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Identifier: 15678728

GI number: 15678728

Start: 623553

End: 624830

Strand: Direct

Name: Not Available

Synonym: MTH701

Alternate gene names: 15678728

Gene position: 623553-624830 (Clockwise)

Preceding gene: 15678727

Following gene: 15678729

Centisome position: 35.6

GC content: 52.58

Gene sequence:

>1278_bases
ATGACTGCTCTCATCAACGAATTCGTGAACCGTGTTGAATTTGATTCATACGAGGATTTCCGTGACAACTTCAGAATAAA
TGTCCCCGAAAACTTCAACTTCGCATACGATGTGGTTGACAGATACGCTGAAATTGAACCTGATAAGGTGGCCCTGGTCT
GGTGCAACGACCATGGCGAGGAGAAAAGGATAACCTTCGGTGAACTCCGGGACCTATCCAGCAGGGCCGCGAATTTCTTC
ACCAAGGAGGGTATACAGAAGGGTGACACAGTCATGCTGACCCTCAAGGCAAGGTATGACTTCTGGTACGCCCTCCTGGG
GCTCCACAGGATAGGGGCCATAGCAATCCCGGCCACACACATGCTCAAGGAGAAGGACATCGTCTACCGTATAAGGGAGG
CGGACATAAAGATGGTTGTCTGCATAGCAGAGGACGGTGTCCCTGAAGTATTTGAGGGAGCCATCGCTGAACTGGGCTCA
GATACCCGGAGGGTCCTGGTTGGTGACACTGATAGGGACGGCTGGATAAATCTCAGAAAAGAAATCATGAAACTTCCAGC
CGACTTCGAAAGGCCAGAGGCCTGTGCCGGTGGGGATGACACCCTCATCGTCTACTTCTCATCGGGCACAACAGGAATGC
CCAAGATGATAGAACACGACCACACCTATCCCCTGGGCCATATAATAACAGCGAAGTACTGGCAGAACGTCAGGGAGGAC
GGCCTCCACTACACGGTTGCAGACACCGGCTGGGCAAAGGCCATGTGGGGTCAGATCTACGGTCAGTGGATAGCTGGAAG
CGCTGTCTTCGTCTATGACTATGACCGCTTTGACCCTGAGAAGATGCTGGAGAAACTTGAAAAATACGAGATAACCACAT
TCTGCGCCCCTCCAACGATATACAGGTTTCTCATAAAGGAGGACCTGTCAAGATATGACCTCTCAGGAATCGAATATGCT
GTTACAGCTGGGGAGCCCCTGAACCCCGAGGTATTTGAGAGGTTCCGGGAACACACCGGCCTCCAGCTAATGGAGGGATT
CGGGCAGACAGAATGCGTTGTGTGCATAGCAAACTTCCCGTGGATGGAGCCAAAACCTGGTTCAATGGGCAAGCCATCCC
CCGGCTACCCTGTTGAACTGGTGGACAGGAACGGTGACCCTGTGGACGTCGGTGAGGAGGGTGAGATAGTCATAAGAACC
GCTGAGGGCAAACCCCTCGGTCTCTTCAACGGATACTACAGGAACCCTGAGAAGACCTCAGAGGTATGGCACGACTGA

Upstream 100 bases:

>100_bases
GGGGACTCCATATTCTTTGACTCATCCTATGAACACGCCATGGAGGCCCTGGACGGCAAAAAGGCAAGGTTCCTGGCAAT
AATAATGTAGAGGTGTACCT

Downstream 100 bases:

>100_bases
TACTACCACACAGGGGACACCGCCTGGATGGATGAAGACGGCTACATGTGGTTCGTTGGGAGAACAGATGACATCATAAA
GAGTTCCGGTTACCGTATAG

Product: acetyl-CoA synthetase related protein

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTALINEFVNRVEFDSYEDFRDNFRINVPENFNFAYDVVDRYAEIEPDKVALVWCNDHGEEKRITFGELRDLSSRAANFF
TKEGIQKGDTVMLTLKARYDFWYALLGLHRIGAIAIPATHMLKEKDIVYRIREADIKMVVCIAEDGVPEVFEGAIAELGS
DTRRVLVGDTDRDGWINLRKEIMKLPADFERPEACAGGDDTLIVYFSSGTTGMPKMIEHDHTYPLGHIITAKYWQNVRED
GLHYTVADTGWAKAMWGQIYGQWIAGSAVFVYDYDRFDPEKMLEKLEKYEITTFCAPPTIYRFLIKEDLSRYDLSGIEYA
VTAGEPLNPEVFERFREHTGLQLMEGFGQTECVVCIANFPWMEPKPGSMGKPSPGYPVELVDRNGDPVDVGEEGEIVIRT
AEGKPLGLFNGYYRNPEKTSEVWHD

Sequences:

>Translated_425_residues
MTALINEFVNRVEFDSYEDFRDNFRINVPENFNFAYDVVDRYAEIEPDKVALVWCNDHGEEKRITFGELRDLSSRAANFF
TKEGIQKGDTVMLTLKARYDFWYALLGLHRIGAIAIPATHMLKEKDIVYRIREADIKMVVCIAEDGVPEVFEGAIAELGS
DTRRVLVGDTDRDGWINLRKEIMKLPADFERPEACAGGDDTLIVYFSSGTTGMPKMIEHDHTYPLGHIITAKYWQNVRED
GLHYTVADTGWAKAMWGQIYGQWIAGSAVFVYDYDRFDPEKMLEKLEKYEITTFCAPPTIYRFLIKEDLSRYDLSGIEYA
VTAGEPLNPEVFERFREHTGLQLMEGFGQTECVVCIANFPWMEPKPGSMGKPSPGYPVELVDRNGDPVDVGEEGEIVIRT
AEGKPLGLFNGYYRNPEKTSEVWHD
>Mature_424_residues
TALINEFVNRVEFDSYEDFRDNFRINVPENFNFAYDVVDRYAEIEPDKVALVWCNDHGEEKRITFGELRDLSSRAANFFT
KEGIQKGDTVMLTLKARYDFWYALLGLHRIGAIAIPATHMLKEKDIVYRIREADIKMVVCIAEDGVPEVFEGAIAELGSD
TRRVLVGDTDRDGWINLRKEIMKLPADFERPEACAGGDDTLIVYFSSGTTGMPKMIEHDHTYPLGHIITAKYWQNVREDG
LHYTVADTGWAKAMWGQIYGQWIAGSAVFVYDYDRFDPEKMLEKLEKYEITTFCAPPTIYRFLIKEDLSRYDLSGIEYAV
TAGEPLNPEVFERFREHTGLQLMEGFGQTECVVCIANFPWMEPKPGSMGKPSPGYPVELVDRNGDPVDVGEEGEIVIRTA
EGKPLGLFNGYYRNPEKTSEVWHD

Specific function: Catalyzes The Synthesis Of Propionyl-CoA From Propionate And CoA. Also Converts Acetate To Acetyl-CoA But With A Lower Specific Activity (By Similarity). [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=418, Percent_Identity=37.3205741626794, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI38505220, Length=403, Percent_Identity=38.9578163771712, Blast_Score=292, Evalue=4e-79,
Organism=Homo sapiens, GI42544134, Length=378, Percent_Identity=36.5079365079365, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI122937307, Length=414, Percent_Identity=37.6811594202899, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI58082049, Length=402, Percent_Identity=35.0746268656716, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI157311624, Length=402, Percent_Identity=34.8258706467662, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI157311622, Length=402, Percent_Identity=34.8258706467662, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI115511026, Length=402, Percent_Identity=33.5820895522388, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI195947378, Length=392, Percent_Identity=29.5918367346939, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI28416953, Length=395, Percent_Identity=27.5949367088608, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI8923896, Length=392, Percent_Identity=25.5102040816327, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI253970489, Length=409, Percent_Identity=25.9168704156479, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786529, Length=399, Percent_Identity=25.8145363408521, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790505, Length=415, Percent_Identity=24.578313253012, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI221142682, Length=388, Percent_Identity=26.0309278350515, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788107, Length=391, Percent_Identity=21.227621483376, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71983001, Length=446, Percent_Identity=25.5605381165919, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982997, Length=446, Percent_Identity=25.5605381165919, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32563687, Length=402, Percent_Identity=22.636815920398, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17558820, Length=394, Percent_Identity=21.5736040609137, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17551278, Length=408, Percent_Identity=24.7549019607843, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115534440, Length=412, Percent_Identity=22.8155339805825, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323182, Length=389, Percent_Identity=26.9922879177378, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319264, Length=405, Percent_Identity=24.6913580246914, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6319699, Length=428, Percent_Identity=22.4299065420561, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24667955, Length=430, Percent_Identity=24.8837209302326, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI62472339, Length=404, Percent_Identity=24.5049504950495, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648260, Length=232, Percent_Identity=28.0172413793103, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281364798, Length=423, Percent_Identity=24.113475177305, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583465, Length=423, Percent_Identity=24.113475177305, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583463, Length=423, Percent_Identity=24.113475177305, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24667959, Length=259, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45552801, Length=426, Percent_Identity=22.3004694835681, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550496, Length=424, Percent_Identity=21.9339622641509, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24653035, Length=225, Percent_Identity=24.8888888888889, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076582, Length=225, Percent_Identity=24.8888888888889, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648255, Length=367, Percent_Identity=24.7956403269755, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648253, Length=367, Percent_Identity=24.2506811989101, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281365686, Length=231, Percent_Identity=24.6753246753247, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 48552; Mature: 48421

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALINEFVNRVEFDSYEDFRDNFRINVPENFNFAYDVVDRYAEIEPDKVALVWCNDHGE
CCHHHHHHHHHCCCCCCHHHHCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCC
EKRITFGELRDLSSRAANFFTKEGIQKGDTVMLTLKARYDFWYALLGLHRIGAIAIPATH
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHCEEEECHHH
MLKEKDIVYRIREADIKMVVCIAEDGVPEVFEGAIAELGSDTRRVLVGDTDRDGWINLRK
HHHHCCHHEEEEECCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
EIMKLPADFERPEACAGGDDTLIVYFSSGTTGMPKMIEHDHTYPLGHIITAKYWQNVRED
HHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHC
GLHYTVADTGWAKAMWGQIYGQWIAGSAVFVYDYDRFDPEKMLEKLEKYEITTFCAPPTI
CCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCEEEEEECCHHH
YRFLIKEDLSRYDLSGIEYAVTAGEPLNPEVFERFREHTGLQLMEGFGQTECVVCIANFP
HHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHCCCCCEEEEEEECCC
WMEPKPGSMGKPSPGYPVELVDRNGDPVDVGEEGEIVIRTAEGKPLGLFNGYYRNPEKTS
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCHHH
EVWHD
HHCCC
>Mature Secondary Structure 
TALINEFVNRVEFDSYEDFRDNFRINVPENFNFAYDVVDRYAEIEPDKVALVWCNDHGE
CHHHHHHHHHCCCCCCHHHHCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCC
EKRITFGELRDLSSRAANFFTKEGIQKGDTVMLTLKARYDFWYALLGLHRIGAIAIPATH
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHCEEEECHHH
MLKEKDIVYRIREADIKMVVCIAEDGVPEVFEGAIAELGSDTRRVLVGDTDRDGWINLRK
HHHHCCHHEEEEECCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
EIMKLPADFERPEACAGGDDTLIVYFSSGTTGMPKMIEHDHTYPLGHIITAKYWQNVRED
HHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHC
GLHYTVADTGWAKAMWGQIYGQWIAGSAVFVYDYDRFDPEKMLEKLEKYEITTFCAPPTI
CCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCEEEEEECCHHH
YRFLIKEDLSRYDLSGIEYAVTAGEPLNPEVFERFREHTGLQLMEGFGQTECVVCIANFP
HHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHCCCCCEEEEEEECCC
WMEPKPGSMGKPSPGYPVELVDRNGDPVDVGEEGEIVIRTAEGKPLGLFNGYYRNPEKTS
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCHHH
EVWHD
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]