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The map label for this gene is adk

Identifier: 11498284

GI number: 11498284

Start: 608500

End: 609153

Strand: Reverse

Name: adk

Synonym: AF0676

Alternate gene names: 11498284

Gene position: 609153-608500 (Counterclockwise)

Preceding gene: 11498285

Following gene: 11498281

Centisome position: 27.96

GC content: 50.0

Gene sequence:

>654_bases
ATGAACCTGATTTTTCTCGGCCCACCCGGAGCGGGTAAGGGTACGCAGGCAAAGAGAGTTTCCGAAAAGTATGGCATTCC
GCAGATTTCAACCGGTGATATGCTGAGGGAGGCTGTTGCTAAGGGGACGGAGCTGGGAAAAAAGGCCAAGGAGTACATGG
ACAAGGGGGAGCTTGTGCCTGACGAGGTTGTTATTGGCATAGTCAAGGAGAGGCTGCAGCAGCCTGACTGTGAGAAGGGC
TTTATCCTCGACGGATTTCCGAGAACTCTCGCTCAAGCAGAGGCTCTCGACGAGATGCTCAAAGAGCTGAACAAGAAAAT
CGATGCCGTCATCAACGTTGTTGTTCCTGAGGAGGAAGTCGTAAAGAGAATCACGTACAGAAGAACGTGCAGAAACTGCG
GAGCCGTCTATCATCTGATTTACGCTCCACCCAAGGAGGATAACAAGTGTGACAAGTGCGGTGGAGAGCTATACCAGAGA
GACGACGATAAGGAGGAAACTGTGAGGGAGAGGTACAGGGTTTACAAGCAAAATACGGAGCCGCTTATCGATTACTACAG
AAAGAAGGGCATACTCTACGACGTGGACGGAACCAAAGATATAGAGGGCGTCTGGAAAGAGATAGAGGCCATATTGGAAA
AGATCAAATCCTGA

Upstream 100 bases:

>100_bases
GGCGGTTGAGAAGCTCAAGAAACTTTAAAAATTTATTCCTTTTTTTCTCTTGCTCCGGTAAAAATCAAAAAGTTTAAAGG
TGTAACTGCAAAGCAATCAC

Downstream 100 bases:

>100_bases
TAATTTTTTCCTTTATTTTCCCGTCAAGCCACTCGGCAATTAGCTCAACAATCCTATTGTCATGCCTTAAAAAGTGGTCT
CCCTTCTCCACCTCCACGAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNLIFLGPPGAGKGTQAKRVSEKYGIPQISTGDMLREAVAKGTELGKKAKEYMDKGELVPDEVVIGIVKERLQQPDCEKG
FILDGFPRTLAQAEALDEMLKELNKKIDAVINVVVPEEEVVKRITYRRTCRNCGAVYHLIYAPPKEDNKCDKCGGELYQR
DDDKEETVRERYRVYKQNTEPLIDYYRKKGILYDVDGTKDIEGVWKEIEAILEKIKS

Sequences:

>Translated_217_residues
MNLIFLGPPGAGKGTQAKRVSEKYGIPQISTGDMLREAVAKGTELGKKAKEYMDKGELVPDEVVIGIVKERLQQPDCEKG
FILDGFPRTLAQAEALDEMLKELNKKIDAVINVVVPEEEVVKRITYRRTCRNCGAVYHLIYAPPKEDNKCDKCGGELYQR
DDDKEETVRERYRVYKQNTEPLIDYYRKKGILYDVDGTKDIEGVWKEIEAILEKIKS
>Mature_217_residues
MNLIFLGPPGAGKGTQAKRVSEKYGIPQISTGDMLREAVAKGTELGKKAKEYMDKGELVPDEVVIGIVKERLQQPDCEKG
FILDGFPRTLAQAEALDEMLKELNKKIDAVINVVVPEEEVVKRITYRRTCRNCGAVYHLIYAPPKEDNKCDKCGGELYQR
DDDKEETVRERYRVYKQNTEPLIDYYRKKGILYDVDGTKDIEGVWKEIEAILEKIKS

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=44.8598130841121, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=45.0236966824645, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI19923437, Length=213, Percent_Identity=38.9671361502347, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI310110345, Length=214, Percent_Identity=35.981308411215, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI53832003, Length=214, Percent_Identity=35.981308411215, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI8051579, Length=214, Percent_Identity=35.981308411215, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI53832001, Length=214, Percent_Identity=35.981308411215, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=30.6976744186047, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=32.0574162679426, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI28144897, Length=214, Percent_Identity=26.6355140186916, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI28144899, Length=214, Percent_Identity=26.6355140186916, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=27.8538812785388, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI21450759, Length=140, Percent_Identity=30.7142857142857, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI237858799, Length=140, Percent_Identity=30.7142857142857, Blast_Score=78, Evalue=7e-15,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=53.4562211981567, Blast_Score=213, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=45.1162790697674, Blast_Score=192, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=30.4147465437788, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=29.1666666666667, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=214, Percent_Identity=25.7009345794392, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=213, Percent_Identity=26.7605633802817, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25147457, Length=216, Percent_Identity=25.462962962963, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=45.4545454545455, Blast_Score=200, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=202, Percent_Identity=41.5841584158416, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=25.3521126760563, Blast_Score=85, Evalue=8e-18,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=41.588785046729, Blast_Score=190, Evalue=6e-49,
Organism=Drosophila melanogaster, GI17737899, Length=210, Percent_Identity=39.0476190476191, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24645822, Length=210, Percent_Identity=39.0476190476191, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24663208, Length=205, Percent_Identity=27.8048780487805, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17647141, Length=205, Percent_Identity=27.8048780487805, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=27.2300469483568, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=27.2300469483568, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ARCFU (O29581)

Other databases:

- EMBL:   AE000782
- PIR:   D69334
- RefSeq:   NP_069510.1
- ProteinModelPortal:   O29581
- SMR:   O29581
- GeneID:   1483894
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0676
- NMPDR:   fig|224325.1.peg.669
- TIGR:   AF_0676
- HOGENOM:   HBG630208
- OMA:   MEPIIKF
- ProtClustDB:   PRK00279
- BioCyc:   AFUL224325:AF_0676-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24704; Mature: 24704

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIFLGPPGAGKGTQAKRVSEKYGIPQISTGDMLREAVAKGTELGKKAKEYMDKGELVP
CCEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DEVVIGIVKERLQQPDCEKGFILDGFPRTLAQAEALDEMLKELNKKIDAVINVVVPEEEV
HHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VKRITYRRTCRNCGAVYHLIYAPPKEDNKCDKCGGELYQRDDDKEETVRERYRVYKQNTE
HHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
PLIDYYRKKGILYDVDGTKDIEGVWKEIEAILEKIKS
HHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLIFLGPPGAGKGTQAKRVSEKYGIPQISTGDMLREAVAKGTELGKKAKEYMDKGELVP
CCEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DEVVIGIVKERLQQPDCEKGFILDGFPRTLAQAEALDEMLKELNKKIDAVINVVVPEEEV
HHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VKRITYRRTCRNCGAVYHLIYAPPKEDNKCDKCGGELYQRDDDKEETVRERYRVYKQNTE
HHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCH
PLIDYYRKKGILYDVDGTKDIEGVWKEIEAILEKIKS
HHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475