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Identifier: 15679218

GI number: 15679218

Start: 1109706

End: 1110263

Strand: Direct

Name: Not Available

Synonym: MTH1207

Alternate gene names: 15679218

Gene position: 1109706-1110263 (Clockwise)

Preceding gene: 15679217

Following gene: 15679220

Centisome position: 63.36

GC content: 54.12

Gene sequence:

>558_bases
ATGATGCTTGAGAGAATTGAAGCCATAGAAAGGATAACGGGTGTCCTTGAGGATGAGCTCGTCATATGTAACCTTGGGTT
TCCTTCAAGGGAGCTCTACAGTATCAGGGACTCGCCAAGGCACTTCTACATGCTTGGATCCATGGGGATGGCATCTTCCA
TCGGGCTTGGACTCGCGCTTTCACAGGAGCGGAGGGTGGTTGTCCTGGACGGTGACGGTTCCATCCTCATGAACCTTGGA
GGCCTGGTCACTGCAGCTGCACAGTCCCCTGGGAACCTCATCATAGTCCTCCTCGACAACAGGTGCTACGCGACAACCGG
CTCACAGTGCACCTACGCCGATGTGATAGACCTTGGGGCCGTTGCAGAGTCCATGGGCTTCAATGTGATCAGGTTCGCCG
ATGATCTGAACTTTGAACAGGCACTGGCGATGGATGGTCCTGTTTTTGCCCATGTCCCTGTGAAGCCCGGGAACGCCGAT
GTCCCTGTCATCGATCTTGATGCAGAGGAGATAATAGAACGCTTCATTAAGGAGGTCCGGGGAGCCACTGAGGATTGA

Upstream 100 bases:

>100_bases
AGTCCTGCTGAGGCCAGGGAATCCATAGGAGAACTTACAGATATCTCCCTGAGGACCAGTAAGGCCGTGGCAGTCCTGCT
GGATGTATCCTACTGGTGAT

Downstream 100 bases:

>100_bases
AACATGTACCCTGATTTTAATTAGCTATCCCCTGTAGGTTGCATAGAAACCATCGGTGTCGGCATAGACCGTGTGGAACC
CAAATTCCTCTGCAGTTTTT

Product: phosphonopyruvate decarboxylase related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MMLERIEAIERITGVLEDELVICNLGFPSRELYSIRDSPRHFYMLGSMGMASSIGLGLALSQERRVVVLDGDGSILMNLG
GLVTAAAQSPGNLIIVLLDNRCYATTGSQCTYADVIDLGAVAESMGFNVIRFADDLNFEQALAMDGPVFAHVPVKPGNAD
VPVIDLDAEEIIERFIKEVRGATED

Sequences:

>Translated_185_residues
MMLERIEAIERITGVLEDELVICNLGFPSRELYSIRDSPRHFYMLGSMGMASSIGLGLALSQERRVVVLDGDGSILMNLG
GLVTAAAQSPGNLIIVLLDNRCYATTGSQCTYADVIDLGAVAESMGFNVIRFADDLNFEQALAMDGPVFAHVPVKPGNAD
VPVIDLDAEEIIERFIKEVRGATED
>Mature_185_residues
MMLERIEAIERITGVLEDELVICNLGFPSRELYSIRDSPRHFYMLGSMGMASSIGLGLALSQERRVVVLDGDGSILMNLG
GLVTAAAQSPGNLIIVLLDNRCYATTGSQCTYADVIDLGAVAESMGFNVIRFADDLNFEQALAMDGPVFAHVPVKPGNAD
VPVIDLDAEEIIERFIKEVRGATED

Specific function: Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COME_METTH (O27275)

Other databases:

- EMBL:   AE000666
- PIR:   B69028
- RefSeq:   NP_276335.1
- ProteinModelPortal:   O27275
- STRING:   O27275
- GeneID:   1471615
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1207
- NMPDR:   fig|187420.1.peg.1190
- eggNOG:   arNOG05426
- HOGENOM:   HBG690174
- OMA:   ATHRADS
- ProtClustDB:   CLSK2750524
- BioCyc:   MTHE187420:MTH1207-MONOMER
- InterPro:   IPR022494
- InterPro:   IPR011766
- TIGRFAMs:   TIGR03846

Pfam domain/function: PF02775 TPP_enzyme_C

EC number: NA

Molecular weight: Translated: 20008; Mature: 20008

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLERIEAIERITGVLEDELVICNLGFPSRELYSIRDSPRHFYMLGSMGMASSIGLGLAL
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCCEEEEEECCCCCHHCCCEEEE
SQERRVVVLDGDGSILMNLGGLVTAAAQSPGNLIIVLLDNRCYATTGSQCTYADVIDLGA
CCCCEEEEEECCCEEEEECCCEEEEECCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHH
VAESMGFNVIRFADDLNFEQALAMDGPVFAHVPVKPGNADVPVIDLDAEEIIERFIKEVR
HHHHHCCEEEEEECCCCHHHHHCCCCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHC
GATED
CCCCC
>Mature Secondary Structure
MMLERIEAIERITGVLEDELVICNLGFPSRELYSIRDSPRHFYMLGSMGMASSIGLGLAL
CCHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCCEEEEEECCCCCHHCCCEEEE
SQERRVVVLDGDGSILMNLGGLVTAAAQSPGNLIIVLLDNRCYATTGSQCTYADVIDLGA
CCCCEEEEEECCCEEEEECCCEEEEECCCCCCEEEEEECCCEEECCCCCCCHHHHHHHHH
VAESMGFNVIRFADDLNFEQALAMDGPVFAHVPVKPGNADVPVIDLDAEEIIERFIKEVR
HHHHHCCEEEEEECCCCHHHHHCCCCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHC
GATED
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463