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The map label for this gene is sdhA

Identifier: 15679499

GI number: 15679499

Start: 1358403

End: 1360079

Strand: Direct

Name: sdhA

Synonym: MTH1502

Alternate gene names: 15679499

Gene position: 1358403-1360079 (Clockwise)

Preceding gene: 15679494

Following gene: 15679503

Centisome position: 77.56

GC content: 54.2

Gene sequence:

>1677_bases
ATGCTAAAAATATTGTCCATGGAAAGTCAGGTCTATGAATGTGATGTTCTGATAATAGGCTCAGGTGGAGCTGGCTGCAG
GGCAGCCATAGAAGTTTCTGAACACAATCTCACGCCATTAATAGTTTCAAAGGGATTATCATTTAAATCAGGGTGCACTG
GAATGGCTGAAGGAGGATACAACGCTGCATTTGCATGTGTTGACCCCGAGGACAGTCCGGATGTGCACTTCGAGGACACC
ATGAGGGGTGGGGGATTCCTCAATGACCCCCAGCTTGTCCGCATACTTGTGGATGAGGCACCCGACAGGTTGAGGGACCT
TGAAACATATGGAGCCCTCTTTGACAGACAGGAATCCGGGCTGCTTGACCAGAGGCCCTTTGGGGGGCAGACCTACAGGA
GGACATGCTACCAGGGGGACCGCACCGGCCATGAGATGATAACAGCCCTCAAGGAGGAGGTCATACGACGGGATATAGAG
ACAGTTGAGGAGATCATGATAACATCCCTCCTTGTGGAGGAGGACCGTGTACTGGGAGCCATGGGTGTGTCCATAAGGGA
CTCAAGCACTGTGGCCTTCAGGGCGTCTTCAACCATCCTGGCAGCCGGTGGGGCCGGTCACATCTACCCCGTTACCTCCA
ACACCATCCAGAAGGGCGGTGATGGATTTTCAGTGGCATGGAAGGCAGGGGCTGACCTCATAGACATGGAACAGGTCCAG
TTCCACCCCACGGGCATGGTCTACCCCGAGTCAAGGAGAGGGGTCCTTGTGACGGAGGCCGTGAGGGGTGAGGGCGGAAT
ACTCCTCAACAGTGAGGGGGAGAGGTTCATGAAGAGATACGACCCCCGCGGCGAACTGGCAACAAGGGATGTTGTTGCAA
GGGCAATCTACACCGAGATCATGGAGGGGAGGGGCACCGGGAATGGTGGAGTCTACCTTGATGTCAGCCACCTGCCCGAT
GAGGTCATAGAGGAGAAGCTTGAGACCATGCTCCTCCAGTTCCAGGATGTTGGTATTGATATAAGGTCCGAGCCAATGGA
GGTGGCACCCACAGCACACCACTTCATGGGAGGCGTCAGGATAGATGAGTGGGGCAGGACAAACCTCAGGAACCTCTTTG
CAGCCGGTGAGGTTACCGGTGGTGTCCATGGAGCCAACAGACTGGGCGGCAATGCACTGGCGGATACCCAGGTATTCGGA
AGGAGGGCCGGGATAGCAGCTGCAAGGAACGCCATCAAATCAGCCCCGGCGTCTATCAAGTCTACTGTTGAGGAGGAGGA
ATACCGTATAAAGTCAATGGTGGCCGAAGGATCACACAGCCCATCCGAGATAAGGGACAGGCTTCATGAGGCCATGTGGA
ACGGTGTTGCCATAGTAAGGAGCCGTGAATCCCTTGAATCAGCCAGAGCAGTTATCCAGGACCTCACGACGATGATGGGG
GATCTGAATGTCCCTGAGACGTCTGGCTTTAACACCTACCTCATCGAGGCCCTCGAACTTGAAAATATGCTTGTAACCTC
ATCAATGGTGGTGGAATCAGCCCTGATAAGGGAGGAGAGCAGGGGATCCCATTACAGGAAGGATTTCCCTGAAACCAGAC
CTGAATGGCTTAAGAGCATAGTCCTCAACAGGAACAGAAGACCCGGCTTCATAGAGAGGGGCCTTAAATCAGCCTAG

Upstream 100 bases:

>100_bases
TCCGTAGAGGACCGGGTGATGGTTCATCACCTGAGCTTGACTTTATTCTCGGTTATGGTTCATCACCTTAACTATTGACT
GCCAAACCTTATAATAATGA

Downstream 100 bases:

>100_bases
GTCCACCTTAAACATAGGTCAGCTCATATGATCTGCTGCCGATGATCACCTGCCATGATCTTCAGCACGGTATCCCGGAG
TTCAGGTTTTCTGTAATCAG

Product: succinate dehydrogenase flavoprotein subunit

Products: fumarate; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MLKILSMESQVYECDVLIIGSGGAGCRAAIEVSEHNLTPLIVSKGLSFKSGCTGMAEGGYNAAFACVDPEDSPDVHFEDT
MRGGGFLNDPQLVRILVDEAPDRLRDLETYGALFDRQESGLLDQRPFGGQTYRRTCYQGDRTGHEMITALKEEVIRRDIE
TVEEIMITSLLVEEDRVLGAMGVSIRDSSTVAFRASSTILAAGGAGHIYPVTSNTIQKGGDGFSVAWKAGADLIDMEQVQ
FHPTGMVYPESRRGVLVTEAVRGEGGILLNSEGERFMKRYDPRGELATRDVVARAIYTEIMEGRGTGNGGVYLDVSHLPD
EVIEEKLETMLLQFQDVGIDIRSEPMEVAPTAHHFMGGVRIDEWGRTNLRNLFAAGEVTGGVHGANRLGGNALADTQVFG
RRAGIAAARNAIKSAPASIKSTVEEEEYRIKSMVAEGSHSPSEIRDRLHEAMWNGVAIVRSRESLESARAVIQDLTTMMG
DLNVPETSGFNTYLIEALELENMLVTSSMVVESALIREESRGSHYRKDFPETRPEWLKSIVLNRNRRPGFIERGLKSA

Sequences:

>Translated_558_residues
MLKILSMESQVYECDVLIIGSGGAGCRAAIEVSEHNLTPLIVSKGLSFKSGCTGMAEGGYNAAFACVDPEDSPDVHFEDT
MRGGGFLNDPQLVRILVDEAPDRLRDLETYGALFDRQESGLLDQRPFGGQTYRRTCYQGDRTGHEMITALKEEVIRRDIE
TVEEIMITSLLVEEDRVLGAMGVSIRDSSTVAFRASSTILAAGGAGHIYPVTSNTIQKGGDGFSVAWKAGADLIDMEQVQ
FHPTGMVYPESRRGVLVTEAVRGEGGILLNSEGERFMKRYDPRGELATRDVVARAIYTEIMEGRGTGNGGVYLDVSHLPD
EVIEEKLETMLLQFQDVGIDIRSEPMEVAPTAHHFMGGVRIDEWGRTNLRNLFAAGEVTGGVHGANRLGGNALADTQVFG
RRAGIAAARNAIKSAPASIKSTVEEEEYRIKSMVAEGSHSPSEIRDRLHEAMWNGVAIVRSRESLESARAVIQDLTTMMG
DLNVPETSGFNTYLIEALELENMLVTSSMVVESALIREESRGSHYRKDFPETRPEWLKSIVLNRNRRPGFIERGLKSA
>Mature_558_residues
MLKILSMESQVYECDVLIIGSGGAGCRAAIEVSEHNLTPLIVSKGLSFKSGCTGMAEGGYNAAFACVDPEDSPDVHFEDT
MRGGGFLNDPQLVRILVDEAPDRLRDLETYGALFDRQESGLLDQRPFGGQTYRRTCYQGDRTGHEMITALKEEVIRRDIE
TVEEIMITSLLVEEDRVLGAMGVSIRDSSTVAFRASSTILAAGGAGHIYPVTSNTIQKGGDGFSVAWKAGADLIDMEQVQ
FHPTGMVYPESRRGVLVTEAVRGEGGILLNSEGERFMKRYDPRGELATRDVVARAIYTEIMEGRGTGNGGVYLDVSHLPD
EVIEEKLETMLLQFQDVGIDIRSEPMEVAPTAHHFMGGVRIDEWGRTNLRNLFAAGEVTGGVHGANRLGGNALADTQVFG
RRAGIAAARNAIKSAPASIKSTVEEEEYRIKSMVAEGSHSPSEIRDRLHEAMWNGVAIVRSRESLESARAVIQDLTTMMG
DLNVPETSGFNTYLIEALELENMLVTSSMVVESALIREESRGSHYRKDFPETRPEWLKSIVLNRNRRPGFIERGLKSA

Specific function: Catalyzes The Oxidation Of L-Aspartate To Iminoaspartate. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=558, Percent_Identity=35.663082437276, Blast_Score=285, Evalue=6e-77,
Organism=Escherichia coli, GI1788928, Length=541, Percent_Identity=34.9353049907579, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1786942, Length=566, Percent_Identity=36.0424028268551, Blast_Score=273, Evalue=3e-74,
Organism=Escherichia coli, GI1790597, Length=511, Percent_Identity=35.2250489236791, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17550100, Length=530, Percent_Identity=35.8490566037736, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17505833, Length=556, Percent_Identity=34.1726618705036, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71986328, Length=431, Percent_Identity=28.538283062645, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322701, Length=562, Percent_Identity=37.7224199288256, Blast_Score=293, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6322416, Length=549, Percent_Identity=36.976320582878, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6322511, Length=478, Percent_Identity=29.9163179916318, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6320788, Length=479, Percent_Identity=30.8977035490605, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24663005, Length=544, Percent_Identity=34.7426470588235, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI17137288, Length=524, Percent_Identity=35.3053435114504, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24655642, Length=524, Percent_Identity=35.3053435114504, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24655647, Length=524, Percent_Identity=35.3053435114504, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: 1.3.99.1

Molecular weight: Translated: 61168; Mature: 61168

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKILSMESQVYECDVLIIGSGGAGCRAAIEVSEHNLTPLIVSKGLSFKSGCTGMAEGGY
CEEEEECCCCEEEEEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
NAAFACVDPEDSPDVHFEDTMRGGGFLNDPQLVRILVDEAPDRLRDLETYGALFDRQESG
CEEEEEECCCCCCCCCCHHCCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHCCHHCC
LLDQRPFGGQTYRRTCYQGDRTGHEMITALKEEVIRRDIETVEEIMITSLLVEEDRVLGA
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGVSIRDSSTVAFRASSTILAAGGAGHIYPVTSNTIQKGGDGFSVAWKAGADLIDMEQVQ
CCCEEECCCEEEEEECCEEEEECCCCEEEECCCCHHHCCCCCEEEEEECCCCCEECHHEE
FHPTGMVYPESRRGVLVTEAVRGEGGILLNSEGERFMKRYDPRGELATRDVVARAIYTEI
ECCCCCCCCCCCCCEEEEEEECCCCCEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHHHH
MEGRGTGNGGVYLDVSHLPDEVIEEKLETMLLQFQDVGIDIRSEPMEVAPTAHHFMGGVR
HHCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCCCE
IDEWGRTNLRNLFAAGEVTGGVHGANRLGGNALADTQVFGRRAGIAAARNAIKSAPASIK
ECCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
STVEEEEYRIKSMVAEGSHSPSEIRDRLHEAMWNGVAIVRSRESLESARAVIQDLTTMMG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHC
DLNVPETSGFNTYLIEALELENMLVTSSMVVESALIREESRGSHYRKDFPETRPEWLKSI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHH
VLNRNRRPGFIERGLKSA
HHCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MLKILSMESQVYECDVLIIGSGGAGCRAAIEVSEHNLTPLIVSKGLSFKSGCTGMAEGGY
CEEEEECCCCEEEEEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCC
NAAFACVDPEDSPDVHFEDTMRGGGFLNDPQLVRILVDEAPDRLRDLETYGALFDRQESG
CEEEEEECCCCCCCCCCHHCCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHCCHHCC
LLDQRPFGGQTYRRTCYQGDRTGHEMITALKEEVIRRDIETVEEIMITSLLVEEDRVLGA
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGVSIRDSSTVAFRASSTILAAGGAGHIYPVTSNTIQKGGDGFSVAWKAGADLIDMEQVQ
CCCEEECCCEEEEEECCEEEEECCCCEEEECCCCHHHCCCCCEEEEEECCCCCEECHHEE
FHPTGMVYPESRRGVLVTEAVRGEGGILLNSEGERFMKRYDPRGELATRDVVARAIYTEI
ECCCCCCCCCCCCCEEEEEEECCCCCEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHHHH
MEGRGTGNGGVYLDVSHLPDEVIEEKLETMLLQFQDVGIDIRSEPMEVAPTAHHFMGGVR
HHCCCCCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCCCE
IDEWGRTNLRNLFAAGEVTGGVHGANRLGGNALADTQVFGRRAGIAAARNAIKSAPASIK
ECCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
STVEEEEYRIKSMVAEGSHSPSEIRDRLHEAMWNGVAIVRSRESLESARAVIQDLTTMMG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHC
DLNVPETSGFNTYLIEALELENMLVTSSMVVESALIREESRGSHYRKDFPETRPEWLKSI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHH
VLNRNRRPGFIERGLKSA
HHCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: succinate; acceptor

Specific reaction: succinate + acceptor = fumarate + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]