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The map label for this gene is ahcY-1

Identifier: 11498491

GI number: 11498491

Start: 790164

End: 791144

Strand: Reverse

Name: ahcY-1

Synonym: AF0886

Alternate gene names: 11498491

Gene position: 791144-790164 (Counterclockwise)

Preceding gene: 11498496

Following gene: 11498490

Centisome position: 36.32

GC content: 48.32

Gene sequence:

>981_bases
ATGAAGCTCGTCAGGAAATTTGCCAGGGACATTGAGGTGGATGAGCTGGCTATCTGCATTCCTCTCGAATACAAGTCCGC
TTGTCTAATTTACGAGCTTTCCAGGTACACCAACGTCTATGCTGCAAAGCTCGACGATTTTTCAACGAAACCTGAGGTTG
TTAGTTGGTTGAAGGAGAAGGGTGTTGAGGTGAAGATGAAAAGGGACGTTGTTAATGCTGAGTACTTCCTTGATTGTGCA
GCGGTGCTTTCGAGAGTGGCGGTAAAAAGCGGGAAGGAAAGGCTTAAGGTTGTGGAGCTCACGAAAACCGGCGAGGAGTA
CCTGCGAAAGATGGATGTTAGGATGAAAGCAATATCGCTTGACTCCTCGACGTTAAAGGGCACTGGAGAGAACACACATG
GGACGGCTTTTGGTTTGCTCGATGCGTTGCTAAGGCTGAACGTGTTTTTGCCGGGAAAAAAGGCCCTTATTCTGGGTTTT
GGCAGAGTTGGGAGAGGTTGTGCGAGACTCCTGAAGTCTGTAGGCTGTGATGTAGCCGTTTGGGACAATGACGAAACGAG
GCAGATTGAAGCTCTTTATGAGGGATTCAGAGTCGAGAAAGATTTTACCGCGGAAGTGGTGGTAACGTGCACCGGAGTTA
AAGGTGTTCTCGGTAAAGAGGAGCTTGAAGAAATCTCTGATGGGAGCATTATTCTGAACATGGGTGCTGAGATGGAAATT
GAGCCTGCAGGTGAGCTTATCAAAGACTACGGCCTGGTTAAGGAGTACGAGATAGCCGGGAAAAGGTATTTCTTGGTCGC
TGACGGTTATGCGGCAAACCTCGCCCTCGGTAGCGGAACACCGATTGAGGTGATGGACAGGACCTTTTCCGCGGCAATCC
TTGCTTTAAACCATTTGAGCAGGAGCGATTTTGACGGAATTATCCCCCTTCCCCACCACATAGAATCGACAATTTTGGAA
GCCATAATGATGTACAAATAG

Upstream 100 bases:

>100_bases
CTCAGCCTGAAGGTCGGTTTATCTCTGAGTCTTTCAATAAGTTGAAATATTTTGCTGCAGAAACTGTATCGTGATATCTG
TTGATTGGTATCACAGAAGA

Downstream 100 bases:

>100_bases
AAATGCTTTTAAAAAAGAAATTCTATCAGGATTGATTGAGGTGGAACTATGCTTTTAAAGCCGGAGGAATACATAGAGAG
GTTGGGTGAATACAAAAGGG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKLVRKFARDIEVDELAICIPLEYKSACLIYELSRYTNVYAAKLDDFSTKPEVVSWLKEKGVEVKMKRDVVNAEYFLDCA
AVLSRVAVKSGKERLKVVELTKTGEEYLRKMDVRMKAISLDSSTLKGTGENTHGTAFGLLDALLRLNVFLPGKKALILGF
GRVGRGCARLLKSVGCDVAVWDNDETRQIEALYEGFRVEKDFTAEVVVTCTGVKGVLGKEELEEISDGSIILNMGAEMEI
EPAGELIKDYGLVKEYEIAGKRYFLVADGYAANLALGSGTPIEVMDRTFSAAILALNHLSRSDFDGIIPLPHHIESTILE
AIMMYK

Sequences:

>Translated_326_residues
MKLVRKFARDIEVDELAICIPLEYKSACLIYELSRYTNVYAAKLDDFSTKPEVVSWLKEKGVEVKMKRDVVNAEYFLDCA
AVLSRVAVKSGKERLKVVELTKTGEEYLRKMDVRMKAISLDSSTLKGTGENTHGTAFGLLDALLRLNVFLPGKKALILGF
GRVGRGCARLLKSVGCDVAVWDNDETRQIEALYEGFRVEKDFTAEVVVTCTGVKGVLGKEELEEISDGSIILNMGAEMEI
EPAGELIKDYGLVKEYEIAGKRYFLVADGYAANLALGSGTPIEVMDRTFSAAILALNHLSRSDFDGIIPLPHHIESTILE
AIMMYK
>Mature_326_residues
MKLVRKFARDIEVDELAICIPLEYKSACLIYELSRYTNVYAAKLDDFSTKPEVVSWLKEKGVEVKMKRDVVNAEYFLDCA
AVLSRVAVKSGKERLKVVELTKTGEEYLRKMDVRMKAISLDSSTLKGTGENTHGTAFGLLDALLRLNVFLPGKKALILGF
GRVGRGCARLLKSVGCDVAVWDNDETRQIEALYEGFRVEKDFTAEVVVTCTGVKGVLGKEELEEISDGSIILNMGAEMEI
EPAGELIKDYGLVKEYEIAGKRYFLVADGYAANLALGSGTPIEVMDRTFSAAILALNHLSRSDFDGIIPLPHHIESTILE
AIMMYK

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=246, Percent_Identity=28.8617886178862, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI239937451, Length=246, Percent_Identity=28.8617886178862, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI21361647, Length=221, Percent_Identity=29.8642533936652, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI298286489, Length=217, Percent_Identity=29.9539170506912, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI195539349, Length=217, Percent_Identity=29.9539170506912, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI195539337, Length=217, Percent_Identity=30.4147465437788, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI24308043, Length=217, Percent_Identity=30.4147465437788, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17506425, Length=322, Percent_Identity=26.7080745341615, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320882, Length=222, Percent_Identity=30.1801801801802, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24642172, Length=326, Percent_Identity=27.3006134969325, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656245, Length=337, Percent_Identity=27.893175074184, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45553387, Length=148, Percent_Identity=33.7837837837838, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45553385, Length=148, Percent_Identity=33.7837837837838, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 36122; Mature: 36122

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVRKFARDIEVDELAICIPLEYKSACLIYELSRYTNVYAAKLDDFSTKPEVVSWLKEK
CHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEHHHHCCEEEEECCCCCCCHHHHHHHHHC
GVEVKMKRDVVNAEYFLDCAAVLSRVAVKSGKERLKVVELTKTGEEYLRKMDVRMKAISL
CCEEEEHHHHCCHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHHHHHHHHHHHHEEEEC
DSSTLKGTGENTHGTAFGLLDALLRLNVFLPGKKALILGFGRVGRGCARLLKSVGCDVAV
CCCCCCCCCCCCCCHHHHHHHHHHHHCEECCCCCEEEEECCCCCHHHHHHHHHCCCCEEE
WDNDETRQIEALYEGFRVEKDFTAEVVVTCTGVKGVLGKEELEEISDGSIILNMGAEMEI
ECCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHCCCCCEEEECCCCEEE
EPAGELIKDYGLVKEYEIAGKRYFLVADGYAANLALGSGTPIEVMDRTFSAAILALNHLS
CCHHHHHHHCCCCEEEEECCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
RSDFDGIIPLPHHIESTILEAIMMYK
CCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLVRKFARDIEVDELAICIPLEYKSACLIYELSRYTNVYAAKLDDFSTKPEVVSWLKEK
CHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEHHHHCCEEEEECCCCCCCHHHHHHHHHC
GVEVKMKRDVVNAEYFLDCAAVLSRVAVKSGKERLKVVELTKTGEEYLRKMDVRMKAISL
CCEEEEHHHHCCHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHHHHHHHHHHHHEEEEC
DSSTLKGTGENTHGTAFGLLDALLRLNVFLPGKKALILGFGRVGRGCARLLKSVGCDVAV
CCCCCCCCCCCCCCHHHHHHHHHHHHCEECCCCCEEEEECCCCCHHHHHHHHHCCCCEEE
WDNDETRQIEALYEGFRVEKDFTAEVVVTCTGVKGVLGKEELEEISDGSIILNMGAEMEI
ECCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHCCCCCEEEECCCCEEE
EPAGELIKDYGLVKEYEIAGKRYFLVADGYAANLALGSGTPIEVMDRTFSAAILALNHLS
CCHHHHHHHCCCCEEEEECCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
RSDFDGIIPLPHHIESTILEAIMMYK
CCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]