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Identifier: 15679214

GI number: 15679214

Start: 1105201

End: 1107111

Strand: Direct

Name: Not Available

Synonym: MTH1203

Alternate gene names: NA

Gene position: 1105201-1107111 (Clockwise)

Preceding gene: 15679213

Following gene: 15679215

Centisome position: 63.1

GC content: 51.33

Gene sequence:

>1911_bases
ATGGTTTCAGAGATGCTTGAAGAAATCAAAAGGACAATAATGCAGAGACTTCCCGAGAGGGTCCAGGTTGCGAAGGTGGA
ATTCGAGGGGCCCGAGGTGGTAATATACACCAAGAATCCGGAGATAATAACCGAGAACGGCAACCTCATAAGGGACATTG
CAAAGGATATCCGGAAGAGGATAATTATAAGATCCGACAGGTCCGTCCTCATGGACCCTGAGAAGGCCATAAGGAAGATA
CATGAGATAGTGCCCGAGGAGGCCAAGATAACCAACATATCCTTTGATGATGTCACCTGTGAGGTGATAATTGAGGCCCG
GAAACCAGGACTTGTGATAGGCAAGTACGGATCCACGTCAAGGGAAATAGTCAAGAACACTGGCTGGGCGCCCAAGATAC
TGAGAACACCACCAATATCCTCTGAGATAATAGAAAGAATACGCAGAACACTGAGGAAGAACAGCAAGGAAAGAAAGAAG
ATTCTGCAGCAACTTGGGAACCGGATACATCAGAAGCCAAAGTATGACAATGACTGGGCAAGGCTCACCGCTATGGGTGG
TTTCAGGGAGGTTGGAAGGTCCTGCCTCTACCTTCAGACCCCCAACAGCAGGGTCCTCCTGGACTGTGGTGTCAACGTTG
CGGGTGGAGATGATAAGAACTCCTATCCCTACCTCAATGTCCCTGAATTCACCCTTGACAGCCTTGACGCAGTCATAATC
ACCCATGCACACCTTGACCACTCAGGTTTCCTCCCATACCTCTACCACTACGGCTACGATGGGCCCGTCTACTGCACGGC
ACCAACAAGGGACCTCATGACGCTCCTGCAGCTGGACCACATCGACATTGCCCACAGGGAGGATGAACCCCTCCCATTCA
ATGTGAAGCACGTTAAGAAGAGCGTGAAGCACACGATAACCCTCGACTATGGTGAGGTGACAGACATAGCCCCTGATATA
AGGCTGACACTCCACAACGCGGGTCACATCCTGGGGTCTGCCATGGCACACCTCCACATAGGGGACGGGCAGCACAACAT
GGTCTACACAGGGGACTTCAAGTATGAGCAGAGCAGACTCCTGGAGGCTGCAGCAAACAGGTTCCCCCGGATTGAAACCC
TTGTGATGGAGAGCACCTACGGGGGCCATGAGGATGTCCAGCCATCAAGGAACCGTGCAGAGAAGGAACTCGTTAAGACC
ATCTACTCAACCCTCAGGAGGGGTGGTAAGATACTGATACCGGTCTTCGCTGTTGGAAGGGCCCAGGAACTCATGATAGT
CCTTGAGGAGTACATAAGGACGGGCATAATCGACGAGGTACCTGTCTACATTGATGGTATGATCTGGGAGGCCAATGCAA
TCCACACTGCAAGGCCAGAGTACCTCAGCAAGGACCTGAGGGACCAGATATTCCACATGGGCCACAATCCCTTCATCTCA
GACATCTTCCACAAGGTGAACGGTATGGATGAGCGGAGGGAAATAGTTGAGGGCGAACCATCCATAATCCTCTCAACTTC
AGGTATGCTGACCGGTGGTAACTCACTGGAGTACTTCAAGTGGCTATGTGAGGACCCTGACAATTCCCTTGTATTTGTCG
GTTACCAGGCCGAGGGGTCCCTTGGTAGAAGGATCCAGAAGGGCTGGAAGGAGATCCCCCTCAAGGATGAGGATGATAAG
ATGAGGGTCTACAATGTCAGGATGAACATAAAGACCATTGAGGGTTTCAGCGGTCACTCAGACAGGAGGCAGCTCATGGA
ATACGTCAAGAGGATATCACCGAAACCCGAGAAGATACTCCTGTGTCACGGAGACAACTACAAGACCCTTGACCTGGCAT
CAAGTATCTACAGGACATACCGGATAGAGACCAAGACCCCCCTGAACCTGGAAACCGTGCGTATCCAGTGA

Upstream 100 bases:

>100_bases
AATCCAGAAAAGGATTGAAAACCTCAACTGATTTTTCTCCTATTTTTAATTGCAGTAAACACCTGTTTACTGATATTCCC
TGTTTTTTAGAAGTGATCTT

Downstream 100 bases:

>100_bases
GGCTAACTATTTAGATAACCTTAAACTATTCTTTAGTGGTGATTTAATGGTAACCTATTCAGAATCTGGAGTGGATATAG
ACCTGGAGGAGCTCACCGTT

Product: cleavage and polyadenylation specificity factor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MVSEMLEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITENGNLIRDIAKDIRKRIIIRSDRSVLMDPEKAIRKI
HEIVPEEAKITNISFDDVTCEVIIEARKPGLVIGKYGSTSREIVKNTGWAPKILRTPPISSEIIERIRRTLRKNSKERKK
ILQQLGNRIHQKPKYDNDWARLTAMGGFREVGRSCLYLQTPNSRVLLDCGVNVAGGDDKNSYPYLNVPEFTLDSLDAVII
THAHLDHSGFLPYLYHYGYDGPVYCTAPTRDLMTLLQLDHIDIAHREDEPLPFNVKHVKKSVKHTITLDYGEVTDIAPDI
RLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQSRLLEAAANRFPRIETLVMESTYGGHEDVQPSRNRAEKELVKT
IYSTLRRGGKILIPVFAVGRAQELMIVLEEYIRTGIIDEVPVYIDGMIWEANAIHTARPEYLSKDLRDQIFHMGHNPFIS
DIFHKVNGMDERREIVEGEPSIILSTSGMLTGGNSLEYFKWLCEDPDNSLVFVGYQAEGSLGRRIQKGWKEIPLKDEDDK
MRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPKPEKILLCHGDNYKTLDLASSIYRTYRIETKTPLNLETVRIQ

Sequences:

>Translated_636_residues
MVSEMLEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITENGNLIRDIAKDIRKRIIIRSDRSVLMDPEKAIRKI
HEIVPEEAKITNISFDDVTCEVIIEARKPGLVIGKYGSTSREIVKNTGWAPKILRTPPISSEIIERIRRTLRKNSKERKK
ILQQLGNRIHQKPKYDNDWARLTAMGGFREVGRSCLYLQTPNSRVLLDCGVNVAGGDDKNSYPYLNVPEFTLDSLDAVII
THAHLDHSGFLPYLYHYGYDGPVYCTAPTRDLMTLLQLDHIDIAHREDEPLPFNVKHVKKSVKHTITLDYGEVTDIAPDI
RLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQSRLLEAAANRFPRIETLVMESTYGGHEDVQPSRNRAEKELVKT
IYSTLRRGGKILIPVFAVGRAQELMIVLEEYIRTGIIDEVPVYIDGMIWEANAIHTARPEYLSKDLRDQIFHMGHNPFIS
DIFHKVNGMDERREIVEGEPSIILSTSGMLTGGNSLEYFKWLCEDPDNSLVFVGYQAEGSLGRRIQKGWKEIPLKDEDDK
MRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPKPEKILLCHGDNYKTLDLASSIYRTYRIETKTPLNLETVRIQ
>Mature_636_residues
MVSEMLEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITENGNLIRDIAKDIRKRIIIRSDRSVLMDPEKAIRKI
HEIVPEEAKITNISFDDVTCEVIIEARKPGLVIGKYGSTSREIVKNTGWAPKILRTPPISSEIIERIRRTLRKNSKERKK
ILQQLGNRIHQKPKYDNDWARLTAMGGFREVGRSCLYLQTPNSRVLLDCGVNVAGGDDKNSYPYLNVPEFTLDSLDAVII
THAHLDHSGFLPYLYHYGYDGPVYCTAPTRDLMTLLQLDHIDIAHREDEPLPFNVKHVKKSVKHTITLDYGEVTDIAPDI
RLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQSRLLEAAANRFPRIETLVMESTYGGHEDVQPSRNRAEKELVKT
IYSTLRRGGKILIPVFAVGRAQELMIVLEEYIRTGIIDEVPVYIDGMIWEANAIHTARPEYLSKDLRDQIFHMGHNPFIS
DIFHKVNGMDERREIVEGEPSIILSTSGMLTGGNSLEYFKWLCEDPDNSLVFVGYQAEGSLGRRIQKGWKEIPLKDEDDK
MRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPKPEKILLCHGDNYKTLDLASSIYRTYRIETKTPLNLETVRIQ

Specific function: Unknown

COG id: COG1782

COG function: function code R; Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI33300633, Length=460, Percent_Identity=31.9565217391304, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI7706427, Length=472, Percent_Identity=29.0254237288136, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI34101288, Length=370, Percent_Identity=23.5135135135135, Blast_Score=110, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI32564696, Length=463, Percent_Identity=31.1015118790497, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32566029, Length=476, Percent_Identity=31.9327731092437, Blast_Score=202, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17559452, Length=435, Percent_Identity=22.9885057471264, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323307, Length=457, Percent_Identity=29.7592997811816, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21358523, Length=462, Percent_Identity=32.2510822510823, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24648013, Length=461, Percent_Identity=28.8503253796095, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21358013, Length=378, Percent_Identity=23.5449735449735, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR004087
- InterPro:   IPR019975
- InterPro:   IPR004044
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF07650 KH_2; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 72882; Mature: 72882

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS50084 KH_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSEMLEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITENGNLIRDIAKDIRKR
CHHHHHHHHHHHHHHHCCHHEEEEEEEECCCEEEEEECCCCEEECCCCCHHHHHHHHHHH
IIIRSDRSVLMDPEKAIRKIHEIVPEEAKITNISFDDVTCEVIIEARKPGLVIGKYGSTS
EEEECCCCEEECHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCEEEECCCCCH
REIVKNTGWAPKILRTPPISSEIIERIRRTLRKNSKERKKILQQLGNRIHQKPKYDNDWA
HHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHH
RLTAMGGFREVGRSCLYLQTPNSRVLLDCGVNVAGGDDKNSYPYLNVPEFTLDSLDAVII
HEEECCCHHHHCCCEEEEECCCCEEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCEEEE
THAHLDHSGFLPYLYHYGYDGPVYCTAPTRDLMTLLQLDHIDIAHREDEPLPFNVKHVKK
EEEECCCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHH
SVKHTITLDYGEVTDIAPDIRLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQSRL
HHCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHEEEEECCCCCCEEEECCCCHHHHHH
LEAAANRFPRIETLVMESTYGGHEDVQPSRNRAEKELVKTIYSTLRRGGKILIPVFAVGR
HHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCC
AQELMIVLEEYIRTGIIDEVPVYIDGMIWEANAIHTARPEYLSKDLRDQIFHMGHNPFIS
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
DIFHKVNGMDERREIVEGEPSIILSTSGMLTGGNSLEYFKWLCEDPDNSLVFVGYQAEGS
HHHHHHCCCHHHHHHHCCCCCEEEEECCEEECCCCHHHHHHHHCCCCCCEEEEEEECCCC
LGRRIQKGWKEIPLKDEDDKMRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPKPEKIL
HHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
LCHGDNYKTLDLASSIYRTYRIETKTPLNLETVRIQ
EEECCCCCHHHHHHHHHHHEEECCCCCCCEEEEEEC
>Mature Secondary Structure
MVSEMLEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITENGNLIRDIAKDIRKR
CHHHHHHHHHHHHHHHCCHHEEEEEEEECCCEEEEEECCCCEEECCCCCHHHHHHHHHHH
IIIRSDRSVLMDPEKAIRKIHEIVPEEAKITNISFDDVTCEVIIEARKPGLVIGKYGSTS
EEEECCCCEEECHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCEEEECCCCCH
REIVKNTGWAPKILRTPPISSEIIERIRRTLRKNSKERKKILQQLGNRIHQKPKYDNDWA
HHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHH
RLTAMGGFREVGRSCLYLQTPNSRVLLDCGVNVAGGDDKNSYPYLNVPEFTLDSLDAVII
HEEECCCHHHHCCCEEEEECCCCEEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCEEEE
THAHLDHSGFLPYLYHYGYDGPVYCTAPTRDLMTLLQLDHIDIAHREDEPLPFNVKHVKK
EEEECCCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHH
SVKHTITLDYGEVTDIAPDIRLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQSRL
HHCEEEEEECCCCCCCCCCEEEEEECCCHHHHHHHEEEEECCCCCCEEEECCCCHHHHHH
LEAAANRFPRIETLVMESTYGGHEDVQPSRNRAEKELVKTIYSTLRRGGKILIPVFAVGR
HHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCC
AQELMIVLEEYIRTGIIDEVPVYIDGMIWEANAIHTARPEYLSKDLRDQIFHMGHNPFIS
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
DIFHKVNGMDERREIVEGEPSIILSTSGMLTGGNSLEYFKWLCEDPDNSLVFVGYQAEGS
HHHHHHCCCHHHHHHHCCCCCEEEEECCEEECCCCHHHHHHHHCCCCCCEEEEEEECCCC
LGRRIQKGWKEIPLKDEDDKMRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPKPEKIL
HHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
LCHGDNYKTLDLASSIYRTYRIETKTPLNLETVRIQ
EEECCCCCHHHHHHHHHHHEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]