALITTAAIILLVVFFEGTRVEIPLAHAVARGARGRFPIKLIYASVLPMIFVRALQANVVALGQVLHARGVTIF
GEFVNGKAVSGLMFFLQPVSSPYDWIPSLVKSQGAAFAAIPDWMIYLHLLIDALILVVGGIIFAWFWVETSGMDARTVAS
QIAKSGMQVPGFRKSPQVLERVLSRYIPKVTILGGAIIGILTLVANMLGTIGNVSGTGLLLAVSIAYRFYEDLAKEQLTE
MHPLIRRMLGEEA
>Mature_493_residues
MDSVIRALQPYFERIPSVERPKGHVHFREKFGWTAAILLLYFILSNVPVFGLSPESIDIFAAYRALFAGSTGSIIALGIG
PIVTASIILQLLVGAGIIKLDLTNPEDRAAYQDFQRFLVFVMIAVEAIPQIAGGLLKPDLNLAAQLGVSPGIISFLIFIQ
LFIGGVLIVYMDEVVSKWGIGSGVSLFILAGIAQSIVVGLFNWVIPPNSAMPAGIIPRWIWIAQNYPLDQLFTGSGLAFL
LIQGGILALITTAAIILLVVFFEGTRVEIPLAHAVARGARGRFPIKLIYASVLPMIFVRALQANVVALGQVLHARGVTIF
GEFVNGKAVSGLMFFLQPVSSPYDWIPSLVKSQGAAFAAIPDWMIYLHLLIDALILVVGGIIFAWFWVETSGMDARTVAS
QIAKSGMQVPGFRKSPQVLERVLSRYIPKVTILGGAIIGILTLVANMLGTIGNVSGTGLLLAVSIAYRFYEDLAKEQLTE
MHPLIRRMLGEEA

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family

Homologues:

Organism=Homo sapiens, GI14589847, Length=495, Percent_Identity=31.9191919191919, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI7019415, Length=495, Percent_Identity=31.1111111111111, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI217330618, Length=495, Percent_Identity=30.1010101010101, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI217330616, Length=450, Percent_Identity=29.5555555555556, Blast_Score=168, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17543770, Length=489, Percent_Identity=30.6748466257669, Blast_Score=202, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323411, Length=508, Percent_Identity=27.3622047244095, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319760, Length=475, Percent_Identity=24.2105263157895, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19920826, Length=515, Percent_Identity=30.2912621359223, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECY_ARCFU (O28377)

Other databases:

- EMBL:   AE000782
- PIR:   E69487
- RefSeq:   NP_070727.1
- ProteinModelPortal:   O28377
- SMR:   O28377
- GeneID:   1485125
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1902
- NMPDR:   fig|224325.1.peg.1888
- TIGR:   AF_1902
- HOGENOM:   HBG589438
- OMA:   NIQLWAR
- ProtClustDB:   PRK08568
- BioCyc:   AFUL224325:AF_1902-MONOMER
- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561
- PANTHER:   PTHR10906
- PIRSF:   PIRSF004557
- PRINTS:   PR00303
- TIGRFAMs:   TIGR00967

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY; SSF103491 SecY

EC number: NA

Molecular weight: Translated: 53352; Mature: 53352

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00755 SECY_1; PS00756 SECY_2; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd284d08)-; HASH(0xc511b98)-; HASH(0xbf5a9a8)-; HASH(0xd9938bc)-; HASH(0xb822d74)-; HASH(0xb3fc140)-; HASH(0xd01c71c)-; HASH(0x43378ef0)-; HASH(0x40454054)-; HASH(0xbf87418)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSVIRALQPYFERIPSVERPKGHVHFREKFGWTAAILLLYFILSNVPVFGLSPESIDIF
CCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCHHHHHHHHHHHHHCCCEECCCCCCHHHH
AAYRALFAGSTGSIIALGIGPIVTASIILQLLVGAGIIKLDLTNPEDRAAYQDFQRFLVF
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHH
VMIAVEAIPQIAGGLLKPDLNLAAQLGVSPGIISFLIFIQLFIGGVLIVYMDEVVSKWGI
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSGVSLFILAGIAQSIVVGLFNWVIPPNSAMPAGIIPRWIWIAQNYPLDQLFTGSGLAFL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCCCHHHHCCCCCHHHH
LIQGGILALITTAAIILLVVFFEGTRVEIPLAHAVARGARGRFPIKLIYASVLPMIFVRA
HHHCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LQANVVALGQVLHARGVTIFGEFVNGKAVSGLMFFLQPVSSPYDWIPSLVKSQGAAFAAI
HHHHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEH
PDWMIYLHLLIDALILVVGGIIFAWFWVETSGMDARTVASQIAKSGMQVPGFRKSPQVLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHH
RVLSRYIPKVTILGGAIIGILTLVANMLGTIGNVSGTGLLLAVSIAYRFYEDLAKEQLTE
HHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MHPLIRRMLGEEA
HHHHHHHHHCCCH
>Mature Secondary Structure
MDSVIRALQPYFERIPSVERPKGHVHFREKFGWTAAILLLYFILSNVPVFGLSPESIDIF
CCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCHHHHHHHHHHHHHCCCEECCCCCCHHHH
AAYRALFAGSTGSIIALGIGPIVTASIILQLLVGAGIIKLDLTNPEDRAAYQDFQRFLVF
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHH
VMIAVEAIPQIAGGLLKPDLNLAAQLGVSPGIISFLIFIQLFIGGVLIVYMDEVVSKWGI
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GSGVSLFILAGIAQSIVVGLFNWVIPPNSAMPAGIIPRWIWIAQNYPLDQLFTGSGLAFL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCCCHHHHCCCCCHHHH
LIQGGILALITTAAIILLVVFFEGTRVEIPLAHAVARGARGRFPIKLIYASVLPMIFVRA
HHHCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LQANVVALGQVLHARGVTIFGEFVNGKAVSGLMFFLQPVSSPYDWIPSLVKSQGAAFAAI
HHHHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEH
PDWMIYLHLLIDALILVVGGIIFAWFWVETSGMDARTVASQIAKSGMQVPGFRKSPQVLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHH
RVLSRYIPKVTILGGAIIGILTLVANMLGTIGNVSGTGLLLAVSIAYRFYEDLAKEQLTE
HHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MHPLIRRMLGEEA
HHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9389475