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The map label for this gene is acd-6

Identifier: 11498569

GI number: 11498569

Start: 864176

End: 865360

Strand: Reverse

Name: acd-6

Synonym: AF0964

Alternate gene names: 11498569

Gene position: 865360-864176 (Counterclockwise)

Preceding gene: 11498570

Following gene: 11498568

Centisome position: 39.72

GC content: 52.91

Gene sequence:

>1185_bases
ATGAATTTTGAGCTTAGCGAAGAGCAGAGAATGATTGCAAACGCTGCGAGAGACATTGCAAAGGACTTTCCGCCCGAGTA
CTGGAGGGAGAAGGAGGAGAATGGTGAGTTTGCGGAGGAGTTTTTCAAGGCGATAAGCGATGCGGGCTTCATGGGCATTG
TTATTCCAGAGGAATACGGTGGTGGCGGCTACGGGATGACAGAGCTGCTCATTGCAATGGAAGAGCTCGCTGCCAACGGC
TGCGGGATGGCTGGAGTCTGGTACATGGTTCTGACGGAGGTTTTTGGTGCCCTTACCATCGTCAGACACGGAACTGAGGA
GCACAAAGAGAAGTATTTGCCGAAGATTGCCAAGGGGGAGATGGAGTTCTGCATGGCCTTAACGGAGCCTGATGCGGGCA
CAAACACTTTGGCAATAAGAACCACTGCCGTGAAGGATGGTGACGAGTGGGTTATAAACGGAAACAAGATTTTCATCAGC
GGGGCGGACAGGGCGAAGGGAATGCTCATCATCGCCAGAACGACGCCGAGGGAGAAGGCTGAGAAGAAAACTCACGGCAT
AAGCCTTTTCCTTGCTGATCTTCCCAACGATGCAGTTAAGGTTAACCCAATTCCAAAGCACGGGATAAACTACTCAAAGA
CCTGCGAGGTGAGCTTCAACAATTTGAGACTGCCTGAAAACGCCCTCATCCCGCCCCTCGATGGCGGGTGGTATCACCTG
CTCGACACACTCAACCCTGAAAGAATGAGCTTCACAACTGCTGCCATCGGCATCAGCAGATTGGCAATAAGCAAGGCTGT
TGAGTATTCAAAGCAGCGCAAGGTTTTTGCAGACCCCATCGGGAGCTATCAGGGCCTGCAGTTCCCCTTAGCTGAGGCTT
ACGCTACCCTCGAATGTGCGGAACTGATGAACTTCAAGGCAGCAACTCTCTTTGATCAGGGGGCACACTACAGAGAAGTT
GGGGCTGCTGCCAACATGGCTAAAGCTGTGGCTGTTGAGGCTGGCATTAAGGCGGTTTACTGGGCAATGCAGACCTTCGG
CGGCTACGGCTACGCTAAAGAGTACGACGTGGAGAGGTGGTGGAGAGAAATCAATCTGATTCGCCTCGCTCCAGTGACGC
AGCAGATGGCGCTGAACTTCATAGCGGAGCACATCCTCGGCATGCCGAAGAGCTACAGGACGTGA

Upstream 100 bases:

>100_bases
GGATGAAGGTAAAGCCCGTTCTGAAGCCAAAGGAGGAAAGAGAGGGCAAAATCACCGACATCCTCTACTTCAAGCCCCTT
TAATTTTTTGAGGTGATTTT

Downstream 100 bases:

>100_bases
AATTATGGCTGCAGTTGAATACAGAGAGGAAGACGGAGTTCTGTGGGTGAAGTTCAACCGTCCCGAAGCGCTCAACGCTA
TAAACAAGGACTTCGTTAAA

Product: acyl-CoA dehydrogenase (acd-6)

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MNFELSEEQRMIANAARDIAKDFPPEYWREKEENGEFAEEFFKAISDAGFMGIVIPEEYGGGGYGMTELLIAMEELAANG
CGMAGVWYMVLTEVFGALTIVRHGTEEHKEKYLPKIAKGEMEFCMALTEPDAGTNTLAIRTTAVKDGDEWVINGNKIFIS
GADRAKGMLIIARTTPREKAEKKTHGISLFLADLPNDAVKVNPIPKHGINYSKTCEVSFNNLRLPENALIPPLDGGWYHL
LDTLNPERMSFTTAAIGISRLAISKAVEYSKQRKVFADPIGSYQGLQFPLAEAYATLECAELMNFKAATLFDQGAHYREV
GAAANMAKAVAVEAGIKAVYWAMQTFGGYGYAKEYDVERWWREINLIRLAPVTQQMALNFIAEHILGMPKSYRT

Sequences:

>Translated_394_residues
MNFELSEEQRMIANAARDIAKDFPPEYWREKEENGEFAEEFFKAISDAGFMGIVIPEEYGGGGYGMTELLIAMEELAANG
CGMAGVWYMVLTEVFGALTIVRHGTEEHKEKYLPKIAKGEMEFCMALTEPDAGTNTLAIRTTAVKDGDEWVINGNKIFIS
GADRAKGMLIIARTTPREKAEKKTHGISLFLADLPNDAVKVNPIPKHGINYSKTCEVSFNNLRLPENALIPPLDGGWYHL
LDTLNPERMSFTTAAIGISRLAISKAVEYSKQRKVFADPIGSYQGLQFPLAEAYATLECAELMNFKAATLFDQGAHYREV
GAAANMAKAVAVEAGIKAVYWAMQTFGGYGYAKEYDVERWWREINLIRLAPVTQQMALNFIAEHILGMPKSYRT
>Mature_394_residues
MNFELSEEQRMIANAARDIAKDFPPEYWREKEENGEFAEEFFKAISDAGFMGIVIPEEYGGGGYGMTELLIAMEELAANG
CGMAGVWYMVLTEVFGALTIVRHGTEEHKEKYLPKIAKGEMEFCMALTEPDAGTNTLAIRTTAVKDGDEWVINGNKIFIS
GADRAKGMLIIARTTPREKAEKKTHGISLFLADLPNDAVKVNPIPKHGINYSKTCEVSFNNLRLPENALIPPLDGGWYHL
LDTLNPERMSFTTAAIGISRLAISKAVEYSKQRKVFADPIGSYQGLQFPLAEAYATLECAELMNFKAATLFDQGAHYREV
GAAANMAKAVAVEAGIKAVYWAMQTFGGYGYAKEYDVERWWREINLIRLAPVTQQMALNFIAEHILGMPKSYRT

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=387, Percent_Identity=29.7157622739018, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI4557233, Length=396, Percent_Identity=31.5656565656566, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=27.3936170212766, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=28.1984334203655, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=27.6967930029155, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI187960098, Length=388, Percent_Identity=28.8659793814433, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI4557231, Length=389, Percent_Identity=28.7917737789203, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=27.7310924369748, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI76496475, Length=348, Percent_Identity=29.0229885057471, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4557235, Length=348, Percent_Identity=29.0229885057471, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI7656849, Length=387, Percent_Identity=27.1317829457364, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI38505218, Length=290, Percent_Identity=27.5862068965517, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI48976061, Length=315, Percent_Identity=23.1746031746032, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI211971008, Length=277, Percent_Identity=23.826714801444, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI7669494, Length=346, Percent_Identity=25.4335260115607, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4503943, Length=329, Percent_Identity=25.531914893617, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=29.1237113402062, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786223, Length=395, Percent_Identity=26.5822784810127, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI87081702, Length=353, Percent_Identity=24.929178470255, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506239, Length=384, Percent_Identity=29.1666666666667, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=384, Percent_Identity=30.7291666666667, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=31.0344827586207, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=29.8153034300792, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=29.5629820051414, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17570075, Length=388, Percent_Identity=27.5773195876289, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71990804, Length=282, Percent_Identity=30.8510638297872, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=356, Percent_Identity=28.9325842696629, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32563615, Length=259, Percent_Identity=29.7297297297297, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=26.9662921348315, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17505929, Length=356, Percent_Identity=26.123595505618, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=356, Percent_Identity=25.2808988764045, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=27.8388278388278, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71985192, Length=297, Percent_Identity=26.9360269360269, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=258, Percent_Identity=27.1317829457364, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17531909, Length=248, Percent_Identity=25.4032258064516, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534353, Length=391, Percent_Identity=20.9718670076726, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666513, Length=383, Percent_Identity=30.5483028720627, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356377, Length=383, Percent_Identity=29.5039164490862, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI21355753, Length=390, Percent_Identity=28.2051282051282, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=27.390180878553, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646207, Length=384, Percent_Identity=27.34375, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI281363737, Length=391, Percent_Identity=29.4117647058824, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI19920834, Length=395, Percent_Identity=24.0506329113924, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43801; Mature: 43801

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFELSEEQRMIANAARDIAKDFPPEYWREKEENGEFAEEFFKAISDAGFMGIVIPEEYG
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
GGGYGMTELLIAMEELAANGCGMAGVWYMVLTEVFGALTIVRHGTEEHKEKYLPKIAKGE
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCCC
MEFCMALTEPDAGTNTLAIRTTAVKDGDEWVINGNKIFISGADRAKGMLIIARTTPREKA
CEEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHH
EKKTHGISLFLADLPNDAVKVNPIPKHGINYSKTCEVSFNNLRLPENALIPPLDGGWYHL
HHHHCCEEEEEEECCCCCEEECCCCCCCCCCCCEEEEEECCEECCCCCCCCCCCCCHHHH
LDTLNPERMSFTTAAIGISRLAISKAVEYSKQRKVFADPIGSYQGLQFPLAEAYATLECA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHH
ELMNFKAATLFDQGAHYREVGAAANMAKAVAVEAGIKAVYWAMQTFGGYGYAKEYDVERW
HHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
WREINLIRLAPVTQQMALNFIAEHILGMPKSYRT
HHHCCEEEECCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNFELSEEQRMIANAARDIAKDFPPEYWREKEENGEFAEEFFKAISDAGFMGIVIPEEYG
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCC
GGGYGMTELLIAMEELAANGCGMAGVWYMVLTEVFGALTIVRHGTEEHKEKYLPKIAKGE
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCCC
MEFCMALTEPDAGTNTLAIRTTAVKDGDEWVINGNKIFISGADRAKGMLIIARTTPREKA
CEEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHH
EKKTHGISLFLADLPNDAVKVNPIPKHGINYSKTCEVSFNNLRLPENALIPPLDGGWYHL
HHHHCCEEEEEEECCCCCEEECCCCCCCCCCCCEEEEEECCEECCCCCCCCCCCCCHHHH
LDTLNPERMSFTTAAIGISRLAISKAVEYSKQRKVFADPIGSYQGLQFPLAEAYATLECA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHH
ELMNFKAATLFDQGAHYREVGAAANMAKAVAVEAGIKAVYWAMQTFGGYGYAKEYDVERW
HHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
WREINLIRLAPVTQQMALNFIAEHILGMPKSYRT
HHHCCEEEECCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]