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Identifier: 11498341

GI number: 11498341

Start: 656982

End: 657641

Strand: Reverse

Name: Not Available

Synonym: AF0734

Alternate gene names: NA

Gene position: 657641-656982 (Counterclockwise)

Preceding gene: 11498346

Following gene: 11498340

Centisome position: 30.19

GC content: 50.76

Gene sequence:

>660_bases
GTGGGAAGTGCATTCGTGTTTCTTGAGGCATCGCTCGAACTAATCCCCCAAAAAATTCGGGGTCATCCTGCGGTGAGGGC
AGATGCAATAAGAAGGGGGAAGAGACCAGAGAAAATCCTTCTGGACGACTCGAAGCACCATACGGCGATGAAATCCCTGG
AATTCAGGGAAAAGAGGGGCAGGCCCGATATAGTCCATCAGTGCCTCCTTCTCCTCCTCGACTCACCTCTGAGGGATTTC
GAAGTTTACGTGCACACCCTCAACGGGGAGATAATATGGGTAAATCGCGAAACAAGGCTTCCGAGGAACTACAACCGCTT
TGTTGGGCTAATGGAGAAGTTATTTGAGGAGAGAAGGATAACAGCTGGGGATACTACCCTCATCGAGTTCAAAGATGTCG
GCCTGAGGGACATCGTCAGAGGGAGGGACGTTCTCCTTTTCAGAGAGAAGGGGGGGCGCTTTGAATTCTCCGAGCTGCTT
GACGGTGACGTTGCGGTCTGCATCGGCGCATTTCCGCACGGTGACTTTTTCGAGGAAACCCTTCGGGAGCTTGGGGAGTT
TAAGGAGGTAAGTCTTGGTACAGAAAGCTACACAAGCCTTTATGTGACGAGTCGTGTTCTATGCGAATATGAAAGAGTTC
GAGCTCATAAAGTTGGTTGA

Upstream 100 bases:

>100_bases
TTCAAAATCCTGCCTGCCAGCTCGGCGGCTCTCTTCAGGAGTTCATTCACAAAAAGAGTTTCGGAGAAAAGAACTTAAAC
TTTTTTGCTCCATTTCCTCT

Downstream 100 bases:

>100_bases
GCGCCTGTTTGGGGATGAAGATGTCATTACTCCCGCAGGAAAGCACGATGCTGCTTACGTCAAAATCGGAAACAGGCTGA
TCGTCCTCACCTGTGATACC

Product: ribosome biogenesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MGSAFVFLEASLELIPQKIRGHPAVRADAIRRGKRPEKILLDDSKHHTAMKSLEFREKRGRPDIVHQCLLLLLDSPLRDF
EVYVHTLNGEIIWVNRETRLPRNYNRFVGLMEKLFEERRITAGDTTLIEFKDVGLRDIVRGRDVLLFREKGGRFEFSELL
DGDVAVCIGAFPHGDFFEETLRELGEFKEVSLGTESYTSLYVTSRVLCEYERVRAHKVG

Sequences:

>Translated_219_residues
MGSAFVFLEASLELIPQKIRGHPAVRADAIRRGKRPEKILLDDSKHHTAMKSLEFREKRGRPDIVHQCLLLLLDSPLRDF
EVYVHTLNGEIIWVNRETRLPRNYNRFVGLMEKLFEERRITAGDTTLIEFKDVGLRDIVRGRDVLLFREKGGRFEFSELL
DGDVAVCIGAFPHGDFFEETLRELGEFKEVSLGTESYTSLYVTSRVLCEYERVRAHKVG
>Mature_218_residues
GSAFVFLEASLELIPQKIRGHPAVRADAIRRGKRPEKILLDDSKHHTAMKSLEFREKRGRPDIVHQCLLLLLDSPLRDFE
VYVHTLNGEIIWVNRETRLPRNYNRFVGLMEKLFEERRITAGDTTLIEFKDVGLRDIVRGRDVLLFREKGGRFEFSELLD
GDVAVCIGAFPHGDFFEETLRELGEFKEVSLGTESYTSLYVTSRVLCEYERVRAHKVG

Specific function: Involved in ribosomal biogenesis. It seems to play a role a methylation reaction in pre-rRNA processing

COG id: COG1756

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NEP1 family

Homologues:

Organism=Homo sapiens, GI194328699, Length=197, Percent_Identity=27.4111675126904, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323215, Length=162, Percent_Identity=30.8641975308642, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639698, Length=196, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NEP1_ARCFU (O29524)

Other databases:

- EMBL:   AE000782
- PIR:   F69341
- RefSeq:   NP_069568.1
- ProteinModelPortal:   O29524
- SMR:   O29524
- GeneID:   1483952
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0734
- NMPDR:   fig|224325.1.peg.727
- TIGR:   AF_0734
- HOGENOM:   HBG512786
- OMA:   YNIILAK
- ProtClustDB:   PRK04171
- BioCyc:   AFUL224325:AF_0734-MONOMER
- HAMAP:   MF_00554
- InterPro:   IPR005304
- PANTHER:   PTHR12636

Pfam domain/function: PF03587 EMG1

EC number: NA

Molecular weight: Translated: 25308; Mature: 25177

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSAFVFLEASLELIPQKIRGHPAVRADAIRRGKRPEKILLDDSKHHTAMKSLEFREKRG
CCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCC
RPDIVHQCLLLLLDSPLRDFEVYVHTLNGEIIWVNRETRLPRNYNRFVGLMEKLFEERRI
CHHHHHHHHHHHHCCCCHHEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCC
TAGDTTLIEFKDVGLRDIVRGRDVLLFREKGGRFEFSELLDGDVAVCIGAFPHGDFFEET
CCCCEEEEEEECCCHHHHHCCCEEEEEECCCCCEEHHHHCCCCEEEEEECCCCCHHHHHH
LRELGEFKEVSLGTESYTSLYVTSRVLCEYERVRAHKVG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GSAFVFLEASLELIPQKIRGHPAVRADAIRRGKRPEKILLDDSKHHTAMKSLEFREKRG
CCEEEEEEHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCC
RPDIVHQCLLLLLDSPLRDFEVYVHTLNGEIIWVNRETRLPRNYNRFVGLMEKLFEERRI
CHHHHHHHHHHHHCCCCHHEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCC
TAGDTTLIEFKDVGLRDIVRGRDVLLFREKGGRFEFSELLDGDVAVCIGAFPHGDFFEET
CCCCEEEEEEECCCHHHHHCCCEEEEEECCCCCEEHHHHCCCCEEEEEECCCCCHHHHHH
LRELGEFKEVSLGTESYTSLYVTSRVLCEYERVRAHKVG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475