Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15678808

GI number: 15678808

Start: 711214

End: 712071

Strand: Direct

Name: Not Available

Synonym: MTH784

Alternate gene names: 15678808

Gene position: 711214-712071 (Clockwise)

Preceding gene: 161484930

Following gene: 15678811

Centisome position: 40.61

GC content: 50.58

Gene sequence:

>858_bases
ATGATAATAGGTTGTTCAGCATCACAGAAACTTGCTGCCTCAGTTGCAGATTTACTAGATGAACCTTTATGCCCCGTTGA
AACCCGTAAATTCCCTGATGGGGAACGTTACATCAGGGTTAAGGAGGAAGTGGAGGGAGAGGTGACCGTTGTGCAGTCAA
CGGGTTACCCCCAGGATGAAAACCTCATGGAACTCCTTTTCATGATAGAGAACCTTAAAGATCTGGGGGCGGATTATGTG
CGTGCAGCCATACCCTACTTTGGATACGGGAGGCAGGAGAGGCGTTTCAAGAGCGGTGAAGCTGTATCGGCGAAAATAGT
CGCCCACCTCCTTGAGGCCGCCGGTGCAGATGAAATTGTAACCGTGAACCTCCATGAGAACTGCCTGAGTGAGTTCTTCC
GTGTACCTGTGAGGGAGCTCTCTGCAATGCCCCTCATCGCTGAACACATCTCATTCCTTGATGACCCGGTAATCATCGCC
CCGGATAAGGGTGCCCTAGGTCATGCCCGGGAGGTCAGTGATATACTTGGATGTGAATGTGACTACATGGAGAAGGTCCG
CATATCCCCTGAGGTGGTTGAGACCCGTGTGAGTGACCTTGATGTTGAAGGAAAGGATGCTGTGGTTGTTGATGACATCA
TAAGCACCGGTGGGACCATAGTAAACGCCGCCGGGATTTTAGGGAAATGTGGAGCCTCAAGCATAACTGTTTGCTGTGTC
CACCCGGTCCTTGTGGAGGACGCCCTCCTGAAGATATTCTCAGCCGGTGTTGAGAGGGTCATTGCAACGGACACCCTTAA
ATCTGATGTTAGCGAGATCTCAGTTGCACCGCTTATTGCAGATGTCATGAAAGATTAA

Upstream 100 bases:

>100_bases
TCATGCACCCATTTCACCTCTTTAGTCTGACAAAATTTTATAATTAGAATTAATAGAGTTATCTATATAAAAATTGTTAA
TTACCGGAAGGTGATTTTTC

Downstream 100 bases:

>100_bases
TTTAACCCATTTCAGATATTTTTTCAGTTCCCGGCCCTTATTAACTTTTTTTAAGAATCATCTGGACCTGAGCACATGAA
AAGGGAGCTCAGTATAAAAA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MIIGCSASQKLAASVADLLDEPLCPVETRKFPDGERYIRVKEEVEGEVTVVQSTGYPQDENLMELLFMIENLKDLGADYV
RAAIPYFGYGRQERRFKSGEAVSAKIVAHLLEAAGADEIVTVNLHENCLSEFFRVPVRELSAMPLIAEHISFLDDPVIIA
PDKGALGHAREVSDILGCECDYMEKVRISPEVVETRVSDLDVEGKDAVVVDDIISTGGTIVNAAGILGKCGASSITVCCV
HPVLVEDALLKIFSAGVERVIATDTLKSDVSEISVAPLIADVMKD

Sequences:

>Translated_285_residues
MIIGCSASQKLAASVADLLDEPLCPVETRKFPDGERYIRVKEEVEGEVTVVQSTGYPQDENLMELLFMIENLKDLGADYV
RAAIPYFGYGRQERRFKSGEAVSAKIVAHLLEAAGADEIVTVNLHENCLSEFFRVPVRELSAMPLIAEHISFLDDPVIIA
PDKGALGHAREVSDILGCECDYMEKVRISPEVVETRVSDLDVEGKDAVVVDDIISTGGTIVNAAGILGKCGASSITVCCV
HPVLVEDALLKIFSAGVERVIATDTLKSDVSEISVAPLIADVMKD
>Mature_285_residues
MIIGCSASQKLAASVADLLDEPLCPVETRKFPDGERYIRVKEEVEGEVTVVQSTGYPQDENLMELLFMIENLKDLGADYV
RAAIPYFGYGRQERRFKSGEAVSAKIVAHLLEAAGADEIVTVNLHENCLSEFFRVPVRELSAMPLIAEHISFLDDPVIIA
PDKGALGHAREVSDILGCECDYMEKVRISPEVVETRVSDLDVEGKDAVVVDDIISTGGTIVNAAGILGKCGASSITVCCV
HPVLVEDALLKIFSAGVERVIATDTLKSDVSEISVAPLIADVMKD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506129, Length=266, Percent_Identity=36.4661654135338, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI4506127, Length=270, Percent_Identity=36.6666666666667, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI84875539, Length=269, Percent_Identity=36.4312267657993, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI28557709, Length=273, Percent_Identity=35.5311355311355, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI194018537, Length=306, Percent_Identity=29.4117647058824, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4506133, Length=307, Percent_Identity=27.0358306188925, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1787458, Length=270, Percent_Identity=33.7037037037037, Blast_Score=160, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17554704, Length=269, Percent_Identity=34.5724907063197, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25149168, Length=269, Percent_Identity=34.5724907063197, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17554702, Length=273, Percent_Identity=34.0659340659341, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71989924, Length=273, Percent_Identity=34.0659340659341, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17570245, Length=305, Percent_Identity=26.5573770491803, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320946, Length=285, Percent_Identity=28.4210526315789, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319403, Length=295, Percent_Identity=27.7966101694915, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6321776, Length=262, Percent_Identity=32.824427480916, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6322667, Length=161, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21355239, Length=264, Percent_Identity=37.5, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI45551540, Length=287, Percent_Identity=34.4947735191638, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI281362873, Length=289, Percent_Identity=24.5674740484429, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651454, Length=289, Percent_Identity=24.5674740484429, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651458, Length=289, Percent_Identity=24.5674740484429, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651456, Length=289, Percent_Identity=24.5674740484429, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552010, Length=181, Percent_Identity=28.7292817679558, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651462, Length=181, Percent_Identity=28.7292817679558, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651464, Length=181, Percent_Identity=28.7292817679558, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_METTH (O26877)

Other databases:

- EMBL:   AE000666
- PIR:   G69204
- RefSeq:   NP_275925.1
- ProteinModelPortal:   O26877
- SMR:   O26877
- STRING:   O26877
- GeneID:   1471192
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH784
- NMPDR:   fig|187420.1.peg.780
- eggNOG:   arNOG07029
- HOGENOM:   HBG519284
- OMA:   NDTILEL
- ProtClustDB:   PRK00934
- BioCyc:   MTHE187420:MTH784-MONOMER
- BRENDA:   2.7.6.1
- GO:   GO:0005737
- HAMAP:   MF_00583_A
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 30794; Mature: 30794

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGCSASQKLAASVADLLDEPLCPVETRKFPDGERYIRVKEEVEGEVTVVQSTGYPQDE
CEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEHHHCCCCEEEEECCCCCCCH
NLMELLFMIENLKDLGADYVRAAIPYFGYGRQERRFKSGEAVSAKIVAHLLEAAGADEIV
HHHHHHHHHHHHHHHCHHHHHHHCCHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCEE
TVNLHENCLSEFFRVPVRELSAMPLIAEHISFLDDPVIIAPDKGALGHAREVSDILGCEC
EEEEHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCC
DYMEKVRISPEVVETRVSDLDVEGKDAVVVDDIISTGGTIVNAAGILGKCGASSITVCCV
CHHHHHCCCHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCEEEHHHHHHCCCCCCEEEEEH
HPVLVEDALLKIFSAGVERVIATDTLKSDVSEISVAPLIADVMKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIGCSASQKLAASVADLLDEPLCPVETRKFPDGERYIRVKEEVEGEVTVVQSTGYPQDE
CEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEHHHCCCCEEEEECCCCCCCH
NLMELLFMIENLKDLGADYVRAAIPYFGYGRQERRFKSGEAVSAKIVAHLLEAAGADEIV
HHHHHHHHHHHHHHHCHHHHHHHCCHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCEE
TVNLHENCLSEFFRVPVRELSAMPLIAEHISFLDDPVIIAPDKGALGHAREVSDILGCEC
EEEEHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCC
DYMEKVRISPEVVETRVSDLDVEGKDAVVVDDIISTGGTIVNAAGILGKCGASSITVCCV
CHHHHHCCCHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCEEEHHHHHHCCCCCCEEEEEH
HPVLVEDALLKIFSAGVERVIATDTLKSDVSEISVAPLIADVMKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463