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Identifier: 15679545

GI number: 15679545

Start: 1414175

End: 1416067

Strand: Direct

Name: Not Available

Synonym: MTH1549

Alternate gene names: 15679545

Gene position: 1414175-1416067 (Clockwise)

Preceding gene: 15679544

Following gene: 15679548

Centisome position: 80.75

GC content: 53.67

Gene sequence:

>1893_bases
ATGATAGAAAAAATTGCAGGGGCTTCCCTGAAGGAATACATGTCCCTCTTCAGGGGTGAACCGACAATATTTATAGGCTC
AGCCACCTGTGGAAGGTCTGCAGGGGCCCAGAAGATAGAGGAGATAATGGGGCAGAGGGCAGCCGAACTCTCAGTTGAGT
GCAGGATGATACACACAGGCTGCATGGGTCTCTGCTACGCCGAACCCATGGTGGTCGTCTTCAATGGTGACAGCCGTGGT
TACATCTACGGTCCGGTGAACCGTAAACTCGCAAAGAGGATAATCCAGGAGCACATCGTGGAGGGCAGGGAGGTTGAACC
CATTGGTTATGTGGACATAGCCTTCAATGGCGACTCATTTGAACCAGTTTACGCTCTGGAATTCATGGAGGGACAGTCAA
GGAGGATACTTCGAAGATGCGGCCTTATAGACCCTGAAAACATGGGACACTATCTGGCAACCGGAGGCTACAGGGGCCTC
ATGAGGGCCCTTGAAATGGAACCCGATGAGGTAATTGAGGAGGTGAAGGACTCCGGCCTGAGGGGCCGCGGAGGCGCAGG
ATTCCCGACATGGCTTAAATGGAGTCTCTGTCGCCAGGAGGCCTCAGAGGTGAAGTACCTCATATGCAACGCCGATGAGG
GAGACCCTGGCGCATTCATGAACCGTTCACTCATAGAGGGGGACCCCCATGCACTGCTTGAGGGGATACTAATCGCCTCA
TACGCGGTGGGGGCCAGGGAGGCCTACATCTACTGCAGGGCAGAGTACCCACTTGCCCTTGAGAGGCTCAGGGTGGCCAT
ATCTGATCTGAGGAATCTGGGACTTCTCGGTAAGGATATCCTCGGGTCAGGGTTCGACCTGGATATAAAGATAAAGGAGG
GTGCAGGGGCATTTGTCTGTGGAGAGGAAACAGCCCTGATATCCTCAATTGAGGGTAAGAGGGGAATGCCAAGGACAAGA
CCCCCATTCCCAACAACACGGGGCCTCTGGGGCAAGCCCACCGTTATAAACAATGTTGAGACCCTTGCAGCTGTTTCAAT
GATAATGCAGCACGGCGCAGACTACTTCAACTCCCTTGGCACCCCTGAAAGTAGGGGAACCAAGACATTCTCCCTTGTGG
GCGATGTCAGGAGGACCGGCCTCATTGAGGTCCCCCTGGGCACAACCCTGAGGGAGGTCATCTTTGATATTGGAGGGGGG
GTTGTGGATGGAGAGCTGAAAGCTGTACAGATAGGGGGACCTTCAGGGGGATGCCTCCCTGCTGAACTTATCGATACAGG
TATAGACTATGACTCCCTCACATCTGCAGGGGCAATAATGGGTTCAGGCGGCCTTGTTGTTTTATCGGACCGCACATGCA
TGGTTGAACTTGCAAGGTACTTCCTTGAGTTCACACAGAGGGAGTCCTGTGGAAAATGCGTACCCTGCCGCGTGGGGACA
AGGCAGATGCTCATGATACTCAATGACATCGTAGAGGGTTCAGGAAGACCTGAAGACCCTGATATACTCAGGGATGTAGC
TGAAAGTGTCAGGGCAGCCTCACTATGCGGCCTCGGCCAGACATCACCAAACCCGGTTCTGACGACACTCAGATACTTTG
AGGACGAGTACCATGACCACATAAAAGGCAGGTGCACAGCCGCAGCATGCAGTGAACTGATGCACTACATGATAGACCCT
GAGAAATGTGATGGATGCATGGCATGCATCAAGACGTGCCCGGCGGAGGCCATAAATGGTTCAAGGGACGAGGTCCATGT
TATAGACCAGGATGGGTGCCTCAAGTGCGGGTCCTGTCTTGATATATGTAAGAGGGATGCTGTCAGGAGGGTTCCCGGTG
CCTACCGTCAGGGAACCTATTCAGCAAGGATTCCTGAGAAGGATGGGTGGTAG

Upstream 100 bases:

>100_bases
TCCCTCGCACCATGTGCAATGGTAAACGATGAGGTTGTATCACGCATAAAACCATCAAGGGTAGGTAAAATATTCCCAAA
AAAGTCTTAGAGTGTCTTAA

Downstream 100 bases:

>100_bases
GGCGCACCTGATCAGCCGCAGCCTTTCAGCCGGCGGAAACCTTCAGGGTACATTAAATTAGTACATTGGATGATCCCTCA
AACGGCATATAATGTTCTCA

Product: NADP-reducing hydrogenase, subunit C

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MIEKIAGASLKEYMSLFRGEPTIFIGSATCGRSAGAQKIEEIMGQRAAELSVECRMIHTGCMGLCYAEPMVVVFNGDSRG
YIYGPVNRKLAKRIIQEHIVEGREVEPIGYVDIAFNGDSFEPVYALEFMEGQSRRILRRCGLIDPENMGHYLATGGYRGL
MRALEMEPDEVIEEVKDSGLRGRGGAGFPTWLKWSLCRQEASEVKYLICNADEGDPGAFMNRSLIEGDPHALLEGILIAS
YAVGAREAYIYCRAEYPLALERLRVAISDLRNLGLLGKDILGSGFDLDIKIKEGAGAFVCGEETALISSIEGKRGMPRTR
PPFPTTRGLWGKPTVINNVETLAAVSMIMQHGADYFNSLGTPESRGTKTFSLVGDVRRTGLIEVPLGTTLREVIFDIGGG
VVDGELKAVQIGGPSGGCLPAELIDTGIDYDSLTSAGAIMGSGGLVVLSDRTCMVELARYFLEFTQRESCGKCVPCRVGT
RQMLMILNDIVEGSGRPEDPDILRDVAESVRAASLCGLGQTSPNPVLTTLRYFEDEYHDHIKGRCTAAACSELMHYMIDP
EKCDGCMACIKTCPAEAINGSRDEVHVIDQDGCLKCGSCLDICKRDAVRRVPGAYRQGTYSARIPEKDGW

Sequences:

>Translated_630_residues
MIEKIAGASLKEYMSLFRGEPTIFIGSATCGRSAGAQKIEEIMGQRAAELSVECRMIHTGCMGLCYAEPMVVVFNGDSRG
YIYGPVNRKLAKRIIQEHIVEGREVEPIGYVDIAFNGDSFEPVYALEFMEGQSRRILRRCGLIDPENMGHYLATGGYRGL
MRALEMEPDEVIEEVKDSGLRGRGGAGFPTWLKWSLCRQEASEVKYLICNADEGDPGAFMNRSLIEGDPHALLEGILIAS
YAVGAREAYIYCRAEYPLALERLRVAISDLRNLGLLGKDILGSGFDLDIKIKEGAGAFVCGEETALISSIEGKRGMPRTR
PPFPTTRGLWGKPTVINNVETLAAVSMIMQHGADYFNSLGTPESRGTKTFSLVGDVRRTGLIEVPLGTTLREVIFDIGGG
VVDGELKAVQIGGPSGGCLPAELIDTGIDYDSLTSAGAIMGSGGLVVLSDRTCMVELARYFLEFTQRESCGKCVPCRVGT
RQMLMILNDIVEGSGRPEDPDILRDVAESVRAASLCGLGQTSPNPVLTTLRYFEDEYHDHIKGRCTAAACSELMHYMIDP
EKCDGCMACIKTCPAEAINGSRDEVHVIDQDGCLKCGSCLDICKRDAVRRVPGAYRQGTYSARIPEKDGW
>Mature_630_residues
MIEKIAGASLKEYMSLFRGEPTIFIGSATCGRSAGAQKIEEIMGQRAAELSVECRMIHTGCMGLCYAEPMVVVFNGDSRG
YIYGPVNRKLAKRIIQEHIVEGREVEPIGYVDIAFNGDSFEPVYALEFMEGQSRRILRRCGLIDPENMGHYLATGGYRGL
MRALEMEPDEVIEEVKDSGLRGRGGAGFPTWLKWSLCRQEASEVKYLICNADEGDPGAFMNRSLIEGDPHALLEGILIAS
YAVGAREAYIYCRAEYPLALERLRVAISDLRNLGLLGKDILGSGFDLDIKIKEGAGAFVCGEETALISSIEGKRGMPRTR
PPFPTTRGLWGKPTVINNVETLAAVSMIMQHGADYFNSLGTPESRGTKTFSLVGDVRRTGLIEVPLGTTLREVIFDIGGG
VVDGELKAVQIGGPSGGCLPAELIDTGIDYDSLTSAGAIMGSGGLVVLSDRTCMVELARYFLEFTQRESCGKCVPCRVGT
RQMLMILNDIVEGSGRPEDPDILRDVAESVRAASLCGLGQTSPNPVLTTLRYFEDEYHDHIKGRCTAAACSELMHYMIDP
EKCDGCMACIKTCPAEAINGSRDEVHVIDQDGCLKCGSCLDICKRDAVRRVPGAYRQGTYSARIPEKDGW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=437, Percent_Identity=38.4439359267735, Blast_Score=299, Evalue=5e-81,
Organism=Homo sapiens, GI260656005, Length=395, Percent_Identity=40.253164556962, Blast_Score=297, Evalue=2e-80,
Organism=Escherichia coli, GI1788620, Length=403, Percent_Identity=41.439205955335, Blast_Score=326, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17531727, Length=389, Percent_Identity=38.8174807197943, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI19920794, Length=378, Percent_Identity=39.4179894179894, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI45550452, Length=378, Percent_Identity=39.1534391534392, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24653819, Length=393, Percent_Identity=32.5699745547074, Blast_Score=215, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24653817, Length=361, Percent_Identity=31.0249307479224, Blast_Score=186, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68596; Mature: 68596

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKIAGASLKEYMSLFRGEPTIFIGSATCGRSAGAQKIEEIMGQRAAELSVECRMIHTG
CCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCHHHHHEEEEEEEEHH
CMGLCYAEPMVVVFNGDSRGYIYGPVNRKLAKRIIQEHIVEGREVEPIGYVDIAFNGDSF
HHHHEECCCEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCC
EPVYALEFMEGQSRRILRRCGLIDPENMGHYLATGGYRGLMRALEMEPDEVIEEVKDSGL
CCEEEEEECCCHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHCCCHHHHHHHHHHCCC
RGRGGAGFPTWLKWSLCRQEASEVKYLICNADEGDPGAFMNRSLIEGDPHALLEGILIAS
CCCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCCHHHCCHHCCCCHHHHHHHHHHHH
YAVGAREAYIYCRAEYPLALERLRVAISDLRNLGLLGKDILGSGFDLDIKIKEGAGAFVC
HHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCEEEE
GEETALISSIEGKRGMPRTRPPFPTTRGLWGKPTVINNVETLAAVSMIMQHGADYFNSLG
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHCHHHHHHCC
TPESRGTKTFSLVGDVRRTGLIEVPLGTTLREVIFDIGGGVVDGELKAVQIGGPSGGCLP
CCCCCCCEEEHHHHHHHHCCEEEECCCHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCH
AELIDTGIDYDSLTSAGAIMGSGGLVVLSDRTCMVELARYFLEFTQRESCGKCVPCRVGT
HHHHHCCCCHHHHHCCCCEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
RQMLMILNDIVEGSGRPEDPDILRDVAESVRAASLCGLGQTSPNPVLTTLRYFEDEYHDH
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
IKGRCTAAACSELMHYMIDPEKCDGCMACIKTCPAEAINGSRDEVHVIDQDGCLKCGSCL
HCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCCCCCHHHHH
DICKRDAVRRVPGAYRQGTYSARIPEKDGW
HHHHHHHHHHCCCCHHCCCEECCCCCCCCC
>Mature Secondary Structure
MIEKIAGASLKEYMSLFRGEPTIFIGSATCGRSAGAQKIEEIMGQRAAELSVECRMIHTG
CCCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCHHHHHEEEEEEEEHH
CMGLCYAEPMVVVFNGDSRGYIYGPVNRKLAKRIIQEHIVEGREVEPIGYVDIAFNGDSF
HHHHEECCCEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCC
EPVYALEFMEGQSRRILRRCGLIDPENMGHYLATGGYRGLMRALEMEPDEVIEEVKDSGL
CCEEEEEECCCHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHCCCHHHHHHHHHHCCC
RGRGGAGFPTWLKWSLCRQEASEVKYLICNADEGDPGAFMNRSLIEGDPHALLEGILIAS
CCCCCCCCHHHHHHHHHHHHHHCEEEEEEECCCCCCCHHHCCHHCCCCHHHHHHHHHHHH
YAVGAREAYIYCRAEYPLALERLRVAISDLRNLGLLGKDILGSGFDLDIKIKEGAGAFVC
HHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCEEEE
GEETALISSIEGKRGMPRTRPPFPTTRGLWGKPTVINNVETLAAVSMIMQHGADYFNSLG
CCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHCHHHHHHCC
TPESRGTKTFSLVGDVRRTGLIEVPLGTTLREVIFDIGGGVVDGELKAVQIGGPSGGCLP
CCCCCCCEEEHHHHHHHHCCEEEECCCHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCH
AELIDTGIDYDSLTSAGAIMGSGGLVVLSDRTCMVELARYFLEFTQRESCGKCVPCRVGT
HHHHHCCCCHHHHHCCCCEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
RQMLMILNDIVEGSGRPEDPDILRDVAESVRAASLCGLGQTSPNPVLTTLRYFEDEYHDH
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
IKGRCTAAACSELMHYMIDPEKCDGCMACIKTCPAEAINGSRDEVHVIDQDGCLKCGSCL
HCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCCCCCHHHHH
DICKRDAVRRVPGAYRQGTYSARIPEKDGW
HHHHHHHHHHCCCCHHCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]