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Identifier: 15679707

GI number: 15679707

Start: 1570004

End: 1571380

Strand: Direct

Name: Not Available

Synonym: MTH1713

Alternate gene names: 15679707

Gene position: 1570004-1571380 (Clockwise)

Preceding gene: 15679706

Following gene: 15679708

Centisome position: 89.64

GC content: 52.58

Gene sequence:

>1377_bases
TTGCAGGTCACTGCCATGGATGTATACCGTTTACTTCCAAAAACAAACTGTGGTAAATGCAATGAGGCCTCATGCATGGC
ATTTGCCACAAAACTCATAGAAAAGGAGGTCACCCTTGATGACTGCCCACAGCTCAGTGGAGATGAAAGACAGAAACTGG
AGAACCTTCTGGCCCCTGCTGTGAAGGAAATAACCTTCGGGCCGGAGGAGAATCAGGTGGTTGTGGGTGGTGATGAGGTC
CTCTACAGGTATGAACTCACATACTACAATCCAACAGCCCTTGTGGTTGATCTTCCAGATGATCTTCCATCAGAGGAGCT
CCTGAACAGAGCCCAAAGGATCATGGAGCTGGAGTTTGAGCGTACCGGCGAAAAACTCACTCTCGATGCAATAGCCCTGA
GGAACAGATCAGGGAGCCCTGAAAAATTTGCCGAGGCAGCAGAAGCCATAAGCAAACTCAACTTCCCTGTGGTCCTGTGC
ACCTTCGATGTAGAGGCCATGAAGGCGGCCCTTGAGGTCCTGGGTGATCAGAAACCGCTCCTCTACGCCGCCAGGGAGGA
CAACCTTGGTGAAATGGCGGAACTCTCAGTTTCATACGGCTGCCCCCTCGTGCTTTTCTCACCCGGCGACCTTGAGGAGA
TGAAGAACCTCTCAAGGAGACTCAGGTCCCTGGGAGTCACTGAAATTGTGCTTGACCCCGGCACATTCACGGGTGAGGGG
ATAGGTGACACCATAGACAACTTCGTCATGATAAGGCGCCTTGCAGTTGAGGACGGGGATGATGACTTCCGCTTCCCAAT
CATGGGCATACCTGCACTCTCAAGGCTCACGGTATCCGATAAAATCGAGGCAAACATAAGGGAGGCCACAGTGGCAGCCA
CCCTCATGAACAGGTACGCTGACATCCTCATACTCGCCGGAACCGAGATATGGGAGATCATGCCGGTCCTAACACTCAGA
CAGGGACTCTACACCGACCCGAGGAAGCCCCAGGCCGTTGATCCAGGTGTCTATGAATTCGGTGATGTTGATGAGAACTC
CCCGGTTATACTCACAACCAACTTCTCACTCACCTACTACACGGTTGAGGGGGATCTCAAGTCAGGTGATGTTACAGCAT
ACCTCCTCGTCCTTGATACAGAGGGCAGGGCCGTGGACGTTTCACTGGCAGGTGGACAGCTCAATGGTCCGGCAGTGGCT
GACCTCATAAAGGAGACAGGTATAGAGGAGCGGGTCAGGGACAAGGTCATGATAATCCCTGGACTTGCAGCTCCTGCAAG
CGGTGAGATAGAGGATGATACTGGCTGGAGAGTCCTTGTTGGACCAAGGGACTCCTCTGGAATACCAGACTACCTTGATA
AACTTGCATCAGAGTGA

Upstream 100 bases:

>100_bases
TGCGGGAGATAGGTGAAACCTTCACAAGGGAGTACATGACAGCTGAAACACCTGACCTGAGGGAATGGATAACTGAACTT
GACTACCAGGAGGTTTAAAA

Downstream 100 bases:

>100_bases
GGGGTGGTTCAGTGAAGATGCTGATGGTCATGGACCCTGCGAGGTGCAGTGGCTGCGATGACTGTATAAATGCGTGCAGG
GAAACCCATGGAGTCGCCAG

Product: acetyl-CoA decarbonylase/synthase complex subunit gamma

Products: CO2; AH2

Alternate protein names: ACDS complex subunit gamma; ACDS complex methyltransferase; Corrinoid/iron-sulfur component large subunit

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MQVTAMDVYRLLPKTNCGKCNEASCMAFATKLIEKEVTLDDCPQLSGDERQKLENLLAPAVKEITFGPEENQVVVGGDEV
LYRYELTYYNPTALVVDLPDDLPSEELLNRAQRIMELEFERTGEKLTLDAIALRNRSGSPEKFAEAAEAISKLNFPVVLC
TFDVEAMKAALEVLGDQKPLLYAAREDNLGEMAELSVSYGCPLVLFSPGDLEEMKNLSRRLRSLGVTEIVLDPGTFTGEG
IGDTIDNFVMIRRLAVEDGDDDFRFPIMGIPALSRLTVSDKIEANIREATVAATLMNRYADILILAGTEIWEIMPVLTLR
QGLYTDPRKPQAVDPGVYEFGDVDENSPVILTTNFSLTYYTVEGDLKSGDVTAYLLVLDTEGRAVDVSLAGGQLNGPAVA
DLIKETGIEERVRDKVMIIPGLAAPASGEIEDDTGWRVLVGPRDSSGIPDYLDKLASE

Sequences:

>Translated_458_residues
MQVTAMDVYRLLPKTNCGKCNEASCMAFATKLIEKEVTLDDCPQLSGDERQKLENLLAPAVKEITFGPEENQVVVGGDEV
LYRYELTYYNPTALVVDLPDDLPSEELLNRAQRIMELEFERTGEKLTLDAIALRNRSGSPEKFAEAAEAISKLNFPVVLC
TFDVEAMKAALEVLGDQKPLLYAAREDNLGEMAELSVSYGCPLVLFSPGDLEEMKNLSRRLRSLGVTEIVLDPGTFTGEG
IGDTIDNFVMIRRLAVEDGDDDFRFPIMGIPALSRLTVSDKIEANIREATVAATLMNRYADILILAGTEIWEIMPVLTLR
QGLYTDPRKPQAVDPGVYEFGDVDENSPVILTTNFSLTYYTVEGDLKSGDVTAYLLVLDTEGRAVDVSLAGGQLNGPAVA
DLIKETGIEERVRDKVMIIPGLAAPASGEIEDDTGWRVLVGPRDSSGIPDYLDKLASE
>Mature_458_residues
MQVTAMDVYRLLPKTNCGKCNEASCMAFATKLIEKEVTLDDCPQLSGDERQKLENLLAPAVKEITFGPEENQVVVGGDEV
LYRYELTYYNPTALVVDLPDDLPSEELLNRAQRIMELEFERTGEKLTLDAIALRNRSGSPEKFAEAAEAISKLNFPVVLC
TFDVEAMKAALEVLGDQKPLLYAAREDNLGEMAELSVSYGCPLVLFSPGDLEEMKNLSRRLRSLGVTEIVLDPGTFTGEG
IGDTIDNFVMIRRLAVEDGDDDFRFPIMGIPALSRLTVSDKIEANIREATVAATLMNRYADILILAGTEIWEIMPVLTLR
QGLYTDPRKPQAVDPGVYEFGDVDENSPVILTTNFSLTYYTVEGDLKSGDVTAYLLVLDTEGRAVDVSLAGGQLNGPAVA
DLIKETGIEERVRDKVMIIPGLAAPASGEIEDDTGWRVLVGPRDSSGIPDYLDKLASE

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2)

COG id: COG1456

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDG_METTH (O27748)

Other databases:

- EMBL:   AE000666
- PIR:   C69096
- RefSeq:   NP_276825.1
- ProteinModelPortal:   O27748
- SMR:   O27748
- STRING:   O27748
- GeneID:   1470798
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1713
- NMPDR:   fig|187420.1.peg.1680
- eggNOG:   arNOG04922
- HOGENOM:   HBG304431
- OMA:   YTDPRKP
- ProtClustDB:   PRK04165
- BioCyc:   MTHE187420:MTH1713-MONOMER
- HAMAP:   MF_01136
- InterPro:   IPR016041
- InterPro:   IPR016218
- InterPro:   IPR011005
- InterPro:   IPR007202
- PIRSF:   PIRSF000376

Pfam domain/function: PF03599 CdhD; PF04060 FeS; SSF51717 DHP_synth_like

EC number: 1.2.99.2

Molecular weight: Translated: 50232; Mature: 50232

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: PS00198 4FE4S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTAMDVYRLLPKTNCGKCNEASCMAFATKLIEKEVTLDDCPQLSGDERQKLENLLAPA
CCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHH
VKEITFGPEENQVVVGGDEVLYRYELTYYNPTALVVDLPDDLPSEELLNRAQRIMELEFE
HHHHCCCCCCCEEEECCCEEEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
RTGEKLTLDAIALRNRSGSPEKFAEAAEAISKLNFPVVLCTFDVEAMKAALEVLGDQKPL
HCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCE
LYAAREDNLGEMAELSVSYGCPLVLFSPGDLEEMKNLSRRLRSLGVTEIVLDPGTFTGEG
EEEECCCCCCHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
IGDTIDNFVMIRRLAVEDGDDDFRFPIMGIPALSRLTVSDKIEANIREATVAATLMNRYA
CCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHEEEECCHHHCCHHHHHHHHHHHHHCC
DILILAGTEIWEIMPVLTLRQGLYTDPRKPQAVDPGVYEFGDVDENSPVILTTNFSLTYY
CEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEEE
TVEGDLKSGDVTAYLLVLDTEGRAVDVSLAGGQLNGPAVADLIKETGIEERVRDKVMIIP
EEECCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHCCCEEEEE
GLAAPASGEIEDDTGWRVLVGPRDSSGIPDYLDKLASE
CCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MQVTAMDVYRLLPKTNCGKCNEASCMAFATKLIEKEVTLDDCPQLSGDERQKLENLLAPA
CCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHH
VKEITFGPEENQVVVGGDEVLYRYELTYYNPTALVVDLPDDLPSEELLNRAQRIMELEFE
HHHHCCCCCCCEEEECCCEEEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
RTGEKLTLDAIALRNRSGSPEKFAEAAEAISKLNFPVVLCTFDVEAMKAALEVLGDQKPL
HCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCE
LYAAREDNLGEMAELSVSYGCPLVLFSPGDLEEMKNLSRRLRSLGVTEIVLDPGTFTGEG
EEEECCCCCCHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
IGDTIDNFVMIRRLAVEDGDDDFRFPIMGIPALSRLTVSDKIEANIREATVAATLMNRYA
CCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHEEEECCHHHCCHHHHHHHHHHHHHCC
DILILAGTEIWEIMPVLTLRQGLYTDPRKPQAVDPGVYEFGDVDENSPVILTTNFSLTYY
CEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEEE
TVEGDLKSGDVTAYLLVLDTEGRAVDVSLAGGQLNGPAVADLIKETGIEERVRDKVMIIP
EEECCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCHHHHHCCCEEEEE
GLAAPASGEIEDDTGWRVLVGPRDSSGIPDYLDKLASE
CCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CO; H2O; A

Specific reaction: CO + H2O + A = CO2 + AH2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463