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Identifier: 11498350

GI number: 11498350

Start: 663206

End: 664903

Strand: Reverse

Name: Not Available

Synonym: AF0744

Alternate gene names: 11498350

Gene position: 664903-663206 (Counterclockwise)

Preceding gene: 11498352

Following gene: 11498349

Centisome position: 30.52

GC content: 49.59

Gene sequence:

>1698_bases
ATGAGAGGGTTTTTCATTCTTAAACCGCCAATCTCCGTTTCCAGCGGGTTCATCGTGTTTATTTTGCATGGACATTATAA
AGGTTTGGTGCTCCAATCGGAAAAATTAAATCCCCAACATGGAAATTTAATTGTGGAAAAAATCCTCAAGCTCCTGGAGA
GGGGAGAGGGAGAAAACGTAGAGTTCAAGGAGTTCTTGGGCAACTTTCACCTTAAAGAGGGCAGGTTCAGGCAGCTCGCC
TGCCAGATGAACCACAGGATTATAATGGGAAAGGGTGTGGCTCTTTACGTTGTTGGCGTGTCAGACAGCGGTGAGATAAA
GGGTATTGATGAAAACAAATTTTCCGAAACCATTGAGGTTTTGAAAAAGCTTGCCACCGAAATTGAGGCTGAGGTAAGCT
CCGTTGAGAGGCATGAGGTTAACGGAGGCTACGTGGGGTTGGTGGAGATAAGGAAGACAAAGGCGAAGGAGCACATATTG
GTAGGAACAGCGGGACATGTTGACCACGGGAAATCAACGCTCGTCGGCTGCCTCATCACGGGAAAGCCAGACGATGGGGA
TGGCGCGACGAGAGTTTATTTAGACGTTCTGAAGCACGAAATTGAGAGGGGGCTGAGTGCTGAAATAAGCTTTGCCGTTT
TCGGTTACAAAGACGGAAAAGTTCTGAGAATGAAAAATCCGCTGAGCAAGGCAGAGAAAGCAATGGTTGTTGAAACGGCC
GACAAGCTGGTGAGCTTCGTTGACACCGTAGGCCACGAGCCGTGGCTCAGGACTACCATAAGAGGTCTGTTGGGGCAGAA
GGTCGATTACGGCCTCCTCGTGGTTGCTGCAAACGATGGTGTGATGAGAACGACAAAAGAACACCTCGGAATAATGCTCG
CGATGGATTTGCCCGTCATCGTGGCTGTAACCAAGGCGGACATGGTCGACGATGCGAGACTCAGTGAGGTTTTGCAGGAG
ATATCAGCCACTCTCAGGAGAGTTGGGAGGGTTCCAACCGTCCTGAAGTCAAGGCACGACGCCAGAAAAGCTGCTGAGAT
GGTAAAAAGCAACAAACTTCTCGTTCCCGTAGTCATAACTTCTGCTGTTACTCTGGAGGGCTACGACATCCTTGAGGAGA
TTTTCCTGCACCTGCCAAAGCGCTATACTGCTGACGAAGACTTCCTCATGTACATCGACAAGATTTACAGTGTTACTGGA
GTGGGGACAGTCGTGAGCGGGAGCGTGAAGAGCGGAGAACTTGCTGAGGGCGATGAGGTTTACATCGGACCCTTTCAGGA
TGGCAGCTTCAGGAGGGTGAGGATTCAGAGCATAGAGATGCACCACTACAGAATCGACAGAGCAAAGGCGGGAGACATAA
TTGGTGCTGCAGTCAAAGGAGTAAGGTACGACGAGTTGAGGAGGGGAATGGTCATAAGCAGGAAAGAGCCAAGGGCTGTC
TGGGAGTTTGATGCTGAGATTTACGTCTTCACCCACCCAACCCTAATCAGCGTCGGCTACGAGCCGGTTATGCACGTCGA
AACCATTTCAGAGACTGTGACGTTTGTTGAGATGGATAAGGAATACCTCAAGCCCGGAGACAGAGGAATAGTGAGAATGA
AGTTCAAATATCACCCCCACTTCGTTTACGAAGGCCAGAAGTTCATCTTCAGGGAGGGAAGGAGCAAGGGGATGGGGGAG
ATAATCAGGGTTTTTTGA

Upstream 100 bases:

>100_bases
CCTCTCCTCAACACCGACAGACTTTGTAACAACCGCTCCCGCATCCCGCGCGATGAGATTGAGGGAGTGAACCTTACTGC
CCATAATCCCGCTTGCAAGC

Downstream 100 bases:

>100_bases
AAACTTTTTAATCGCCTCTCGCCTTTTTAAGAGCTTTTCAGAATTTTTCACGAAAACTCAAAATAGCCACTATTATAGGG
CGCACGGAATTTTCTTGACA

Product: GTP-binding protein

Products: GDP; phosphate

Alternate protein names: EF-1-alpha; Elongation factor Tu; EF-Tu [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MRGFFILKPPISVSSGFIVFILHGHYKGLVLQSEKLNPQHGNLIVEKILKLLERGEGENVEFKEFLGNFHLKEGRFRQLA
CQMNHRIIMGKGVALYVVGVSDSGEIKGIDENKFSETIEVLKKLATEIEAEVSSVERHEVNGGYVGLVEIRKTKAKEHIL
VGTAGHVDHGKSTLVGCLITGKPDDGDGATRVYLDVLKHEIERGLSAEISFAVFGYKDGKVLRMKNPLSKAEKAMVVETA
DKLVSFVDTVGHEPWLRTTIRGLLGQKVDYGLLVVAANDGVMRTTKEHLGIMLAMDLPVIVAVTKADMVDDARLSEVLQE
ISATLRRVGRVPTVLKSRHDARKAAEMVKSNKLLVPVVITSAVTLEGYDILEEIFLHLPKRYTADEDFLMYIDKIYSVTG
VGTVVSGSVKSGELAEGDEVYIGPFQDGSFRRVRIQSIEMHHYRIDRAKAGDIIGAAVKGVRYDELRRGMVISRKEPRAV
WEFDAEIYVFTHPTLISVGYEPVMHVETISETVTFVEMDKEYLKPGDRGIVRMKFKYHPHFVYEGQKFIFREGRSKGMGE
IIRVF

Sequences:

>Translated_565_residues
MRGFFILKPPISVSSGFIVFILHGHYKGLVLQSEKLNPQHGNLIVEKILKLLERGEGENVEFKEFLGNFHLKEGRFRQLA
CQMNHRIIMGKGVALYVVGVSDSGEIKGIDENKFSETIEVLKKLATEIEAEVSSVERHEVNGGYVGLVEIRKTKAKEHIL
VGTAGHVDHGKSTLVGCLITGKPDDGDGATRVYLDVLKHEIERGLSAEISFAVFGYKDGKVLRMKNPLSKAEKAMVVETA
DKLVSFVDTVGHEPWLRTTIRGLLGQKVDYGLLVVAANDGVMRTTKEHLGIMLAMDLPVIVAVTKADMVDDARLSEVLQE
ISATLRRVGRVPTVLKSRHDARKAAEMVKSNKLLVPVVITSAVTLEGYDILEEIFLHLPKRYTADEDFLMYIDKIYSVTG
VGTVVSGSVKSGELAEGDEVYIGPFQDGSFRRVRIQSIEMHHYRIDRAKAGDIIGAAVKGVRYDELRRGMVISRKEPRAV
WEFDAEIYVFTHPTLISVGYEPVMHVETISETVTFVEMDKEYLKPGDRGIVRMKFKYHPHFVYEGQKFIFREGRSKGMGE
IIRVF
>Mature_565_residues
MRGFFILKPPISVSSGFIVFILHGHYKGLVLQSEKLNPQHGNLIVEKILKLLERGEGENVEFKEFLGNFHLKEGRFRQLA
CQMNHRIIMGKGVALYVVGVSDSGEIKGIDENKFSETIEVLKKLATEIEAEVSSVERHEVNGGYVGLVEIRKTKAKEHIL
VGTAGHVDHGKSTLVGCLITGKPDDGDGATRVYLDVLKHEIERGLSAEISFAVFGYKDGKVLRMKNPLSKAEKAMVVETA
DKLVSFVDTVGHEPWLRTTIRGLLGQKVDYGLLVVAANDGVMRTTKEHLGIMLAMDLPVIVAVTKADMVDDARLSEVLQE
ISATLRRVGRVPTVLKSRHDARKAAEMVKSNKLLVPVVITSAVTLEGYDILEEIFLHLPKRYTADEDFLMYIDKIYSVTG
VGTVVSGSVKSGELAEGDEVYIGPFQDGSFRRVRIQSIEMHHYRIDRAKAGDIIGAAVKGVRYDELRRGMVISRKEPRAV
WEFDAEIYVFTHPTLISVGYEPVMHVETISETVTFVEMDKEYLKPGDRGIVRMKFKYHPHFVYEGQKFIFREGRSKGMGE
IIRVF

Specific function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis [H]

COG id: COG5258

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily [H]

Homologues:

Organism=Homo sapiens, GI82546879, Length=503, Percent_Identity=34.3936381709742, Blast_Score=282, Evalue=7e-76,
Organism=Homo sapiens, GI45593140, Length=532, Percent_Identity=32.1428571428571, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI34147630, Length=453, Percent_Identity=29.5805739514349, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4503475, Length=433, Percent_Identity=27.4826789838337, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI4503471, Length=433, Percent_Identity=27.7136258660508, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI54607086, Length=328, Percent_Identity=25.609756097561, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI223555963, Length=380, Percent_Identity=23.4210526315789, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI5729864, Length=380, Percent_Identity=23.4210526315789, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI2367247, Length=314, Percent_Identity=31.2101910828025, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1790412, Length=436, Percent_Identity=28.2110091743119, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789737, Length=436, Percent_Identity=28.2110091743119, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17563834, Length=531, Percent_Identity=29.9435028248588, Blast_Score=251, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI17565438, Length=495, Percent_Identity=32.7272727272727, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17552884, Length=437, Percent_Identity=29.0617848970252, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17569207, Length=437, Percent_Identity=29.0617848970252, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32566303, Length=423, Percent_Identity=27.6595744680851, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25141371, Length=423, Percent_Identity=29.0780141843972, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17556456, Length=418, Percent_Identity=25.5980861244019, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI32566629, Length=474, Percent_Identity=24.2616033755274, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324761, Length=433, Percent_Identity=29.7921478060046, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325337, Length=448, Percent_Identity=29.2410714285714, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319594, Length=448, Percent_Identity=29.2410714285714, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320377, Length=438, Percent_Identity=24.6575342465753, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19922512, Length=491, Percent_Identity=33.8085539714868, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24654852, Length=491, Percent_Identity=33.8085539714868, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI28573213, Length=538, Percent_Identity=33.457249070632, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI221378008, Length=538, Percent_Identity=33.457249070632, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24644462, Length=538, Percent_Identity=33.457249070632, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24644464, Length=538, Percent_Identity=33.457249070632, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24644466, Length=538, Percent_Identity=33.457249070632, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI281363316, Length=422, Percent_Identity=26.7772511848341, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17864358, Length=422, Percent_Identity=26.7772511848341, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24652838, Length=433, Percent_Identity=27.2517321016166, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17137572, Length=433, Percent_Identity=27.2517321016166, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45553807, Length=404, Percent_Identity=28.2178217821782, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45553816, Length=404, Percent_Identity=28.2178217821782, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24651721, Length=404, Percent_Identity=28.2178217821782, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17864154, Length=404, Percent_Identity=28.2178217821782, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI19922690, Length=382, Percent_Identity=24.869109947644, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45550900, Length=384, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137380, Length=434, Percent_Identity=25.5760368663594, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004539
- InterPro:   IPR004161
- InterPro:   IPR004160
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF03143 GTP_EFTU_D3 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 63214; Mature: 63214

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGFFILKPPISVSSGFIVFILHGHYKGLVLQSEKLNPQHGNLIVEKILKLLERGEGENV
CCCEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCE
EFKEFLGNFHLKEGRFRQLACQMNHRIIMGKGVALYVVGVSDSGEIKGIDENKFSETIEV
EHHHHHCCCCCCCCHHHHHHHHCCCEEEEECCEEEEEEEECCCCCEECCCCHHHHHHHHH
LKKLATEIEAEVSSVERHEVNGGYVGLVEIRKTKAKEHILVGTAGHVDHGKSTLVGCLIT
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCCEEEEEEEE
GKPDDGDGATRVYLDVLKHEIERGLSAEISFAVFGYKDGKVLRMKNPLSKAEKAMVVETA
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHH
DKLVSFVDTVGHEPWLRTTIRGLLGQKVDYGLLVVAANDGVMRTTKEHLGIMLAMDLPVI
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECHHHCCEEEEECCCEE
VAVTKADMVDDARLSEVLQEISATLRRVGRVPTVLKSRHDARKAAEMVKSNKLLVPVVIT
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEE
SAVTLEGYDILEEIFLHLPKRYTADEDFLMYIDKIYSVTGVGTVVSGSVKSGELAEGDEV
EEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEE
YIGPFQDGSFRRVRIQSIEMHHYRIDRAKAGDIIGAAVKGVRYDELRRGMVISRKEPRAV
EEECCCCCCEEEEEEEEEEEEEEEECCCCCCCHHHHHHCCCCHHHHHCCEEEECCCCCEE
WEFDAEIYVFTHPTLISVGYEPVMHVETISETVTFVEMDKEYLKPGDRGIVRMKFKYHPH
EEECCEEEEEECCEEEECCCCCEEHHHHHHHHHHHEEECHHHCCCCCCCEEEEEEEECCE
FVYEGQKFIFREGRSKGMGEIIRVF
EEECCCEEEEECCCCCCCHHHHHCC
>Mature Secondary Structure
MRGFFILKPPISVSSGFIVFILHGHYKGLVLQSEKLNPQHGNLIVEKILKLLERGEGENV
CCCEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCE
EFKEFLGNFHLKEGRFRQLACQMNHRIIMGKGVALYVVGVSDSGEIKGIDENKFSETIEV
EHHHHHCCCCCCCCHHHHHHHHCCCEEEEECCEEEEEEEECCCCCEECCCCHHHHHHHHH
LKKLATEIEAEVSSVERHEVNGGYVGLVEIRKTKAKEHILVGTAGHVDHGKSTLVGCLIT
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCCEEEEEEEE
GKPDDGDGATRVYLDVLKHEIERGLSAEISFAVFGYKDGKVLRMKNPLSKAEKAMVVETA
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEEECCCHHHHHHHHHHHHH
DKLVSFVDTVGHEPWLRTTIRGLLGQKVDYGLLVVAANDGVMRTTKEHLGIMLAMDLPVI
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEECHHHCCEEEEECCCEE
VAVTKADMVDDARLSEVLQEISATLRRVGRVPTVLKSRHDARKAAEMVKSNKLLVPVVIT
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEE
SAVTLEGYDILEEIFLHLPKRYTADEDFLMYIDKIYSVTGVGTVVSGSVKSGELAEGDEV
EEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEE
YIGPFQDGSFRRVRIQSIEMHHYRIDRAKAGDIIGAAVKGVRYDELRRGMVISRKEPRAV
EEECCCCCCEEEEEEEEEEEEEEEECCCCCCCHHHHHHCCCCHHHHHCCEEEECCCCCEE
WEFDAEIYVFTHPTLISVGYEPVMHVETISETVTFVEMDKEYLKPGDRGIVRMKFKYHPH
EEECCEEEEEECCEEEECCCCCEEHHHHHHHHHHHEEECHHHCCCCCCCEEEEEEEECCE
FVYEGQKFIFREGRSKGMGEIIRVF
EEECCCEEEEECCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]