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The map label for this gene is ribH

Identifier: 15679389

GI number: 15679389

Start: 1257953

End: 1258372

Strand: Direct

Name: ribH

Synonym: MTH1390

Alternate gene names: 15679389

Gene position: 1257953-1258372 (Clockwise)

Preceding gene: 15679388

Following gene: 15679390

Centisome position: 71.83

GC content: 50.71

Gene sequence:

>420_bases
ATGAAAAAAGTCAGGATAGGGGCTGTTGTAGCTGAGTTTAACTATGACATAACCCATATGATGCTGGAACTTGCAAAGGA
ACATGCCAGATTCCTTGATGCAGAGATAACCAGGGTGATTGCTGTACCCGGCGTGTTTGACATGCCACTTGCAGTGAAGA
AACTCCTTCTGGAAGATGAGATAGACGCCGTGATAACCCTAGGGGCGGTCATCGAGGGAGCCACCGACCATGACCAGATA
GTCGTGCAGCACGCCTCACGTAAAATAGCCGACCTGGCCCTTGATTATGACAAGCCCGTGGCCCTCGGAATATCAGGACC
CGGAATGACGAGGCTCGAGGCCCACCAGCGCGTTGACTACGCCAAGAGGGCTGTTGAGGCAGCTGTTAAAATGTACAGAA
GACTTAAAGAGGATATTTAG

Upstream 100 bases:

>100_bases
GATTTAATGAATAAGGCACAGGCAATAGCATTACTGATAGTGATAATAATGGTCCTGAGTACCATTGCAGGTGCACTTGT
ACTCTAAATGGAGGTATTGA

Downstream 100 bases:

>100_bases
TTTCCGGGGAGCTTCCATGGAGATACTCAGGCCATCTGACCTGAAGGAGAGGTTCCAGGACCCCTGGATCTCACCATACC
GGAAGGTCCTCACAATGGTG

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MKKVRIGAVVAEFNYDITHMMLELAKEHARFLDAEITRVIAVPGVFDMPLAVKKLLLEDEIDAVITLGAVIEGATDHDQI
VVQHASRKIADLALDYDKPVALGISGPGMTRLEAHQRVDYAKRAVEAAVKMYRRLKEDI

Sequences:

>Translated_139_residues
MKKVRIGAVVAEFNYDITHMMLELAKEHARFLDAEITRVIAVPGVFDMPLAVKKLLLEDEIDAVITLGAVIEGATDHDQI
VVQHASRKIADLALDYDKPVALGISGPGMTRLEAHQRVDYAKRAVEAAVKMYRRLKEDI
>Mature_139_residues
MKKVRIGAVVAEFNYDITHMMLELAKEHARFLDAEITRVIAVPGVFDMPLAVKKLLLEDEIDAVITLGAVIEGATDHDQI
VVQHASRKIADLALDYDKPVALGISGPGMTRLEAHQRVDYAKRAVEAAVKMYRRLKEDI

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=104, Percent_Identity=39.4230769230769, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_METTH (O27443)

Other databases:

- EMBL:   AE000666
- PIR:   A69052
- RefSeq:   NP_276506.1
- ProteinModelPortal:   O27443
- STRING:   O27443
- GeneID:   1471107
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1390
- NMPDR:   fig|187420.1.peg.1361
- eggNOG:   arNOG09975
- HOGENOM:   HBG311126
- OMA:   AVIQGAT
- ProtClustDB:   PRK00061
- BioCyc:   MTHE187420:MTH1390-MONOMER
- BRENDA:   2.5.1.9
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 15464; Mature: 15464

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVRIGAVVAEFNYDITHMMLELAKEHARFLDAEITRVIAVPGVFDMPLAVKKLLLEDE
CCCEEHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
IDAVITLGAVIEGATDHDQIVVQHASRKIADLALDYDKPVALGISGPGMTRLEAHQRVDY
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
AKRAVEAAVKMYRRLKEDI
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVRIGAVVAEFNYDITHMMLELAKEHARFLDAEITRVIAVPGVFDMPLAVKKLLLEDE
CCCEEHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
IDAVITLGAVIEGATDHDQIVVQHASRKIADLALDYDKPVALGISGPGMTRLEAHQRVDY
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
AKRAVEAAVKMYRRLKEDI
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463