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Identifier: 15678891

GI number: 15678891

Start: 792079

End: 792921

Strand: Direct

Name: Not Available

Synonym: MTH871

Alternate gene names: 15678891

Gene position: 792079-792921 (Clockwise)

Preceding gene: 15678890

Following gene: 15678892

Centisome position: 45.23

GC content: 54.21

Gene sequence:

>843_bases
ATGGAGGAATCTGATATTTACTACTGGAAGGGTGTTGCCGTGAGAATGGCTGAGCAGGTTGAAAGGGCCGTATCTCCCCT
TGTTGGGACAGAAGACGCAGGGGAGATAATCAAAATGGGGGCCGATGGCACACCCACCAAACTTATAGACCTCGTTGCGG
AGGATGAAGCCGTTGGTGTCCTTGAGAGTACGGGTAGGCCTGTCACAATAATAAGTGAGGAGATAGGTGTCCTCCACATA
AACAGCGAGGGGGATGAACCCGGGATAATCTTCGTTGTGGACCCCCTGGACGGTACAAGCAACGCCATAAGGAACATACC
CTTCTACGGCATATCAGTGGCTGTGGCAGAACGCCACCCCGACGGTGCAGCCCCAACCCTTAATAACGTCCTGATGGGCT
TTGTTAAGAACTTCGCCACGGGGGACCTCTACTGGGCAATAAAAGGCCAGGGGGCCTTCCTCAATGAGAAAGCGATAAGC
TCATCCTCACAGAGCTCCCTCGACAGGACATCCCTGGGGGCCTTCATATATGGCACGCGCTTCAGGAGGGTGGACAGCAT
CTGCAGGGTGATCCGGAGAATGCGTATCCTGGGATCCGTGGCCCTTGAACTGGCCTACGTTGCAAGCGGTTCCTACGACG
CCTTCATGGACCTCAGGGAGAATCTCAGGATAGTTGACATAGCAGCATCCAAGCTCATTGTGGAGGAGGCAGGCGGTGTG
GTGACCAATGAGAGGGGTGGAGAAATAGACGGCCTTCTGAACGTTAAGGCAAGAACATCCCTTGTTGCCGCCGGAAACCT
GGAGCTCCACGAGAAGATAATGCAGACCCTGGAGGTCATATGA

Upstream 100 bases:

>100_bases
AAAGGAATTAATAGTAGAAGAGACAAATCATGTTGTTGAGAAATGCGGTGCTGCTGTATCTGCCGTCGTATATCTTGATT
GAAGTCAGGAAGGGGGTTTC

Downstream 100 bases:

>100_bases
TGCGCATAGGGATAATAGCCCGTTTTGATGTTGCAGAGGCCGTTGAAATCGCTGAAAGAGTGGCCTCATTCCTCCTGAAC
AGGGGGGTTGAAATTACGGT

Product: bifunctional inositol-1 monophosphatase/fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MEESDIYYWKGVAVRMAEQVERAVSPLVGTEDAGEIIKMGADGTPTKLIDLVAEDEAVGVLESTGRPVTIISEEIGVLHI
NSEGDEPGIIFVVDPLDGTSNAIRNIPFYGISVAVAERHPDGAAPTLNNVLMGFVKNFATGDLYWAIKGQGAFLNEKAIS
SSSQSSLDRTSLGAFIYGTRFRRVDSICRVIRRMRILGSVALELAYVASGSYDAFMDLRENLRIVDIAASKLIVEEAGGV
VTNERGGEIDGLLNVKARTSLVAAGNLELHEKIMQTLEVI

Sequences:

>Translated_280_residues
MEESDIYYWKGVAVRMAEQVERAVSPLVGTEDAGEIIKMGADGTPTKLIDLVAEDEAVGVLESTGRPVTIISEEIGVLHI
NSEGDEPGIIFVVDPLDGTSNAIRNIPFYGISVAVAERHPDGAAPTLNNVLMGFVKNFATGDLYWAIKGQGAFLNEKAIS
SSSQSSLDRTSLGAFIYGTRFRRVDSICRVIRRMRILGSVALELAYVASGSYDAFMDLRENLRIVDIAASKLIVEEAGGV
VTNERGGEIDGLLNVKARTSLVAAGNLELHEKIMQTLEVI
>Mature_280_residues
MEESDIYYWKGVAVRMAEQVERAVSPLVGTEDAGEIIKMGADGTPTKLIDLVAEDEAVGVLESTGRPVTIISEEIGVLHI
NSEGDEPGIIFVVDPLDGTSNAIRNIPFYGISVAVAERHPDGAAPTLNNVLMGFVKNFATGDLYWAIKGQGAFLNEKAIS
SSSQSSLDRTSLGAFIYGTRFRRVDSICRVIRRMRILGSVALELAYVASGSYDAFMDLRENLRIVDIAASKLIVEEAGGV
VTNERGGEIDGLLNVKARTSLVAAGNLELHEKIMQTLEVI

Specific function: Unknown

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family

Homologues:

Organism=Homo sapiens, GI5031789, Length=205, Percent_Identity=29.7560975609756, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI221625487, Length=205, Percent_Identity=29.7560975609756, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI7657236, Length=199, Percent_Identity=27.6381909547739, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788882, Length=247, Percent_Identity=33.6032388663968, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI193202570, Length=192, Percent_Identity=32.2916666666667, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193202572, Length=192, Percent_Identity=30.7291666666667, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320493, Length=202, Percent_Identity=30.1980198019802, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664922, Length=196, Percent_Identity=30.6122448979592, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24664918, Length=191, Percent_Identity=31.9371727748691, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357957, Length=195, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21357303, Length=217, Percent_Identity=31.7972350230415, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24664926, Length=196, Percent_Identity=29.5918367346939, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21357329, Length=202, Percent_Identity=31.6831683168317, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SUHB_METTH (O26957)

Other databases:

- EMBL:   AE000666
- PIR:   D69216
- RefSeq:   NP_276008.1
- ProteinModelPortal:   O26957
- STRING:   O26957
- GeneID:   1471279
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH871
- NMPDR:   fig|187420.1.peg.863
- eggNOG:   arNOG05430
- HOGENOM:   HBG730251
- OMA:   DIRNYVR
- ProtClustDB:   PRK12676
- BioCyc:   MTHE187420:MTH871-MONOMER
- BRENDA:   3.1.3.25
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550
- PANTHER:   PTHR20854
- PRINTS:   PR00377

Pfam domain/function: PF00459 Inositol_P

EC number: =3.1.3.25

Molecular weight: Translated: 30174; Mature: 30174

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00629 IMP_1; PS00630 IMP_2

Important sites: BINDING 97-97 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEESDIYYWKGVAVRMAEQVERAVSPLVGTEDAGEIIKMGADGTPTKLIDLVAEDEAVGV
CCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCCCHHHHHHHHHCCCCCCH
LESTGRPVTIISEEIGVLHINSEGDEPGIIFVVDPLDGTSNAIRNIPFYGISVAVAERHP
HHCCCCCEEEEECCCCEEEECCCCCCCCEEEEECCCCCCCHHHHCCCCEEEEEEEEECCC
DGAAPTLNNVLMGFVKNFATGDLYWAIKGQGAFLNEKAISSSSQSSLDRTSLGAFIYGTR
CCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEECHHHHCCCCHHHCHHHHHHHHHHHHH
FRRVDSICRVIRRMRILGSVALELAYVASGSYDAFMDLRENLRIVDIAASKLIVEEAGGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEHHHHHHHHHCCCE
VTNERGGEIDGLLNVKARTSLVAAGNLELHEKIMQTLEVI
EECCCCCCCCCEEEEEHHEEEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEESDIYYWKGVAVRMAEQVERAVSPLVGTEDAGEIIKMGADGTPTKLIDLVAEDEAVGV
CCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCCCHHHHHHHHHCCCCCCH
LESTGRPVTIISEEIGVLHINSEGDEPGIIFVVDPLDGTSNAIRNIPFYGISVAVAERHP
HHCCCCCEEEEECCCCEEEECCCCCCCCEEEEECCCCCCCHHHHCCCCEEEEEEEEECCC
DGAAPTLNNVLMGFVKNFATGDLYWAIKGQGAFLNEKAISSSSQSSLDRTSLGAFIYGTR
CCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEECHHHHCCCCHHHCHHHHHHHHHHHHH
FRRVDSICRVIRRMRILGSVALELAYVASGSYDAFMDLRENLRIVDIAASKLIVEEAGGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEHHHHHHHHHCCCE
VTNERGGEIDGLLNVKARTSLVAAGNLELHEKIMQTLEVI
EECCCCCCCCCEEEEEHHEEEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463