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The map label for this gene is merR

Identifier: 11498281

GI number: 11498281

Start: 606868

End: 607260

Strand: Reverse

Name: merR

Synonym: AF0673

Alternate gene names: 11498281

Gene position: 607260-606868 (Counterclockwise)

Preceding gene: 11498284

Following gene: 11498280

Centisome position: 27.88

GC content: 45.8

Gene sequence:

>393_bases
ATGAAGAAAAAAGACCGCTACACGATTTCGGAGCTTGCAAGAGAGTTCGAGATAAGCACGAGGACCATTCGGTATTACGA
GGAAATTGGTCTTCTCAACCCCGAAAGAACGCCGGGAAATCAGAGAATTTTTTCGAGAAAAGACAGGGCAAAGCTGAAGT
TGATTTTAAGGGGTAGGAGGCTCGGTTTCAGCCTTGAGGAGATTAGAGAGATGATTGAGATGTACGATGTGGCAGGAGAG
CCGGAGCAGATAAGGCTGACGCTGAAGTACGGCGAAAAGAAGCTTAAAGAGATTGAGGAAAAAATCAGGGAGCTCGAGCT
TCTAAAAGAGGACCTTCTCAACTTAAGGGAGATGCTAGTCAAGAGACTTGAGGAGCTGGAAAAGGGAAGTTAA

Upstream 100 bases:

>100_bases
TTTTTGCATTTAGGTATTTATCTAATATCCAATCGCTATTTTGTCAGATAAATCATTAGATGGGAAATATTATAAAGTCC
TAAAGCCGACAATCCTTAAA

Downstream 100 bases:

>100_bases
CGTAAACGTTAAATTTAAATATTATTTATGGCTTATTTTTGTTTGGGTGAGAGTGTGTTTACTATACCGTATCTTCTGGA
AAGAGCGGCAAAGCTTTTTC

Product: mercuric resistance operon regulatory protein (merR)

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MKKKDRYTISELAREFEISTRTIRYYEEIGLLNPERTPGNQRIFSRKDRAKLKLILRGRRLGFSLEEIREMIEMYDVAGE
PEQIRLTLKYGEKKLKEIEEKIRELELLKEDLLNLREMLVKRLEELEKGS

Sequences:

>Translated_130_residues
MKKKDRYTISELAREFEISTRTIRYYEEIGLLNPERTPGNQRIFSRKDRAKLKLILRGRRLGFSLEEIREMIEMYDVAGE
PEQIRLTLKYGEKKLKEIEEKIRELELLKEDLLNLREMLVKRLEELEKGS
>Mature_130_residues
MKKKDRYTISELAREFEISTRTIRYYEEIGLLNPERTPGNQRIFSRKDRAKLKLILRGRRLGFSLEEIREMIEMYDVAGE
PEQIRLTLKYGEKKLKEIEEKIRELELLKEDLLNLREMLVKRLEELEKGS

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=136, Percent_Identity=34.5588235294118, Blast_Score=66, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15674; Mature: 15674

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKDRYTISELAREFEISTRTIRYYEEIGLLNPERTPGNQRIFSRKDRAKLKLILRGRR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
LGFSLEEIREMIEMYDVAGEPEQIRLTLKYGEKKLKEIEEKIRELELLKEDLLNLREMLV
CCCCHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRLEELEKGS
HHHHHHHCCC
>Mature Secondary Structure
MKKKDRYTISELAREFEISTRTIRYYEEIGLLNPERTPGNQRIFSRKDRAKLKLILRGRR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
LGFSLEEIREMIEMYDVAGEPEQIRLTLKYGEKKLKEIEEKIRELELLKEDLLNLREMLV
CCCCHHHHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRLEELEKGS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]