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Identifier: 15679509

GI number: 15679509

Start: 1369439

End: 1370473

Strand: Direct

Name: Not Available

Synonym: MTH1512

Alternate gene names: NA

Gene position: 1369439-1370473 (Clockwise)

Preceding gene: 15679508

Following gene: 15679512

Centisome position: 78.19

GC content: 49.47

Gene sequence:

>1035_bases
GTGAGCACTATGAAAGTTGCAGTTTATGGCGCGGGTAACCAGAAACTTTATGTGGACCAGCTGAACTTGCCTGAAAAATA
TGGGGGTGAGGCACCCTACGGTGGAAGCAGAATGGCAATTGAATTTGCAGAGGCCGGACATGACGTTGTACTGGCAGAAC
CAGCAAGGGATATGCTGGATGATGCACACTGGAAGGTGGTTGAGGATGCAGGGGTCACAGTAACAGACAACGATGCAGAG
GCAGCCAGTGAGGCTGAAATAGCAGTACTCTTCACACCCTTCGGTAAGAAGACCTTTGAGATAGCAAAGAACATAACAAA
TCACCTGCCAGAGGGGGCTGTCATAGCAAACACCTGTACGGTCTCACCTGTGGTACTCTACTACGTACTTGAAAGGGAGC
TTAGAAGGGATCGTAAGGACCTGGGTATAGCATCAATGCACCCTGCAGCCGTCCCTGGTACACCACAGCACGGCCACTAT
GTCATAGGGGGTCACTCAAGCAGTGAACTTGACATAGCAACAGATGAACAGATATCAAGATGCGTTGAACTCGCTGAAAG
CTGCGGTAAGGTAGCCTATGTTGTACCAGCCGACGTATCAAGTGCAGTTGCAGATATGGGGTCACTTGTTACAGCGGTCA
CACTTTCAGGTGTCCTTGACTACTACTATGTGGGTACACAGATAATCAGGGCCCCCAAGGAGATGGTTGAAAAGCAGATC
CTCATGACACTCCAGACCATAGCTTCACTCGTTGAAACCTCAGGTGTTAATGGAATGCTCAAGGCCATGAACCCTGAACT
CCTTGTGAGGAGCGCTAAATCAATGCACCTCCTTGAGGAGCAGGAGGAACTGGATGCAGCACTCAACACCCTATCAGACC
TTGATGATGAGGTAAATAAATGGATAGAGAAGGGTGAGATCAGGCACACGGATCTGGTTGCTGCACAGGCCCTTGCAAAG
GAGATAAAGAACCTCATGGGTGGAAAGGCTGCCGAGGGTACAATAAGGCGCTGCATGAGGAAGATGTTTGAATAA

Upstream 100 bases:

>100_bases
AATGTATTTTAGGATGCTGGGGGCTCCTAATTTTTTCAAAGAAAAAAATGCCAAAATTTATAATATTCATTCAAATTACT
TAACAATATATTAATGTTAG

Downstream 100 bases:

>100_bases
TAATTTTTCCTTATCTTATTTTGTGCAACAAATTTTTTTGAGACCAATTCGGCAGCTGATTTTTGCAATGATTTGATGTT
ATCCAGAATAAGTTTTTAGT

Product: H(2)-dependent methylenetetrahydromethanopterin dehydrogenase-related protein

Products: 5,10-methenyltetrahydromethanopterin; reduced coenzyme F420

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSTMKVAVYGAGNQKLYVDQLNLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAE
AASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRRDRKDLGIASMHPAAVPGTPQHGHY
VIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQI
LMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVAAQALAK
EIKNLMGGKAAEGTIRRCMRKMFE

Sequences:

>Translated_344_residues
MSTMKVAVYGAGNQKLYVDQLNLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAE
AASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRRDRKDLGIASMHPAAVPGTPQHGHY
VIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQI
LMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVAAQALAK
EIKNLMGGKAAEGTIRRCMRKMFE
>Mature_343_residues
STMKVAVYGAGNQKLYVDQLNLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPARDMLDDAHWKVVEDAGVTVTDNDAEA
ASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYVLERELRRDRKDLGIASMHPAAVPGTPQHGHYV
IGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQIL
MTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNKWIEKGEIRHTDLVAAQALAKE
IKNLMGGKAAEGTIRRCMRKMFE

Specific function: Unknown

COG id: COG4007

COG function: function code R; Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR010063
- InterPro:   IPR004889
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03201 HMD [H]

EC number: 1.5.99.9

Molecular weight: Translated: 37297; Mature: 37166

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMKVAVYGAGNQKLYVDQLNLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPARDMLD
CCCEEEEEEECCCCEEEEEECCCCHHCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHC
DAHWKVVEDAGVTVTDNDAEAASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCT
CCCEEEEECCCCEEECCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCC
VSPVVLYYVLERELRRDRKDLGIASMHPAAVPGTPQHGHYVIGGHSSSELDIATDEQISR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHH
CVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQI
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNK
HHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIEKGEIRHTDLVAAQALAKEIKNLMGGKAAEGTIRRCMRKMFE
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
STMKVAVYGAGNQKLYVDQLNLPEKYGGEAPYGGSRMAIEFAEAGHDVVLAEPARDMLD
CCEEEEEEECCCCEEEEEECCCCHHCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHC
DAHWKVVEDAGVTVTDNDAEAASEAEIAVLFTPFGKKTFEIAKNITNHLPEGAVIANTCT
CCCEEEEECCCCEEECCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCC
VSPVVLYYVLERELRRDRKDLGIASMHPAAVPGTPQHGHYVIGGHSSSELDIATDEQISR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHH
CVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQIIRAPKEMVEKQI
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTLQTIASLVETSGVNGMLKAMNPELLVRSAKSMHLLEEQEELDAALNTLSDLDDEVNK
HHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIEKGEIRHTDLVAAQALAKEIKNLMGGKAAEGTIRRCMRKMFE
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,10-methylenetetrahydromethanopterin; coenzyme F420

Specific reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]