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Identifier: 15679651

GI number: 15679651

Start: 1520389

End: 1520979

Strand: Direct

Name: Not Available

Synonym: MTH1656

Alternate gene names: 15679651

Gene position: 1520389-1520979 (Clockwise)

Preceding gene: 15679650

Following gene: 15679652

Centisome position: 86.81

GC content: 50.42

Gene sequence:

>591_bases
ATGGTTGTGATCCTGATAATTGATAACTATGACTCATTCACCCATAACCTCTACCAGCTTGCAGGGGAGATCCTCCGGGA
TGAGGGGATGGATGAGGAGATAATGGTCCTCAGGAACGATGAGGCCAGGATATCAGATCTTAGGGCCCTGGATCCAGAAA
AGATAATCATATCCCCGGGTCCTGGCAATCCTTCAAGGAGGAGTGACTTCGGTGTTTGCATGGATGTGATAGGGGAATTC
ACGGACAGGCCCCTCCTGGGGGTATGCCTTGGACACCAGGGCATATTCCACGCCTTTGGCGGAAGGGTTGACCAGGGGGA
ACCGGTTCATGGAAAGATAGTTGAGGTATTCCATGACGGATCAGAACTCTTCAGGGACGTTCCAAATCCCTTCAGGGCAA
CCAGGTACCATTCACTCGTATGCAGACCCGAAGACACACCTGCAGATATAGAGGTAACTGCTGTGACATCAGATGAAATT
ATAATGGCCATAAAGCACAGAGAATATCCAGTCTACGGGCTGCAGTTTCACCCGGAGTCAGCCGGAACCCCAAGCGGAAG
AACCGTCATTAGAAATTTCCTCAGGATGTGA

Upstream 100 bases:

>100_bases
AATACGTGGAGTGCCAGAACAAGGCCATGGCGGTCCTTAAATCAATGGAACTGGCAGGTGATGGCTTTGATTCTGATGAA
CCATTTATCGCCAGGAGGTA

Downstream 100 bases:

>100_bases
ACACATGCTCAGGGATATTATAAGGTCAAAGAAACTCGAAGTTAAGGAACTCATGAAAAAAACACCCCTCAGCATCCTAA
GGGATGATATAACAGTCATG

Product: anthranilate synthase component II

Products: NA

Alternate protein names: Glutamine amido-transferase

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MVVILIIDNYDSFTHNLYQLAGEILRDEGMDEEIMVLRNDEARISDLRALDPEKIIISPGPGNPSRRSDFGVCMDVIGEF
TDRPLLGVCLGHQGIFHAFGGRVDQGEPVHGKIVEVFHDGSELFRDVPNPFRATRYHSLVCRPEDTPADIEVTAVTSDEI
IMAIKHREYPVYGLQFHPESAGTPSGRTVIRNFLRM

Sequences:

>Translated_196_residues
MVVILIIDNYDSFTHNLYQLAGEILRDEGMDEEIMVLRNDEARISDLRALDPEKIIISPGPGNPSRRSDFGVCMDVIGEF
TDRPLLGVCLGHQGIFHAFGGRVDQGEPVHGKIVEVFHDGSELFRDVPNPFRATRYHSLVCRPEDTPADIEVTAVTSDEI
IMAIKHREYPVYGLQFHPESAGTPSGRTVIRNFLRM
>Mature_196_residues
MVVILIIDNYDSFTHNLYQLAGEILRDEGMDEEIMVLRNDEARISDLRALDPEKIIISPGPGNPSRRSDFGVCMDVIGEF
TDRPLLGVCLGHQGIFHAFGGRVDQGEPVHGKIVEVFHDGSELFRDVPNPFRATRYHSLVCRPEDTPADIEVTAVTSDEI
IMAIKHREYPVYGLQFHPESAGTPSGRTVIRNFLRM

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI1789760, Length=194, Percent_Identity=46.3917525773196, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1787517, Length=199, Percent_Identity=36.6834170854271, Blast_Score=115, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322638, Length=195, Percent_Identity=43.5897435897436, Blast_Score=162, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324361, Length=210, Percent_Identity=27.6190476190476, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPG_METTH (O27693)

Other databases:

- EMBL:   AE000666
- PIR:   D69088
- RefSeq:   NP_276768.1
- ProteinModelPortal:   O27693
- SMR:   O27693
- STRING:   O27693
- GeneID:   1470741
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1656
- NMPDR:   fig|187420.1.peg.1623
- eggNOG:   arNOG07708
- HOGENOM:   HBG292341
- OMA:   HGKQSIL
- ProtClustDB:   CLSK342504
- BioCyc:   MTHE187420:MTH1656-MONOMER
- BRENDA:   4.1.3.27
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00566

Pfam domain/function: PF00117 GATase

EC number: =4.1.3.27

Molecular weight: Translated: 22004; Mature: 22004

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 89-89 ACT_SITE 177-177 ACT_SITE 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVILIIDNYDSFTHNLYQLAGEILRDEGMDEEIMVLRNDEARISDLRALDPEKIIISPG
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCEEEEECC
PGNPSRRSDFGVCMDVIGEFTDRPLLGVCLGHQGIFHAFGGRVDQGEPVHGKIVEVFHDG
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCEEEEEEECC
SELFRDVPNPFRATRYHSLVCRPEDTPADIEVTAVTSDEIIMAIKHREYPVYGLQFHPES
HHHHHHCCCHHHHHHEEEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEECCCC
AGTPSGRTVIRNFLRM
CCCCCCHHHHHHHHCC
>Mature Secondary Structure
MVVILIIDNYDSFTHNLYQLAGEILRDEGMDEEIMVLRNDEARISDLRALDPEKIIISPG
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCEEEEECC
PGNPSRRSDFGVCMDVIGEFTDRPLLGVCLGHQGIFHAFGGRVDQGEPVHGKIVEVFHDG
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCCCCCEEEEEEECC
SELFRDVPNPFRATRYHSLVCRPEDTPADIEVTAVTSDEIIMAIKHREYPVYGLQFHPES
HHHHHHCCCHHHHHHEEEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEECCCC
AGTPSGRTVIRNFLRM
CCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463