Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15678895

GI number: 15678895

Start: 796074

End: 797030

Strand: Direct

Name: Not Available

Synonym: MTH875

Alternate gene names: 15678895

Gene position: 796074-797030 (Clockwise)

Preceding gene: 15678894

Following gene: 15678896

Centisome position: 45.45

GC content: 48.8

Gene sequence:

>957_bases
TTGAGACAGATAAATGTGGGTGTAATCGGCGTTGGAGCCATGGGTTACAACCATGCCAGAGTTTACTACAGACTTAAAAA
TGCAAATCTTATGGCTGTATCAGACATCATGAAGGGAACACTTCAGAAGGTCGCCAACAAGTATGACACCGTTGGATACG
TGGACTATGAGAACCTCCTGGAGATACCTGAGATAGAGGTTGTCAGTGTCTGCGTGCCAACCACCCACCATTACAATGTG
GTCATGGATGCCCTTGAACACGACAAACACGTCCTCGTTGAGAAGCCCATCGCATTCACCCTTGAAGAGGCAGAGGATAT
GGTGAAAACGGCACGCAAAAAGGGGCTGAAGCTGGGCACGGGCCATGTTGAAAGGTTCAACCCCGCAGTTCAGAAGGCCA
AGGAACTCATTGAGAACGATGTTATAGGTGACGTGGTATCTGCATCAGCGAAGAGGGTCGGACCATTCCCTCCCCGAATA
AAGGACGTTGGAGTCACCATCGACCTCGCCATACACGACCTCGATGTGATGCATTACCTCTTCAGCGAACCGGTTGCAGA
GGTCTACGCGGTTATGGGAAGCATACTCGAGAAGTGTGAGTACGAGGACCATGCCGAGATAATGACCAAGTTCAAAAGTG
GAATCACAGGGATACTCGAGGTTAACTGGCTCACACCCTACAAGAGGAGGAAGCTGGCCATCACAGGTACAGATGGAATA
ATCAACGTTGACTACATAGACCAGAGGCTGGATGTCTATGGTAAATTCGCCCAGGACGTGGATATCAAACATGAGGAACC
CCTGAAGAATGAGATCAAATCATTCCTCATGTCTGTTATAAATGATGAGGAGCCTGAAATAACAGGTGAGGATGGTATAT
ACGCCCTCAGGACTGTGCTTGCAGCAATGAAGTCTGCGAGGGAGCACAGGCCCGTGAAGGTTAATGGTGATATTTGA

Upstream 100 bases:

>100_bases
CCAGAGAAGGTGAAATGCTCAGGAAGGTAACCGTTAGGGGGCCTCTTGCTGAAGCAGAGGATATAGGTAAAAAAGCTGCC
AAAGAAATGGAGGATTATAT

Downstream 100 bases:

>100_bases
GGTGCTTGTATGGAAAATGAACTTATAAGGAAGGCCCGGGAACTCAGGAGCAGGGGATTTACAACAGGGGAAATTGCAGA
TGAACTGAACGTGTCTAAGG

Product: 3-chlorobenzoate-3,4-dioxygenase dyhydrogenase related protein

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MRQINVGVIGVGAMGYNHARVYYRLKNANLMAVSDIMKGTLQKVANKYDTVGYVDYENLLEIPEIEVVSVCVPTTHHYNV
VMDALEHDKHVLVEKPIAFTLEEAEDMVKTARKKGLKLGTGHVERFNPAVQKAKELIENDVIGDVVSASAKRVGPFPPRI
KDVGVTIDLAIHDLDVMHYLFSEPVAEVYAVMGSILEKCEYEDHAEIMTKFKSGITGILEVNWLTPYKRRKLAITGTDGI
INVDYIDQRLDVYGKFAQDVDIKHEEPLKNEIKSFLMSVINDEEPEITGEDGIYALRTVLAAMKSAREHRPVKVNGDI

Sequences:

>Translated_318_residues
MRQINVGVIGVGAMGYNHARVYYRLKNANLMAVSDIMKGTLQKVANKYDTVGYVDYENLLEIPEIEVVSVCVPTTHHYNV
VMDALEHDKHVLVEKPIAFTLEEAEDMVKTARKKGLKLGTGHVERFNPAVQKAKELIENDVIGDVVSASAKRVGPFPPRI
KDVGVTIDLAIHDLDVMHYLFSEPVAEVYAVMGSILEKCEYEDHAEIMTKFKSGITGILEVNWLTPYKRRKLAITGTDGI
INVDYIDQRLDVYGKFAQDVDIKHEEPLKNEIKSFLMSVINDEEPEITGEDGIYALRTVLAAMKSAREHRPVKVNGDI
>Mature_318_residues
MRQINVGVIGVGAMGYNHARVYYRLKNANLMAVSDIMKGTLQKVANKYDTVGYVDYENLLEIPEIEVVSVCVPTTHHYNV
VMDALEHDKHVLVEKPIAFTLEEAEDMVKTARKKGLKLGTGHVERFNPAVQKAKELIENDVIGDVVSASAKRVGPFPPRI
KDVGVTIDLAIHDLDVMHYLFSEPVAEVYAVMGSILEKCEYEDHAEIMTKFKSGITGILEVNWLTPYKRRKLAITGTDGI
INVDYIDQRLDVYGKFAQDVDIKHEEPLKNEIKSFLMSVINDEEPEITGEDGIYALRTVLAAMKSAREHRPVKVNGDI

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI87082405, Length=253, Percent_Identity=30.0395256916996, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787574, Length=193, Percent_Identity=32.6424870466321, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789848, Length=254, Percent_Identity=25.9842519685039, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081947, Length=194, Percent_Identity=29.3814432989691, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323975, Length=276, Percent_Identity=25.7246376811594, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24584727, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 35654; Mature: 35654

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQINVGVIGVGAMGYNHARVYYRLKNANLMAVSDIMKGTLQKVANKYDTVGYVDYENLL
CCEEEEEEEEECCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHCCCEEECHHHHC
EIPEIEVVSVCVPTTHHYNVVMDALEHDKHVLVEKPIAFTLEEAEDMVKTARKKGLKLGT
CCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEECCHHEEHHHHHHHHHHHHHCCCCCCC
GHVERFNPAVQKAKELIENDVIGDVVSASAKRVGPFPPRIKDVGVTIDLAIHDLDVMHYL
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHH
FSEPVAEVYAVMGSILEKCEYEDHAEIMTKFKSGITGILEVNWLTPYKRRKLAITGTDGI
HHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCE
INVDYIDQRLDVYGKFAQDVDIKHEEPLKNEIKSFLMSVINDEEPEITGEDGIYALRTVL
EEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AAMKSAREHRPVKVNGDI
HHHHHHHHCCCEEECCCC
>Mature Secondary Structure
MRQINVGVIGVGAMGYNHARVYYRLKNANLMAVSDIMKGTLQKVANKYDTVGYVDYENLL
CCEEEEEEEEECCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHCCCEEECHHHHC
EIPEIEVVSVCVPTTHHYNVVMDALEHDKHVLVEKPIAFTLEEAEDMVKTARKKGLKLGT
CCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEECCHHEEHHHHHHHHHHHHHCCCCCCC
GHVERFNPAVQKAKELIENDVIGDVVSASAKRVGPFPPRIKDVGVTIDLAIHDLDVMHYL
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHH
FSEPVAEVYAVMGSILEKCEYEDHAEIMTKFKSGITGILEVNWLTPYKRRKLAITGTDGI
HHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCE
INVDYIDQRLDVYGKFAQDVDIKHEEPLKNEIKSFLMSVINDEEPEITGEDGIYALRTVL
EEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
AAMKSAREHRPVKVNGDI
HHHHHHHHCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]