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Identifier: 15679512

GI number: 15679512

Start: 1375901

End: 1377100

Strand: Direct

Name: Not Available

Synonym: MTH1515

Alternate gene names: 15679512

Gene position: 1375901-1377100 (Clockwise)

Preceding gene: 15679509

Following gene: 15679513

Centisome position: 78.56

GC content: 53.08

Gene sequence:

>1200_bases
GTGATAACAATGATCCAGATTGCAGTCACAGGAAAACCCAACGTTGGAAAATCATCATTCTTCAATGCAGCCACCCTATC
TGAGGCCGAGGTTGCATCATATCCCTTCACAACAATCGATGCCAACCATGCAGTGGCCTATGCATCCTGCAGATGCCCCT
GCAGGGAACTTGGAGTTGAATGCAACCCCCGGAACTCCCGGTGCATCAATGGTGTCAGACTAATACCAGTGGAGCTCATA
GACGTCGCCGGCCTGGTACCAGGGGCCCATGAGGGGAGGGGCCTCGGGAACAAGTTCCTTGATGACCTCAGACAGGCGAG
GGCATTTCTCCATGTCATAGACGCCTCGGGTTCCACCGATGAGGAGGGGAGACCCGTTGAAGCAGGAAGCCACGACCCCC
TGGAGGACGTTGAGTTCCTGGAGGAGGAGATAACCATGTGGCTCTACGGGATCCTCGAGAGGAACTGGGAGAGGCTCCTC
AGAAAGGCTGCTTCAGAGAAGCTCGACATGAACCGAATCATACATGAACAGCTCTCAGGTACCGGAATAACACCTGAGGA
CATCATTGAGGCATCAAGAAAGGTGGATGCCGATGTTTATTCATGGGGGAAGGATGAGCTTCTGCAGTTCCTTGATGAGC
TCCTCAGAATAGCAAAGCCAATGCTCATAGTTGCAAATAAGGCTGACCTTCCCTCAGCCGGTGAGAATATTGAGCGCCTG
AAGGATGCCTACCCCCACGTGGTACCCGCATCTGCAGAGGCTGAACTGGCCCTCAGAAGGGCAGCAGAGGCGGGTTTAAT
CAGTTACACCCCCGGTGGCAGTGAATTTGAGATAATCGATGAATCAAAGCTCACAGATAAACAGAGGGCGGCCCTTGAGT
ACATACGTGAAAATGTCCTGGAGGTTTACGGAAGCACAGGTGTCCAGGAGGCCATCAACAGGGCCGTATTTGATCTTCTG
GACATGATAGTTGTCTTCCCGGTTGAGGATGAGCACAGATTCACTGACCAGAAGGGGAATGTGCTGCCAGACGCCATCCT
TGTACCGCGGGGCTCCAGTCCAAGGGACCTTGCCTACCTGATACACACGGAGATAGGTGACTCCTTCCTCCATGCGGTGG
ATGCCAGAAAGGGTATGAGGGTCGCATCCGACCATGAACTGGAGGATGGGGACATAATAAGCATTATATGCAGCAGATAG

Upstream 100 bases:

>100_bases
AGCACGGAGGCAGATATTCACTGGGTCTCAGCAATCTCTCCATTAAAGAGAGTGTCCCATACCAACATTTTATTATAATA
TCCCGGCACTACTTATTAAT

Downstream 100 bases:

>100_bases
TTTCATAGGATATCACATTAATTTAATAACATGAGTGGTGCATTTCAAGTGTAAGTCCCCTTGATGAAGCTGGTGGCTGT
GCAACCCCAAGGGTATGGGA

Product: translation-associated GTPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MITMIQIAVTGKPNVGKSSFFNAATLSEAEVASYPFTTIDANHAVAYASCRCPCRELGVECNPRNSRCINGVRLIPVELI
DVAGLVPGAHEGRGLGNKFLDDLRQARAFLHVIDASGSTDEEGRPVEAGSHDPLEDVEFLEEEITMWLYGILERNWERLL
RKAASEKLDMNRIIHEQLSGTGITPEDIIEASRKVDADVYSWGKDELLQFLDELLRIAKPMLIVANKADLPSAGENIERL
KDAYPHVVPASAEAELALRRAAEAGLISYTPGGSEFEIIDESKLTDKQRAALEYIRENVLEVYGSTGVQEAINRAVFDLL
DMIVVFPVEDEHRFTDQKGNVLPDAILVPRGSSPRDLAYLIHTEIGDSFLHAVDARKGMRVASDHELEDGDIISIICSR

Sequences:

>Translated_399_residues
MITMIQIAVTGKPNVGKSSFFNAATLSEAEVASYPFTTIDANHAVAYASCRCPCRELGVECNPRNSRCINGVRLIPVELI
DVAGLVPGAHEGRGLGNKFLDDLRQARAFLHVIDASGSTDEEGRPVEAGSHDPLEDVEFLEEEITMWLYGILERNWERLL
RKAASEKLDMNRIIHEQLSGTGITPEDIIEASRKVDADVYSWGKDELLQFLDELLRIAKPMLIVANKADLPSAGENIERL
KDAYPHVVPASAEAELALRRAAEAGLISYTPGGSEFEIIDESKLTDKQRAALEYIRENVLEVYGSTGVQEAINRAVFDLL
DMIVVFPVEDEHRFTDQKGNVLPDAILVPRGSSPRDLAYLIHTEIGDSFLHAVDARKGMRVASDHELEDGDIISIICSR
>Mature_399_residues
MITMIQIAVTGKPNVGKSSFFNAATLSEAEVASYPFTTIDANHAVAYASCRCPCRELGVECNPRNSRCINGVRLIPVELI
DVAGLVPGAHEGRGLGNKFLDDLRQARAFLHVIDASGSTDEEGRPVEAGSHDPLEDVEFLEEEITMWLYGILERNWERLL
RKAASEKLDMNRIIHEQLSGTGITPEDIIEASRKVDADVYSWGKDELLQFLDELLRIAKPMLIVANKADLPSAGENIERL
KDAYPHVVPASAEAELALRRAAEAGLISYTPGGSEFEIIDESKLTDKQRAALEYIRENVLEVYGSTGVQEAINRAVFDLL
DMIVVFPVEDEHRFTDQKGNVLPDAILVPRGSSPRDLAYLIHTEIGDSFLHAVDARKGMRVASDHELEDGDIISIICSR

Specific function: Unknown

COG id: COG0012

COG function: function code J; Predicted GTPase, probable translation factor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI58761500, Length=229, Percent_Identity=29.2576419213974, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787454, Length=164, Percent_Identity=31.7073170731707, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321649, Length=396, Percent_Identity=35.8585858585859, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321773, Length=230, Percent_Identity=30, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640873, Length=164, Percent_Identity=34.1463414634146, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24640877, Length=164, Percent_Identity=34.1463414634146, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24640875, Length=164, Percent_Identity=34.1463414634146, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR006073
- InterPro:   IPR013646
- InterPro:   IPR002917
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01926 MMR_HSR1; PF08438 MMR_HSR1_C; PF02824 TGS [H]

EC number: NA

Molecular weight: Translated: 44020; Mature: 44020

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00022 EGF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITMIQIAVTGKPNVGKSSFFNAATLSEAEVASYPFTTIDANHAVAYASCRCPCRELGVE
CEEEEEEEEECCCCCCCHHCCCHHHCCCHHHHCCCCEEECCCCEEEEHHCCCCHHHCCCC
CNPRNSRCINGVRLIPVELIDVAGLVPGAHEGRGLGNKFLDDLRQARAFLHVIDASGSTD
CCCCCCHHHCCEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCC
EEGRPVEAGSHDPLEDVEFLEEEITMWLYGILERNWERLLRKAASEKLDMNRIIHEQLSG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGITPEDIIEASRKVDADVYSWGKDELLQFLDELLRIAKPMLIVANKADLPSAGENIERL
CCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHH
KDAYPHVVPASAEAELALRRAAEAGLISYTPGGSEFEIIDESKLTDKQRAALEYIRENVL
HHHCCCEECCCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
EVYGSTGVQEAINRAVFDLLDMIVVFPVEDEHRFTDQKGNVLPDAILVPRGSSPRDLAYL
HHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEE
IHTEIGDSFLHAVDARKGMRVASDHELEDGDIISIICSR
EEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MITMIQIAVTGKPNVGKSSFFNAATLSEAEVASYPFTTIDANHAVAYASCRCPCRELGVE
CEEEEEEEEECCCCCCCHHCCCHHHCCCHHHHCCCCEEECCCCEEEEHHCCCCHHHCCCC
CNPRNSRCINGVRLIPVELIDVAGLVPGAHEGRGLGNKFLDDLRQARAFLHVIDASGSTD
CCCCCCHHHCCEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCC
EEGRPVEAGSHDPLEDVEFLEEEITMWLYGILERNWERLLRKAASEKLDMNRIIHEQLSG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGITPEDIIEASRKVDADVYSWGKDELLQFLDELLRIAKPMLIVANKADLPSAGENIERL
CCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHH
KDAYPHVVPASAEAELALRRAAEAGLISYTPGGSEFEIIDESKLTDKQRAALEYIRENVL
HHHCCCEECCCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
EVYGSTGVQEAINRAVFDLLDMIVVFPVEDEHRFTDQKGNVLPDAILVPRGSSPRDLAYL
HHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEE
IHTEIGDSFLHAVDARKGMRVASDHELEDGDIISIICSR
EEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]