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Identifier: 15679392

GI number: 15679392

Start: 1261232

End: 1262248

Strand: Direct

Name: Not Available

Synonym: MTH1393

Alternate gene names: 15679392

Gene position: 1261232-1262248 (Clockwise)

Preceding gene: 15679390

Following gene: 15679393

Centisome position: 72.01

GC content: 51.13

Gene sequence:

>1017_bases
GTGAATCTCCAGATGAAGCCCAGAGTGATGATACTCCTTGGAAGTGCATCTGATTTCAGGATAGCCGAAAAGGCAATGGA
AATCTTTGAGGAACTCAGGATACCCTATGACCTGAGGGTTGCCTCAGCCCACAGGACACATGAAAAGGTAAAGGCAATAG
TCTCAGAGGCCGTGAAGGCGGGTGTTGAGGTATTCATAGGAATAGCAGGACTATCAGCCCATCTTCCAGGCATGATATCT
GCAAACACCCACAGACCCGTCATAGGGGTCCCTGTTGACGTTAAACTTGGAGGGCTCGACGCCCTCTTTGCATGTTCACA
GATGCCCTTCCCTGCCCCCGTCGCCACTGTGGGGGTAGACAGGGGAGAAAACGCCGCAATACTCGCTGCCCAGATAATAG
GGATAGGAGATCCCGGGGTAAGGGAAAGGGTTGCAGATCTAAGGAGAGGTTTCTATGAACGCGTGCGGAGAGATGAATGT
CAGGTGCTCAACAGCATAGAGGGGTCCTACTATGCACCCCTGGAGGTTGAAATGCCTCCCATTGGTGATAAGGTCCCGTC
AGATTCCCAGGATGACCCCATGGTATCTGTGATACCTGGCAGCTACTCTGACATGAAGATAGCCAAGAAGACCACCATGT
TCCTCGAAAGGATGGGTATAAGCTATGATCTGAACGTCATATCACCCATAAGGTACCCTGAAAGATTTGAGAGGTACCTT
GAGAAGATGGAGAACGTGAAGCTCTTCATAGCCATAAGCGGCCTCTCTGCACATGTTACGGGTGCTGTTGTTGCCCTCAG
CGACAGGCCGGTGATAGGGGTTCCCTGCCCCCTCAAGATGAACGGCTGGGACTCACTCCTCTCAATGATCAACATGCCGC
CGGGTGTACCTGTTGGAACGGTGGGGGTAGGTAACGGTGGTAACGCCGCAATACTGGCTGCTGAAATGCTTGGAATATAC
GATGAAAAGATAGAATCGAGGATAAAGAGGATAAAGAGCCGTTCCGTTAAGTTCTAA

Upstream 100 bases:

>100_bases
TCCCCTTATATACTGTTATGAAGACCTGTAAATGGTCCCTGCGGGAGGTGCCATCTATTAAATATGACCTCCGATAGATT
CTCTATATATAAAGTTAAAG

Downstream 100 bases:

>100_bases
ATATGAAAAATGGAGATCAGGATAAAGAGCCGTTCCATAACTTCTGATGGTGATTGAATGAGAAACTTTCTTGATAAAAT
CGGCGAGGAGGCCCTGGTGG

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MNLQMKPRVMILLGSASDFRIAEKAMEIFEELRIPYDLRVASAHRTHEKVKAIVSEAVKAGVEVFIGIAGLSAHLPGMIS
ANTHRPVIGVPVDVKLGGLDALFACSQMPFPAPVATVGVDRGENAAILAAQIIGIGDPGVRERVADLRRGFYERVRRDEC
QVLNSIEGSYYAPLEVEMPPIGDKVPSDSQDDPMVSVIPGSYSDMKIAKKTTMFLERMGISYDLNVISPIRYPERFERYL
EKMENVKLFIAISGLSAHVTGAVVALSDRPVIGVPCPLKMNGWDSLLSMINMPPGVPVGTVGVGNGGNAAILAAEMLGIY
DEKIESRIKRIKSRSVKF

Sequences:

>Translated_338_residues
MNLQMKPRVMILLGSASDFRIAEKAMEIFEELRIPYDLRVASAHRTHEKVKAIVSEAVKAGVEVFIGIAGLSAHLPGMIS
ANTHRPVIGVPVDVKLGGLDALFACSQMPFPAPVATVGVDRGENAAILAAQIIGIGDPGVRERVADLRRGFYERVRRDEC
QVLNSIEGSYYAPLEVEMPPIGDKVPSDSQDDPMVSVIPGSYSDMKIAKKTTMFLERMGISYDLNVISPIRYPERFERYL
EKMENVKLFIAISGLSAHVTGAVVALSDRPVIGVPCPLKMNGWDSLLSMINMPPGVPVGTVGVGNGGNAAILAAEMLGIY
DEKIESRIKRIKSRSVKF
>Mature_338_residues
MNLQMKPRVMILLGSASDFRIAEKAMEIFEELRIPYDLRVASAHRTHEKVKAIVSEAVKAGVEVFIGIAGLSAHLPGMIS
ANTHRPVIGVPVDVKLGGLDALFACSQMPFPAPVATVGVDRGENAAILAAQIIGIGDPGVRERVADLRRGFYERVRRDEC
QVLNSIEGSYYAPLEVEMPPIGDKVPSDSQDDPMVSVIPGSYSDMKIAKKTTMFLERMGISYDLNVISPIRYPERFERYL
EKMENVKLFIAISGLSAHVTGAVVALSDRPVIGVPCPLKMNGWDSLLSMINMPPGVPVGTVGVGNGGNAAILAAEMLGIY
DEKIESRIKRIKSRSVKF

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=46.8468468468468, Blast_Score=95, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=134, Percent_Identity=41.7910447761194, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 36732; Mature: 36732

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQMKPRVMILLGSASDFRIAEKAMEIFEELRIPYDLRVASAHRTHEKVKAIVSEAVKA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHC
GVEVFIGIAGLSAHLPGMISANTHRPVIGVPVDVKLGGLDALFACSQMPFPAPVATVGVD
CHHEEEEEECHHHHCCCCEECCCCCCEEECCEEEEECCHHHHHHHCCCCCCCCEEEEECC
RGENAAILAAQIIGIGDPGVRERVADLRRGFYERVRRDECQVLNSIEGSYYAPLEVEMPP
CCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECCC
IGDKVPSDSQDDPMVSVIPGSYSDMKIAKKTTMFLERMGISYDLNVISPIRYPERFERYL
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHH
EKMENVKLFIAISGLSAHVTGAVVALSDRPVIGVPCPLKMNGWDSLLSMINMPPGVPVGT
HHHCCEEEEEEEECCCEEECEEEEEECCCCEEECCCCCEECCHHHHHHHHCCCCCCCEEE
VGVGNGGNAAILAAEMLGIYDEKIESRIKRIKSRSVKF
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLQMKPRVMILLGSASDFRIAEKAMEIFEELRIPYDLRVASAHRTHEKVKAIVSEAVKA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHC
GVEVFIGIAGLSAHLPGMISANTHRPVIGVPVDVKLGGLDALFACSQMPFPAPVATVGVD
CHHEEEEEECHHHHCCCCEECCCCCCEEECCEEEEECCHHHHHHHCCCCCCCCEEEEECC
RGENAAILAAQIIGIGDPGVRERVADLRRGFYERVRRDECQVLNSIEGSYYAPLEVEMPP
CCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECCC
IGDKVPSDSQDDPMVSVIPGSYSDMKIAKKTTMFLERMGISYDLNVISPIRYPERFERYL
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHH
EKMENVKLFIAISGLSAHVTGAVVALSDRPVIGVPCPLKMNGWDSLLSMINMPPGVPVGT
HHHCCEEEEEEEECCCEEECEEEEEECCCCEEECCCCCEECCHHHHHHHHCCCCCCCEEE
VGVGNGGNAAILAAEMLGIYDEKIESRIKRIKSRSVKF
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3936936; 9371463 [H]