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Identifier: 15679650

GI number: 15679650

Start: 1518995

End: 1520389

Strand: Direct

Name: Not Available

Synonym: MTH1655

Alternate gene names: 15679650

Gene position: 1518995-1520389 (Clockwise)

Preceding gene: 15679645

Following gene: 15679651

Centisome position: 86.73

GC content: 50.47

Gene sequence:

>1395_bases
GTGAATGTTTTTGGCATTACAGAACTGAAAAACCCGGTAAAGGAAAAGATAGAATTTAAAGAACCCTTTGAACTATTCAA
AAGTATTTATTCTGAATACGACTCATCATTCCTTCTGGAGTCAATGGAAAGCGACACGGGTCTTGCAAGATACTCATTCA
TGGGATTCGAGCCACAGATGATAATAAGGGCCCGTTCAGGTTTTATAGAAGTTGAATACGAGGGATCAAGGGAGGAGTTT
GATACAGAAAACCCCTTTGAATTCCTGAGGCAGTTCACAAGACCCGCTGGAAAATCCAGGGGCTTCTGTGGGGGCCTTGT
TGGCTACATATCCTATCAGGCTGCAAGGTTCTTTGACAGTATCAACCTCAGCCCCGGAAACTTCCCGGACTTTGAATTCG
GACTCTTCCTTGACGGTATCATGTTCAACCACCTCACAGGAGAATGCAGTTACATCAGCCTCAAGGAGAACAGACTCCCG
GAAATATCAGAACTGCTGCGCGAGGAAACCCCAACAGGGCACCTTAAATACAGGAGCATGGGGACCCTGTTCTCAAGGAG
GAGATACCTTGGAATGGTGGAGGAGGCAAGGGAGAGGATAGCTGAGGGCGAAATATTCCAGGCAGTCCTCTCAAATGCCA
CTGACTACAGGCTCCGTGGTGACAGGCTTGCCCTCTACGAAGCCCTCAGGAGGGTTAACCCCTCCCCCTACATGTACCAC
CTGAAACTTGGCAGCAGGGAGATAACAGGTTCAAGTCCTGAAATGCTTGTCCGTGTGGAGGATAAACAGATTGAAACCTT
CCCAATCGCAGGAACCAGGCCAAGGGGGAAAACACCCCATGAGGATGAGAGAATAGCGGCGGAACTGCTGTCAGATGAGA
AGGAACTTGCAGAGCACCTCATGCTCGTTGACCTTGCAAGGAACGACCTCGGGAGAATATCTGAGTTTGGCACGGTCCAG
GTACCGGAGTACATGACCATAAGGAGGTTCTCCCATGTTCAGCACATCCTCTCCCATGTAACCGGCAGACTCAGGAAGGG
CATGGATGCCCTTGATGCCCTTGGCGCGGTCTTCCCGGCAGGTACAGTGAGCGGGGCGCCCAAAATAAGGGCTATGGAAA
TAATAGAGTCACTTGAGGGGGTGCCGAGGAATGCCTACGCCGGTGCCCTGGGCTATCTCTCACTGAACGGTAACGCAGAC
TTCGCAATAACCATAAGATCCATGGTCGCTGAGGGAGCGTATGGAAGAATACAGGCAGGGGCAGGTATAGTACATGACTC
CGTACCTGAGAGGGAATACGTGGAGTGCCAGAACAAGGCCATGGCGGTCCTTAAATCAATGGAACTGGCAGGTGATGGCT
TTGATTCTGATGAACCATTTATCGCCAGGAGGTAA

Upstream 100 bases:

>100_bases
ACTTCACCACATTGATGTACATTATTATACAGACAAGATTTAAATAGTACCTCCGTGTATATGTACTTTGTGGATACAGA
GGTGATATGCATGTACAGGA

Downstream 100 bases:

>100_bases
TGGTTGTGATCCTGATAATTGATAACTATGACTCATTCACCCATAACCTCTACCAGCTTGCAGGGGAGATCCTCCGGGAT
GAGGGGATGGATGAGGAGAT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNVFGITELKNPVKEKIEFKEPFELFKSIYSEYDSSFLLESMESDTGLARYSFMGFEPQMIIRARSGFIEVEYEGSREEF
DTENPFEFLRQFTRPAGKSRGFCGGLVGYISYQAARFFDSINLSPGNFPDFEFGLFLDGIMFNHLTGECSYISLKENRLP
EISELLREETPTGHLKYRSMGTLFSRRRYLGMVEEARERIAEGEIFQAVLSNATDYRLRGDRLALYEALRRVNPSPYMYH
LKLGSREITGSSPEMLVRVEDKQIETFPIAGTRPRGKTPHEDERIAAELLSDEKELAEHLMLVDLARNDLGRISEFGTVQ
VPEYMTIRRFSHVQHILSHVTGRLRKGMDALDALGAVFPAGTVSGAPKIRAMEIIESLEGVPRNAYAGALGYLSLNGNAD
FAITIRSMVAEGAYGRIQAGAGIVHDSVPEREYVECQNKAMAVLKSMELAGDGFDSDEPFIARR

Sequences:

>Translated_464_residues
MNVFGITELKNPVKEKIEFKEPFELFKSIYSEYDSSFLLESMESDTGLARYSFMGFEPQMIIRARSGFIEVEYEGSREEF
DTENPFEFLRQFTRPAGKSRGFCGGLVGYISYQAARFFDSINLSPGNFPDFEFGLFLDGIMFNHLTGECSYISLKENRLP
EISELLREETPTGHLKYRSMGTLFSRRRYLGMVEEARERIAEGEIFQAVLSNATDYRLRGDRLALYEALRRVNPSPYMYH
LKLGSREITGSSPEMLVRVEDKQIETFPIAGTRPRGKTPHEDERIAAELLSDEKELAEHLMLVDLARNDLGRISEFGTVQ
VPEYMTIRRFSHVQHILSHVTGRLRKGMDALDALGAVFPAGTVSGAPKIRAMEIIESLEGVPRNAYAGALGYLSLNGNAD
FAITIRSMVAEGAYGRIQAGAGIVHDSVPEREYVECQNKAMAVLKSMELAGDGFDSDEPFIARR
>Mature_464_residues
MNVFGITELKNPVKEKIEFKEPFELFKSIYSEYDSSFLLESMESDTGLARYSFMGFEPQMIIRARSGFIEVEYEGSREEF
DTENPFEFLRQFTRPAGKSRGFCGGLVGYISYQAARFFDSINLSPGNFPDFEFGLFLDGIMFNHLTGECSYISLKENRLP
EISELLREETPTGHLKYRSMGTLFSRRRYLGMVEEARERIAEGEIFQAVLSNATDYRLRGDRLALYEALRRVNPSPYMYH
LKLGSREITGSSPEMLVRVEDKQIETFPIAGTRPRGKTPHEDERIAAELLSDEKELAEHLMLVDLARNDLGRISEFGTVQ
VPEYMTIRRFSHVQHILSHVTGRLRKGMDALDALGAVFPAGTVSGAPKIRAMEIIESLEGVPRNAYAGALGYLSLNGNAD
FAITIRSMVAEGAYGRIQAGAGIVHDSVPEREYVECQNKAMAVLKSMELAGDGFDSDEPFIARR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family

Homologues:

Organism=Escherichia coli, GI1787518, Length=375, Percent_Identity=39.2, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788114, Length=438, Percent_Identity=32.648401826484, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI87082077, Length=264, Percent_Identity=31.4393939393939, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786809, Length=258, Percent_Identity=28.2945736434109, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320935, Length=454, Percent_Identity=35.9030837004405, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6324361, Length=370, Percent_Identity=24.5945945945946, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPE_METTH (O27692)

Other databases:

- EMBL:   AE000666
- PIR:   C69088
- RefSeq:   NP_276767.1
- ProteinModelPortal:   O27692
- SMR:   O27692
- STRING:   O27692
- GeneID:   1470740
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1655
- NMPDR:   fig|187420.1.peg.1622
- eggNOG:   arNOG04620
- HOGENOM:   HBG507440
- OMA:   IRMAEID
- PhylomeDB:   O27692
- ProtClustDB:   CLSK878523
- BioCyc:   MTHE187420:MTH1655-MONOMER
- BRENDA:   4.1.3.27
- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR010116
- InterPro:   IPR015890
- Gene3D:   G3DSA:3.60.120.10
- PANTHER:   PTHR11236
- PRINTS:   PR00095
- TIGRFAMs:   TIGR01820

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind; SSF56322 TRPE_1_chor_bd

EC number: =4.1.3.27

Molecular weight: Translated: 52322; Mature: 52322

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVFGITELKNPVKEKIEFKEPFELFKSIYSEYDSSFLLESMESDTGLARYSFMGFEPQM
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCEEEECCCCHHE
IIRARSGFIEVEYEGSREEFDTENPFEFLRQFTRPAGKSRGFCGGLVGYISYQAARFFDS
EEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
INLSPGNFPDFEFGLFLDGIMFNHLTGECSYISLKENRLPEISELLREETPTGHLKYRSM
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEHHHH
GTLFSRRRYLGMVEEARERIAEGEIFQAVLSNATDYRLRGDRLALYEALRRVNPSPYMYH
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCEEEE
LKLGSREITGSSPEMLVRVEDKQIETFPIAGTRPRGKTPHEDERIAAELLSDEKELAEHL
EEECCEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
MLVDLARNDLGRISEFGTVQVPEYMTIRRFSHVQHILSHVTGRLRKGMDALDALGAVFPA
HHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
GTVSGAPKIRAMEIIESLEGVPRNAYAGALGYLSLNGNADFAITIRSMVAEGAYGRIQAG
CCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEHHHHHHCCCCCEEECC
AGIVHDSVPEREYVECQNKAMAVLKSMELAGDGFDSDEPFIARR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNVFGITELKNPVKEKIEFKEPFELFKSIYSEYDSSFLLESMESDTGLARYSFMGFEPQM
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCEEEECCCCHHE
IIRARSGFIEVEYEGSREEFDTENPFEFLRQFTRPAGKSRGFCGGLVGYISYQAARFFDS
EEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
INLSPGNFPDFEFGLFLDGIMFNHLTGECSYISLKENRLPEISELLREETPTGHLKYRSM
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEHHHH
GTLFSRRRYLGMVEEARERIAEGEIFQAVLSNATDYRLRGDRLALYEALRRVNPSPYMYH
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCEEEE
LKLGSREITGSSPEMLVRVEDKQIETFPIAGTRPRGKTPHEDERIAAELLSDEKELAEHL
EEECCEECCCCCCCEEEEEECCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
MLVDLARNDLGRISEFGTVQVPEYMTIRRFSHVQHILSHVTGRLRKGMDALDALGAVFPA
HHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
GTVSGAPKIRAMEIIESLEGVPRNAYAGALGYLSLNGNADFAITIRSMVAEGAYGRIQAG
CCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEHHHHHHCCCCCEEECC
AGIVHDSVPEREYVECQNKAMAVLKSMELAGDGFDSDEPFIARR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463