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The map label for this gene is dapA

Identifier: 11498515

GI number: 11498515

Start: 814053

End: 814922

Strand: Reverse

Name: dapA

Synonym: AF0910

Alternate gene names: 11498515

Gene position: 814922-814053 (Counterclockwise)

Preceding gene: 11498516

Following gene: 11498514

Centisome position: 37.41

GC content: 51.72

Gene sequence:

>870_bases
ATGTTTGAGGGCGTGATTCCCGCAATGGTAACGCCCTTCAAGGAGGACTTCAGCGTTGACTACGAGGGGATAGCGAAGAA
TCTCGACTACCTTGAGAAGCACGTCAACGCTCTGGTTCCTGCTGGGACAACAGGAGAGGCTGCAACACTCAGCTACGAGG
AGCACATCGATGTTGTGAGGTATGTTGCAGAGACGTCAAAGCTTCCTGTAATTGGTGGTGCAGGTTCAAACTCAACGAGG
GAGGCAATTTGGCTTGCAAAGGAAGTTGAGAAGGCTGGTGCAGAGGCTGCAATGCTCGTCACTCCCTACTACAACAAGCC
CAACGCTGAGGGGCTCTACCAGCACTACAAGGCTGTTGCGTCTGAAGTTTCCATTCCAATCATAGTTTACAACGTTCCCA
GCAGGACGGGCATAAACACAACTCCCGAACTCGTAAGAAGGCTGGCGGAGATTGACAACATTTTTGGCATTAAGGAGGCG
AGCGGGAACCTCAAGCAGATCTCCGAGATTATAAGAACAACACCAGACGACTTTGTCCTGCTTTCTGGCGATGATTTTCT
CACCCTGCCCATTCTCTGCCTTGGAGGAAAGGGCGTAATCAGCGTTGCCGCCAACGTCGCCCCCCACCTGATGAAGGAGA
TGTACGAAGCTTTCGTTGAGGGGAACATAGAAAGGGCGAGGGAGATGCACCACAGGCTTACGCCACTCTTCGACGTGCTC
TTCATCGACACCAATCCTATTCCGGTTAAGAAGGCTTTGCAGCTTATGGGGCTTGCAGCGGGAAAGCCGAGGCTGCCTCT
GGTCGAGCTCTCTGAAGAGAAAACTCAGAAGGTTAAAGAAGTTCTCAAGAGTCTTGAGCTGATTAGCTGA

Upstream 100 bases:

>100_bases
AACAAGAGGCTCGTGGCGGAGCTTACCAACATCCAGAGCAAGACCGTGAGAAACAGGGTTGCTGGATACATCACGAGGAG
AGTTAACAGAGGGTTGGTCA

Downstream 100 bases:

>100_bases
ACATTTTATATACTCCAGCTCAATTTTATTTATGCGAGTTGCGGTTTCCGGGGCAGCGGGCAGAATGGGCAGGCTTGTTG
TTAAAAATGCAGTGGCAGAG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MFEGVIPAMVTPFKEDFSVDYEGIAKNLDYLEKHVNALVPAGTTGEAATLSYEEHIDVVRYVAETSKLPVIGGAGSNSTR
EAIWLAKEVEKAGAEAAMLVTPYYNKPNAEGLYQHYKAVASEVSIPIIVYNVPSRTGINTTPELVRRLAEIDNIFGIKEA
SGNLKQISEIIRTTPDDFVLLSGDDFLTLPILCLGGKGVISVAANVAPHLMKEMYEAFVEGNIERAREMHHRLTPLFDVL
FIDTNPIPVKKALQLMGLAAGKPRLPLVELSEEKTQKVKEVLKSLELIS

Sequences:

>Translated_289_residues
MFEGVIPAMVTPFKEDFSVDYEGIAKNLDYLEKHVNALVPAGTTGEAATLSYEEHIDVVRYVAETSKLPVIGGAGSNSTR
EAIWLAKEVEKAGAEAAMLVTPYYNKPNAEGLYQHYKAVASEVSIPIIVYNVPSRTGINTTPELVRRLAEIDNIFGIKEA
SGNLKQISEIIRTTPDDFVLLSGDDFLTLPILCLGGKGVISVAANVAPHLMKEMYEAFVEGNIERAREMHHRLTPLFDVL
FIDTNPIPVKKALQLMGLAAGKPRLPLVELSEEKTQKVKEVLKSLELIS
>Mature_289_residues
MFEGVIPAMVTPFKEDFSVDYEGIAKNLDYLEKHVNALVPAGTTGEAATLSYEEHIDVVRYVAETSKLPVIGGAGSNSTR
EAIWLAKEVEKAGAEAAMLVTPYYNKPNAEGLYQHYKAVASEVSIPIIVYNVPSRTGINTTPELVRRLAEIDNIFGIKEA
SGNLKQISEIIRTTPDDFVLLSGDDFLTLPILCLGGKGVISVAANVAPHLMKEMYEAFVEGNIERAREMHHRLTPLFDVL
FIDTNPIPVKKALQLMGLAAGKPRLPLVELSEEKTQKVKEVLKSLELIS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=284, Percent_Identity=28.8732394366197, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI13540533, Length=303, Percent_Identity=27.3927392739274, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=46.2328767123288, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI87082415, Length=292, Percent_Identity=31.8493150684932, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1786463, Length=274, Percent_Identity=32.1167883211679, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789620, Length=243, Percent_Identity=29.2181069958848, Blast_Score=110, Evalue=9e-26,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_ARCFU (O29352)

Other databases:

- EMBL:   AE000782
- PIR:   F69363
- RefSeq:   NP_069743.1
- ProteinModelPortal:   O29352
- SMR:   O29352
- GeneID:   1484133
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0910
- NMPDR:   fig|224325.1.peg.902
- TIGR:   AF_0910
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- ProtClustDB:   PRK03170
- BioCyc:   AFUL224325:AF_0910-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31692; Mature: 31692

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 158-158 BINDING 103-103

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEGVIPAMVTPFKEDFSVDYEGIAKNLDYLEKHVNALVPAGTTGEAATLSYEEHIDVVR
CCCCCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHH
YVAETSKLPVIGGAGSNSTREAIWLAKEVEKAGAEAAMLVTPYYNKPNAEGLYQHYKAVA
HHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHH
SEVSIPIIVYNVPSRTGINTTPELVRRLAEIDNIFGIKEASGNLKQISEIIRTTPDDFVL
HHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCCCEEE
LSGDDFLTLPILCLGGKGVISVAANVAPHLMKEMYEAFVEGNIERAREMHHRLTPLFDVL
ECCCCEEEEHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEE
FIDTNPIPVKKALQLMGLAAGKPRLPLVELSEEKTQKVKEVLKSLELIS
EECCCCCCHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFEGVIPAMVTPFKEDFSVDYEGIAKNLDYLEKHVNALVPAGTTGEAATLSYEEHIDVVR
CCCCCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHH
YVAETSKLPVIGGAGSNSTREAIWLAKEVEKAGAEAAMLVTPYYNKPNAEGLYQHYKAVA
HHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHH
SEVSIPIIVYNVPSRTGINTTPELVRRLAEIDNIFGIKEASGNLKQISEIIRTTPDDFVL
HHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCCCEEE
LSGDDFLTLPILCLGGKGVISVAANVAPHLMKEMYEAFVEGNIERAREMHHRLTPLFDVL
ECCCCEEEEHHEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEE
FIDTNPIPVKKALQLMGLAAGKPRLPLVELSEEKTQKVKEVLKSLELIS
EECCCCCCHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475