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The map label for this gene is gcdH

Identifier: 11498596

GI number: 11498596

Start: 892416

End: 893603

Strand: Reverse

Name: gcdH

Synonym: AF0991

Alternate gene names: 11498596

Gene position: 893603-892416 (Counterclockwise)

Preceding gene: 11498598

Following gene: 11498595

Centisome position: 41.02

GC content: 53.37

Gene sequence:

>1188_bases
ATGTTCAGAGGAGTGGACTTTTACAATGTTGACGAGCTTTTGAGCGACGAGGACAGGCTTGTAAGGCAGTCGGTGAGAGA
GTTTCTGGAGAAGGAGGTTGTGCCGCTTGTTGCCGATGCCTGGCACGAGGAGAAGCCGTTAAACTTCCATGAGCTGGGGA
AGAAGTTTGGGGAGCTTGGAATGCTCGGCACCTTCCTGCCAGAGGAGTATGGATGCCCCGGAATGACCTACACAACTTTT
GGTGTAGTCTGTCAGGAGGTCGAGAGGGTTGACAGCGCTCTGAGAAGCTTTGTTGCCGTCACATCTGGCTTGGTAATGTA
TCCCATCTGGAGATACGGCAGTGAGGAGCAGAAGGGGGAATACCTGCCAAAACTTGCAAGGGGAGAAATTATCGGGGCTT
TCGGCCTTACAGAGCCGAATCACGGCAGCGACCCGGGCAGCATGGAGGCAACTGCAAGGAGAGATGGGGATGAGTGGGTG
CTGAATGGCACCAAGACCTGGATCAGCGAGGCTGATGTGGCTGACATAGCTGTTGTCTGGGCGAGGGATGTTGAAGATGG
AAAGATAAAGGGCTTTATTGTAGAGAGAGGCACGAAGGGATTCCAGCAGACGGCAATAACAAAGAAAGCCTCGATGAGGG
CTGGAAGTGTGGGCGAGCTTGGCCTTGTCAACTGCAGAGTGCCCGAGGAGAACAGGTTGCCTGAGGCAAGAGGGCTGGGG
GCACCGCTCAGCTGCCTGAATCAGGCGAGGTTTGGAATCTCATGGGGGGCGATAGGAGCAGCAATGGACTGCTACGAGAC
TGCGTTAAACTACACGAAGGAGAGGAAGCAGTTTGGAGCTCCTTTAGCATCTTACCAGCTTGTGCAGGAGAAGCTGGTTA
ACATGCTCATTGAGATAACCAAGGGGCAGCTTCTCGCGTGGAGGCTGGCAAAGCTGATGGATGAGGGGAAGGCTACAACC
GAGCAGATTTCAATGGCCAAGAAGAACAATGTTAGAGTGGCTCGCTACTGTGCAAGAACTGCGAGAGAATTGCTTGGGGC
CAATGGCATAAGCCTTGACTACTCGCCGATAAGGCACATGGCCAACATTGAGTCCGTCTATACTTACGAGGGCACGGATG
ACATCCACACGCTGATTTTGGGCAGGGCTATAACAGGATATCAGGCCTTCAGAAGGGAGCTAAGGTGA

Upstream 100 bases:

>100_bases
GTTGCAGTTGAACCATCCTACATCTTTATTGGCAAACTTTTTCCGAAATCTTTTTAAACGCTCAAAAAAAGAATGTTAAA
TACAGAAAAAAGGTGGTAGC

Downstream 100 bases:

>100_bases
TATTTTGGCCTTCCAGCCCTTCAACAACCTGCTCATTCTCGAACTGGGGCAGGCTGTAGCAGGGCCCTACATCGGAACTC
TGCTGGCTGATCTGGGGGCT

Product: glutaryl-CoA dehydrogenase (gcdH)

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MFRGVDFYNVDELLSDEDRLVRQSVREFLEKEVVPLVADAWHEEKPLNFHELGKKFGELGMLGTFLPEEYGCPGMTYTTF
GVVCQEVERVDSALRSFVAVTSGLVMYPIWRYGSEEQKGEYLPKLARGEIIGAFGLTEPNHGSDPGSMEATARRDGDEWV
LNGTKTWISEADVADIAVVWARDVEDGKIKGFIVERGTKGFQQTAITKKASMRAGSVGELGLVNCRVPEENRLPEARGLG
APLSCLNQARFGISWGAIGAAMDCYETALNYTKERKQFGAPLASYQLVQEKLVNMLIEITKGQLLAWRLAKLMDEGKATT
EQISMAKKNNVRVARYCARTARELLGANGISLDYSPIRHMANIESVYTYEGTDDIHTLILGRAITGYQAFRRELR

Sequences:

>Translated_395_residues
MFRGVDFYNVDELLSDEDRLVRQSVREFLEKEVVPLVADAWHEEKPLNFHELGKKFGELGMLGTFLPEEYGCPGMTYTTF
GVVCQEVERVDSALRSFVAVTSGLVMYPIWRYGSEEQKGEYLPKLARGEIIGAFGLTEPNHGSDPGSMEATARRDGDEWV
LNGTKTWISEADVADIAVVWARDVEDGKIKGFIVERGTKGFQQTAITKKASMRAGSVGELGLVNCRVPEENRLPEARGLG
APLSCLNQARFGISWGAIGAAMDCYETALNYTKERKQFGAPLASYQLVQEKLVNMLIEITKGQLLAWRLAKLMDEGKATT
EQISMAKKNNVRVARYCARTARELLGANGISLDYSPIRHMANIESVYTYEGTDDIHTLILGRAITGYQAFRRELR
>Mature_395_residues
MFRGVDFYNVDELLSDEDRLVRQSVREFLEKEVVPLVADAWHEEKPLNFHELGKKFGELGMLGTFLPEEYGCPGMTYTTF
GVVCQEVERVDSALRSFVAVTSGLVMYPIWRYGSEEQKGEYLPKLARGEIIGAFGLTEPNHGSDPGSMEATARRDGDEWV
LNGTKTWISEADVADIAVVWARDVEDGKIKGFIVERGTKGFQQTAITKKASMRAGSVGELGLVNCRVPEENRLPEARGLG
APLSCLNQARFGISWGAIGAAMDCYETALNYTKERKQFGAPLASYQLVQEKLVNMLIEITKGQLLAWRLAKLMDEGKATT
EQISMAKKNNVRVARYCARTARELLGANGISLDYSPIRHMANIESVYTYEGTDDIHTLILGRAITGYQAFRRELR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=48.9583333333333, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=46.978021978022, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI4557233, Length=381, Percent_Identity=33.3333333333333, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=30.4232804232804, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4501859, Length=386, Percent_Identity=29.7927461139896, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=30.7017543859649, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=29.0575916230367, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI21361497, Length=348, Percent_Identity=31.6091954022989, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI76496475, Length=336, Percent_Identity=31.25, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4557235, Length=336, Percent_Identity=31.25, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=27.3209549071618, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=27.3209549071618, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=26.6666666666667, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI38505218, Length=382, Percent_Identity=25.9162303664921, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=24.7395833333333, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI87081958, Length=389, Percent_Identity=26.4781491002571, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17534353, Length=389, Percent_Identity=48.0719794344473, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17538396, Length=384, Percent_Identity=32.2916666666667, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=30.8510638297872, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=29.3650793650794, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=33.5766423357664, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17534899, Length=388, Percent_Identity=28.3505154639175, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=28.051948051948, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=392, Percent_Identity=28.8265306122449, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=313, Percent_Identity=30.9904153354633, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=245, Percent_Identity=33.0612244897959, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=282, Percent_Identity=31.9148936170213, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17570075, Length=392, Percent_Identity=25.765306122449, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=380, Percent_Identity=25.7894736842105, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17551932, Length=390, Percent_Identity=23.3333333333333, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505929, Length=392, Percent_Identity=22.4489795918367, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=387, Percent_Identity=25.0645994832041, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=26.5560165975104, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19920834, Length=394, Percent_Identity=47.7157360406091, Blast_Score=352, Evalue=2e-97,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=31.3984168865435, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=31.7460317460317, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=31.7333333333333, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=32.0954907161804, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI281363737, Length=343, Percent_Identity=33.5276967930029, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=29.3650793650794, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 44044; Mature: 44044

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRGVDFYNVDELLSDEDRLVRQSVREFLEKEVVPLVADAWHEEKPLNFHELGKKFGELG
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
MLGTFLPEEYGCPGMTYTTFGVVCQEVERVDSALRSFVAVTSGLVMYPIWRYGSEEQKGE
HHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCHH
YLPKLARGEIIGAFGLTEPNHGSDPGSMEATARRDGDEWVLNGTKTWISEADVADIAVVW
HCCHHHCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCEEECCHHHHHCCCCHHHEEEEE
ARDVEDGKIKGFIVERGTKGFQQTAITKKASMRAGSVGELGLVNCRVPEENRLPEARGLG
ECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHCCCC
APLSCLNQARFGISWGAIGAAMDCYETALNYTKERKQFGAPLASYQLVQEKLVNMLIEIT
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KGQLLAWRLAKLMDEGKATTEQISMAKKNNVRVARYCARTARELLGANGISLDYSPIRHM
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ANIESVYTYEGTDDIHTLILGRAITGYQAFRRELR
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFRGVDFYNVDELLSDEDRLVRQSVREFLEKEVVPLVADAWHEEKPLNFHELGKKFGELG
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
MLGTFLPEEYGCPGMTYTTFGVVCQEVERVDSALRSFVAVTSGLVMYPIWRYGSEEQKGE
HHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCHH
YLPKLARGEIIGAFGLTEPNHGSDPGSMEATARRDGDEWVLNGTKTWISEADVADIAVVW
HCCHHHCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCEEECCHHHHHCCCCHHHEEEEE
ARDVEDGKIKGFIVERGTKGFQQTAITKKASMRAGSVGELGLVNCRVPEENRLPEARGLG
ECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHCCCC
APLSCLNQARFGISWGAIGAAMDCYETALNYTKERKQFGAPLASYQLVQEKLVNMLIEIT
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KGQLLAWRLAKLMDEGKATTEQISMAKKNNVRVARYCARTARELLGANGISLDYSPIRHM
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ANIESVYTYEGTDDIHTLILGRAITGYQAFRRELR
HHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]