Definition Methanothermobacter thermautotrophicus str. Delta H chromosome, complete genome.
Accession NC_000916
Length 1,751,377

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Identifier: 15679706

GI number: 15679706

Start: 1568832

End: 1570001

Strand: Direct

Name: Not Available

Synonym: MTH1712

Alternate gene names: 15679706

Gene position: 1568832-1570001 (Clockwise)

Preceding gene: 15679705

Following gene: 15679707

Centisome position: 89.58

GC content: 54.1

Gene sequence:

>1170_bases
GTGCTTATGGATAAATTAACGGAACTTCTGAAACTACTTCAGAATACGGAATCCATCGAGATAAACGAGTTCAGGATGGA
TGTTGAGGAACTGGAACTCTACCTGATGCCTGCAGTCCAGCAGGCCATACAGAAAACAGTTGAGGTGAGGGAGGCTGTCG
AGGCACTGCCCGCGGAGGAGTTCAACCCACCCATAAGGTCATACCCCGGTGAGGTTGCCCAGGTAAAGCTTGGTGAGGGC
ACCCGCAAAAGTGTTTACCTTGGGGGGCAGAAGGCCCTCTACAGGTTCGAGGAGCCACAGCCAAACCCGCCGGTTGTCAC
ATTTGACGTATTTGACATACCCATGCCTGGACTGCCGAGGCCAATAAGGGAACACTTCAGTGACGTCATGGAGGACCCGG
GGGACTGGGCACGGAAGGCCGTGAAGGAATACGGCGCCAACATGGTCACAATACACCTCATAGGAACAGGCCCCAAGGTC
ATGGACAAATCACCCAGGGAGGCCGCAAAGGATATCGAGGAGGTCCTCCAGGCAGTGGACGTCCCACTGGTGATAGGGGG
ATCCGGGGACCCTGAAAAGGACCCCCTGGTCCTTGAAAAGGCTGCAGAGGCAGCTGAAGGTGAAAGGTGCCTCCTTGCAT
CTGCCAACCTTGACCTGGACTACAGGAAGGTTGCAAGGGCAGCCCTTGACCACAACCATGCGGTCCTCTCATGGGCCATC
ACAGACGTCAACATGCAGAAGACCCTCAACCGTTACCTGCTTAAGGAGGGACTTAAACGTGAGGACATCGTCATGGACCC
AACAACATGTGCCCTGGGTTACGGTATAGAATTCTCAATAGACGTCATCACAAGGACCCGGCTGGCAGCCCTCAAGGGGG
ATTCTGATCTCCAGATGCCAATGTCCTCAGGTACCACAAACGCCTGGGGTTCAAGGGAGGCCTGGATGAAGAAGGATGAA
TGGGGACCCACAGATTACAGGGGGCCCCTCTGGGAAATCGTAACCGGACTTACCATGATGCTCTCAGGTGTGGACATATT
CATGATGCTACACCCCACCTCAGTCAGACTGCTGCGGGAGATAGGTGAAACCTTCACAAGGGAGTACATGACAGCTGAAA
CACCTGACCTGAGGGAATGGATAACTGAACTTGACTACCAGGAGGTTTAA

Upstream 100 bases:

>100_bases
TACGACATGGAGGGCAGACCACTCTATGAGTTACCTGAGGATTCTGAATCATTCAGGGCCATAAAAAAGGTTGCAGAGAA
GATTTTAAGTTTATAGAGGT

Downstream 100 bases:

>100_bases
AATTGCAGGTCACTGCCATGGATGTATACCGTTTACTTCCAAAAACAAACTGTGGTAAATGCAATGAGGCCTCATGCATG
GCATTTGCCACAAAACTCAT

Product: acetyl-CoA decarbonylase/synthase complex subunit delta

Products: CO2; AH2

Alternate protein names: ACDS complex subunit delta; Corrinoid/iron-sulfur component small subunit

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MLMDKLTELLKLLQNTESIEINEFRMDVEELELYLMPAVQQAIQKTVEVREAVEALPAEEFNPPIRSYPGEVAQVKLGEG
TRKSVYLGGQKALYRFEEPQPNPPVVTFDVFDIPMPGLPRPIREHFSDVMEDPGDWARKAVKEYGANMVTIHLIGTGPKV
MDKSPREAAKDIEEVLQAVDVPLVIGGSGDPEKDPLVLEKAAEAAEGERCLLASANLDLDYRKVARAALDHNHAVLSWAI
TDVNMQKTLNRYLLKEGLKREDIVMDPTTCALGYGIEFSIDVITRTRLAALKGDSDLQMPMSSGTTNAWGSREAWMKKDE
WGPTDYRGPLWEIVTGLTMMLSGVDIFMMLHPTSVRLLREIGETFTREYMTAETPDLREWITELDYQEV

Sequences:

>Translated_389_residues
MLMDKLTELLKLLQNTESIEINEFRMDVEELELYLMPAVQQAIQKTVEVREAVEALPAEEFNPPIRSYPGEVAQVKLGEG
TRKSVYLGGQKALYRFEEPQPNPPVVTFDVFDIPMPGLPRPIREHFSDVMEDPGDWARKAVKEYGANMVTIHLIGTGPKV
MDKSPREAAKDIEEVLQAVDVPLVIGGSGDPEKDPLVLEKAAEAAEGERCLLASANLDLDYRKVARAALDHNHAVLSWAI
TDVNMQKTLNRYLLKEGLKREDIVMDPTTCALGYGIEFSIDVITRTRLAALKGDSDLQMPMSSGTTNAWGSREAWMKKDE
WGPTDYRGPLWEIVTGLTMMLSGVDIFMMLHPTSVRLLREIGETFTREYMTAETPDLREWITELDYQEV
>Mature_389_residues
MLMDKLTELLKLLQNTESIEINEFRMDVEELELYLMPAVQQAIQKTVEVREAVEALPAEEFNPPIRSYPGEVAQVKLGEG
TRKSVYLGGQKALYRFEEPQPNPPVVTFDVFDIPMPGLPRPIREHFSDVMEDPGDWARKAVKEYGANMVTIHLIGTGPKV
MDKSPREAAKDIEEVLQAVDVPLVIGGSGDPEKDPLVLEKAAEAAEGERCLLASANLDLDYRKVARAALDHNHAVLSWAI
TDVNMQKTLNRYLLKEGLKREDIVMDPTTCALGYGIEFSIDVITRTRLAALKGDSDLQMPMSSGTTNAWGSREAWMKKDE
WGPTDYRGPLWEIVTGLTMMLSGVDIFMMLHPTSVRLLREIGETFTREYMTAETPDLREWITELDYQEV

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex

COG id: COG2069

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CdhD family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDD_METTH (O27747)

Other databases:

- EMBL:   AE000666
- PIR:   B69096
- RefSeq:   NP_276824.1
- ProteinModelPortal:   O27747
- SMR:   O27747
- STRING:   O27747
- GeneID:   1470797
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1712
- NMPDR:   fig|187420.1.peg.1679
- eggNOG:   arNOG04921
- HOGENOM:   HBG456967
- OMA:   IVMDPTT
- ProtClustDB:   PRK04452
- BioCyc:   MTHE187420:MTH1712-MONOMER
- HAMAP:   MF_01135
- InterPro:   IPR016041
- InterPro:   IPR004486
- InterPro:   IPR011005
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- TIGRFAMs:   TIGR00381

Pfam domain/function: PF03599 CdhD; SSF51717 DHP_synth_like

EC number: 1.2.99.2

Molecular weight: Translated: 43786; Mature: 43786

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLMDKLTELLKLLQNTESIEINEFRMDVEELELYLMPAVQQAIQKTVEVREAVEALPAEE
CCHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FNPPIRSYPGEVAQVKLGEGTRKSVYLGGQKALYRFEEPQPNPPVVTFDVFDIPMPGLPR
CCCCHHHCCCCEEEEEECCCCCCEEEECCHHHHHCCCCCCCCCCEEEEEEEECCCCCCCH
PIREHFSDVMEDPGDWARKAVKEYGANMVTIHLIGTGPKVMDKSPREAAKDIEEVLQAVD
HHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCC
VPLVIGGSGDPEKDPLVLEKAAEAAEGERCLLASANLDLDYRKVARAALDHNHAVLSWAI
CCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEE
TDVNMQKTLNRYLLKEGLKREDIVMDPTTCALGYGIEFSIDVITRTRLAALKGDSDLQMP
ECCCHHHHHHHHHHHHCCCCCCEEECCCHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCC
MSSGTTNAWGSREAWMKKDEWGPTDYRGPLWEIVTGLTMMLSGVDIFMMLHPTSVRLLRE
CCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
IGETFTREYMTAETPDLREWITELDYQEV
HHHHHHHHHHCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MLMDKLTELLKLLQNTESIEINEFRMDVEELELYLMPAVQQAIQKTVEVREAVEALPAEE
CCHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FNPPIRSYPGEVAQVKLGEGTRKSVYLGGQKALYRFEEPQPNPPVVTFDVFDIPMPGLPR
CCCCHHHCCCCEEEEEECCCCCCEEEECCHHHHHCCCCCCCCCCEEEEEEEECCCCCCCH
PIREHFSDVMEDPGDWARKAVKEYGANMVTIHLIGTGPKVMDKSPREAAKDIEEVLQAVD
HHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCC
VPLVIGGSGDPEKDPLVLEKAAEAAEGERCLLASANLDLDYRKVARAALDHNHAVLSWAI
CCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEE
TDVNMQKTLNRYLLKEGLKREDIVMDPTTCALGYGIEFSIDVITRTRLAALKGDSDLQMP
ECCCHHHHHHHHHHHHCCCCCCEEECCCHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCC
MSSGTTNAWGSREAWMKKDEWGPTDYRGPLWEIVTGLTMMLSGVDIFMMLHPTSVRLLRE
CCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
IGETFTREYMTAETPDLREWITELDYQEV
HHHHHHHHHHCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CO; H2O; A

Specific reaction: CO + H2O + A = CO2 + AH2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463