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Identifier: 15679654

GI number: 15679654

Start: 1522508

End: 1523686

Strand: Direct

Name: Not Available

Synonym: MTH1659

Alternate gene names: 15679654

Gene position: 1522508-1523686 (Clockwise)

Preceding gene: 15679653

Following gene: 15679655

Centisome position: 86.93

GC content: 53.52

Gene sequence:

>1179_bases
ATGATAATGGATGGAAAATTCGGTAAATATGGAGGCATATTCGTGCCGGAGCTTCTTATACCGGCACTTGAGGAACTTGA
GAGGGCCTTCCTCCATTACAGGGATGACAGGAAGTTCATGGCTGAACTCGAGTACCATCTCCGGGAGTACGCTGGAAAGC
CCACAGGCCTTTACTATGCCAGGAACCTGTCAGAGAAACTCGGATGCAGGGTGTACCTCAAGAGGGAGGACATGCTGCAC
ACAGGGGCCCACAAGATAAACAACACCATAGGCCAGGCTCTGCTCGCAAGGTACATGGGCAAGACCAGGATCATAGCCGA
GACAGGGGCAGGGCAGCACGGGATAGCCACCGCCGCTGCCGGGGCCCTCTTTGGAATGGACGTTGATATCTACATGGGCA
CAGAGGATGTTGAGAGGCAGAAGCTCAATGTATTCAGAATGGAGGTATCAGGTGCGGAGGTCATACCGGTCGACTCAGGT
TCAAGGACCCTTAAGGACGCCATAAACGAGGCCATGAGGGACTGGATTAGCAACGTGGATGACACCCACTACCTCATAGG
TTCCACCATGGGCCCCCACCCCTACCCGACCATGGTGAAGCACTTCCAGAGCGTCATAGGGAGGGAGGCCAGGGAACAGA
TACTCGAAGTCGAGGGAGAACTTCCAGACACGGTTATAGCGTGTGTTGGGGGCGGAAGCAATGCCATAGGCATATTCTCT
GCCTTCATGGATGATGATGTTGAACTCATAGGTGCAGAGGGGGGTGGAGAAGGTATAGAGTCAGGAAACCATGGAGCCAC
ACTCTCTGCGGGCTCAGAGGGAATCCTTCATGGTTCATTATCATACGTCCTTCAGGATGGGGATGGTCAGATAAGTGAGG
CACATTCTGTCTCAGCTGGTCTGGATTATCCGGGTGTTGGACCAGAACACGCCCATCTCATGGATACAGGCAGGGCAAGG
TATGAGCCGGTAACAGACACCGAGGCACTCAGGGGCTTCAGGCTCCTCTCAAGATATGAGGGTATAATGCCAGCCCTTGA
GAGTGCCCATGCAATAGCCTGCCTTGAAAGGTACGCTGAGAAACCTGAGAACCGGGGAAAAACGGTTATCGTCAATCTCT
CAGGAAGGGGAGATAAGGACATGTTCATGGTTGCTGGTTTGCTGGGGGTGGGTGTGTGA

Upstream 100 bases:

>100_bases
CGGGGATAAAGGATCATGCAATGATGTTTGAACTCATGGAGTACATGGGGAGGACGGGCGGACTTCAGAAACCGTCCAGG
TTACAGAGAGGTGAGTTATC

Downstream 100 bases:

>100_bases
TTGCTGATGTGTTCATGGTTGCTGGTTTGCTGGGAGTGTGATTGTAATGTCAGGAGCTAAATCAATGAGTTATGCTGAGA
TGTTCAGACGGGCGGATGGC

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MIMDGKFGKYGGIFVPELLIPALEELERAFLHYRDDRKFMAELEYHLREYAGKPTGLYYARNLSEKLGCRVYLKREDMLH
TGAHKINNTIGQALLARYMGKTRIIAETGAGQHGIATAAAGALFGMDVDIYMGTEDVERQKLNVFRMEVSGAEVIPVDSG
SRTLKDAINEAMRDWISNVDDTHYLIGSTMGPHPYPTMVKHFQSVIGREAREQILEVEGELPDTVIACVGGGSNAIGIFS
AFMDDDVELIGAEGGGEGIESGNHGATLSAGSEGILHGSLSYVLQDGDGQISEAHSVSAGLDYPGVGPEHAHLMDTGRAR
YEPVTDTEALRGFRLLSRYEGIMPALESAHAIACLERYAEKPENRGKTVIVNLSGRGDKDMFMVAGLLGVGV

Sequences:

>Translated_392_residues
MIMDGKFGKYGGIFVPELLIPALEELERAFLHYRDDRKFMAELEYHLREYAGKPTGLYYARNLSEKLGCRVYLKREDMLH
TGAHKINNTIGQALLARYMGKTRIIAETGAGQHGIATAAAGALFGMDVDIYMGTEDVERQKLNVFRMEVSGAEVIPVDSG
SRTLKDAINEAMRDWISNVDDTHYLIGSTMGPHPYPTMVKHFQSVIGREAREQILEVEGELPDTVIACVGGGSNAIGIFS
AFMDDDVELIGAEGGGEGIESGNHGATLSAGSEGILHGSLSYVLQDGDGQISEAHSVSAGLDYPGVGPEHAHLMDTGRAR
YEPVTDTEALRGFRLLSRYEGIMPALESAHAIACLERYAEKPENRGKTVIVNLSGRGDKDMFMVAGLLGVGV
>Mature_392_residues
MIMDGKFGKYGGIFVPELLIPALEELERAFLHYRDDRKFMAELEYHLREYAGKPTGLYYARNLSEKLGCRVYLKREDMLH
TGAHKINNTIGQALLARYMGKTRIIAETGAGQHGIATAAAGALFGMDVDIYMGTEDVERQKLNVFRMEVSGAEVIPVDSG
SRTLKDAINEAMRDWISNVDDTHYLIGSTMGPHPYPTMVKHFQSVIGREAREQILEVEGELPDTVIACVGGGSNAIGIFS
AFMDDDVELIGAEGGGEGIESGNHGATLSAGSEGILHGSLSYVLQDGDGQISEAHSVSAGLDYPGVGPEHAHLMDTGRAR
YEPVTDTEALRGFRLLSRYEGIMPALESAHAIACLERYAEKPENRGKTVIVNLSGRGDKDMFMVAGLLGVGV

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=388, Percent_Identity=55.1546391752577, Blast_Score=441, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321412, Length=388, Percent_Identity=52.8350515463918, Blast_Score=416, Evalue=1e-117,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB1_METTH (O27696)

Other databases:

- EMBL:   AE000666
- PIR:   G69088
- RefSeq:   NP_276771.1
- ProteinModelPortal:   O27696
- SMR:   O27696
- STRING:   O27696
- GeneID:   1470744
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1659
- NMPDR:   fig|187420.1.peg.1626
- eggNOG:   arNOG04577
- HOGENOM:   HBG303148
- OMA:   TFENTHY
- PhylomeDB:   O27696
- ProtClustDB:   PRK04346
- BioCyc:   MTHE187420:MTH1659-MONOMER
- BRENDA:   4.2.1.20
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 42528; Mature: 42528

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMDGKFGKYGGIFVPELLIPALEELERAFLHYRDDRKFMAELEYHLREYAGKPTGLYYA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHH
RNLSEKLGCRVYLKREDMLHTGAHKINNTIGQALLARYMGKTRIIAETGAGQHGIATAAA
HHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
GALFGMDVDIYMGTEDVERQKLNVFRMEVSGAEVIPVDSGSRTLKDAINEAMRDWISNVD
HHHHCCEEEEEECCHHHHHHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHCCCC
DTHYLIGSTMGPHPYPTMVKHFQSVIGREAREQILEVEGELPDTVIACVGGGSNAIGIFS
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
AFMDDDVELIGAEGGGEGIESGNHGATLSAGSEGILHGSLSYVLQDGDGQISEAHSVSAG
HHHCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEEECCEEEEEECCCCCCHHHHHCCCC
LDYPGVGPEHAHLMDTGRARYEPVTDTEALRGFRLLSRYEGIMPALESAHAIACLERYAE
CCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KPENRGKTVIVNLSGRGDKDMFMVAGLLGVGV
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIMDGKFGKYGGIFVPELLIPALEELERAFLHYRDDRKFMAELEYHLREYAGKPTGLYYA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHH
RNLSEKLGCRVYLKREDMLHTGAHKINNTIGQALLARYMGKTRIIAETGAGQHGIATAAA
HHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
GALFGMDVDIYMGTEDVERQKLNVFRMEVSGAEVIPVDSGSRTLKDAINEAMRDWISNVD
HHHHCCEEEEEECCHHHHHHHHEEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHCCCC
DTHYLIGSTMGPHPYPTMVKHFQSVIGREAREQILEVEGELPDTVIACVGGGSNAIGIFS
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
AFMDDDVELIGAEGGGEGIESGNHGATLSAGSEGILHGSLSYVLQDGDGQISEAHSVSAG
HHHCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEEECCEEEEEECCCCCCHHHHHCCCC
LDYPGVGPEHAHLMDTGRARYEPVTDTEALRGFRLLSRYEGIMPALESAHAIACLERYAE
CCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KPENRGKTVIVNLSGRGDKDMFMVAGLLGVGV
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463