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Identifier: 15679388

GI number: 15679388

Start: 1256652

End: 1257854

Strand: Direct

Name: Not Available

Synonym: MTH1389

Alternate gene names: 15679388

Gene position: 1256652-1257854 (Clockwise)

Preceding gene: 15679387

Following gene: 15679389

Centisome position: 71.75

GC content: 55.28

Gene sequence:

>1203_bases
TTGATATTCATGCGTACAGAGGACGTCAGGAGAGACATACCCCTCCTCAGGGATCATGTCTACCTCGACGCTGCCAGCAC
AACCCCCACTCCACTCCCGGTTGTCAGGGCCATGACAGAATACTTTAAGGAATACAATGCCAACACCGGGAGGGGGGCCT
ACTCCCTGGTGCTAAGGGCCACCAGGAAACTCCAGGAGGCCAGGGAGAAGGTGGCTGGGTTCATAAACGCCTCCAGTGAT
GAGATAGTATTCACCAAGAACACCTCTGAGGCCATCAACATCGTGGCGGGGGGACTCAGGTTCAGGAAGGGGGACTCAGT
TGTTGTGCCAAACATCGAACACCACTCCAACTTCCTCCCCTGGCTGAGGCTCCGTGAGAGGGGAGTTGATGTGAGGGTGG
TGAAGGCAGATGAAGGGGGAGTGGTGGACCCCGGCAGAATAGAGGACGCCGTTGATGAGACCACAAGGCTCGTCACCGTG
ACCCACATCTCCAATGCCCTCGGTACGGTGCAGGACGTGAAGGAGATAGGGAGGATAGCCCATGACGTGGGGGCCCTCTA
CCTGGTTGATGCCGCCCAGTCGATAGGCCACATGGAGGTTGATGTGAGGGCCATTGGGGCTGACTTCGCAGCATTCCCTG
GACACAAGGGGACCCTGGGACCTGTTGGCACGGGATTCCTCTACTGCAGCACTGATGTCCAGGGAGAACTTGAACCCCTG
ATGCTGGGGGGAGGTACGGTGCTTGATGTCTCAGAGGACGGATATGTGCTCGAGGACTTCCCGGCGAAGTTTGAGGCCGG
CACCCTCAACATTGCAGGATTCATAGGCCTCGGTGCCTCAATAGACTACATGAACAGGATAGGAATCAGGAGGATCCAGA
AACATGGCATGAAGATGACAGAGGAACTCCACGCTACCGTTTCATCCATCGATGGTATTGAATGCTATGGTGACCCCCAA
AATATTTATGGTATCCTCTCCTTCAACATAAATAACATGGACCCCCACGACGTTGCAAAGATTCTTGACGAAACCGCCGG
GATCTGTGTTAGAAGTGGTCACCACTGCGCTATACCTGCAATGAAGCACCTGGCGCTCCATGAAACCGGCGGCACCGTCA
GGGCATCCATACACTACTACAACACATCAGAGGAAATCCAGCTCCTCGGAGAGACCCTCGAGGAAATAGCAGGGATGGGG
TGA

Upstream 100 bases:

>100_bases
CACTCCAAAAAACCCTTGCAGAGGGTCTTGTGACACCGGACCTCGGTGGGAAGCTTGGCACCATGGAGATGGCTGCCGAG
ATAGCCAGACACCTGGAGGA

Downstream 100 bases:

>100_bases
TTTAATGAATAAGGCACAGGCAATAGCATTACTGATAGTGATAATAATGGTCCTGAGTACCATTGCAGGTGCACTTGTAC
TCTAAATGGAGGTATTGAAT

Product: nifS protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MIFMRTEDVRRDIPLLRDHVYLDAASTTPTPLPVVRAMTEYFKEYNANTGRGAYSLVLRATRKLQEAREKVAGFINASSD
EIVFTKNTSEAINIVAGGLRFRKGDSVVVPNIEHHSNFLPWLRLRERGVDVRVVKADEGGVVDPGRIEDAVDETTRLVTV
THISNALGTVQDVKEIGRIAHDVGALYLVDAAQSIGHMEVDVRAIGADFAAFPGHKGTLGPVGTGFLYCSTDVQGELEPL
MLGGGTVLDVSEDGYVLEDFPAKFEAGTLNIAGFIGLGASIDYMNRIGIRRIQKHGMKMTEELHATVSSIDGIECYGDPQ
NIYGILSFNINNMDPHDVAKILDETAGICVRSGHHCAIPAMKHLALHETGGTVRASIHYYNTSEEIQLLGETLEEIAGMG

Sequences:

>Translated_400_residues
MIFMRTEDVRRDIPLLRDHVYLDAASTTPTPLPVVRAMTEYFKEYNANTGRGAYSLVLRATRKLQEAREKVAGFINASSD
EIVFTKNTSEAINIVAGGLRFRKGDSVVVPNIEHHSNFLPWLRLRERGVDVRVVKADEGGVVDPGRIEDAVDETTRLVTV
THISNALGTVQDVKEIGRIAHDVGALYLVDAAQSIGHMEVDVRAIGADFAAFPGHKGTLGPVGTGFLYCSTDVQGELEPL
MLGGGTVLDVSEDGYVLEDFPAKFEAGTLNIAGFIGLGASIDYMNRIGIRRIQKHGMKMTEELHATVSSIDGIECYGDPQ
NIYGILSFNINNMDPHDVAKILDETAGICVRSGHHCAIPAMKHLALHETGGTVRASIHYYNTSEEIQLLGETLEEIAGMG
>Mature_400_residues
MIFMRTEDVRRDIPLLRDHVYLDAASTTPTPLPVVRAMTEYFKEYNANTGRGAYSLVLRATRKLQEAREKVAGFINASSD
EIVFTKNTSEAINIVAGGLRFRKGDSVVVPNIEHHSNFLPWLRLRERGVDVRVVKADEGGVVDPGRIEDAVDETTRLVTV
THISNALGTVQDVKEIGRIAHDVGALYLVDAAQSIGHMEVDVRAIGADFAAFPGHKGTLGPVGTGFLYCSTDVQGELEPL
MLGGGTVLDVSEDGYVLEDFPAKFEAGTLNIAGFIGLGASIDYMNRIGIRRIQKHGMKMTEELHATVSSIDGIECYGDPQ
NIYGILSFNINNMDPHDVAKILDETAGICVRSGHHCAIPAMKHLALHETGGTVRASIHYYNTSEEIQLLGETLEEIAGMG

Specific function: Cysteine Desulfurases Mobilize The Sulfur From L- Cysteine To Yield L-Alanine, An Essential Step In Sulfur Metabolism For Biosynthesis Of A Variety Of Sulfur-Containing Biomolecules. Component Of The Suf Operon, Which Is Activated And Required Under Speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily

Homologues:

Organism=Homo sapiens, GI32307132, Length=386, Percent_Identity=26.4248704663212, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI156713448, Length=306, Percent_Identity=29.4117647058824, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1787970, Length=408, Percent_Identity=37.5, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1789175, Length=386, Percent_Identity=32.1243523316062, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI48994898, Length=389, Percent_Identity=26.9922879177378, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25143064, Length=230, Percent_Identity=30.4347826086957, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=342, Percent_Identity=23.3918128654971, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147498, Length=374, Percent_Identity=25.668449197861, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319831, Length=379, Percent_Identity=26.9129287598945, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI20129463, Length=266, Percent_Identity=30.4511278195489, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CSD_METTH (O27442)

Other databases:

- EMBL:   AE000666
- PIR:   G69051
- RefSeq:   NP_276505.1
- ProteinModelPortal:   O27442
- SMR:   O27442
- STRING:   O27442
- GeneID:   1471106
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1389
- NMPDR:   fig|187420.1.peg.1360
- eggNOG:   arNOG04077
- HOGENOM:   HBG635316
- OMA:   IAITHES
- ProtClustDB:   CLSK2750569
- BioCyc:   MTHE187420:MTH1389-MONOMER
- BRENDA:   2.8.1.7
- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.8.1.7

Molecular weight: Translated: 43546; Mature: 43546

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFMRTEDVRRDIPLLRDHVYLDAASTTPTPLPVVRAMTEYFKEYNANTGRGAYSLVLRA
CEEEECHHHHHCCCHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
TRKLQEAREKVAGFINASSDEIVFTKNTSEAINIVAGGLRFRKGDSVVVPNIEHHSNFLP
HHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHEEECCEEEECCCEEEECCCHHCCCCCH
WLRLRERGVDVRVVKADEGGVVDPGRIEDAVDETTRLVTVTHISNALGTVQDVKEIGRIA
HHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHH
HDVGALYLVDAAQSIGHMEVDVRAIGADFAAFPGHKGTLGPVGTGFLYCSTDVQGELEPL
HHHHHEEEEEHHHHCCCEEEEEEEECCCHHCCCCCCCCCCCCCCCEEEEECCCCCCCCEE
MLGGGTVLDVSEDGYVLEDFPAKFEAGTLNIAGFIGLGASIDYMNRIGIRRIQKHGMKMT
EECCCEEEEECCCCEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHH
EELHATVSSIDGIECYGDPQNIYGILSFNINNMDPHDVAKILDETAGICVRSGHHCAIPA
HHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHCCEEEECCCEEECHH
MKHLALHETGGTVRASIHYYNTSEEIQLLGETLEEIAGMG
HHHHEEECCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIFMRTEDVRRDIPLLRDHVYLDAASTTPTPLPVVRAMTEYFKEYNANTGRGAYSLVLRA
CEEEECHHHHHCCCHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
TRKLQEAREKVAGFINASSDEIVFTKNTSEAINIVAGGLRFRKGDSVVVPNIEHHSNFLP
HHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHEEECCEEEECCCEEEECCCHHCCCCCH
WLRLRERGVDVRVVKADEGGVVDPGRIEDAVDETTRLVTVTHISNALGTVQDVKEIGRIA
HHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHH
HDVGALYLVDAAQSIGHMEVDVRAIGADFAAFPGHKGTLGPVGTGFLYCSTDVQGELEPL
HHHHHEEEEEHHHHCCCEEEEEEEECCCHHCCCCCCCCCCCCCCCEEEEECCCCCCCCEE
MLGGGTVLDVSEDGYVLEDFPAKFEAGTLNIAGFIGLGASIDYMNRIGIRRIQKHGMKMT
EECCCEEEEECCCCEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHH
EELHATVSSIDGIECYGDPQNIYGILSFNINNMDPHDVAKILDETAGICVRSGHHCAIPA
HHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHCCEEEECCCEEECHH
MKHLALHETGGTVRASIHYYNTSEEIQLLGETLEEIAGMG
HHHHEEECCCCEEEEEEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463