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Identifier: 15679393

GI number: 15679393

Start: 1262306

End: 1263577

Strand: Direct

Name: Not Available

Synonym: MTH1394

Alternate gene names: 15679393

Gene position: 1262306-1263577 (Clockwise)

Preceding gene: 15679392

Following gene: 15679398

Centisome position: 72.08

GC content: 53.14

Gene sequence:

>1272_bases
ATGAGAAACTTTCTTGATAAAATCGGCGAGGAGGCCCTGGTGGTTGAGGATGAGGTATCAACCAGTTTCGAGGCTGCCAG
CATACTCAGAGAGCATCCAAGGGACCTTGTTATACTCAAAAACCTGAAGGAATCCGATATACCCGTCATATCAGGGCTCT
GCAATACCCGGGAGAAGATAGCCCTCTCCCTGAACTGCAGGGTCCATGAGATAACCCACAGGATCGTTGAGGCCATGGAA
AACCCCACCCCAATCAGTAGCGTGGGGGGACTGGATGGTTACAGATCAGGGAGGGCTGACCTCTCAGAGCTCCCCATCCT
CAGGCACTACAGGAGGGATGGTGGACCCTACATAACTGCAGGGGTCATATTTGCCAGGGACCCTGATACAGGGGTGAGGA
ACGCCTCAATTCACAGGATGATGGTCATCGGTGATGACAGGCTGGCTGTCCGCATAGTACCCAGGCACCTCTACACCTAC
CTCCAGAAGGCTGAGGAGAGGGGTGAGGACCTTGAAATAGCCATAGCCATAGGTATGGACCCTGCAACGCTCCTTGCCAC
CACCACCTCCATACCCATCGATGCAGATGAGATGGAGGTGGCGAACACCTTCCATGAAGGTGAACTGGAACTTGTCAGAT
GTGAGGGAGTCGACATGGAGGTCCCCCCTGCAGAGATAATCCTTGAGGGACGTATACTCTGTGGTGTGAGGGAGAGGGAG
GGCCCCTTTGTTGATCTGACAGACACCTATGATGTTGTAAGGGATGAACCTGTTATCTCCCTTGAAAGGATGCATATCAG
GAAGGATGCAATGTACCACGCCATTCTGCCAGCCGGCTTTGAGCACCGTCTCCTTCAGGGTCTCCCCCAGGAGCCAAGGA
TATACAGGGCCGTTAAGAATACAGTCCCCACTGTAAGGAACGTTGTTCTGACGGAGGGTGGGTGCTGCTGGCTCCACGCC
GCTGTATCAATTAAAAAACAGACTGAAGGTGATGGTAAGAACGTTATAATGGCTGCCCTTGCAGCACACCCCTCCCTGAA
GCATGTCGTGGTTGTGGATGAGGATATAGACGTCCTTGACCCTGAGGAAATTGAATATGCCATTGCAACCAGGGTTAAGG
GTGATGATGACATCCTCATAGTTCCAGGGGCCAGGGGTTCATCCCTTGATCCTGCAGCACTGCCTGATGGCACCACCACC
AAGGTTGGTGTCGATGCAACCGCGCCCCTTGCTTCAGCTGAAAAATTCCAGAGGGTCAGCAGGTCAGAGTAA

Upstream 100 bases:

>100_bases
ATCGAGGATAAAGAGGATAAAGAGCCGTTCCGTTAAGTTCTAAATATGAAAAATGGAGATCAGGATAAAGAGCCGTTCCA
TAACTTCTGATGGTGATTGA

Downstream 100 bases:

>100_bases
CCGGGGCCTCAACCCCCTTTTCCTTAAGTTATAAATTCATGGTTAAACATCATCATTCGCTTGAATCTTAATTCAGTCAG
TAACAACATCAATTTTGGAG

Product: hypothetical protein

Products: 2-octaprenylphenol; CO2 [C]

Alternate protein names: ORF-B(T)

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MRNFLDKIGEEALVVEDEVSTSFEAASILREHPRDLVILKNLKESDIPVISGLCNTREKIALSLNCRVHEITHRIVEAME
NPTPISSVGGLDGYRSGRADLSELPILRHYRRDGGPYITAGVIFARDPDTGVRNASIHRMMVIGDDRLAVRIVPRHLYTY
LQKAEERGEDLEIAIAIGMDPATLLATTTSIPIDADEMEVANTFHEGELELVRCEGVDMEVPPAEIILEGRILCGVRERE
GPFVDLTDTYDVVRDEPVISLERMHIRKDAMYHAILPAGFEHRLLQGLPQEPRIYRAVKNTVPTVRNVVLTEGGCCWLHA
AVSIKKQTEGDGKNVIMAALAAHPSLKHVVVVDEDIDVLDPEEIEYAIATRVKGDDDILIVPGARGSSLDPAALPDGTTT
KVGVDATAPLASAEKFQRVSRSE

Sequences:

>Translated_423_residues
MRNFLDKIGEEALVVEDEVSTSFEAASILREHPRDLVILKNLKESDIPVISGLCNTREKIALSLNCRVHEITHRIVEAME
NPTPISSVGGLDGYRSGRADLSELPILRHYRRDGGPYITAGVIFARDPDTGVRNASIHRMMVIGDDRLAVRIVPRHLYTY
LQKAEERGEDLEIAIAIGMDPATLLATTTSIPIDADEMEVANTFHEGELELVRCEGVDMEVPPAEIILEGRILCGVRERE
GPFVDLTDTYDVVRDEPVISLERMHIRKDAMYHAILPAGFEHRLLQGLPQEPRIYRAVKNTVPTVRNVVLTEGGCCWLHA
AVSIKKQTEGDGKNVIMAALAAHPSLKHVVVVDEDIDVLDPEEIEYAIATRVKGDDDILIVPGARGSSLDPAALPDGTTT
KVGVDATAPLASAEKFQRVSRSE
>Mature_423_residues
MRNFLDKIGEEALVVEDEVSTSFEAASILREHPRDLVILKNLKESDIPVISGLCNTREKIALSLNCRVHEITHRIVEAME
NPTPISSVGGLDGYRSGRADLSELPILRHYRRDGGPYITAGVIFARDPDTGVRNASIHRMMVIGDDRLAVRIVPRHLYTY
LQKAEERGEDLEIAIAIGMDPATLLATTTSIPIDADEMEVANTFHEGELELVRCEGVDMEVPPAEIILEGRILCGVRERE
GPFVDLTDTYDVVRDEPVISLERMHIRKDAMYHAILPAGFEHRLLQGLPQEPRIYRAVKNTVPTVRNVVLTEGGCCWLHA
AVSIKKQTEGDGKNVIMAALAAHPSLKHVVVVDEDIDVLDPEEIEYAIATRVKGDDDILIVPGARGSSLDPAALPDGTTT
KVGVDATAPLASAEKFQRVSRSE

Specific function: Unknown

COG id: COG0043

COG function: function code H; 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiD family

Homologues:

Organism=Escherichia coli, GI1790277, Length=324, Percent_Identity=32.0987654320988, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320748, Length=425, Percent_Identity=24, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1394_METTH (P41655)

Other databases:

- EMBL:   AE000666
- EMBL:   X03250
- PIR:   E69052
- RefSeq:   NP_276510.1
- ProteinModelPortal:   P41655
- STRING:   P41655
- GeneID:   1471111
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1394
- NMPDR:   fig|187420.1.peg.1365
- eggNOG:   arNOG04414
- HOGENOM:   HBG564733
- OMA:   PFVDITG
- PhylomeDB:   P41655
- ProtClustDB:   CLSK798157
- BioCyc:   MTHE187420:MTH1394-MONOMER
- InterPro:   IPR002830
- InterPro:   IPR009002
- TIGRFAMs:   TIGR00148

Pfam domain/function: PF01977 UbiD; SSF50475 FMN_binding

EC number: NA

Molecular weight: Translated: 46562; Mature: 46562

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNFLDKIGEEALVVEDEVSTSFEAASILREHPRDLVILKNLKESDIPVISGLCNTREKI
CCCHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCEEE
ALSLNCRVHEITHRIVEAMENPTPISSVGGLDGYRSGRADLSELPILRHYRRDGGPYITA
EEEECCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCHHHCHHHHHHHHCCCCEEEE
GVIFARDPDTGVRNASIHRMMVIGDDRLAVRIVPRHLYTYLQKAEERGEDLEIAIAIGMD
EEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCC
PATLLATTTSIPIDADEMEVANTFHEGELELVRCEGVDMEVPPAEIILEGRILCGVRERE
CHHEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCHHHEEEECEEEEEEECCC
GPFVDLTDTYDVVRDEPVISLERMHIRKDAMYHAILPAGFEHRLLQGLPQEPRIYRAVKN
CCEEEECCCHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHH
TVPTVRNVVLTEGGCCWLHAAVSIKKQTEGDGKNVIMAALAAHPSLKHVVVVDEDIDVLD
CCCHHHEEEEECCCEEEEEEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCC
PEEIEYAIATRVKGDDDILIVPGARGSSLDPAALPDGTTTKVGVDATAPLASAEKFQRVS
HHHHEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHH
RSE
CCC
>Mature Secondary Structure
MRNFLDKIGEEALVVEDEVSTSFEAASILREHPRDLVILKNLKESDIPVISGLCNTREKI
CCCHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCEEE
ALSLNCRVHEITHRIVEAMENPTPISSVGGLDGYRSGRADLSELPILRHYRRDGGPYITA
EEEECCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCHHHCHHHHHHHHCCCCEEEE
GVIFARDPDTGVRNASIHRMMVIGDDRLAVRIVPRHLYTYLQKAEERGEDLEIAIAIGMD
EEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCC
PATLLATTTSIPIDADEMEVANTFHEGELELVRCEGVDMEVPPAEIILEGRILCGVRERE
CHHEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCHHHEEEECEEEEEEECCC
GPFVDLTDTYDVVRDEPVISLERMHIRKDAMYHAILPAGFEHRLLQGLPQEPRIYRAVKN
CCEEEECCCHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHH
TVPTVRNVVLTEGGCCWLHAAVSIKKQTEGDGKNVIMAALAAHPSLKHVVVVDEDIDVLD
CCCHHHEEEEECCCEEEEEEEEEEEECCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCC
PEEIEYAIATRVKGDDDILIVPGARGSSLDPAALPDGTTTKVGVDATAPLASAEKFQRVS
HHHHEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHH
RSE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-octaprenyl-4-hydroxybenzoate [C]

Specific reaction: 3-octaprenyl-4-hydroxybenzoate = 2-octaprenylphenol + CO2 [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 3936936