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The map label for this gene is trpD

Identifier: 15679656

GI number: 15679656

Start: 1524542

End: 1525600

Strand: Direct

Name: trpD

Synonym: MTH1661

Alternate gene names: 15679656

Gene position: 1524542-1525600 (Clockwise)

Preceding gene: 15679655

Following gene: 15679669

Centisome position: 87.05

GC content: 52.69

Gene sequence:

>1059_bases
ATGAAATTCAGGAGGATGATCTCTGAAATAATGGACTTCAGGAACCTCAGTGAGGATGAGGCCTACAGTCTGATGGAGAT
GATAATGGCTGGTGAACTTGATGATATTAAGATAGCCGCAATTCTAACGGCCCTTGCAATGAAGGGGGAAACAGTGGATG
AGATAACAGGCTTCGCCAGGGCCATGCGGGATAGATCCCCCAGGGTCAGGGTTTCAGGGTCCCATGAGGTTGTTGATTCC
TGCGGGACCGGAGGCGACAGTTTCAGGTCATACAATATAAGCACAGCAGCCGCCATGATAGCAGCCGCTGCAGGTGTGAG
GGTTGCAAAGCATGGTAACAGGGCGGTCACCGGGTCATGTGGGGGTGCAGATATACTCGAGGCTGCAGGTGTGAACATAG
AACTGGATGCAGCTGCAGCTGCGAGGTCCCTCAGTGATGTGGGCATCTCATTCATGTTCGCACCCCTATTCCACAGGGCA
ACTGCTAGGGTGGCGGCGGTGAGGAGGTCCCTGGGATTCAAGACAGTATTCAACATACTGGGACCATTAACATCCCCTGC
TGCAGCAGGAATACAGCTTCTGGGGGTATTTGACCCTCAGCTTGTGGGCCCGGTTGCTGAGGTGCTCAGGAACCTCGGAA
CACGCTGTGCAATGGTTGTTCATGGATTCGATGCTAACCTCAACCCTGCCCTGGATGAGATATCAACCGTTGGCCCCACC
CTGGTGGCGTTCCTTGAGGATGATGAGATCAGGATTGATAGACTGATGCCCCCTGACTTTGGAGTTGAGGTGGGAGAACT
TGAACATCTGAGGGCAGGATCAACCACCGCTGAGAACCTGGAGCTGTTCATGGATGTCCTCAGGGGACGTGAGGATACAC
CTGAACAGAAATCAAGACTCGATATAGCCCTTGCAAATGCCGGAGCCCTTATCTACCTTGCAGGCCTGGCTGATACACTG
CCTGAGGGAACAGAGACTGCAAAAAGAACAGTTAAATCTGGAGCTGCCCTGGAGCTCCTGGAAGAATTTGTATCATACAC
AAGGAACCTGCAGTCCTGA

Upstream 100 bases:

>100_bases
CCATCATAGACGTGATATCCGGGAACCTCGGCGACAGGGAGCTTATGCTCCAGAGGATCCATGAAATGGCAGGCACTCTG
AAAGCCGCAGGAGGATCAGG

Downstream 100 bases:

>100_bases
ATTCTCAGATATCCGATATAAAAAGGTGGATGGGCCCGCTGGGATTCGAACCCAGGGCCTCACGGTTATCAGCCGTGCGC
TCTAACCACCTGAGCCACGG

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKFRRMISEIMDFRNLSEDEAYSLMEMIMAGELDDIKIAAILTALAMKGETVDEITGFARAMRDRSPRVRVSGSHEVVDS
CGTGGDSFRSYNISTAAAMIAAAAGVRVAKHGNRAVTGSCGGADILEAAGVNIELDAAAAARSLSDVGISFMFAPLFHRA
TARVAAVRRSLGFKTVFNILGPLTSPAAAGIQLLGVFDPQLVGPVAEVLRNLGTRCAMVVHGFDANLNPALDEISTVGPT
LVAFLEDDEIRIDRLMPPDFGVEVGELEHLRAGSTTAENLELFMDVLRGREDTPEQKSRLDIALANAGALIYLAGLADTL
PEGTETAKRTVKSGAALELLEEFVSYTRNLQS

Sequences:

>Translated_352_residues
MKFRRMISEIMDFRNLSEDEAYSLMEMIMAGELDDIKIAAILTALAMKGETVDEITGFARAMRDRSPRVRVSGSHEVVDS
CGTGGDSFRSYNISTAAAMIAAAAGVRVAKHGNRAVTGSCGGADILEAAGVNIELDAAAAARSLSDVGISFMFAPLFHRA
TARVAAVRRSLGFKTVFNILGPLTSPAAAGIQLLGVFDPQLVGPVAEVLRNLGTRCAMVVHGFDANLNPALDEISTVGPT
LVAFLEDDEIRIDRLMPPDFGVEVGELEHLRAGSTTAENLELFMDVLRGREDTPEQKSRLDIALANAGALIYLAGLADTL
PEGTETAKRTVKSGAALELLEEFVSYTRNLQS
>Mature_352_residues
MKFRRMISEIMDFRNLSEDEAYSLMEMIMAGELDDIKIAAILTALAMKGETVDEITGFARAMRDRSPRVRVSGSHEVVDS
CGTGGDSFRSYNISTAAAMIAAAAGVRVAKHGNRAVTGSCGGADILEAAGVNIELDAAAAARSLSDVGISFMFAPLFHRA
TARVAAVRRSLGFKTVFNILGPLTSPAAAGIQLLGVFDPQLVGPVAEVLRNLGTRCAMVVHGFDANLNPALDEISTVGPT
LVAFLEDDEIRIDRLMPPDFGVEVGELEHLRAGSTTAENLELFMDVLRGREDTPEQKSRLDIALANAGALIYLAGLADTL
PEGTETAKRTVKSGAALELLEEFVSYTRNLQS

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=293, Percent_Identity=38.2252559726962, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1787019, Length=237, Percent_Identity=25.3164556962025, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320561, Length=285, Percent_Identity=29.8245614035088, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_METTH (O27698)

Other databases:

- EMBL:   AE000666
- PIR:   B69089
- RefSeq:   NP_276773.1
- ProteinModelPortal:   O27698
- SMR:   O27698
- STRING:   O27698
- GeneID:   1470746
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1661
- NMPDR:   fig|187420.1.peg.1628
- eggNOG:   arNOG05391
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- PhylomeDB:   O27698
- ProtClustDB:   PRK00188
- BioCyc:   MTHE187420:MTH1661-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 37534; Mature: 37534

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRRMISEIMDFRNLSEDEAYSLMEMIMAGELDDIKIAAILTALAMKGETVDEITGFAR
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
AMRDRSPRVRVSGSHEVVDSCGTGGDSFRSYNISTAAAMIAAAAGVRVAKHGNRAVTGSC
HHHCCCCCEEECCCHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCEEEECCC
GGADILEAAGVNIELDAAAAARSLSDVGISFMFAPLFHRATARVAAVRRSLGFKTVFNIL
CCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPLTSPAAAGIQLLGVFDPQLVGPVAEVLRNLGTRCAMVVHGFDANLNPALDEISTVGPT
CCCCCCHHHCEEEEECCCHHHHHHHHHHHHHHCHHEEEEEECCCCCCCHHHHHHHHCCHH
LVAFLEDDEIRIDRLMPPDFGVEVGELEHLRAGSTTAENLELFMDVLRGREDTPEQKSRL
EEEEECCCCEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHC
DIALANAGALIYLAGLADTLPEGTETAKRTVKSGAALELLEEFVSYTRNLQS
EEEEECCCCEEEEECHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKFRRMISEIMDFRNLSEDEAYSLMEMIMAGELDDIKIAAILTALAMKGETVDEITGFAR
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
AMRDRSPRVRVSGSHEVVDSCGTGGDSFRSYNISTAAAMIAAAAGVRVAKHGNRAVTGSC
HHHCCCCCEEECCCHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCEEEECCC
GGADILEAAGVNIELDAAAAARSLSDVGISFMFAPLFHRATARVAAVRRSLGFKTVFNIL
CCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPLTSPAAAGIQLLGVFDPQLVGPVAEVLRNLGTRCAMVVHGFDANLNPALDEISTVGPT
CCCCCCHHHCEEEEECCCHHHHHHHHHHHHHHCHHEEEEEECCCCCCCHHHHHHHHCCHH
LVAFLEDDEIRIDRLMPPDFGVEVGELEHLRAGSTTAENLELFMDVLRGREDTPEQKSRL
EEEEECCCCEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHC
DIALANAGALIYLAGLADTLPEGTETAKRTVKSGAALELLEEFVSYTRNLQS
EEEEECCCCEEEEECHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463