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Identifier: 11499010

GI number: 11499010

Start: 1274153

End: 1275922

Strand: Reverse

Name: Not Available

Synonym: AF1415

Alternate gene names: 11499010

Gene position: 1275922-1274153 (Counterclockwise)

Preceding gene: 11499011

Following gene: 11499009

Centisome position: 58.57

GC content: 48.47

Gene sequence:

>1770_bases
GTGAAAAGAAGGGCGCCATTAAGCTCCAAGTACCTCATACTTCTGGCCGCTATTGTGGGTGTAATCTCCGGCTTAGGAGC
CTTCATCTTTTACTTCCTACTTGACCTATTCACAAAAATTTTCCTTTCCGGATTGGACAGCTTTAATCCGCCTCTCGCCG
GAGGAGAAGCTGAGGTAGTAAAGATAGAACTTCATCTGGGGATACTACCTCTGCCTGTTGTTGTTGCTCTTGGAGGACTG
CTGAGCGGGTTGATTGTTTACAAATTCGCACCGGAAGCAGAGGGTCACGGCACAGATGCTGTAATAAGAGCCTTTCACAG
AGCAAGAGGTGAGATAAGGGCTAGAGTGCCTATCGTTAAAACAATTGCCTCAGCAATCACAATCGGAAGCGGTGGTAGTG
CCGGGAGAGAGGGGCCAATAGCTCAGATAGGGGCAGGTTTTGGCTCATTTGTCGGGGAGTTGCTGAGATTGTCCGACAAG
GATAGAAGAATTCTGGTTATCTGCGGTGTTGCGGGGGGCATAGGGAGCATTTTCAGAAGCCCGTTCGGAGGGGCAATGTT
CGGGATTGAGGTCCTTTACAAGAGGGATAACGAGGTTGAGGCAATCGTTCCCGCGTTTGTGTCGTCCATTGTGGCTTTCA
TAGTATTCGACGTGATAATGAGCTACTTCGCAAACACACCCTTCGGAGTTCTACCGATTTTCAAAATCCCGCAGGTTACG
ATTCACTCACCGCTTGAGTTTCCAATTTACGCGATCGTTTCGGTCTTGGCAGCGTTTTTTGGCATTATTTACGTTAAAGT
TTTTTACACTGTCCATAACTACTCTAAGAGGGTCAGCATTCCCCCTTACTTCAAGCCGGCGATCGGAGGGTTCTTCACCG
GAGTTATAGGGCTGTTTTTACCCGGAGTTCTCGGTATGGGGTACGGTTACGTTCAGATGGCCATCGACGGTAAACTTGCA
GTAACGGTAATGCTTCTTTTGATTTTTGGCAAAATCGTTGCCACTTCTCTTACAGTTGGAACCGGTGGTAGCGGGGGAGT
CTTTGCTCCTTCTATAGTGATAGGGAGCATGGTTGGCGGATTCGTAGGCTACTCCTTCCACTACCTCTTTCCGAACGTTA
TTGTTCAGCCAGAAGCCTTCGTTCTGATAGGCATGTCTGCCTTTGTCGCAGCGGTGGCAAAAACACCGATCGCAGCGATT
TTAATGGTTCTTGAAATGTGTGGCGGGTACTCGCTCCTTCCAGCTTTAATGACTGCTGCAACTCTTGCGTACTATCTCGC
TGGAGATTACTCAATTTATGCTGAGCAAGTAGCAACGAGGGCCGAGAGTCCTGCACACAGGATGGAGATGTCAATCGACG
TTCTTGAAAATGTGAGAGTTCAGGATGCGATGGTGTCAGCAGACAAGCTCGTGGTCGTTACGCCCTATCAGAGAGTGAGC
GAAGTCCTCGAACTTATTGAGAAAACGGGTCACATGGGTTTTCCGGTAGTGATGGACGGCAGGTTAGTTGGAATGGTTAC
TTTCGAGGACGTTGAGAGAGTTCCGCTGGAGGAGAGGGACAAAAAGCTTGTCAGGGATATCATGACGAGGGAACTGATTG
TCACGTATCCTGACGAAACGCTTGAGGAGGCTTTGATAAAGCTGGTGGACAAAGGAATAGGCAGACTCCCGGTAGTTGAC
CGCAACGACGAGAAAAAGCTTTTAGGAATTATAACAAGAAGCGACATAATGAAAGCCCACGCAAGAGAGGTTAAGAGGAT
AGTTTCATGA

Upstream 100 bases:

>100_bases
CCTACTGCTGGCAGCACAAAAATTCGAAATGGCAATTTTGTAAGTTGGTGACAGAATCTGAAAGAAAAATATATCATCAC
TCCCCCAGCAAAAACGAAGC

Downstream 100 bases:

>100_bases
GGGTCTTGCTCGTCACGGGGAAGCTGGCTGAGGAAATGGTGAGGAAATATGGCAAGGGTGCTGACGTTAAAGTGTACAAC
ATAGACATTGCGGCCTTCAT

Product: chloride channel, putative

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MKRRAPLSSKYLILLAAIVGVISGLGAFIFYFLLDLFTKIFLSGLDSFNPPLAGGEAEVVKIELHLGILPLPVVVALGGL
LSGLIVYKFAPEAEGHGTDAVIRAFHRARGEIRARVPIVKTIASAITIGSGGSAGREGPIAQIGAGFGSFVGELLRLSDK
DRRILVICGVAGGIGSIFRSPFGGAMFGIEVLYKRDNEVEAIVPAFVSSIVAFIVFDVIMSYFANTPFGVLPIFKIPQVT
IHSPLEFPIYAIVSVLAAFFGIIYVKVFYTVHNYSKRVSIPPYFKPAIGGFFTGVIGLFLPGVLGMGYGYVQMAIDGKLA
VTVMLLLIFGKIVATSLTVGTGGSGGVFAPSIVIGSMVGGFVGYSFHYLFPNVIVQPEAFVLIGMSAFVAAVAKTPIAAI
LMVLEMCGGYSLLPALMTAATLAYYLAGDYSIYAEQVATRAESPAHRMEMSIDVLENVRVQDAMVSADKLVVVTPYQRVS
EVLELIEKTGHMGFPVVMDGRLVGMVTFEDVERVPLEERDKKLVRDIMTRELIVTYPDETLEEALIKLVDKGIGRLPVVD
RNDEKKLLGIITRSDIMKAHAREVKRIVS

Sequences:

>Translated_589_residues
MKRRAPLSSKYLILLAAIVGVISGLGAFIFYFLLDLFTKIFLSGLDSFNPPLAGGEAEVVKIELHLGILPLPVVVALGGL
LSGLIVYKFAPEAEGHGTDAVIRAFHRARGEIRARVPIVKTIASAITIGSGGSAGREGPIAQIGAGFGSFVGELLRLSDK
DRRILVICGVAGGIGSIFRSPFGGAMFGIEVLYKRDNEVEAIVPAFVSSIVAFIVFDVIMSYFANTPFGVLPIFKIPQVT
IHSPLEFPIYAIVSVLAAFFGIIYVKVFYTVHNYSKRVSIPPYFKPAIGGFFTGVIGLFLPGVLGMGYGYVQMAIDGKLA
VTVMLLLIFGKIVATSLTVGTGGSGGVFAPSIVIGSMVGGFVGYSFHYLFPNVIVQPEAFVLIGMSAFVAAVAKTPIAAI
LMVLEMCGGYSLLPALMTAATLAYYLAGDYSIYAEQVATRAESPAHRMEMSIDVLENVRVQDAMVSADKLVVVTPYQRVS
EVLELIEKTGHMGFPVVMDGRLVGMVTFEDVERVPLEERDKKLVRDIMTRELIVTYPDETLEEALIKLVDKGIGRLPVVD
RNDEKKLLGIITRSDIMKAHAREVKRIVS
>Mature_589_residues
MKRRAPLSSKYLILLAAIVGVISGLGAFIFYFLLDLFTKIFLSGLDSFNPPLAGGEAEVVKIELHLGILPLPVVVALGGL
LSGLIVYKFAPEAEGHGTDAVIRAFHRARGEIRARVPIVKTIASAITIGSGGSAGREGPIAQIGAGFGSFVGELLRLSDK
DRRILVICGVAGGIGSIFRSPFGGAMFGIEVLYKRDNEVEAIVPAFVSSIVAFIVFDVIMSYFANTPFGVLPIFKIPQVT
IHSPLEFPIYAIVSVLAAFFGIIYVKVFYTVHNYSKRVSIPPYFKPAIGGFFTGVIGLFLPGVLGMGYGYVQMAIDGKLA
VTVMLLLIFGKIVATSLTVGTGGSGGVFAPSIVIGSMVGGFVGYSFHYLFPNVIVQPEAFVLIGMSAFVAAVAKTPIAAI
LMVLEMCGGYSLLPALMTAATLAYYLAGDYSIYAEQVATRAESPAHRMEMSIDVLENVRVQDAMVSADKLVVVTPYQRVS
EVLELIEKTGHMGFPVVMDGRLVGMVTFEDVERVPLEERDKKLVRDIMTRELIVTYPDETLEEALIKLVDKGIGRLPVVD
RNDEKKLLGIITRSDIMKAHAREVKRIVS

Specific function: Selective chloride channel [C]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=378, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87081943, Length=339, Percent_Identity=27.4336283185841, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17532615, Length=587, Percent_Identity=21.4650766609881, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665008, Length=610, Percent_Identity=21.9672131147541, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 63444; Mature: 63444

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRAPLSSKYLILLAAIVGVISGLGAFIFYFLLDLFTKIFLSGLDSFNPPLAGGEAEVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
KIELHLGILPLPVVVALGGLLSGLIVYKFAPEAEGHGTDAVIRAFHRARGEIRARVPIVK
EEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCHHHCCHHHH
TIASAITIGSGGSAGREGPIAQIGAGFGSFVGELLRLSDKDRRILVICGVAGGIGSIFRS
HHHHHHEECCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHC
PFGGAMFGIEVLYKRDNEVEAIVPAFVSSIVAFIVFDVIMSYFANTPFGVLPIFKIPQVT
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
IHSPLEFPIYAIVSVLAAFFGIIYVKVFYTVHNYSKRVSIPPYFKPAIGGFFTGVIGLFL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
PGVLGMGYGYVQMAIDGKLAVTVMLLLIFGKIVATSLTVGTGGSGGVFAPSIVIGSMVGG
HHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHH
FVGYSFHYLFPNVIVQPEAFVLIGMSAFVAAVAKTPIAAILMVLEMCGGYSLLPALMTAA
HHHHHHHHHCCCCEECCCHHEEECHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHH
TLAYYLAGDYSIYAEQVATRAESPAHRMEMSIDVLENVRVQDAMVSADKLVVVTPYQRVS
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCEEEECCHHHHH
EVLELIEKTGHMGFPVVMDGRLVGMVTFEDVERVPLEERDKKLVRDIMTRELIVTYPDET
HHHHHHHHCCCCCCCEEECCEEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCEEEECCCHH
LEEALIKLVDKGIGRLPVVDRNDEKKLLGIITRSDIMKAHAREVKRIVS
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRRAPLSSKYLILLAAIVGVISGLGAFIFYFLLDLFTKIFLSGLDSFNPPLAGGEAEVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
KIELHLGILPLPVVVALGGLLSGLIVYKFAPEAEGHGTDAVIRAFHRARGEIRARVPIVK
EEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCHHHCCHHHH
TIASAITIGSGGSAGREGPIAQIGAGFGSFVGELLRLSDKDRRILVICGVAGGIGSIFRS
HHHHHHEECCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHC
PFGGAMFGIEVLYKRDNEVEAIVPAFVSSIVAFIVFDVIMSYFANTPFGVLPIFKIPQVT
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
IHSPLEFPIYAIVSVLAAFFGIIYVKVFYTVHNYSKRVSIPPYFKPAIGGFFTGVIGLFL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
PGVLGMGYGYVQMAIDGKLAVTVMLLLIFGKIVATSLTVGTGGSGGVFAPSIVIGSMVGG
HHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHH
FVGYSFHYLFPNVIVQPEAFVLIGMSAFVAAVAKTPIAAILMVLEMCGGYSLLPALMTAA
HHHHHHHHHCCCCEECCCHHEEECHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHH
TLAYYLAGDYSIYAEQVATRAESPAHRMEMSIDVLENVRVQDAMVSADKLVVVTPYQRVS
HHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCEEEECCHHHHH
EVLELIEKTGHMGFPVVMDGRLVGMVTFEDVERVPLEERDKKLVRDIMTRELIVTYPDET
HHHHHHHHCCCCCCCEEECCEEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCEEEECCCHH
LEEALIKLVDKGIGRLPVVDRNDEKKLLGIITRSDIMKAHAREVKRIVS
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]