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The map label for this gene is hisG

Identifier: 15679503

GI number: 15679503

Start: 1362267

End: 1363130

Strand: Direct

Name: hisG

Synonym: MTH1506

Alternate gene names: 15679503

Gene position: 1362267-1363130 (Clockwise)

Preceding gene: 15679499

Following gene: 15679504

Centisome position: 77.78

GC content: 52.31

Gene sequence:

>864_bases
ATGAAGATAAGAATAGCGGTTCCCTCCAAGGGAAGGATAAGCGAGCCTGCAATAAGGTTACTTGAAAATGCAGGTGTCGG
CCTTAAGGACACTGTTAACAGGAAATTATTCTCAAAGACACAGCACCCCCAGATTGAGGTAATGTTCAGCAGAGCAGCGG
ATATACCGGAATTCGTTGCCGACGGTGCCGCTGACCTGGGGATCACCGGCTATGACCTCATAGTTGAAAGGGGAAGTGAC
GTTGAAATCCTGGAGGACCTCAAATACGGGAGGGCCAGCCTGGTTCTTGCAGCCCCTGAGGACTCCACCATCAGGGGCCC
GGAGGACATACCTCGGGGTGCAGTTATAGCCACAGAGTTCCCGGGGATAACAGAGAACTATCTCAGGGAGCATGGTATAG
ATGCGGAGGTTGTTGAACTCACAGGATCAACAGAGATAGCGCCCTTCATTGGAGTCGCTGACCTCATAACAGACCTCAGC
AGCACAGGGACAACCCTCAGGATGAACCACCTCCGGGTAATCGACACCATCCTCGAAAGTTCGGTTAAGCTCATAGCAAA
CAGGGAAAGCTACGCCACCAAATCAGGGATAATAGAGGAACTCAGAACAGGGATACGTGGAGTCATAGATGCCGAGGGGA
AGAGACTGGTGATGCTTAACATCGACCGCAAAAACCTTGACAGGGTCAGGGCCCTGATGCCCGGGATGACAGGTCCCACG
GTCTCAGAGGTGCTCTCAGATAACGGGGTTGTGGCAGTACACGCAGTGGTGGATGAAAAGGAGGTCTTCAACCTCATAAA
CAGGCTCAAGGCGGTGGGGGCAAGGGATATACTTGTTGTGCCCATTGAGAGGATAATACCCTGA

Upstream 100 bases:

>100_bases
AAGTTAATCTCCAGTGAAGAATGATAGATCCTGCAGATGAACGGATAAACCCTGCAGGAGCTTAATGTAAAATAAATTTA
ACCAGTCATCGAGGGATTTA

Downstream 100 bases:

>100_bases
GGGTGATTGAATTGAAATTCCTGAGGTTCATGAAGGATGGAAGGCTCCTTCACGGGTTCACAGAGAACAGAAGGATATTG
GAGATCCGGGAGGAGGAATA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKIRIAVPSKGRISEPAIRLLENAGVGLKDTVNRKLFSKTQHPQIEVMFSRAADIPEFVADGAADLGITGYDLIVERGSD
VEILEDLKYGRASLVLAAPEDSTIRGPEDIPRGAVIATEFPGITENYLREHGIDAEVVELTGSTEIAPFIGVADLITDLS
STGTTLRMNHLRVIDTILESSVKLIANRESYATKSGIIEELRTGIRGVIDAEGKRLVMLNIDRKNLDRVRALMPGMTGPT
VSEVLSDNGVVAVHAVVDEKEVFNLINRLKAVGARDILVVPIERIIP

Sequences:

>Translated_287_residues
MKIRIAVPSKGRISEPAIRLLENAGVGLKDTVNRKLFSKTQHPQIEVMFSRAADIPEFVADGAADLGITGYDLIVERGSD
VEILEDLKYGRASLVLAAPEDSTIRGPEDIPRGAVIATEFPGITENYLREHGIDAEVVELTGSTEIAPFIGVADLITDLS
STGTTLRMNHLRVIDTILESSVKLIANRESYATKSGIIEELRTGIRGVIDAEGKRLVMLNIDRKNLDRVRALMPGMTGPT
VSEVLSDNGVVAVHAVVDEKEVFNLINRLKAVGARDILVVPIERIIP
>Mature_287_residues
MKIRIAVPSKGRISEPAIRLLENAGVGLKDTVNRKLFSKTQHPQIEVMFSRAADIPEFVADGAADLGITGYDLIVERGSD
VEILEDLKYGRASLVLAAPEDSTIRGPEDIPRGAVIATEFPGITENYLREHGIDAEVVELTGSTEIAPFIGVADLITDLS
STGTTLRMNHLRVIDTILESSVKLIANRESYATKSGIIEELRTGIRGVIDAEGKRLVMLNIDRKNLDRVRALMPGMTGPT
VSEVLSDNGVVAVHAVVDEKEVFNLINRLKAVGARDILVVPIERIIP

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=295, Percent_Identity=35.9322033898305, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320896, Length=287, Percent_Identity=30.3135888501742, Blast_Score=129, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_METTH (O27550)

Other databases:

- EMBL:   AE000666
- PIR:   H69067
- RefSeq:   NP_276620.1
- PDB:   2VD3
- PDBsum:   2VD3
- ProteinModelPortal:   O27550
- SMR:   O27550
- STRING:   O27550
- GeneID:   1471775
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1506
- NMPDR:   fig|187420.1.peg.1475
- eggNOG:   arNOG04876
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- PhylomeDB:   O27550
- ProtClustDB:   PRK00489
- BioCyc:   MTHE187420:MTH1506-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 31165; Mature: 31165

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRIAVPSKGRISEPAIRLLENAGVGLKDTVNRKLFSKTQHPQIEVMFSRAADIPEFVA
CEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEHHHCCCHHHHH
DGAADLGITGYDLIVERGSDVEILEDLKYGRASLVLAAPEDSTIRGPEDIPRGAVIATEF
CCCCCCCCCCEEEEEECCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECC
PGITENYLREHGIDAEVVELTGSTEIAPFIGVADLITDLSSTGTTLRMNHLRVIDTILES
CCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
SVKLIANRESYATKSGIIEELRTGIRGVIDAEGKRLVMLNIDRKNLDRVRALMPGMTGPT
HHHHHHCCHHHHHHHHHHHHHHHHHCEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCH
VSEVLSDNGVVAVHAVVDEKEVFNLINRLKAVGARDILVVPIERIIP
HHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEECHHHHCC
>Mature Secondary Structure
MKIRIAVPSKGRISEPAIRLLENAGVGLKDTVNRKLFSKTQHPQIEVMFSRAADIPEFVA
CEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEHHHCCCHHHHH
DGAADLGITGYDLIVERGSDVEILEDLKYGRASLVLAAPEDSTIRGPEDIPRGAVIATEF
CCCCCCCCCCEEEEEECCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECC
PGITENYLREHGIDAEVVELTGSTEIAPFIGVADLITDLSSTGTTLRMNHLRVIDTILES
CCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
SVKLIANRESYATKSGIIEELRTGIRGVIDAEGKRLVMLNIDRKNLDRVRALMPGMTGPT
HHHHHHCCHHHHHHHHHHHHHHHHHCEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCH
VSEVLSDNGVVAVHAVVDEKEVFNLINRLKAVGARDILVVPIERIIP
HHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463