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Identifier: 15678896

GI number: 15678896

Start: 797040

End: 797648

Strand: Direct

Name: Not Available

Synonym: MTH876

Alternate gene names: 15678896

Gene position: 797040-797648 (Clockwise)

Preceding gene: 15678895

Following gene: 15678897

Centisome position: 45.51

GC content: 52.55

Gene sequence:

>609_bases
ATGGAAAATGAACTTATAAGGAAGGCCCGGGAACTCAGGAGCAGGGGATTTACAACAGGGGAAATTGCAGATGAACTGAA
CGTGTCTAAGGACACTGCGAGGTGGCTTACACTTCAGACCACGACCTCTGTTTCCAGGAAGGAGGCCCCTGTGGATTTCG
CGATCAACTGGGAGAGCCTGGGGGGCAGTTCATCCAGGATGAGGTATGTTTCAGCCGCCATGGCAGACATGGCCCTCAAG
TATGGTGTTGCGGATGTTGTTCTTGGCATCGCCATAAGCGGTGTTCCCTTCGCAACGCTGATGGCTGATGTTATGGGCGC
TGAAACTGGACTGGAAACATCACTTGCAGTTTTCCACCCCGTAAAGCACAGGAAGGATGAGGGTGCAGAGGGAGCCATAA
GCAGTAACTTTGCAAAGGTGAAGGGCAAGAGGGTTGTTGTTGTTGATGATGTTATAACAAGCGGCCGGACCATAGCTGAG
GTGGTTGAGGTCCTCAAGAACCAGGGAGCAAAGCCCATAGCCGTCACTGTCCTCATAGACAAGAAGGGCATCTCTGAGGT
TGACGGTGTGCCGGTGGAGTCACTCATAAGGGTTAGCAGGCTGGGATGA

Upstream 100 bases:

>100_bases
TGAGGATGGTATATACGCCCTCAGGACTGTGCTTGCAGCAATGAAGTCTGCGAGGGAGCACAGGCCCGTGAAGGTTAATG
GTGATATTTGAGGTGCTTGT

Downstream 100 bases:

>100_bases
TTTACCTTCATCTAGTCTACTAACCCTCTTGTCTCACCGAAAACTCCTTTTTTGTAATTTCCTTTAATAAAACAGAATAA
ATAAGTCAAAGAACTAATTT

Product: orotate phosphoribosyltransferase-like protein

Products: orotate; 5-phospho-alpha-D-ribose 1-diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MENELIRKARELRSRGFTTGEIADELNVSKDTARWLTLQTTTSVSRKEAPVDFAINWESLGGSSSRMRYVSAAMADMALK
YGVADVVLGIAISGVPFATLMADVMGAETGLETSLAVFHPVKHRKDEGAEGAISSNFAKVKGKRVVVVDDVITSGRTIAE
VVEVLKNQGAKPIAVTVLIDKKGISEVDGVPVESLIRVSRLG

Sequences:

>Translated_202_residues
MENELIRKARELRSRGFTTGEIADELNVSKDTARWLTLQTTTSVSRKEAPVDFAINWESLGGSSSRMRYVSAAMADMALK
YGVADVVLGIAISGVPFATLMADVMGAETGLETSLAVFHPVKHRKDEGAEGAISSNFAKVKGKRVVVVDDVITSGRTIAE
VVEVLKNQGAKPIAVTVLIDKKGISEVDGVPVESLIRVSRLG
>Mature_202_residues
MENELIRKARELRSRGFTTGEIADELNVSKDTARWLTLQTTTSVSRKEAPVDFAINWESLGGSSSRMRYVSAAMADMALK
YGVADVVLGIAISGVPFATLMADVMGAETGLETSLAVFHPVKHRKDEGAEGAISSNFAKVKGKRVVVVDDVITSGRTIAE
VVEVLKNQGAKPIAVTVLIDKKGISEVDGVPVESLIRVSRLG

Specific function: Pyrimidine biosynthesis; fifth step. [C]

COG id: COG0856

COG function: function code F; Orotate phosphoribosyltransferase homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYREL_METTH (O26962)

Other databases:

- EMBL:   AE000666
- PIR:   A69217
- RefSeq:   NP_276013.1
- ProteinModelPortal:   O26962
- STRING:   O26962
- GeneID:   1471284
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH876
- NMPDR:   fig|187420.1.peg.868
- eggNOG:   arNOG07847
- HOGENOM:   HBG497993
- OMA:   KDVHIDW
- ProtClustDB:   PRK02277
- BioCyc:   MTHE187420:MTH876-MONOMER
- HAMAP:   MF_01214
- InterPro:   IPR022854
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: 2.4.2.10

Molecular weight: Translated: 21616; Mature: 21616

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENELIRKARELRSRGFTTGEIADELNVSKDTARWLTLQTTTSVSRKEAPVDFAINWESL
CCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEHHHC
GGSSSRMRYVSAAMADMALKYGVADVVLGIAISGVPFATLMADVMGAETGLETSLAVFHP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
VKHRKDEGAEGAISSNFAKVKGKRVVVVDDVITSGRTIAEVVEVLKNQGAKPIAVTVLID
HHHCCCCCCCCCHHCCHHHHCCCEEEEEECCHHCCCHHHHHHHHHHCCCCCCEEEEEEEE
KKGISEVDGVPVESLIRVSRLG
CCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MENELIRKARELRSRGFTTGEIADELNVSKDTARWLTLQTTTSVSRKEAPVDFAINWESL
CCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEHHHC
GGSSSRMRYVSAAMADMALKYGVADVVLGIAISGVPFATLMADVMGAETGLETSLAVFHP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHH
VKHRKDEGAEGAISSNFAKVKGKRVVVVDDVITSGRTIAEVVEVLKNQGAKPIAVTVLID
HHHCCCCCCCCCHHCCHHHHCCCEEEEEECCHHCCCHHHHHHHHHHCCCCCCEEEEEEEE
KKGISEVDGVPVESLIRVSRLG
CCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ba2+; Ca2+; Co2+; Mg2+; Mn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.22 {diphosphate}} 0.013 {diphosphate}} 0.0031 {orotidine} 0.44 {orotate}} 0.03 {orotate}} 0.36 {phosphoribose} 0.038 {phosphoribose} [C]

Substrates: orotidine 5'-phosphate; diphosphate

Specific reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate

General reaction: Glycosyl and Pentosyl group transfer [C]

Inhibitor: HgCl2; IAA; NEM; PCMB; Zn2+ [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463