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Identifier: 15679508

GI number: 15679508

Start: 1368148

End: 1369122

Strand: Direct

Name: Not Available

Synonym: MTH1511

Alternate gene names: NA

Gene position: 1368148-1369122 (Clockwise)

Preceding gene: 15679504

Following gene: 15679509

Centisome position: 78.12

GC content: 51.79

Gene sequence:

>975_bases
ATGGCATTTAAGGATCTCTTCAAGTTCAATAAGGGCAAAACAACATTTGTATTCATAGGTGGAAAGGGAGGAGTTGGTAA
GACAACCATATCGGCTGCAACAGCCCTCTGGATGGCAAGGTCAGGTAAAAAGACCCTGGTGATCTCAACTGACCCTGCAC
ACTCACTTTCAGATTCACTGGAGAGGGAGATAGGCCACACCCCCACAAAGATAACCGAGAACCTCTATGCGGTTGAGATA
GACCCTGAGGTTGCAATGGAGGAGTACCAGGCAAAACTTCAGGAACAGGCTGCAATGAACCCTGGCATGGGCCTGGATAT
GCTCCAGGACCAGATGGACATGGCATCAATGTCCCCGGGTATCGATGAGGCTGCGGCCTTCGACCAGTTCCTGAGGTACA
TGACAACCGATGAATACGACATCGTTATCTTTGACACGGCACCAACCGGTCACACCCTCCGCCTCCTATCCTTCCCTGAA
ATAATGGACTCATGGGTCGGGAAGATGATAAAGATAAGGAGGCAGATAGGAAGCATGGCCAAGGCCTTCAAGAACATACT
CCCATTCATGGGTGATGAGGAAGAGGAGGACAGGGCGCTGCAGGACATGGAGGCCACCAAGAAGCAGATAAACGCTGCAA
GGGAGGTCATGTCAGACCCTGAGAGGACATCCTTCAAGATGGTTGTCATCCCTGAGGAGATGTCCATCTACGAGTCAGAG
AGGGCAATGAAGGCCCTCGAGAAGTACAGTATCCACGCCGACGGCGTAATAGTGAACCAGGTCCTCCCGGAGGAGAGCGA
CTGCGAGTTCTGTAATGCCCGCAGAAAACTCCAGCAGGAGAGGCTTAAGCAGATCCGGGAGAAATTCAGTGATAAGGTGG
TTGCAGAGGTCCCGCTTCTCAAGAAGGAGGCAAAGGGTATTGAAACCCTGGAGAAGATAGCAGAGCAGCTTTACGGCGAA
CCCGAGCCAGAATAG

Upstream 100 bases:

>100_bases
GTAAGTAGGGTATATTTTATATAACTATCAAAAGAGGTAGAAAAACTTATATCAGTGATGCTGATCTTGGATCGATGATT
AATTTTACAGGAGGAGTATA

Downstream 100 bases:

>100_bases
ATCCCTTAAATTTTTTATGATCAGTACATTGAGCACCTGATTTTTCCTCTTTTTACCACCTTTAAGGCCACTGTATTATA
GAATCACCATCTTTTATTAA

Product: arsenical pump-driving ATPase

Products: NA

Alternate protein names: Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAFKDLFKFNKGKTTFVFIGGKGGVGKTTISAATALWMARSGKKTLVISTDPAHSLSDSLEREIGHTPTKITENLYAVEI
DPEVAMEEYQAKLQEQAAMNPGMGLDMLQDQMDMASMSPGIDEAAAFDQFLRYMTTDEYDIVIFDTAPTGHTLRLLSFPE
IMDSWVGKMIKIRRQIGSMAKAFKNILPFMGDEEEEDRALQDMEATKKQINAAREVMSDPERTSFKMVVIPEEMSIYESE
RAMKALEKYSIHADGVIVNQVLPEESDCEFCNARRKLQQERLKQIREKFSDKVVAEVPLLKKEAKGIETLEKIAEQLYGE
PEPE

Sequences:

>Translated_324_residues
MAFKDLFKFNKGKTTFVFIGGKGGVGKTTISAATALWMARSGKKTLVISTDPAHSLSDSLEREIGHTPTKITENLYAVEI
DPEVAMEEYQAKLQEQAAMNPGMGLDMLQDQMDMASMSPGIDEAAAFDQFLRYMTTDEYDIVIFDTAPTGHTLRLLSFPE
IMDSWVGKMIKIRRQIGSMAKAFKNILPFMGDEEEEDRALQDMEATKKQINAAREVMSDPERTSFKMVVIPEEMSIYESE
RAMKALEKYSIHADGVIVNQVLPEESDCEFCNARRKLQQERLKQIREKFSDKVVAEVPLLKKEAKGIETLEKIAEQLYGE
PEPE
>Mature_323_residues
AFKDLFKFNKGKTTFVFIGGKGGVGKTTISAATALWMARSGKKTLVISTDPAHSLSDSLEREIGHTPTKITENLYAVEID
PEVAMEEYQAKLQEQAAMNPGMGLDMLQDQMDMASMSPGIDEAAAFDQFLRYMTTDEYDIVIFDTAPTGHTLRLLSFPEI
MDSWVGKMIKIRRQIGSMAKAFKNILPFMGDEEEEDRALQDMEATKKQINAAREVMSDPERTSFKMVVIPEEMSIYESER
AMKALEKYSIHADGVIVNQVLPEESDCEFCNARRKLQQERLKQIREKFSDKVVAEVPLLKKEAKGIETLEKIAEQLYGEP
EPE

Specific function: Anion-transporting ATPase. Catalyzes the extrusion of arsenite

COG id: COG0003

COG function: function code P; Oxyanion-translocating ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arsA ATPase family

Homologues:

Organism=Homo sapiens, GI50428938, Length=313, Percent_Identity=38.0191693290735, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17557003, Length=312, Percent_Identity=33.0128205128205, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71990781, Length=143, Percent_Identity=31.4685314685315, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320103, Length=315, Percent_Identity=33.968253968254, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24586297, Length=307, Percent_Identity=32.8990228013029, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARSA_METTH (O27555)

Other databases:

- EMBL:   AE000666
- PIR:   F69068
- RefSeq:   NP_276625.1
- ProteinModelPortal:   O27555
- SMR:   O27555
- STRING:   O27555
- GeneID:   1471780
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1511
- NMPDR:   fig|187420.1.peg.1480
- eggNOG:   arNOG04878
- HOGENOM:   HBG646947
- OMA:   IPEEMSI
- ProtClustDB:   CLSK876470
- BioCyc:   MTHE187420:MTH1511-MONOMER
- BRENDA:   3.6.3.16
- InterPro:   IPR003348
- TIGRFAMs:   TIGR00345

Pfam domain/function: NA

EC number: =3.6.3.16

Molecular weight: Translated: 36544; Mature: 36413

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFKDLFKFNKGKTTFVFIGGKGGVGKTTISAATALWMARSGKKTLVISTDPAHSLSDSL
CCHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
EREIGHTPTKITENLYAVEIDPEVAMEEYQAKLQEQAAMNPGMGLDMLQDQMDMASMSPG
HHHHCCCCHHHHCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
IDEAAAFDQFLRYMTTDEYDIVIFDTAPTGHTLRLLSFPEIMDSWVGKMIKIRRQIGSMA
CHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
KAFKNILPFMGDEEEEDRALQDMEATKKQINAAREVMSDPERTSFKMVVIPEEMSIYESE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHH
RAMKALEKYSIHADGVIVNQVLPEESDCEFCNARRKLQQERLKQIREKFSDKVVAEVPLL
HHHHHHHHHCCCCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKEAKGIETLEKIAEQLYGEPEPE
HHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AFKDLFKFNKGKTTFVFIGGKGGVGKTTISAATALWMARSGKKTLVISTDPAHSLSDSL
CHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
EREIGHTPTKITENLYAVEIDPEVAMEEYQAKLQEQAAMNPGMGLDMLQDQMDMASMSPG
HHHHCCCCHHHHCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
IDEAAAFDQFLRYMTTDEYDIVIFDTAPTGHTLRLLSFPEIMDSWVGKMIKIRRQIGSMA
CHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
KAFKNILPFMGDEEEEDRALQDMEATKKQINAAREVMSDPERTSFKMVVIPEEMSIYESE
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHH
RAMKALEKYSIHADGVIVNQVLPEESDCEFCNARRKLQQERLKQIREKFSDKVVAEVPLL
HHHHHHHHHCCCCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKEAKGIETLEKIAEQLYGEPEPE
HHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463