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The map label for this gene is acd-5

Identifier: 11498451

GI number: 11498451

Start: 750761

End: 751906

Strand: Reverse

Name: acd-5

Synonym: AF0845

Alternate gene names: 11498451

Gene position: 751906-750761 (Counterclockwise)

Preceding gene: 11498452

Following gene: 11498450

Centisome position: 34.52

GC content: 51.66

Gene sequence:

>1146_bases
ATGAACTTTGAGTTTGAGGAGGAGCACCGAATTCTGAGGGACAGCGTTAGAGAGTTTGCTGAAAAGGAGATCATGCCTTA
CGGCAAGGAGTACGACGAAAAGGGAGAGTATCCCTGGGAAATATTCAGGAAAGCCGCCAAGCTCGGCTATGTGGCTGCGG
ACATTCCCGAGAAGTACGGTGGTGCGGGGCTCGATTACCTCGGATGCGCCATAATTGCTGAAGAGTTCACAAGGGCTGAC
AGCAGCATAGGCTCAGCGGTTTTGACAGCTTCCCTTGGTTGCCCGATGGTCAAGTACTTTGGAACGGAGGAGCAGAAGGA
GAGGTATCTGCCGAAAGTTGTAAAGGGTGAGACGCCCTCGGCTATCGCCATAACCGAACCGGATGCGGGGAGCGATGTGC
AGGCCATAAAGACAAAGGCGGAAAGGGTTGATGGGGGCTGGAAGCTTAACGGAACCAAGACCTTCATAACCAACGGCAGC
GTCTCGGAGTGGGTTGTGATTCTCGCCAAAACTCAGCCTGATGCTGGCTACAGAGGAATTTCCGCCTTTCTCGTCGAAAC
GGGATGGGATGGGTATGAAGCGAGGAGAATAAAGAAGATGGGGCTGAATTGCCACGATACTGCGGAGATATACCTGAAGG
ACGTTTTCGTTCCCGAAACGCACATTATCGGCCAGGAGAACTTTGGCTTTTACCAGCTTATGAGGTTCTTCAACGAGAGC
AGGGTGTTTGTTGGTGCCGTTCAGCTCGGAATGGCTGTTGGAGCCTACGAAAGGGCTTTGGAGTACGCGAAGCAGAGAAA
GGCCTTTGGAAAACCGCTCATAGAGCATCAGGCGATACAGTTCAAGCTCGCTGATATGTGGAAGGATATTGAGGCTGCTA
AGCTTCTGATTTACAAGGCCGCTTGGCTTATTGATAGGGGAAAAGCGAATCCTGCGTTGAGCTCTGCAGCAAAGCTCTTC
GCCAGCGAGACTGCGATTAAGGCAACGTATGAAGCTTTGCAGATTTTCGGCGGCTACGGCTACAGCAAGGAGTACGACAT
CGAGCGCTACTACAGAGATGCCAGAGTTGGAACGATTTATGAGGGTACGAGCGAGATACAGAAGCTCATCATCGCGAGAG
CCATTGCTGGAAAGCTCAGATTATGA

Upstream 100 bases:

>100_bases
AGCAAAACCGCCGAACTTATGGAATGAGTTGTCTGCCACTATTTAACTGCCCTACAACAAAGTGGCAAATCTTATATTTT
GAAAATGAGAAGTTAAAATC

Downstream 100 bases:

>100_bases
AAAGCTTTTTATTTATTACATTCCAGAAAAGTTCATGGAAAAGTTCATTGAGAGTGTGGCCAATTTTATTGACGAAGAGG
ACGTTAAAGTTTTGAAGGCA

Product: acyl-CoA dehydrogenase (acd-5)

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNFEFEEEHRILRDSVREFAEKEIMPYGKEYDEKGEYPWEIFRKAAKLGYVAADIPEKYGGAGLDYLGCAIIAEEFTRAD
SSIGSAVLTASLGCPMVKYFGTEEQKERYLPKVVKGETPSAIAITEPDAGSDVQAIKTKAERVDGGWKLNGTKTFITNGS
VSEWVVILAKTQPDAGYRGISAFLVETGWDGYEARRIKKMGLNCHDTAEIYLKDVFVPETHIIGQENFGFYQLMRFFNES
RVFVGAVQLGMAVGAYERALEYAKQRKAFGKPLIEHQAIQFKLADMWKDIEAAKLLIYKAAWLIDRGKANPALSSAAKLF
ASETAIKATYEALQIFGGYGYSKEYDIERYYRDARVGTIYEGTSEIQKLIIARAIAGKLRL

Sequences:

>Translated_381_residues
MNFEFEEEHRILRDSVREFAEKEIMPYGKEYDEKGEYPWEIFRKAAKLGYVAADIPEKYGGAGLDYLGCAIIAEEFTRAD
SSIGSAVLTASLGCPMVKYFGTEEQKERYLPKVVKGETPSAIAITEPDAGSDVQAIKTKAERVDGGWKLNGTKTFITNGS
VSEWVVILAKTQPDAGYRGISAFLVETGWDGYEARRIKKMGLNCHDTAEIYLKDVFVPETHIIGQENFGFYQLMRFFNES
RVFVGAVQLGMAVGAYERALEYAKQRKAFGKPLIEHQAIQFKLADMWKDIEAAKLLIYKAAWLIDRGKANPALSSAAKLF
ASETAIKATYEALQIFGGYGYSKEYDIERYYRDARVGTIYEGTSEIQKLIIARAIAGKLRL
>Mature_381_residues
MNFEFEEEHRILRDSVREFAEKEIMPYGKEYDEKGEYPWEIFRKAAKLGYVAADIPEKYGGAGLDYLGCAIIAEEFTRAD
SSIGSAVLTASLGCPMVKYFGTEEQKERYLPKVVKGETPSAIAITEPDAGSDVQAIKTKAERVDGGWKLNGTKTFITNGS
VSEWVVILAKTQPDAGYRGISAFLVETGWDGYEARRIKKMGLNCHDTAEIYLKDVFVPETHIIGQENFGFYQLMRFFNES
RVFVGAVQLGMAVGAYERALEYAKQRKAFGKPLIEHQAIQFKLADMWKDIEAAKLLIYKAAWLIDRGKANPALSSAAKLF
ASETAIKATYEALQIFGGYGYSKEYDIERYYRDARVGTIYEGTSEIQKLIIARAIAGKLRL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=39.3617021276596, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=39.3617021276596, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=38.2352941176471, Blast_Score=264, Evalue=9e-71,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=39.9463806970509, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=34.2175066312997, Blast_Score=236, Evalue=4e-62,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=34.0482573726542, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=33.7801608579088, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=35, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=33.4277620396601, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=34.2939481268012, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=34.2939481268012, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4503943, Length=372, Percent_Identity=32.5268817204301, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=31.4606741573034, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI48976061, Length=358, Percent_Identity=29.8882681564246, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI211971008, Length=358, Percent_Identity=29.8882681564246, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI38505218, Length=390, Percent_Identity=27.9487179487179, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87081958, Length=378, Percent_Identity=32.2751322751323, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1786223, Length=393, Percent_Identity=29.0076335877863, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI87082384, Length=262, Percent_Identity=27.8625954198473, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081702, Length=373, Percent_Identity=24.1286863270777, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=383, Percent_Identity=38.6422976501305, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=37.696335078534, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=36.8421052631579, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=33.9572192513369, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=34.8284960422164, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=33.2439678284182, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=32.3607427055703, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17551932, Length=376, Percent_Identity=33.2446808510638, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=32, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=33.4470989761092, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=29.8153034300792, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=31.6239316239316, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=30.6569343065693, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=32.4675324675325, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=30.8943089430894, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=30.5263157894737, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17531913, Length=181, Percent_Identity=32.0441988950276, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17562446, Length=407, Percent_Identity=28.2555282555283, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=277, Percent_Identity=27.4368231046931, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=277, Percent_Identity=27.4368231046931, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=39.6825396825397, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=37.8016085790885, Blast_Score=258, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=37.6344086021505, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=36.745406824147, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=30.8310991957105, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI281363737, Length=339, Percent_Identity=35.1032448377581, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19920834, Length=385, Percent_Identity=31.1688311688312, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42729; Mature: 42729

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFEFEEEHRILRDSVREFAEKEIMPYGKEYDEKGEYPWEIFRKAAKLGYVAADIPEKYG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCHHHC
GAGLDYLGCAIIAEEFTRADSSIGSAVLTASLGCPMVKYFGTEEQKERYLPKVVKGETPS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCHHHCCCCCC
AIAITEPDAGSDVQAIKTKAERVDGGWKLNGTKTFITNGSVSEWVVILAKTQPDAGYRGI
EEEEECCCCCCCHHHHHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEEECCCCCCCCHH
SAFLVETGWDGYEARRIKKMGLNCHDTAEIYLKDVFVPETHIIGQENFGFYQLMRFFNES
EEEEEECCCCCHHHHHHHHHCCCCCCCHHEEEEEEECCCCEECCCCCCCHHHHHHHHCCC
RVFVGAVQLGMAVGAYERALEYAKQRKAFGKPLIEHQAIQFKLADMWKDIEAAKLLIYKA
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEHHHHHHHHHHHHHHHHHH
AWLIDRGKANPALSSAAKLFASETAIKATYEALQIFGGYGYSKEYDIERYYRDARVGTIY
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEE
EGTSEIQKLIIARAIAGKLRL
CCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFEFEEEHRILRDSVREFAEKEIMPYGKEYDEKGEYPWEIFRKAAKLGYVAADIPEKYG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCHHHC
GAGLDYLGCAIIAEEFTRADSSIGSAVLTASLGCPMVKYFGTEEQKERYLPKVVKGETPS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCHHHCCCCCC
AIAITEPDAGSDVQAIKTKAERVDGGWKLNGTKTFITNGSVSEWVVILAKTQPDAGYRGI
EEEEECCCCCCCHHHHHHHHHHCCCCEEECCEEEEEECCCCCEEEEEEEECCCCCCCCHH
SAFLVETGWDGYEARRIKKMGLNCHDTAEIYLKDVFVPETHIIGQENFGFYQLMRFFNES
EEEEEECCCCCHHHHHHHHHCCCCCCCHHEEEEEEECCCCEECCCCCCCHHHHHHHHCCC
RVFVGAVQLGMAVGAYERALEYAKQRKAFGKPLIEHQAIQFKLADMWKDIEAAKLLIYKA
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEHHHHHHHHHHHHHHHHHH
AWLIDRGKANPALSSAAKLFASETAIKATYEALQIFGGYGYSKEYDIERYYRDARVGTIY
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEE
EGTSEIQKLIIARAIAGKLRL
CCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]