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Identifier: 15678738

GI number: 15678738

Start: 634220

End: 634675

Strand: Direct

Name: Not Available

Synonym: MTH711

Alternate gene names: 15678738

Gene position: 634220-634675 (Clockwise)

Preceding gene: 15678737

Following gene: 15678739

Centisome position: 36.21

GC content: 51.1

Gene sequence:

>456_bases
ATGAAAGACAGGATCCCGATATTCTCTGTTGCAAAAAACCGTGTTGAAATGGTTGAGAGGATTGAACTCTCAGATGATGA
GTGGCGGGAGATACTTGACCCCGAAGCCTTCCGTGTTGCAAGGAAAGCCGGCACAGAGCCACCATTCACAGGTAAATATC
ATGACCTCCACGATGACGGCATATACCGCTGCATATGCTGTGGTACAGACCTCTTTGACTCAGAAACCAAATTCGATTCA
GGGACAGGATGGCCGAGCTTCTATGATGTGGTATCAGAACACAACATTAAACTGAGGGAGGATCGCAGCCTCGGGATGGT
ACGCTGTGAGGTCCTCTGTGCAAGGTGCGACGCCCACCTTGGCCATGTATTCGATGATGGTCCCAGGCCCACAGGGAAGA
GGTACTGCATGAACTCAGCGGCACTGAAGTTCATCCCGAGGGATCAGATAGGGTGA

Upstream 100 bases:

>100_bases
GATGCTTGAAAAAACACCAGCAGTTCCCCTTCAAGAGATGGAGATTATGAAAGTGAATCCCTCATTAACTAAATAAGTTA
TGAGTCACATAATTTGACGT

Downstream 100 bases:

>100_bases
AATGCAGGAAGGTGCTGGAATGGCTGAGGACTTTGGAAGGTACTGGGTGGCTGGACTCATAATGGCAGTTGCAACAGAGT
TCATCAACACCCTCACATAC

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MKDRIPIFSVAKNRVEMVERIELSDDEWREILDPEAFRVARKAGTEPPFTGKYHDLHDDGIYRCICCGTDLFDSETKFDS
GTGWPSFYDVVSEHNIKLREDRSLGMVRCEVLCARCDAHLGHVFDDGPRPTGKRYCMNSAALKFIPRDQIG

Sequences:

>Translated_151_residues
MKDRIPIFSVAKNRVEMVERIELSDDEWREILDPEAFRVARKAGTEPPFTGKYHDLHDDGIYRCICCGTDLFDSETKFDS
GTGWPSFYDVVSEHNIKLREDRSLGMVRCEVLCARCDAHLGHVFDDGPRPTGKRYCMNSAALKFIPRDQIG
>Mature_151_residues
MKDRIPIFSVAKNRVEMVERIELSDDEWREILDPEAFRVARKAGTEPPFTGKYHDLHDDGIYRCICCGTDLFDSETKFDS
GTGWPSFYDVVSEHNIKLREDRSLGMVRCEVLCARCDAHLGHVFDDGPRPTGKRYCMNSAALKFIPRDQIG

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI301336164, Length=132, Percent_Identity=55.3030303030303, Blast_Score=162, Evalue=9e-41,
Organism=Homo sapiens, GI301336162, Length=132, Percent_Identity=55.3030303030303, Blast_Score=162, Evalue=9e-41,
Organism=Homo sapiens, GI73089054, Length=132, Percent_Identity=55.3030303030303, Blast_Score=162, Evalue=9e-41,
Organism=Homo sapiens, GI37620216, Length=132, Percent_Identity=55.3030303030303, Blast_Score=162, Evalue=1e-40,
Organism=Homo sapiens, GI117606353, Length=136, Percent_Identity=50.7352941176471, Blast_Score=146, Evalue=6e-36,
Organism=Homo sapiens, GI7706511, Length=100, Percent_Identity=32, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788077, Length=122, Percent_Identity=54.0983606557377, Blast_Score=143, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17553450, Length=149, Percent_Identity=46.3087248322148, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI115532676, Length=129, Percent_Identity=49.6124031007752, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319816, Length=129, Percent_Identity=41.0852713178295, Blast_Score=101, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45553335, Length=131, Percent_Identity=50.381679389313, Blast_Score=149, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21356369, Length=131, Percent_Identity=50.381679389313, Blast_Score=149, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24645799, Length=131, Percent_Identity=50.381679389313, Blast_Score=149, Evalue=6e-37,
Organism=Drosophila melanogaster, GI221378664, Length=128, Percent_Identity=50.78125, Blast_Score=147, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221378662, Length=135, Percent_Identity=48.1481481481481, Blast_Score=146, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24645804, Length=142, Percent_Identity=46.4788732394366, Blast_Score=145, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24645801, Length=142, Percent_Identity=46.4788732394366, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRB_METTH (O26807)

Other databases:

- EMBL:   AE000666
- PIR:   A69195
- RefSeq:   NP_275854.1
- PDB:   2K8D
- PDBsum:   2K8D
- ProteinModelPortal:   O26807
- SMR:   O26807
- STRING:   O26807
- GeneID:   1470672
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH711
- NMPDR:   fig|187420.1.peg.709
- eggNOG:   arNOG10043
- HOGENOM:   HBG715255
- OMA:   RTEVHCN
- PhylomeDB:   O26807
- ProtClustDB:   PRK00222
- BioCyc:   MTHE187420:MTH711-MONOMER
- BRENDA:   1.8.4.12
- HAMAP:   MF_01400
- InterPro:   IPR002579
- InterPro:   IPR011057
- Gene3D:   G3DSA:2.170.150.20
- TIGRFAMs:   TIGR00357

Pfam domain/function: PF01641 SelR; SSF51316 Mss4_like

EC number: =1.8.4.12

Molecular weight: Translated: 17303; Mature: 17303

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDRIPIFSVAKNRVEMVERIELSDDEWREILDPEAFRVARKAGTEPPFTGKYHDLHDDG
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
IYRCICCGTDLFDSETKFDSGTGWPSFYDVVSEHNIKLREDRSLGMVRCEVLCARCDAHL
EEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHH
GHVFDDGPRPTGKRYCMNSAALKFIPRDQIG
CCCCCCCCCCCCHHHHHCCHHHEECCCCCCC
>Mature Secondary Structure
MKDRIPIFSVAKNRVEMVERIELSDDEWREILDPEAFRVARKAGTEPPFTGKYHDLHDDG
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
IYRCICCGTDLFDSETKFDSGTGWPSFYDVVSEHNIKLREDRSLGMVRCEVLCARCDAHL
EEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHH
GHVFDDGPRPTGKRYCMNSAALKFIPRDQIG
CCCCCCCCCCCCHHHHHCCHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463