Click here to switch to the map view.

The map label for this gene is cofG

Identifier: 15679209

GI number: 15679209

Start: 1100475

End: 1101554

Strand: Direct

Name: cofG

Synonym: MTH1198

Alternate gene names: 15679209

Gene position: 1100475-1101554 (Clockwise)

Preceding gene: 15679208

Following gene: 15679212

Centisome position: 62.83

GC content: 53.33

Gene sequence:

>1080_bases
ATGCTCCACTCAAAGGACGAAGTACTCGAAGTCCTCCTCATGAAGGGGCCGGATATACTGGACCTCATGAAGAGGGCCTG
TGAAACTGGAAGCGTGACCTACTCAAGGAACATATTCATACCCCTCACAAGGGCCTGCCGGAACCGCTGCGGATACTGCA
CCTTCAGGTCAGACACCCCCGAGCCCCCCCTACTCGAACCTGAAGACGTTATGGGTGAGGTGAGGAGAGCCCTCTCCCTC
GGCTGTACCGAGGCCCTCTTCACCTTCGGTGAGGATGCCCATGAGTTCCCAGGGGTTCGGGACAAGCTTGAATCCCTTGG
CTTTGGAGATATGACTGATTACACATATCACCTCTGTGAGCTGACACTTGATGCTGGACTCCTGCCACACACCAACATGG
GTGTGATAGGCTACCGCGAACTGAGGATGCTGAAGGAGGTAAACGCATCCATGGGGCTCATGCTCGAATCAGCGAGTCCC
AGGCTCATGGAAACAGAGGCCCACCGTGAAAGCCCTGGTAAGAACCCCAGATTGAGGATAAAAATGATAGAGGACGCTGG
GAGACTCAGGATACCATTCACCACTGGCTTGCTCATAGGTATAGGTGAAACCATCGAGGAGAGGGCCGAGTCCCTCCTTG
AGCTTAGGAGAATACAGGACAGGTACGGGCATATACAGGAGATAATAATCCAGAACTTCCGCTCAAAACCTGGAATCCCC
ATGGAGAACCAGCGGGAACCCTCCCTCCTTGAAATGGTGAAGATGGTTGCGGCTGCAAAGATAATGTTCCCTGATGTGAG
CATACAGGTCCCTCCGAACCTGAACAGGGAAACCGGTGAGATATTCCTCCTGGCCGGTGCAGATGACTGGGGTGGTGTAT
CACCCATCAGCCGGGACTATGTGAATCCCGAGGCGCCATGGCCAGAGATAGATGAACTTAAAAGGATCACCGAATCTGCT
GGATTTGCTCTTGAGGAGAGGCTCCCTGTATACAGAAAATTCATCTCCAGGGAGTTTCTGAGCCCCCGTGTGATGGAACG
GATAGAAGAGCTTTATCCCCGGTTCATCGAGACTCTGTGA

Upstream 100 bases:

>100_bases
CTTTGTTGTTCTCTACAGGGACCGGAGCGGAGTCGGACCCTGCTTTGTTGAGGCTGTTGTCTCTGACCTATCTGAATAAT
CTAATTTTAACGGTGCTCCC

Downstream 100 bases:

>100_bases
GTCCCGGACACCTGCTCCCATGACACTGAATCCTACAATTCCACGCCAGGGGATGGTAGAATTATTGTGCCCTCCACCGG
ATCTCCCAGTTCGATGAAGT

Product: FO synthase subunit 1

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1 [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MLHSKDEVLEVLLMKGPDILDLMKRACETGSVTYSRNIFIPLTRACRNRCGYCTFRSDTPEPPLLEPEDVMGEVRRALSL
GCTEALFTFGEDAHEFPGVRDKLESLGFGDMTDYTYHLCELTLDAGLLPHTNMGVIGYRELRMLKEVNASMGLMLESASP
RLMETEAHRESPGKNPRLRIKMIEDAGRLRIPFTTGLLIGIGETIEERAESLLELRRIQDRYGHIQEIIIQNFRSKPGIP
MENQREPSLLEMVKMVAAAKIMFPDVSIQVPPNLNRETGEIFLLAGADDWGGVSPISRDYVNPEAPWPEIDELKRITESA
GFALEERLPVYRKFISREFLSPRVMERIEELYPRFIETL

Sequences:

>Translated_359_residues
MLHSKDEVLEVLLMKGPDILDLMKRACETGSVTYSRNIFIPLTRACRNRCGYCTFRSDTPEPPLLEPEDVMGEVRRALSL
GCTEALFTFGEDAHEFPGVRDKLESLGFGDMTDYTYHLCELTLDAGLLPHTNMGVIGYRELRMLKEVNASMGLMLESASP
RLMETEAHRESPGKNPRLRIKMIEDAGRLRIPFTTGLLIGIGETIEERAESLLELRRIQDRYGHIQEIIIQNFRSKPGIP
MENQREPSLLEMVKMVAAAKIMFPDVSIQVPPNLNRETGEIFLLAGADDWGGVSPISRDYVNPEAPWPEIDELKRITESA
GFALEERLPVYRKFISREFLSPRVMERIEELYPRFIETL
>Mature_359_residues
MLHSKDEVLEVLLMKGPDILDLMKRACETGSVTYSRNIFIPLTRACRNRCGYCTFRSDTPEPPLLEPEDVMGEVRRALSL
GCTEALFTFGEDAHEFPGVRDKLESLGFGDMTDYTYHLCELTLDAGLLPHTNMGVIGYRELRMLKEVNASMGLMLESASP
RLMETEAHRESPGKNPRLRIKMIEDAGRLRIPFTTGLLIGIGETIEERAESLLELRRIQDRYGHIQEIIIQNFRSKPGIP
MENQREPSLLEMVKMVAAAKIMFPDVSIQVPPNLNRETGEIFLLAGADDWGGVSPISRDYVNPEAPWPEIDELKRITESA
GFALEERLPVYRKFISREFLSPRVMERIEELYPRFIETL

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofG family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR010722
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 40876; Mature: 40876

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHSKDEVLEVLLMKGPDILDLMKRACETGSVTYSRNIFIPLTRACRNRCGYCTFRSDTP
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCEEEEHHHHHHCCCCEEEECCCCC
EPPLLEPEDVMGEVRRALSLGCTEALFTFGEDAHEFPGVRDKLESLGFGDMTDYTYHLCE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHCCCCCCHHHHHHHHH
LTLDAGLLPHTNMGVIGYRELRMLKEVNASMGLMLESASPRLMETEAHRESPGKNPRLRI
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHCCCCCCCCEEE
KMIEDAGRLRIPFTTGLLIGIGETIEERAESLLELRRIQDRYGHIQEIIIQNFRSKPGIP
EEECCCCCEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MENQREPSLLEMVKMVAAAKIMFPDVSIQVPPNLNRETGEIFLLAGADDWGGVSPISRDY
CCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEECCCCCCCCCCCHHCC
VNPEAPWPEIDELKRITESAGFALEERLPVYRKFISREFLSPRVMERIEELYPRFIETL
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLHSKDEVLEVLLMKGPDILDLMKRACETGSVTYSRNIFIPLTRACRNRCGYCTFRSDTP
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCEEEEHHHHHHCCCCEEEECCCCC
EPPLLEPEDVMGEVRRALSLGCTEALFTFGEDAHEFPGVRDKLESLGFGDMTDYTYHLCE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHCCCCCCHHHHHHHHH
LTLDAGLLPHTNMGVIGYRELRMLKEVNASMGLMLESASPRLMETEAHRESPGKNPRLRI
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHCCCCCCCCEEE
KMIEDAGRLRIPFTTGLLIGIGETIEERAESLLELRRIQDRYGHIQEIIIQNFRSKPGIP
EEECCCCCEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MENQREPSLLEMVKMVAAAKIMFPDVSIQVPPNLNRETGEIFLLAGADDWGGVSPISRDY
CCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEECCCCCCCCCCCHHCC
VNPEAPWPEIDELKRITESAGFALEERLPVYRKFISREFLSPRVMERIEELYPRFIETL
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]