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Identifier: 11499314

GI number: 11499314

Start: 1548270

End: 1549211

Strand: Reverse

Name: Not Available

Synonym: AF1725

Alternate gene names: NA

Gene position: 1549211-1548270 (Counterclockwise)

Preceding gene: 11499315

Following gene: 11499309

Centisome position: 71.12

GC content: 49.36

Gene sequence:

>942_bases
ATGAGCTGGTTCGATAAAAAAATCAAGCCGATGCTTGCTGTCAGGTCAAAGCCCTTCAGCAGCGACGACCACATTTACGA
GGTTAAGTGGGATGGAACGAGGTGCCTCGCTTTCGTTGATGTGGAGGGAAAGAGGGTCAGGCTGCAGAACAGAAGGCTAC
TGGACATAACCTACCGCTACCCCGAGATTAAACTGCTGGATGCTGTCGAGAGAAACGCGATTCTCGACGGTGAGGTTGTT
GTGATAAAGGACGGTAAGCCCTCCTTCCCTCTTCTGCAGAAAAGAGAGCATGTGGACAGCAGATTCAAGATTGAGATTCT
CAGCAAAACCATTCCCGCAGTTTACATAGTTTTCGACGTTCTTTACTGCGACGGCTGGGTTGTGGATTTGGAGCTGATGG
AGAGGAAGAAGATACTCTCCGAAGTTCTCCAAAGCAGGGGAAGGGTTGTGGTGGAGGAGTGGATTGAAGGTAAAGGGGAG
GAGTTCTACAGAAAAGCGGTGGAAATGGGGCTTGAAGGGATTGTAGCAAAGAAAAAGGATGGAAGATACTTGATAGGCAA
AAGGAGCAGACTCTGGAAGAAGATAAAGAAGAGGAACACACTGGACTGCGTTATAGTGGGATGGATTGAGGGAGAGGGAG
AGAGGGCAAAGACCTTTGGCTCCCTCGTTCTGGCTGTTTACGAGGATGGAAGGCTTAAACATGTCGGCAACGTTGGTACC
GGCTTTGATTCTGAGTTTCTGAACTGGTTCTCGGAGAGGTTGAGGGAAATAGAGGTTGCAAAGCCGCACTTCGAAATCGA
GACCAAAAACGTTCACTGGGTTAAGCCGAGATACGTCTGCGAGGTGGAGTTCCTCGAGTTCACCGAAGACGGGAAGCTCA
GAGCACCGGTGTTTCTGAGACTGAGAGAGGACAAAAGTCCCGATGAATGCAGGATTGATTAA

Upstream 100 bases:

>100_bases
TTGAGGCGAAGCTCTCCGGCAGAGAGATTGTTGTCAGCGAGGGAGTTGAAGAGGTTAAATCGCTGATTGATGCGTTGAAA
GCCAGTCTTGAGGCAGTCAA

Downstream 100 bases:

>100_bases
GTGAGCTTAACAATTCTCATGTGCAATTCGTAGAGCTTCGTCGCCAGCTCCTCTAGGAACTCTCTGTCTTTCAGCCCCTC
AAGCCACCTCTCGGGAATTG

Product: DNA ligase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSWFDKKIKPMLAVRSKPFSSDDHIYEVKWDGTRCLAFVDVEGKRVRLQNRRLLDITYRYPEIKLLDAVERNAILDGEVV
VIKDGKPSFPLLQKREHVDSRFKIEILSKTIPAVYIVFDVLYCDGWVVDLELMERKKILSEVLQSRGRVVVEEWIEGKGE
EFYRKAVEMGLEGIVAKKKDGRYLIGKRSRLWKKIKKRNTLDCVIVGWIEGEGERAKTFGSLVLAVYEDGRLKHVGNVGT
GFDSEFLNWFSERLREIEVAKPHFEIETKNVHWVKPRYVCEVEFLEFTEDGKLRAPVFLRLREDKSPDECRID

Sequences:

>Translated_313_residues
MSWFDKKIKPMLAVRSKPFSSDDHIYEVKWDGTRCLAFVDVEGKRVRLQNRRLLDITYRYPEIKLLDAVERNAILDGEVV
VIKDGKPSFPLLQKREHVDSRFKIEILSKTIPAVYIVFDVLYCDGWVVDLELMERKKILSEVLQSRGRVVVEEWIEGKGE
EFYRKAVEMGLEGIVAKKKDGRYLIGKRSRLWKKIKKRNTLDCVIVGWIEGEGERAKTFGSLVLAVYEDGRLKHVGNVGT
GFDSEFLNWFSERLREIEVAKPHFEIETKNVHWVKPRYVCEVEFLEFTEDGKLRAPVFLRLREDKSPDECRID
>Mature_312_residues
SWFDKKIKPMLAVRSKPFSSDDHIYEVKWDGTRCLAFVDVEGKRVRLQNRRLLDITYRYPEIKLLDAVERNAILDGEVVV
IKDGKPSFPLLQKREHVDSRFKIEILSKTIPAVYIVFDVLYCDGWVVDLELMERKKILSEVLQSRGRVVVEEWIEGKGEE
FYRKAVEMGLEGIVAKKKDGRYLIGKRSRLWKKIKKRNTLDCVIVGWIEGEGERAKTFGSLVLAVYEDGRLKHVGNVGTG
FDSEFLNWFSERLREIEVAKPHFEIETKNVHWVKPRYVCEVEFLEFTEDGKLRAPVFLRLREDKSPDECRID

Specific function: Unknown

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=356, Percent_Identity=28.6516853932584, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71985269, Length=358, Percent_Identity=25.9776536312849, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320038, Length=349, Percent_Identity=28.080229226361, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24762424, Length=356, Percent_Identity=29.2134831460674, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR014146
- InterPro:   IPR002755
- InterPro:   IPR014144
- InterPro:   IPR014145
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF01896 DNA_primase_S [H]

EC number: NA

Molecular weight: Translated: 36643; Mature: 36512

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWFDKKIKPMLAVRSKPFSSDDHIYEVKWDGTRCLAFVDVEGKRVRLQNRRLLDITYRY
CCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEECCCCEEEECCCEEEEEEEEC
PEIKLLDAVERNAILDGEVVVIKDGKPSFPLLQKREHVDSRFKIEILSKTIPAVYIVFDV
CCEEEEHHHHHCCEECCCEEEEECCCCCCCHHHHHHCCCCEEEEEEHHHHCCHHHHHHHH
LYCDGWVVDLELMERKKILSEVLQSRGRVVVEEWIEGKGEEFYRKAVEMGLEGIVAKKKD
HHCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHCHHHEEEECCC
GRYLIGKRSRLWKKIKKRNTLDCVIVGWIEGEGERAKTFGSLVLAVYEDGRLKHVGNVGT
CCEEECCHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHEEEEEEECCCCEEECCCCCC
GFDSEFLNWFSERLREIEVAKPHFEIETKNVHWVKPRYVCEVEFLEFTEDGKLRAPVFLR
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCEEEEEEEEEECCCCCEECCEEEE
LREDKSPDECRID
EECCCCCCCCCCC
>Mature Secondary Structure 
SWFDKKIKPMLAVRSKPFSSDDHIYEVKWDGTRCLAFVDVEGKRVRLQNRRLLDITYRY
CCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEECCCCEEEECCCEEEEEEEEC
PEIKLLDAVERNAILDGEVVVIKDGKPSFPLLQKREHVDSRFKIEILSKTIPAVYIVFDV
CCEEEEHHHHHCCEECCCEEEEECCCCCCCHHHHHHCCCCEEEEEEHHHHCCHHHHHHHH
LYCDGWVVDLELMERKKILSEVLQSRGRVVVEEWIEGKGEEFYRKAVEMGLEGIVAKKKD
HHCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHCHHHEEEECCC
GRYLIGKRSRLWKKIKKRNTLDCVIVGWIEGEGERAKTFGSLVLAVYEDGRLKHVGNVGT
CCEEECCHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHEEEEEEECCCCEEECCCCCC
GFDSEFLNWFSERLREIEVAKPHFEIETKNVHWVKPRYVCEVEFLEFTEDGKLRAPVFLR
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCEEEEEEEEEECCCCCEECCEEEE
LREDKSPDECRID
EECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]