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The map label for this gene is nhe2

Identifier: 11498452

GI number: 11498452

Start: 751980

End: 753464

Strand: Reverse

Name: nhe2

Synonym: AF0846

Alternate gene names: 11498452

Gene position: 753464-751980 (Counterclockwise)

Preceding gene: 11498457

Following gene: 11498451

Centisome position: 34.59

GC content: 51.18

Gene sequence:

>1485_bases
ATGATAGAGGAGAATCTGGTTGAATTCATCGAGATTCTCATGCTCGCTACCGCTGTTGCAGTTACGGTTAAATTCATCCG
ATTACCCTACACCATAGCTCTCGTTCTTGCTGGGCTTTTCGTTGGACTTGCCGGCCTTTTGCCGGAAGTCCCTCTGAGCA
GGGAAATCGTCTTTTTCATTTTCCTCCCTCCTCTGCTGTTCGAGGCGGCGATGAACATGGATTTAAAGGAGCTGAGGGAG
AATTTCGGGCCGATTGCGCTTATCGCCTTTTTGGGAGTCGTGGTTACAACTACTGTCGTTGGATTTTCTTTGAACTGGAT
TCTCGGTATCCCTCTGGCACTTGCCCTCATTTTCGGTGCGATGGTCTCCGCAACCGACCCTGTTTCGGTTCTCGCAACGT
TCAAGTCGATCTCCGCTCCGAAGAAGCTTTCCATACTCATCGAGGGTGAGAGCGTATTGAATGATGGCGCCGCAATCGTG
GTTTTCGCAATAGCCCTCGAAATGATGCTCAAGGGCGTTTTCGACCCTCTGAACGCTGCGTTGGACTTCGCTGTTGTCTG
CGTTGGTGGTGCGGCTGTTGGATTGGCGGTAGGCTACCTTGCCTACAGAATACTTGCAAAAATCGACGACGCCCTTGTTG
AGATAGCTGTAACGATAGTCGCAGCCTACCTCGGTTTCGTTCTGGCGGAGAGGTTTCACTTCTCCGGTGTGATTGCGGTG
GTTGCAGCAGGCCTAATCCTCGGAAACTACGGCAGGGACTTTTCAATGTCCCCCACAACGAGAGTTATCATGCTGGATTT
CTGGAGCGTCATTGTTTTTCTCGTGAACTCCATAATATTCATTCTGATCGGCGTTAACACGCACATAACAATTTTCTCGG
CATGGAAGGAGATTTTGGTGGCCATAGCTGCCGTGATTCTCGCAAGAGCCTTTGTTGTTTACCCGGTAATGACCTACTAC
CGATTTCCAAACCTGTGGAAGCACGTGGTTTTCTGGGGTGGTTTAAGGGGTGTAATTCCCGTTGCCCTCGCCCTCAGCTT
CGGCAACCAGCTTCTCTCGGCAATGGCATTCGGTGTCGTGCTTTTCTCCCTGCTTCTGCAGGGCATTTCACTCGAAATTT
TCGTCAAGCGGAAGTTCGTCAGCGAGAGTGAGAGGGAGTTGGAGGAAATTATAGCCAGGTACATCGCTGCAAGGAGCGCG
AAGTTTGAGCTGATGAAGGCGGTTGAGCAGGGGAGAATCGTTGAGCCTGTGGCGAGAGAAATGCTGCCGAACCTCGATGC
GGAGATTGAGGAATTGAGGTCGAAGCTTGAGGAGAAGATAAGGGGAGGTATGGGGTCGAAGTTAAGGAAAGCCGCTGTGA
AGTACGTCATCGACGCAAAGAAGAGTGCCGTGGTTGACGCAATGGCCGGAGGGCTGGTTTCTCAGGAGGTTGCGCTTGAG
ATAATGCGAGAGCTTGATAGCAAAACCGCCGAACTTATGGAATGA

Upstream 100 bases:

>100_bases
TGGTTTGGTCTTCAGGTGAATTAAAAGCTTTTTTGATGTTCATGAAATTTCAAAATTGCAGACAAATAACTTTAATAATT
TCGTACAGCCTTTCCACATT

Downstream 100 bases:

>100_bases
GTTGTCTGCCACTATTTAACTGCCCTACAACAAAGTGGCAAATCTTATATTTTGAAAATGAGAAGTTAAAATCATGAACT
TTGAGTTTGAGGAGGAGCAC

Product: Na+/H+ antiporter (nhe2)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MIEENLVEFIEILMLATAVAVTVKFIRLPYTIALVLAGLFVGLAGLLPEVPLSREIVFFIFLPPLLFEAAMNMDLKELRE
NFGPIALIAFLGVVVTTTVVGFSLNWILGIPLALALIFGAMVSATDPVSVLATFKSISAPKKLSILIEGESVLNDGAAIV
VFAIALEMMLKGVFDPLNAALDFAVVCVGGAAVGLAVGYLAYRILAKIDDALVEIAVTIVAAYLGFVLAERFHFSGVIAV
VAAGLILGNYGRDFSMSPTTRVIMLDFWSVIVFLVNSIIFILIGVNTHITIFSAWKEILVAIAAVILARAFVVYPVMTYY
RFPNLWKHVVFWGGLRGVIPVALALSFGNQLLSAMAFGVVLFSLLLQGISLEIFVKRKFVSESERELEEIIARYIAARSA
KFELMKAVEQGRIVEPVAREMLPNLDAEIEELRSKLEEKIRGGMGSKLRKAAVKYVIDAKKSAVVDAMAGGLVSQEVALE
IMRELDSKTAELME

Sequences:

>Translated_494_residues
MIEENLVEFIEILMLATAVAVTVKFIRLPYTIALVLAGLFVGLAGLLPEVPLSREIVFFIFLPPLLFEAAMNMDLKELRE
NFGPIALIAFLGVVVTTTVVGFSLNWILGIPLALALIFGAMVSATDPVSVLATFKSISAPKKLSILIEGESVLNDGAAIV
VFAIALEMMLKGVFDPLNAALDFAVVCVGGAAVGLAVGYLAYRILAKIDDALVEIAVTIVAAYLGFVLAERFHFSGVIAV
VAAGLILGNYGRDFSMSPTTRVIMLDFWSVIVFLVNSIIFILIGVNTHITIFSAWKEILVAIAAVILARAFVVYPVMTYY
RFPNLWKHVVFWGGLRGVIPVALALSFGNQLLSAMAFGVVLFSLLLQGISLEIFVKRKFVSESERELEEIIARYIAARSA
KFELMKAVEQGRIVEPVAREMLPNLDAEIEELRSKLEEKIRGGMGSKLRKAAVKYVIDAKKSAVVDAMAGGLVSQEVALE
IMRELDSKTAELME
>Mature_494_residues
MIEENLVEFIEILMLATAVAVTVKFIRLPYTIALVLAGLFVGLAGLLPEVPLSREIVFFIFLPPLLFEAAMNMDLKELRE
NFGPIALIAFLGVVVTTTVVGFSLNWILGIPLALALIFGAMVSATDPVSVLATFKSISAPKKLSILIEGESVLNDGAAIV
VFAIALEMMLKGVFDPLNAALDFAVVCVGGAAVGLAVGYLAYRILAKIDDALVEIAVTIVAAYLGFVLAERFHFSGVIAV
VAAGLILGNYGRDFSMSPTTRVIMLDFWSVIVFLVNSIIFILIGVNTHITIFSAWKEILVAIAAVILARAFVVYPVMTYY
RFPNLWKHVVFWGGLRGVIPVALALSFGNQLLSAMAFGVVLFSLLLQGISLEIFVKRKFVSESERELEEIIARYIAARSA
KFELMKAVEQGRIVEPVAREMLPNLDAEIEELRSKLEEKIRGGMGSKLRKAAVKYVIDAKKSAVVDAMAGGLVSQEVALE
IMRELDSKTAELME

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI41872703, Length=410, Percent_Identity=28.2926829268293, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI15529998, Length=502, Percent_Identity=26.2948207171315, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148727259, Length=501, Percent_Identity=25.1497005988024, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI14211919, Length=364, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI27734935, Length=472, Percent_Identity=23.9406779661017, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI294997330, Length=361, Percent_Identity=27.4238227146814, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI110227626, Length=361, Percent_Identity=27.4238227146814, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI5454070, Length=357, Percent_Identity=27.4509803921569, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI27777632, Length=411, Percent_Identity=27.7372262773723, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI194239733, Length=413, Percent_Identity=24.9394673123487, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4759144, Length=363, Percent_Identity=27.8236914600551, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1790501, Length=552, Percent_Identity=25, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87081854, Length=328, Percent_Identity=26.8292682926829, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147678, Length=503, Percent_Identity=26.6401590457256, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71992107, Length=316, Percent_Identity=27.8481012658228, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71992101, Length=316, Percent_Identity=27.8481012658228, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71980847, Length=478, Percent_Identity=24.2677824267782, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71993590, Length=420, Percent_Identity=27.6190476190476, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71993582, Length=420, Percent_Identity=27.6190476190476, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71999821, Length=441, Percent_Identity=24.7165532879819, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71999819, Length=442, Percent_Identity=25.1131221719457, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71999817, Length=440, Percent_Identity=25, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71990924, Length=438, Percent_Identity=25.1141552511416, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71990932, Length=387, Percent_Identity=26.0981912144703, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71987535, Length=536, Percent_Identity=22.9477611940299, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71987537, Length=536, Percent_Identity=22.9477611940299, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71987559, Length=388, Percent_Identity=25.7731958762887, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71987545, Length=392, Percent_Identity=26.0204081632653, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25150332, Length=373, Percent_Identity=25.7372654155496, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320663, Length=392, Percent_Identity=25.2551020408163, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281360447, Length=457, Percent_Identity=25.164113785558, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221510734, Length=362, Percent_Identity=28.1767955801105, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221510738, Length=362, Percent_Identity=28.1767955801105, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221510732, Length=362, Percent_Identity=28.1767955801105, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI221510736, Length=362, Percent_Identity=28.1767955801105, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI221473215, Length=443, Percent_Identity=26.1851015801354, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585580, Length=362, Percent_Identity=28.1767955801105, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585578, Length=362, Percent_Identity=28.1767955801105, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI221510740, Length=363, Percent_Identity=27.8236914600551, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI281364513, Length=351, Percent_Identity=28.7749287749288, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI221473212, Length=351, Percent_Identity=28.7749287749288, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221473222, Length=444, Percent_Identity=26.1261261261261, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 53711; Mature: 53711

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEENLVEFIEILMLATAVAVTVKFIRLPYTIALVLAGLFVGLAGLLPEVPLSREIVFFI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FLPPLLFEAAMNMDLKELRENFGPIALIAFLGVVVTTTVVGFSLNWILGIPLALALIFGA
HHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVSATDPVSVLATFKSISAPKKLSILIEGESVLNDGAAIVVFAIALEMMLKGVFDPLNAA
HHCCCCHHHHHHHHHHCCCCCCEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDFAVVCVGGAAVGLAVGYLAYRILAKIDDALVEIAVTIVAAYLGFVLAERFHFSGVIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAGLILGNYGRDFSMSPTTRVIMLDFWSVIVFLVNSIIFILIGVNTHITIFSAWKEILV
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AIAAVILARAFVVYPVMTYYRFPNLWKHVVFWGGLRGVIPVALALSFGNQLLSAMAFGVV
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFSLLLQGISLEIFVKRKFVSESERELEEIIARYIAARSAKFELMKAVEQGRIVEPVARE
HHHHHHCCCCCEEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MLPNLDAEIEELRSKLEEKIRGGMGSKLRKAAVKYVIDAKKSAVVDAMAGGLVSQEVALE
HCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IMRELDSKTAELME
HHHHHHHHHHHHCC
>Mature Secondary Structure
MIEENLVEFIEILMLATAVAVTVKFIRLPYTIALVLAGLFVGLAGLLPEVPLSREIVFFI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FLPPLLFEAAMNMDLKELRENFGPIALIAFLGVVVTTTVVGFSLNWILGIPLALALIFGA
HHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVSATDPVSVLATFKSISAPKKLSILIEGESVLNDGAAIVVFAIALEMMLKGVFDPLNAA
HHCCCCHHHHHHHHHHCCCCCCEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDFAVVCVGGAAVGLAVGYLAYRILAKIDDALVEIAVTIVAAYLGFVLAERFHFSGVIAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAGLILGNYGRDFSMSPTTRVIMLDFWSVIVFLVNSIIFILIGVNTHITIFSAWKEILV
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AIAAVILARAFVVYPVMTYYRFPNLWKHVVFWGGLRGVIPVALALSFGNQLLSAMAFGVV
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFSLLLQGISLEIFVKRKFVSESERELEEIIARYIAARSAKFELMKAVEQGRIVEPVARE
HHHHHHCCCCCEEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MLPNLDAEIEELRSKLEEKIRGGMGSKLRKAAVKYVIDAKKSAVVDAMAGGLVSQEVALE
HCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IMRELDSKTAELME
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]