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Identifier: 15679544

GI number: 15679544

Start: 1413715

End: 1414164

Strand: Direct

Name: Not Available

Synonym: MTH1548

Alternate gene names: 15679544

Gene position: 1413715-1414164 (Clockwise)

Preceding gene: 15679542

Following gene: 15679545

Centisome position: 80.72

GC content: 48.89

Gene sequence:

>450_bases
ATGGATGAGGAATTGAAGAGAATATTTGCGGGTTACACTGGCCATAAATCTGAAATCATACCAATACTGCAGGATATACA
GGATGCATACGGTTATCTTCCAGAGGATGCCCTGGAGGAGGTAGCAAGCTTCACAGGGGTTAGCAGGGCCCATTTATACG
GGGTCGCCACCTTCTATGCCCAGTTCAGGTTCAAACCAAGGGGGAGAAAGCATATCATGGTCTGCACTGGAACGGCATGT
CATGTCAGCGGAGCGGAACAGGTTCTTGATGCCCTTGAGAGGCACCTGGGCATAGAGGAGGGGGATGTTACAGATGACAT
GGAATACTCCCTCGAATCCGTGGGCTGTATAGGGTGCTGCTCCCTCGCACCATGTGCAATGGTAAACGATGAGGTTGTAT
CACGCATAAAACCATCAAGGGTAGGTAAAATATTCCCAAAAAAGTCTTAG

Upstream 100 bases:

>100_bases
CTAAAAACATATATCCATCTTTGATTAACAGTTAAACAGATCTTTTGTCCTTAATCTATAATATATTTGAGTTCATGACT
CTTTAACCTGGAGGCTTTGA

Downstream 100 bases:

>100_bases
AGTGTCTTAAATGATAGAAAAAATTGCAGGGGCTTCCCTGAAGGAATACATGTCCCTCTTCAGGGGTGAACCGACAATAT
TTATAGGCTCAGCCACCTGT

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E 2; NDH-1 subunit E 2 [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MDEELKRIFAGYTGHKSEIIPILQDIQDAYGYLPEDALEEVASFTGVSRAHLYGVATFYAQFRFKPRGRKHIMVCTGTAC
HVSGAEQVLDALERHLGIEEGDVTDDMEYSLESVGCIGCCSLAPCAMVNDEVVSRIKPSRVGKIFPKKS

Sequences:

>Translated_149_residues
MDEELKRIFAGYTGHKSEIIPILQDIQDAYGYLPEDALEEVASFTGVSRAHLYGVATFYAQFRFKPRGRKHIMVCTGTAC
HVSGAEQVLDALERHLGIEEGDVTDDMEYSLESVGCIGCCSLAPCAMVNDEVVSRIKPSRVGKIFPKKS
>Mature_149_residues
MDEELKRIFAGYTGHKSEIIPILQDIQDAYGYLPEDALEEVASFTGVSRAHLYGVATFYAQFRFKPRGRKHIMVCTGTAC
HVSGAEQVLDALERHLGIEEGDVTDDMEYSLESVGCIGCCSLAPCAMVNDEVVSRIKPSRVGKIFPKKS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=162, Percent_Identity=34.5679012345679, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788621, Length=136, Percent_Identity=28.6764705882353, Blast_Score=83, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17561328, Length=145, Percent_Identity=37.9310344827586, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI18859877, Length=119, Percent_Identity=40.3361344537815, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21355353, Length=143, Percent_Identity=30.0699300699301, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 16433; Mature: 16433

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEELKRIFAGYTGHKSEIIPILQDIQDAYGYLPEDALEEVASFTGVSRAHLYGVATFYA
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
QFRFKPRGRKHIMVCTGTACHVSGAEQVLDALERHLGIEEGDVTDDMEYSLESVGCIGCC
HHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHH
SLAPCAMVNDEVVSRIKPSRVGKIFPKKS
HCCCHHHHCHHHHHHCCHHHHCCCCCCCC
>Mature Secondary Structure
MDEELKRIFAGYTGHKSEIIPILQDIQDAYGYLPEDALEEVASFTGVSRAHLYGVATFYA
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
QFRFKPRGRKHIMVCTGTACHVSGAEQVLDALERHLGIEEGDVTDDMEYSLESVGCIGCC
HHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHH
SLAPCAMVNDEVVSRIKPSRVGKIFPKKS
HCCCHHHHCHHHHHHCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]