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The map label for this gene is purP

Identifier: 15679212

GI number: 15679212

Start: 1103129

End: 1104262

Strand: Direct

Name: purP

Synonym: MTH1201

Alternate gene names: 15679212

Gene position: 1103129-1104262 (Clockwise)

Preceding gene: 15679209

Following gene: 15679213

Centisome position: 62.99

GC content: 49.03

Gene sequence:

>1134_bases
ATGAAATTAAACCACTTATATATAAATCCAAGGGGTTTTTTTATGAGTAAGGTAAACCGTGATGAGATACTCGACATCCT
TGAAGGATACAGCAGGGAAGATATAACAGTAGCAACCCTGGGCAGCCACACATCACTGCACATACTGAACGGTGCAAAGC
AGGAGGGCTTCAAGACCGCAGTTGTCTGTGAGAAGGGTCGTGAAGTTCCATATCAGCGGTTCAGAGTTGCAGATGAATTC
ATAATGGTTGATAAATTCAGTGATATAGTGAATGATGATGTTCAGGACGAACTGAGGTCAATGAACAGCATAATAGTCCC
TCACGGCTCCTTTGTGGCCTATGCAGGTCTTGATCACATTGAAAACGACTTCTATGTCCCCATGTTCGGTAACAGGGATA
TACTGAGATGGGAATCCGAACGTGACCTTGAGAGGAAGCTCATGGAGGAGGCAGGTATAAGGATACCCTTCAAGTACACT
GACCCTGAGGAAATAGACAGGACAGTCATGGTCAAGTTCCCTGGTGCCAGGGGTGGTCGTGGATACTTCGTGGCTTCAAG
TACAGAGGAGTTCAATGAAAAGATCGACTCCATGCTGGAGAGGGGCTGGATAACTGAGGATGATGTCAAAGATGCCCACA
TCGAGGAATACATAGCAGGTACCAACTTCTGCATCCACTACTTCTACTCAATCATGAACGATGAGGTCGAACTCATGGGT
ATGGACAGCAGATTCGAGTCAAACATCGACGGCCTCGTAAGGATACCCGCAAGGGACCAGCTTGATATAAACCTTGACCC
CTCCTACGTGATAACCGGTAACCACCCGGTTGCCATGAGGGAATCCCTTCTCCCACAGGCCTTTGATATGGGAGACCGGA
TGGTGGAAGCAGCGAGCAAGATTGTTCCCCCTGGCATGAACGGTCCCTTCTGTCTCCAGACCATGTGCACAGATAACCTT
GAGATTGTGACATTTGAGATGAGCGCACGCACAGATGGGGGTACAAACACCTTCATGCACGGTTCAACCTACAGTTACCT
CCTCCATGGTGAGGGCATGAGCATGGGCCGTCGCGTTGCAAGGGAGATCAGGGTGGCCGCAGAGCAGGACCGCCTCCCAG
AAATCATAACCTGA

Upstream 100 bases:

>100_bases
TTCACTGTTTAGGGGAGTGTTTAAAAAAATAAATCCATAAGTGTTCTTTTTTCCTCCAAGTATTTAATGGCTTTTACGGA
AGACAAAAAAGATAATTATC

Downstream 100 bases:

>100_bases
TACTCCCACCTCATTCCTTTTAATGACCGGATAACCGTTCTTCAACCCCTCAGGAAGCCCCATCTATTATAAAAAAATCG
CAAAGTTTAATAAGGACCTC

Product: 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase

Products: NA

Alternate protein names: 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKLNHLYINPRGFFMSKVNRDEILDILEGYSREDITVATLGSHTSLHILNGAKQEGFKTAVVCEKGREVPYQRFRVADEF
IMVDKFSDIVNDDVQDELRSMNSIIVPHGSFVAYAGLDHIENDFYVPMFGNRDILRWESERDLERKLMEEAGIRIPFKYT
DPEEIDRTVMVKFPGARGGRGYFVASSTEEFNEKIDSMLERGWITEDDVKDAHIEEYIAGTNFCIHYFYSIMNDEVELMG
MDSRFESNIDGLVRIPARDQLDINLDPSYVITGNHPVAMRESLLPQAFDMGDRMVEAASKIVPPGMNGPFCLQTMCTDNL
EIVTFEMSARTDGGTNTFMHGSTYSYLLHGEGMSMGRRVAREIRVAAEQDRLPEIIT

Sequences:

>Translated_377_residues
MKLNHLYINPRGFFMSKVNRDEILDILEGYSREDITVATLGSHTSLHILNGAKQEGFKTAVVCEKGREVPYQRFRVADEF
IMVDKFSDIVNDDVQDELRSMNSIIVPHGSFVAYAGLDHIENDFYVPMFGNRDILRWESERDLERKLMEEAGIRIPFKYT
DPEEIDRTVMVKFPGARGGRGYFVASSTEEFNEKIDSMLERGWITEDDVKDAHIEEYIAGTNFCIHYFYSIMNDEVELMG
MDSRFESNIDGLVRIPARDQLDINLDPSYVITGNHPVAMRESLLPQAFDMGDRMVEAASKIVPPGMNGPFCLQTMCTDNL
EIVTFEMSARTDGGTNTFMHGSTYSYLLHGEGMSMGRRVAREIRVAAEQDRLPEIIT
>Mature_377_residues
MKLNHLYINPRGFFMSKVNRDEILDILEGYSREDITVATLGSHTSLHILNGAKQEGFKTAVVCEKGREVPYQRFRVADEF
IMVDKFSDIVNDDVQDELRSMNSIIVPHGSFVAYAGLDHIENDFYVPMFGNRDILRWESERDLERKLMEEAGIRIPFKYT
DPEEIDRTVMVKFPGARGGRGYFVASSTEEFNEKIDSMLERGWITEDDVKDAHIEEYIAGTNFCIHYFYSIMNDEVELMG
MDSRFESNIDGLVRIPARDQLDINLDPSYVITGNHPVAMRESLLPQAFDMGDRMVEAASKIVPPGMNGPFCLQTMCTDNL
EIVTFEMSARTDGGTNTFMHGSTYSYLLHGEGMSMGRRVAREIRVAAEQDRLPEIIT

Specific function: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates [H]

COG id: COG1759

COG function: function code R; ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR009720
- InterPro:   IPR010672
- InterPro:   IPR013817 [H]

Pfam domain/function: PF06849 DUF1246; PF06973 DUF1297 [H]

EC number: NA

Molecular weight: Translated: 42985; Mature: 42985

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNHLYINPRGFFMSKVNRDEILDILEGYSREDITVATLGSHTSLHILNGAKQEGFKTA
CCCEEEEECCCCCEEHHCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEE
VVCEKGREVPYQRFRVADEFIMVDKFSDIVNDDVQDELRSMNSIIVPHGSFVAYAGLDHI
EEECCCCCCCHHHHHHHHHEEEHHHHHHHHCCCHHHHHHHCCCEEECCCCEEEEECHHHC
ENDFYVPMFGNRDILRWESERDLERKLMEEAGIRIPFKYTDPEEIDRTVMVKFPGARGGR
CCCEEEEEECCCCEEEECCHHHHHHHHHHHCCCEEEEECCCHHHCCCEEEEEECCCCCCC
GYFVASSTEEFNEKIDSMLERGWITEDDVKDAHIEEYIAGTNFCIHYFYSIMNDEVELMG
EEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCEEEEE
MDSRFESNIDGLVRIPARDQLDINLDPSYVITGNHPVAMRESLLPQAFDMGDRMVEAASK
CCCHHHCCCCCEEECCCCCCEEEECCCCEEEECCCCHHHHHHHCHHHHHHHHHHHHHHHH
IVPPGMNGPFCLQTMCTDNLEIVTFEMSARTDGGTNTFMHGSTYSYLLHGEGMSMGRRVA
CCCCCCCCCEEEHHHCCCCEEEEEEEEECCCCCCCCEEECCCEEEEEEECCCHHHHHHHH
REIRVAAEQDRLPEIIT
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLNHLYINPRGFFMSKVNRDEILDILEGYSREDITVATLGSHTSLHILNGAKQEGFKTA
CCCEEEEECCCCCEEHHCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEE
VVCEKGREVPYQRFRVADEFIMVDKFSDIVNDDVQDELRSMNSIIVPHGSFVAYAGLDHI
EEECCCCCCCHHHHHHHHHEEEHHHHHHHHCCCHHHHHHHCCCEEECCCCEEEEECHHHC
ENDFYVPMFGNRDILRWESERDLERKLMEEAGIRIPFKYTDPEEIDRTVMVKFPGARGGR
CCCEEEEEECCCCEEEECCHHHHHHHHHHHCCCEEEEECCCHHHCCCEEEEEECCCCCCC
GYFVASSTEEFNEKIDSMLERGWITEDDVKDAHIEEYIAGTNFCIHYFYSIMNDEVELMG
EEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCEEEEE
MDSRFESNIDGLVRIPARDQLDINLDPSYVITGNHPVAMRESLLPQAFDMGDRMVEAASK
CCCHHHCCCCCEEECCCCCCEEEECCCCEEEECCCCHHHHHHHCHHHHHHHHHHHHHHHH
IVPPGMNGPFCLQTMCTDNLEIVTFEMSARTDGGTNTFMHGSTYSYLLHGEGMSMGRRVA
CCCCCCCCCEEEHHHCCCCEEEEEEEEECCCCCCCCEEECCCEEEEEEECCCHHHHHHHH
REIRVAAEQDRLPEIIT
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]