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The map label for this gene is citZ

Identifier: 11498938

GI number: 11498938

Start: 1197731

End: 1198849

Strand: Reverse

Name: citZ

Synonym: AF1340

Alternate gene names: 11498938

Gene position: 1198849-1197731 (Counterclockwise)

Preceding gene: 11498939

Following gene: 11498937

Centisome position: 55.03

GC content: 51.47

Gene sequence:

>1119_bases
ATGAAGGACGGATTGGAAGATGTGATTGCCTGCAAAACCACGATTTCGAGGATTGCCCTTGAAAACGGGAGGGCAATTCT
TGAGTACAGGGGTTACGACATCCGTGACCTTGCGAGAAAGGCAAGCTACGAGGAGGTGGCTTACCTTCTGCTTTACGGAG
AGCTGCCGAAGAAATACGAGCTTCAGGACTTCAAAATAGAGCTTGCTGAGAGGAGGGAGCTACCACCTCAAATCATAGGT
CTCCTCACTCATCTGCCGCCATACACGCACCCCATGGTCGTGCTCAGAACTGCAACAAGCTACCTCGGCAGCCTTGACAA
GAAGATAGCTGTAAGGACGAGGGAGGAAACTTTCAACAAGGCAAAGGACTTGATTGCCAAGTTTCCCACAATAGTGGCTT
ACTATCACAGAATCAGGACGGGAAGGAACATAATTCCGCCAGCTCTTGAATTCAGCCATGCTGCAAACTTTCTGTACATG
CTTCACGGGGAGGAACCAACCAAAACTGCTGAGAGAGCGCTGGACATGGATTTAATTCTTCACGCGGAGCACGAGCTAAA
TGCCTCAACCTTTGCGGCGAGGATTGCAGCGTCAACTCTTGCAGACATCTACGCCTGCGTTGTTGCCGCAACTGGAACGC
TGATGGGGCCGCTGCATGGAGGAGCGGCGCAGGAGGTCATGAGGATGCTTAGGGAGGTTGCATCTCCAAGAAGGGCTGAG
GAGTACGTGAAAAGAAAAATAGAGGCTGGAGAGAGGATAATGGGATTCGGGCACAGGGTTTACAGAGGAGTTATGGACCC
AAGGGCGGAGTTGCTGAGGTATCTGGCTAAAAGACTTGCTGCTGAAGGCTCAACGAAGTGGTTCGAAATCAGCGAGGCCA
TCGCCAAGGCTGCTTACAAGTACAAGAAGCTCCTTCCAAACGTTGACTTCTACTCCGCAAGCGTTTACGCCAACCTCGGC
ATTCCCGACGACCTCTTCGTCAACATCTTCGCTATGGGCAGGATTTCAGGCTGGACTGCCCACATCATAGAGCAGTACGA
GAACAACAGGCTTATAAGGCCAAGAGCGGAGTATGTGGGGGAGAAGGAGAAGAAGTTCATCCCTCTGTCGAAAAGGTGA

Upstream 100 bases:

>100_bases
GAGTGGAAGCTCGACAACGCAATAGAGGTTGCGAACACCGAGAGGCCAATTGTGGTTTCGGGAATGGTGCTGGAAGTTTA
CGGAAGAAGAGGTGTGTAAA

Downstream 100 bases:

>100_bases
CGAAACCTTTATTTGACATGCTGAGGTGGTGGGGAACATGGCAAGAAAACCAGCGAGAATGTGGCGAAGGCTTGAAAGGC
CATACACAAGAACCGAGTAC

Product: citrate synthase (citZ)

Products: NA

Alternate protein names: Citrate synthase II [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKDGLEDVIACKTTISRIALENGRAILEYRGYDIRDLARKASYEEVAYLLLYGELPKKYELQDFKIELAERRELPPQIIG
LLTHLPPYTHPMVVLRTATSYLGSLDKKIAVRTREETFNKAKDLIAKFPTIVAYYHRIRTGRNIIPPALEFSHAANFLYM
LHGEEPTKTAERALDMDLILHAEHELNASTFAARIAASTLADIYACVVAATGTLMGPLHGGAAQEVMRMLREVASPRRAE
EYVKRKIEAGERIMGFGHRVYRGVMDPRAELLRYLAKRLAAEGSTKWFEISEAIAKAAYKYKKLLPNVDFYSASVYANLG
IPDDLFVNIFAMGRISGWTAHIIEQYENNRLIRPRAEYVGEKEKKFIPLSKR

Sequences:

>Translated_372_residues
MKDGLEDVIACKTTISRIALENGRAILEYRGYDIRDLARKASYEEVAYLLLYGELPKKYELQDFKIELAERRELPPQIIG
LLTHLPPYTHPMVVLRTATSYLGSLDKKIAVRTREETFNKAKDLIAKFPTIVAYYHRIRTGRNIIPPALEFSHAANFLYM
LHGEEPTKTAERALDMDLILHAEHELNASTFAARIAASTLADIYACVVAATGTLMGPLHGGAAQEVMRMLREVASPRRAE
EYVKRKIEAGERIMGFGHRVYRGVMDPRAELLRYLAKRLAAEGSTKWFEISEAIAKAAYKYKKLLPNVDFYSASVYANLG
IPDDLFVNIFAMGRISGWTAHIIEQYENNRLIRPRAEYVGEKEKKFIPLSKR
>Mature_372_residues
MKDGLEDVIACKTTISRIALENGRAILEYRGYDIRDLARKASYEEVAYLLLYGELPKKYELQDFKIELAERRELPPQIIG
LLTHLPPYTHPMVVLRTATSYLGSLDKKIAVRTREETFNKAKDLIAKFPTIVAYYHRIRTGRNIIPPALEFSHAANFLYM
LHGEEPTKTAERALDMDLILHAEHELNASTFAARIAASTLADIYACVVAATGTLMGPLHGGAAQEVMRMLREVASPRRAE
EYVKRKIEAGERIMGFGHRVYRGVMDPRAELLRYLAKRLAAEGSTKWFEISEAIAKAAYKYKKLLPNVDFYSASVYANLG
IPDDLFVNIFAMGRISGWTAHIIEQYENNRLIRPRAEYVGEKEKKFIPLSKR

Specific function: Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=326, Percent_Identity=29.4478527607362, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1786527, Length=353, Percent_Identity=39.3767705382436, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1786939, Length=385, Percent_Identity=35.0649350649351, Blast_Score=216, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17555174, Length=375, Percent_Identity=27.7333333333333, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=384, Percent_Identity=26.5625, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324328, Length=348, Percent_Identity=27.8735632183908, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=338, Percent_Identity=28.1065088757396, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24640124, Length=379, Percent_Identity=28.4960422163588, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24640126, Length=379, Percent_Identity=28.4960422163588, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21356863, Length=370, Percent_Identity=25.1351351351351, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42271; Mature: 42271

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDGLEDVIACKTTISRIALENGRAILEYRGYDIRDLARKASYEEVAYLLLYGELPKKYE
CCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCHHHHHHHHHCCCCCCCCC
LQDFKIELAERRELPPQIIGLLTHLPPYTHPMVVLRTATSYLGSLDKKIAVRTREETFNK
CHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKDLIAKFPTIVAYYHRIRTGRNIIPPALEFSHAANFLYMLHGEEPTKTAERALDMDLIL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEECCCCHHHHHHHHCHHHEE
HAEHELNASTFAARIAASTLADIYACVVAATGTLMGPLHGGAAQEVMRMLREVASPRRAE
ECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHH
EYVKRKIEAGERIMGFGHRVYRGVMDPRAELLRYLAKRLAAEGSTKWFEISEAIAKAAYK
HHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
YKKLLPNVDFYSASVYANLGIPDDLFVNIFAMGRISGWTAHIIEQYENNRLIRPRAEYVG
HHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHCC
EKEKKFIPLSKR
CCHHCCCCCCCC
>Mature Secondary Structure
MKDGLEDVIACKTTISRIALENGRAILEYRGYDIRDLARKASYEEVAYLLLYGELPKKYE
CCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCHHHHHHHHHCCCCCCCCC
LQDFKIELAERRELPPQIIGLLTHLPPYTHPMVVLRTATSYLGSLDKKIAVRTREETFNK
CHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKDLIAKFPTIVAYYHRIRTGRNIIPPALEFSHAANFLYMLHGEEPTKTAERALDMDLIL
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEECCCCHHHHHHHHCHHHEE
HAEHELNASTFAARIAASTLADIYACVVAATGTLMGPLHGGAAQEVMRMLREVASPRRAE
ECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHH
EYVKRKIEAGERIMGFGHRVYRGVMDPRAELLRYLAKRLAAEGSTKWFEISEAIAKAAYK
HHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
YKKLLPNVDFYSASVYANLGIPDDLFVNIFAMGRISGWTAHIIEQYENNRLIRPRAEYVG
HHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHCC
EKEKKFIPLSKR
CCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377 [H]