| Definition | Methanothermobacter thermautotrophicus str. Delta H chromosome, complete genome. |
|---|---|
| Accession | NC_000916 |
| Length | 1,751,377 |
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Identifier: 15678729
GI number: 15678729
Start: 624858
End: 625232
Strand: Direct
Name: Not Available
Synonym: MTH702
Alternate gene names: 15678729
Gene position: 624858-625232 (Clockwise)
Preceding gene: 15678728
Following gene: 15678730
Centisome position: 35.68
GC content: 51.73
Gene sequence:
>375_bases ATGGATGAAGACGGCTACATGTGGTTCGTTGGGAGAACAGATGACATCATAAAGAGTTCCGGTTACCGTATAGGGCCCTT CGAGGTTGAAAGTGCCATCATATCCCACCCATCGGTCCTGGAGTGTGCAGTAACAGGATACCCTGACCCCATAAGGGGAC AGGTTGTGAAGGCCACCATCGTCCTTGCCAGGGGCTATGAACCCTCAGAGGAGCTGAAAAAGGAGATCCAGGACCATGTT AAGCGTGTGACCGCGCCCTACAAGTACCCGAGGATAGTTGAATTCGTTGATGAGCTGCCCAAGACCATAAGCGGTAAGAT AAGGCGTGTCGAGATCCGTGAACATGACCTTGAAGGAGACGGTGAAAACCCATGA
Upstream 100 bases:
>100_bases GGGCAAACCCCTCGGTCTCTTCAACGGATACTACAGGAACCCTGAGAAGACCTCAGAGGTATGGCACGACTGATACTACC ACACAGGGGACACCGCCTGG
Downstream 100 bases:
>100_bases AGAAGGCCTATCCTGTAATAAACAGTGTGGAGTGCAAGGCATGTGAACGCTGCATAATCGCATGCCCCAGGAAGGTCCTC CAGATGAGCAGCAAAATCAA
Product: acetyl-CoA synthetase related protein
Products: AMP; diphosphate; acetyl-CoA
Alternate protein names: NA
Number of amino acids: Translated: 124; Mature: 124
Protein sequence:
>124_residues MDEDGYMWFVGRTDDIIKSSGYRIGPFEVESAIISHPSVLECAVTGYPDPIRGQVVKATIVLARGYEPSEELKKEIQDHV KRVTAPYKYPRIVEFVDELPKTISGKIRRVEIREHDLEGDGENP
Sequences:
>Translated_124_residues MDEDGYMWFVGRTDDIIKSSGYRIGPFEVESAIISHPSVLECAVTGYPDPIRGQVVKATIVLARGYEPSEELKKEIQDHV KRVTAPYKYPRIVEFVDELPKTISGKIRRVEIREHDLEGDGENP >Mature_124_residues MDEDGYMWFVGRTDDIIKSSGYRIGPFEVESAIISHPSVLECAVTGYPDPIRGQVVKATIVLARGYEPSEELKKEIQDHV KRVTAPYKYPRIVEFVDELPKTISGKIRRVEIREHDLEGDGENP
Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]
COG id: COG0365
COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]
Homologues:
Organism=Homo sapiens, GI122937307, Length=122, Percent_Identity=65.5737704918033, Blast_Score=164, Evalue=2e-41, Organism=Homo sapiens, GI42544132, Length=118, Percent_Identity=65.2542372881356, Blast_Score=162, Evalue=6e-41, Organism=Homo sapiens, GI38505220, Length=118, Percent_Identity=64.4067796610169, Blast_Score=159, Evalue=4e-40, Organism=Homo sapiens, GI58082049, Length=123, Percent_Identity=58.5365853658537, Blast_Score=155, Evalue=1e-38, Organism=Homo sapiens, GI157311624, Length=123, Percent_Identity=57.7235772357724, Blast_Score=155, Evalue=1e-38, Organism=Homo sapiens, GI157311622, Length=123, Percent_Identity=57.7235772357724, Blast_Score=155, Evalue=1e-38, Organism=Homo sapiens, GI115511026, Length=118, Percent_Identity=64.4067796610169, Blast_Score=152, Evalue=7e-38, Organism=Homo sapiens, GI8923896, Length=121, Percent_Identity=36.3636363636364, Blast_Score=91, Evalue=2e-19, Organism=Homo sapiens, GI253970489, Length=121, Percent_Identity=36.3636363636364, Blast_Score=91, Evalue=2e-19, Organism=Homo sapiens, GI13375727, Length=113, Percent_Identity=41.5929203539823, Blast_Score=88, Evalue=2e-18, Organism=Homo sapiens, GI187761345, Length=114, Percent_Identity=37.719298245614, Blast_Score=81, Evalue=2e-16, Organism=Homo sapiens, GI187761343, Length=114, Percent_Identity=37.719298245614, Blast_Score=81, Evalue=2e-16, Organism=Homo sapiens, GI28416953, Length=112, Percent_Identity=41.0714285714286, Blast_Score=81, Evalue=3e-16, Organism=Homo sapiens, GI156151445, Length=115, Percent_Identity=37.3913043478261, Blast_Score=71, Evalue=2e-13, Organism=Escherichia coli, GI1790505, Length=113, Percent_Identity=45.1327433628319, Blast_Score=112, Evalue=8e-27, Organism=Escherichia coli, GI1788107, Length=114, Percent_Identity=38.5964912280702, Blast_Score=79, Evalue=8e-17, Organism=Escherichia coli, GI221142682, Length=112, Percent_Identity=33.9285714285714, Blast_Score=68, Evalue=1e-13, Organism=Escherichia coli, GI145693145, Length=114, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-13, Organism=Escherichia coli, GI1786529, Length=117, Percent_Identity=38.4615384615385, Blast_Score=66, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17559526, Length=115, Percent_Identity=37.3913043478261, Blast_Score=80, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17557194, Length=114, Percent_Identity=35.0877192982456, Blast_Score=77, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17538037, Length=114, Percent_Identity=34.2105263157895, Blast_Score=75, Evalue=8e-15, Organism=Caenorhabditis elegans, GI71982997, Length=113, Percent_Identity=36.283185840708, Blast_Score=71, Evalue=1e-13, Organism=Caenorhabditis elegans, GI71983001, Length=113, Percent_Identity=36.283185840708, Blast_Score=71, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17558820, Length=113, Percent_Identity=34.5132743362832, Blast_Score=69, Evalue=5e-13, Organism=Caenorhabditis elegans, GI71996755, Length=108, Percent_Identity=34.2592592592593, Blast_Score=69, Evalue=7e-13, Organism=Caenorhabditis elegans, GI32563687, Length=114, Percent_Identity=32.4561403508772, Blast_Score=64, Evalue=2e-11, Organism=Caenorhabditis elegans, GI71994690, Length=116, Percent_Identity=35.3448275862069, Blast_Score=64, Evalue=2e-11, Organism=Caenorhabditis elegans, GI71994694, Length=116, Percent_Identity=35.3448275862069, Blast_Score=64, Evalue=2e-11, Organism=Caenorhabditis elegans, GI71994703, Length=116, Percent_Identity=35.3448275862069, Blast_Score=64, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6319264, Length=120, Percent_Identity=41.6666666666667, Blast_Score=99, Evalue=2e-22, Organism=Saccharomyces cerevisiae, GI6319699, Length=113, Percent_Identity=39.8230088495575, Blast_Score=87, Evalue=6e-19, Organism=Saccharomyces cerevisiae, GI6323182, Length=125, Percent_Identity=36, Blast_Score=84, Evalue=6e-18, Organism=Drosophila melanogaster, GI24667955, Length=113, Percent_Identity=34.5132743362832, Blast_Score=79, Evalue=8e-16, Organism=Drosophila melanogaster, GI62472339, Length=113, Percent_Identity=34.5132743362832, Blast_Score=79, Evalue=8e-16, Organism=Drosophila melanogaster, GI24667959, Length=113, Percent_Identity=34.5132743362832, Blast_Score=79, Evalue=8e-16, Organism=Drosophila melanogaster, GI18859661, Length=114, Percent_Identity=39.4736842105263, Blast_Score=77, Evalue=2e-15, Organism=Drosophila melanogaster, GI24581924, Length=114, Percent_Identity=34.2105263157895, Blast_Score=70, Evalue=3e-13, Organism=Drosophila melanogaster, GI21355225, Length=109, Percent_Identity=33.9449541284404, Blast_Score=68, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020845 - InterPro: IPR000873 [H]
Pfam domain/function: PF00501 AMP-binding [H]
EC number: 6.2.1.1
Molecular weight: Translated: 14075; Mature: 14075
Theoretical pI: Translated: 4.85; Mature: 4.85
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDEDGYMWFVGRTDDIIKSSGYRIGPFEVESAIISHPSVLECAVTGYPDPIRGQVVKATI CCCCCEEEEEECCHHHHHCCCCEECCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEE VLARGYEPSEELKKEIQDHVKRVTAPYKYPRIVEFVDELPKTISGKIRRVEIREHDLEGD EEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC GENP CCCC >Mature Secondary Structure MDEDGYMWFVGRTDDIIKSSGYRIGPFEVESAIISHPSVLECAVTGYPDPIRGQVVKATI CCCCCEEEEEECCHHHHHCCCCEECCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEE VLARGYEPSEELKKEIQDHVKRVTAPYKYPRIVEFVDELPKTISGKIRRVEIREHDLEGD EEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC GENP CCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: ATP; acetate; CoA
Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
General reaction: Acid-thiol ligation [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]