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Identifier: 15679022

GI number: 15679022

Start: 917752

End: 918051

Strand: Direct

Name: Not Available

Synonym: MTH1004

Alternate gene names: 15679022

Gene position: 917752-918051 (Clockwise)

Preceding gene: 15679020

Following gene: 15679023

Centisome position: 52.4

GC content: 51.67

Gene sequence:

>300_bases
TTGAGTAGAGGACATCAGACACAGGAAGTCAGGCGTGTTAGGACCCCCAGGAGGGGTGAGATACCGGGAGTTGTTGAACA
GATAATGGGCCACGGAAAACTGAAGGTGAGGTGTGCCGATGGCCATATAAGGCTCGGCCGTATCCCCGGGAAGATGAAAA
AGAGGATATGGATACGTGAAGGGGACGTGGTCCTCGTTAAGCCCTGGGAGTTCCAGAGCGAAGAGAAGGCTGATATCGTC
TGGAGATACACACGTACAGAGTCAAACTGGCTCGAAAGGAAGGGTTACCTTAAACTGTAA

Upstream 100 bases:

>100_bases
CTGCACGGGTAATAAATTATAATGTCTATTTCTTTGATTGCTGGATATTAAATTCCATTAAAATCAAAGTTAACCAACGA
AAAAATCAGGAGGAGAGTAT

Downstream 100 bases:

>100_bases
AGTTGATTTTAATGGACCCCGAAGAAACCGGGAAGGCCCCCGAGATCAGGGCCCTTAAATCCAGGGCAGTGAACAGGGTT
GATTCCGACCTCGGCCGGAT

Product: translation initiation factor IF-1A

Products: NA

Alternate protein names: aIF-1A

Number of amino acids: Translated: 99; Mature: 98

Protein sequence:

>99_residues
MSRGHQTQEVRRVRTPRRGEIPGVVEQIMGHGKLKVRCADGHIRLGRIPGKMKKRIWIREGDVVLVKPWEFQSEEKADIV
WRYTRTESNWLERKGYLKL

Sequences:

>Translated_99_residues
MSRGHQTQEVRRVRTPRRGEIPGVVEQIMGHGKLKVRCADGHIRLGRIPGKMKKRIWIREGDVVLVKPWEFQSEEKADIV
WRYTRTESNWLERKGYLKL
>Mature_98_residues
SRGHQTQEVRRVRTPRRGEIPGVVEQIMGHGKLKVRCADGHIRLGRIPGKMKKRIWIREGDVVLVKPWEFQSEEKADIVW
RYTRTESNWLERKGYLKL

Specific function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

COG id: COG0361

COG function: function code J; Translation initiation factor 1 (IF-1)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1-like domain

Homologues:

Organism=Saccharomyces cerevisiae, GI6323916, Length=73, Percent_Identity=32.8767123287671, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF1A_METTH (O27085)

Other databases:

- EMBL:   AE000666
- PIR:   H69000
- RefSeq:   NP_276139.1
- ProteinModelPortal:   O27085
- SMR:   O27085
- STRING:   O27085
- GeneID:   1471412
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1004
- NMPDR:   fig|187420.1.peg.994
- eggNOG:   arNOG11452
- HOGENOM:   HBG521228
- OMA:   IWIREGD
- ProtClustDB:   PRK04012
- BioCyc:   MTHE187420:MTH1004-MONOMER
- HAMAP:   MF_00216
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR006196
- InterPro:   IPR001253
- InterPro:   IPR018104
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR21668
- ProDom:   PD005579
- SMART:   SM00652
- TIGRFAMs:   TIGR00523

Pfam domain/function: PF01176 eIF-1a; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 11749; Mature: 11618

Theoretical pI: Translated: 11.21; Mature: 11.21

Prosite motif: PS01262 IF1A; PS50832 S1_IF1_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGHQTQEVRRVRTPRRGEIPGVVEQIMGHGKLKVRCADGHIRLGRIPGKMKKRIWIRE
CCCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEEECCCCEEEECCCCCCCEEEEEEC
GDVVLVKPWEFQSEEKADIVWRYTRTESNWLERKGYLKL
CCEEEEECCCCCCCCCCEEEEEEECCCCCHHHCCCCCCC
>Mature Secondary Structure 
SRGHQTQEVRRVRTPRRGEIPGVVEQIMGHGKLKVRCADGHIRLGRIPGKMKKRIWIRE
CCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEEECCCCEEEECCCCCCCEEEEEEC
GDVVLVKPWEFQSEEKADIVWRYTRTESNWLERKGYLKL
CCEEEEECCCCCCCCCCEEEEEEECCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463