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The map label for this gene is hbd-8

Identifier: 11498805

GI number: 11498805

Start: 1077415

End: 1078362

Strand: Reverse

Name: hbd-8

Synonym: AF1206

Alternate gene names: 11498805

Gene position: 1078362-1077415 (Counterclockwise)

Preceding gene: 11498806

Following gene: 11498804

Centisome position: 49.5

GC content: 50.95

Gene sequence:

>948_bases
GTGGGCGTAAAGGTTGCCTGCATTGGCGCCGGAACAGTTGGCGCAAGCTGGGCGTCACTTTTTGCTTGGCGTGGTTGTGA
CGTTGCGGTTTACGACCCGTTTCCTGAGGCTCTGAATAGGGCAGAAGCGAGCATCGCTCGCACAGTTTCAACTCTCAGTG
AAATTTTTTCTGGTAGTGAGGATGACGTGAAAAGCGCCCTGAGCAGAGTTAAATTCACTGAAAACCTCGAAGAGGCACTG
AAAGGGGCATACTACGTTCAGGAGTCGGCGGTGGAAAAGCTGGAAGTTAAGAGAGACCTTTTTGAAAAGATGGATGCAAT
TGCAGAACCGGAAACGATTCTCGCCACGAGCACATCAGGTCTGAGCATATCAGAAATTCAGACCGCTGCCAGAAAGCATC
CCGAGAGGTGCATTACCGCCCATCCGTACAATCCGCCCCACCTCATTCCGCTTGTTGAGGTCGTTCCGAGAAAGCAGACG
GACGAAAGCTGCACAGAGAAAACAGTTGAATTCATGGAGAGAATGGGCAAGAAGCCCATCGTCGTAAAGAAGGACGTTCC
GGGAATGGTGGCGAACAGACTTGCTGCAGCACTGTGGAGGGAGGCGGTGAACCTCGTTTATCAGGGAATAGCCACACCTG
AGGAGATAGATGTGGCAGTTAAATACGGTCCGGGAATCAGATGGGCGATTACTGGGGTTTACCTCACCTACCATCTCGGT
GGTGGTCAGGGCGGGATGAAGTACTTCCTCGAATTCTTCGATGACCACTACAGGCGACTGTGGTCTGATCTGGCGAACTG
GTCGGAGTATCCGGAAGGCTCATTTGACGCCATACTCAAATCAATGGAGGGGTACGATATCATCAAAAGAATGTCATACG
ATGAGCTTGCGAAGTGGAGAGATGATCAGCTGGCGAAGATTCTCAAATTGATTTTGGAGGATGGTTAA

Upstream 100 bases:

>100_bases
GGTATCCAGACGACCTTATTGGTGCAGTTGTTTTCTTCGCCTCTGACGCGTCGAACTTCGTGACAGGGCAGATACTCTAC
ATCGATGGAGGGGTTACTTC

Downstream 100 bases:

>100_bases
TTGCAGGAGGTGGTATTTTGGAGGCAAGATGGGATATACTGATACCCGTTTTGGTGTATTTCCTGGTGACAACCCTTGGT
GTTGGATTCTACCTGATGAA

Product: 3-hydroxyacyl-CoA dehydrogenase (hbd-8)

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MGVKVACIGAGTVGASWASLFAWRGCDVAVYDPFPEALNRAEASIARTVSTLSEIFSGSEDDVKSALSRVKFTENLEEAL
KGAYYVQESAVEKLEVKRDLFEKMDAIAEPETILATSTSGLSISEIQTAARKHPERCITAHPYNPPHLIPLVEVVPRKQT
DESCTEKTVEFMERMGKKPIVVKKDVPGMVANRLAAALWREAVNLVYQGIATPEEIDVAVKYGPGIRWAITGVYLTYHLG
GGQGGMKYFLEFFDDHYRRLWSDLANWSEYPEGSFDAILKSMEGYDIIKRMSYDELAKWRDDQLAKILKLILEDG

Sequences:

>Translated_315_residues
MGVKVACIGAGTVGASWASLFAWRGCDVAVYDPFPEALNRAEASIARTVSTLSEIFSGSEDDVKSALSRVKFTENLEEAL
KGAYYVQESAVEKLEVKRDLFEKMDAIAEPETILATSTSGLSISEIQTAARKHPERCITAHPYNPPHLIPLVEVVPRKQT
DESCTEKTVEFMERMGKKPIVVKKDVPGMVANRLAAALWREAVNLVYQGIATPEEIDVAVKYGPGIRWAITGVYLTYHLG
GGQGGMKYFLEFFDDHYRRLWSDLANWSEYPEGSFDAILKSMEGYDIIKRMSYDELAKWRDDQLAKILKLILEDG
>Mature_314_residues
GVKVACIGAGTVGASWASLFAWRGCDVAVYDPFPEALNRAEASIARTVSTLSEIFSGSEDDVKSALSRVKFTENLEEALK
GAYYVQESAVEKLEVKRDLFEKMDAIAEPETILATSTSGLSISEIQTAARKHPERCITAHPYNPPHLIPLVEVVPRKQTD
ESCTEKTVEFMERMGKKPIVVKKDVPGMVANRLAAALWREAVNLVYQGIATPEEIDVAVKYGPGIRWAITGVYLTYHLGG
GQGGMKYFLEFFDDHYRRLWSDLANWSEYPEGSFDAILKSMEGYDIIKRMSYDELAKWRDDQLAKILKLILEDG

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=313, Percent_Identity=33.2268370607029, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI296179429, Length=226, Percent_Identity=31.4159292035398, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI296179427, Length=243, Percent_Identity=29.2181069958848, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI20127408, Length=222, Percent_Identity=27.9279279279279, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI261878539, Length=245, Percent_Identity=27.7551020408163, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI68989263, Length=245, Percent_Identity=27.7551020408163, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1787661, Length=221, Percent_Identity=35.2941176470588, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788682, Length=137, Percent_Identity=35.7664233576642, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790281, Length=224, Percent_Identity=27.2321428571429, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203623, Length=249, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI115533614, Length=248, Percent_Identity=33.0645161290323, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17549919, Length=229, Percent_Identity=32.7510917030568, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17553560, Length=226, Percent_Identity=29.2035398230088, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71985923, Length=213, Percent_Identity=25.8215962441315, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17563036, Length=230, Percent_Identity=26.9565217391304, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17508953, Length=220, Percent_Identity=25.9090909090909, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=229, Percent_Identity=25.764192139738, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=220, Percent_Identity=25.9090909090909, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=226, Percent_Identity=26.1061946902655, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71985930, Length=215, Percent_Identity=26.5116279069767, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45549573, Length=256, Percent_Identity=33.203125, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI20129993, Length=251, Percent_Identity=32.2709163346614, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24583077, Length=222, Percent_Identity=26.5765765765766, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583079, Length=222, Percent_Identity=26.5765765765766, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921000, Length=222, Percent_Identity=26.5765765765766, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 35141; Mature: 35010

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVKVACIGAGTVGASWASLFAWRGCDVAVYDPFPEALNRAEASIARTVSTLSEIFSGSE
CCEEEEEEECCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCH
DDVKSALSRVKFTENLEEALKGAYYVQESAVEKLEVKRDLFEKMDAIAEPETILATSTSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LSISEIQTAARKHPERCITAHPYNPPHLIPLVEVVPRKQTDESCTEKTVEFMERMGKKPI
CCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCE
VVKKDVPGMVANRLAAALWREAVNLVYQGIATPEEIDVAVKYGPGIRWAITGVYLTYHLG
EEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCEEEEEEEEEEEEEC
GGQGGMKYFLEFFDDHYRRLWSDLANWSEYPEGSFDAILKSMEGYDIIKRMSYDELAKWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHCCHHHHHHCC
DDQLAKILKLILEDG
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
GVKVACIGAGTVGASWASLFAWRGCDVAVYDPFPEALNRAEASIARTVSTLSEIFSGSE
CEEEEEEECCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCH
DDVKSALSRVKFTENLEEALKGAYYVQESAVEKLEVKRDLFEKMDAIAEPETILATSTSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LSISEIQTAARKHPERCITAHPYNPPHLIPLVEVVPRKQTDESCTEKTVEFMERMGKKPI
CCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCE
VVKKDVPGMVANRLAAALWREAVNLVYQGIATPEEIDVAVKYGPGIRWAITGVYLTYHLG
EEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCEEEEEEEEEEEEEC
GGQGGMKYFLEFFDDHYRRLWSDLANWSEYPEGSFDAILKSMEGYDIIKRMSYDELAKWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHCCHHHHHHCC
DDQLAKILKLILEDG
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA