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Identifier: 15679215

GI number: 15679215

Start: 1107158

End: 1108174

Strand: Direct

Name: Not Available

Synonym: MTH1204

Alternate gene names: 15679215

Gene position: 1107158-1108174 (Clockwise)

Preceding gene: 15679214

Following gene: 15679216

Centisome position: 63.22

GC content: 54.87

Gene sequence:

>1017_bases
ATGGTAACCTATTCAGAATCTGGAGTGGATATAGACCTGGAGGAGCTCACCGTTTCCAGCTTAACTTCCAGGTTGAGTGA
CACCCTTAAGTACTGTGACGTTATCACCGGAGCCGGCCACTTCGCGGCCCTGGTGAGGATGGGTGATGTGGCCATCGCCA
TGAGCACCGATGGTGTCGGGAGCAAGATCCTTGTGGCGGAGATGATGAACCGTTACGATACCGTGGGTATAGACTGCATT
GCAATGGTGGTCAATGACATCCTCTGCGTGGGTGCAAGGCCGGCTGCCCTGGTCGACTACCTTGCAGTCGAACGTCCGGA
CCCTGAAGTGGCCGGGGAGATAGGAAAGGGACTTGCAATGGGTGCTGAAATGGCAAGGGTTGCCATAATAGGTGGGGAGA
CAGCATCCCTTCCCGGCATAATCCGGAACCTTGACCTGGCAGCCACGGGGATCGGCTTTGTTGATGTGGACAGGATCATA
ACCGGGGAGGATGTGTCCCCCGGCGACACTGTCATAGGACTTGAGAGCAGCGGGATACACAGCAATGGCCTCAGCCTCGC
GCGCAGGGTATTCTTTGATGAACTTGAACTTTCCCCGGAGGATGAGATGCCCGGATCCAGCAGCAGCGTTGGGGACGAAC
TCCTCAGACCCACAAGGATATACGTGGAGCCCATCATGGAACTGATTGAATCAGATGTTGATGTCCATGGACTGGCCCAC
ATAACCGGGGGAGGTTTTGGCAACCTCAAGAGACTGAGAAAGGATGTCGGGTACCGCCTGGATTCCCTCCCAGAACCACA
GCAGATATTTAGAGTTATCCACGAGGCAGGCGTTGACATAAGGGAGATGTACAGGGTCTTCAACATGGGAGTGGGTTTCT
GTGCAGTTGTAGCTCCGGATGACGTGGATGAAGCCCTCAGCATACTCGGAGACAGGGCCCACCCCATCGGGGAGGTTACA
GATAGGGGATCAGAGGTTGAACTCGAAGCCTGCACCGGTGAAACCATAAAACTTTAG

Upstream 100 bases:

>100_bases
TACCGGATAGAGACCAAGACCCCCCTGAACCTGGAAACCGTGCGTATCCAGTGAGGCTAACTATTTAGATAACCTTAAAC
TATTCTTTAGTGGTGATTTA

Downstream 100 bases:

>100_bases
GAGGACTTTTATGAGGATAAGCCCTGAAGAGGAAGTTAAAATCATAAAGGAAATACTCACCGCCATGAATGTTCCGGAGG
AGAGCTCAGATATAGTTGCA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MVTYSESGVDIDLEELTVSSLTSRLSDTLKYCDVITGAGHFAALVRMGDVAIAMSTDGVGSKILVAEMMNRYDTVGIDCI
AMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGKGLAMGAEMARVAIIGGETASLPGIIRNLDLAATGIGFVDVDRII
TGEDVSPGDTVIGLESSGIHSNGLSLARRVFFDELELSPEDEMPGSSSSVGDELLRPTRIYVEPIMELIESDVDVHGLAH
ITGGGFGNLKRLRKDVGYRLDSLPEPQQIFRVIHEAGVDIREMYRVFNMGVGFCAVVAPDDVDEALSILGDRAHPIGEVT
DRGSEVELEACTGETIKL

Sequences:

>Translated_338_residues
MVTYSESGVDIDLEELTVSSLTSRLSDTLKYCDVITGAGHFAALVRMGDVAIAMSTDGVGSKILVAEMMNRYDTVGIDCI
AMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGKGLAMGAEMARVAIIGGETASLPGIIRNLDLAATGIGFVDVDRII
TGEDVSPGDTVIGLESSGIHSNGLSLARRVFFDELELSPEDEMPGSSSSVGDELLRPTRIYVEPIMELIESDVDVHGLAH
ITGGGFGNLKRLRKDVGYRLDSLPEPQQIFRVIHEAGVDIREMYRVFNMGVGFCAVVAPDDVDEALSILGDRAHPIGEVT
DRGSEVELEACTGETIKL
>Mature_338_residues
MVTYSESGVDIDLEELTVSSLTSRLSDTLKYCDVITGAGHFAALVRMGDVAIAMSTDGVGSKILVAEMMNRYDTVGIDCI
AMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGKGLAMGAEMARVAIIGGETASLPGIIRNLDLAATGIGFVDVDRII
TGEDVSPGDTVIGLESSGIHSNGLSLARRVFFDELELSPEDEMPGSSSSVGDELLRPTRIYVEPIMELIESDVDVHGLAH
ITGGGFGNLKRLRKDVGYRLDSLPEPQQIFRVIHEAGVDIREMYRVFNMGVGFCAVVAPDDVDEALSILGDRAHPIGEVT
DRGSEVELEACTGETIKL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=35.2941176470588, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=35.2941176470588, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=35.2941176470588, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1788845, Length=341, Percent_Identity=38.41642228739, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=33.9285714285714, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321203, Length=333, Percent_Identity=33.6336336336336, Blast_Score=149, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24582400, Length=287, Percent_Identity=39.0243902439024, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_METTH (O27272)

Other databases:

- EMBL:   AE000666
- PIR:   G69027
- RefSeq:   NP_276332.1
- ProteinModelPortal:   O27272
- SMR:   O27272
- STRING:   O27272
- GeneID:   1471612
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1204
- NMPDR:   fig|187420.1.peg.1187
- eggNOG:   arNOG04189
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   MTHE187420:MTH1204-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_A
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35983; Mature: 35983

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTYSESGVDIDLEELTVSSLTSRLSDTLKYCDVITGAGHFAALVRMGDVAIAMSTDGVG
CCEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCCC
SKILVAEMMNRYDTVGIDCIAMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGKGLAM
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCHHHH
GAEMARVAIIGGETASLPGIIRNLDLAATGIGFVDVDRIITGEDVSPGDTVIGLESSGIH
CHHHHEEEEECCCCCCCCHHHHHCHHHHCCCCCEEHHHEEECCCCCCCCCEEEECCCCCC
SNGLSLARRVFFDELELSPEDEMPGSSSSVGDELLRPTRIYVEPIMELIESDVDVHGLAH
CHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEE
ITGGGFGNLKRLRKDVGYRLDSLPEPQQIFRVIHEAGVDIREMYRVFNMGVGFCAVVAPD
ECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCC
DVDEALSILGDRAHPIGEVTDRGSEVELEACTGETIKL
CHHHHHHHHCCCCCCCCHHHCCCCEEEEEECCCCEECC
>Mature Secondary Structure
MVTYSESGVDIDLEELTVSSLTSRLSDTLKYCDVITGAGHFAALVRMGDVAIAMSTDGVG
CCEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCCC
SKILVAEMMNRYDTVGIDCIAMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGKGLAM
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCHHHH
GAEMARVAIIGGETASLPGIIRNLDLAATGIGFVDVDRIITGEDVSPGDTVIGLESSGIH
CHHHHEEEEECCCCCCCCHHHHHCHHHHCCCCCEEHHHEEECCCCCCCCCEEEECCCCCC
SNGLSLARRVFFDELELSPEDEMPGSSSSVGDELLRPTRIYVEPIMELIESDVDVHGLAH
CHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEE
ITGGGFGNLKRLRKDVGYRLDSLPEPQQIFRVIHEAGVDIREMYRVFNMGVGFCAVVAPD
ECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCC
DVDEALSILGDRAHPIGEVTDRGSEVELEACTGETIKL
CHHHHHHHHCCCCCCCCHHHCCCCEEEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463