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Identifier: 15678449

GI number: 15678449

Start: 359309

End: 360466

Strand: Direct

Name: Not Available

Synonym: MTH421

Alternate gene names: NA

Gene position: 359309-360466 (Clockwise)

Preceding gene: 15678447

Following gene: 15678450

Centisome position: 20.52

GC content: 51.38

Gene sequence:

>1158_bases
GTGATATTAATGGTCATAGAGTTACTCTCGGTATTCATAGCACTTCTGGCCTGTTTCTATGCTTCATACAGTGATATAAA
AAGGGGTATAATACCCAACCGTCTGACCTTTCCTGTTATCGGGCTCGGTCTTCTCCTGAATGGTGCGAGGGCCCTCATGG
AATCGGATCCCTGGATATTCATTTACACAGCCATCTTCACAGCCGGGATATTCGCCCTGGGATACATCCTCTGGAGGATG
GTGGCCTGGGCAGGTGGTGATGTGAAGCTCTTCACAGCGGTAACCTCCCTGCTACCATTCCAGCCGTCACTGGTAAGCTA
CAGCTTCCTCGGAACGGCCTTCCCTGTCACGGCATCCTACCCCTTTCCACTCACGGTCATAATAAACAGTATACTGGCGC
TCCTCCCCTTCCTCCTGGTCTATGTGTTCTTCATCATCTACACATCCAGGAGGCACCTCATGGACGAGTTCATGGAGCCC
CTCCGCCAGTACAGGACCAGCATGGTCCTGGCCCTGGTTATAACATCCGCCGTTACCCTGACATTCCTCATAACAGACTT
CCTCCCATTCCAGATCATAGTACTTTCCCTGATCCTTGTCTACCTCCTCACCATGGTCATCTCACGCCTACCGCCAAGGA
TTAAGGCGGTTATAGTATCGGTGATCATAGTCTACTCGCTCTACAAGAACTTTGAGTTGACCGTGAGTGGAGTTGTAATT
CTCTGGGTCTCCATAACGGTTATACAGCTCATAAGGAAGCTCCTCACATCCATCACGAGGGAGGCCCTCCAGGACACCAT
GGGCGTGGATGAACTGAAGGAGGGCATGATACTCGCAAGCACCCTCTACAGGAAGGGCGATGAATACTACTTCGATGACA
GTTCACTCCTTGACAGGTTCCGGACAGCTGCGAGGACCGGTGATGTATCTGCACTGACCTACAGGGGTGAACCTGTGGTG
TCTGCCATGGCAGCCGGTCTCCGGGAGGAGGAGATTGAGACCCTCAGGGACCTTGTATCCAGGGGCAAGATAAAGGATGA
GTTCCGGATAAGACGCGGTATGCCCTTTGCTCCTGCAATCTTCATAGGGCTCCTGGTTTCACTCCTTATAGGGGACCTTG
CAATGATACTGTTCAGGTTATTTGACATCATATTCTAG

Upstream 100 bases:

>100_bases
TGCACCCGGAGAAATCAACCACAAAAACTTAAATAGAGATCACTGAGAATTAATTAATAAATCATGATTTTCTGTAATAT
CCATCTCTAAGCTTCAAGGA

Downstream 100 bases:

>100_bases
TTCAGGTGGTGAGGGTTACCGGTCTGGTGAGCCAGATAACGGGGTGGGCACTGCCATGATCTCCCGGATGTTCACCAAAT
ATATAAGTGTAGCCCTACAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MILMVIELLSVFIALLACFYASYSDIKRGIIPNRLTFPVIGLGLLLNGARALMESDPWIFIYTAIFTAGIFALGYILWRM
VAWAGGDVKLFTAVTSLLPFQPSLVSYSFLGTAFPVTASYPFPLTVIINSILALLPFLLVYVFFIIYTSRRHLMDEFMEP
LRQYRTSMVLALVITSAVTLTFLITDFLPFQIIVLSLILVYLLTMVISRLPPRIKAVIVSVIIVYSLYKNFELTVSGVVI
LWVSITVIQLIRKLLTSITREALQDTMGVDELKEGMILASTLYRKGDEYYFDDSSLLDRFRTAARTGDVSALTYRGEPVV
SAMAAGLREEEIETLRDLVSRGKIKDEFRIRRGMPFAPAIFIGLLVSLLIGDLAMILFRLFDIIF

Sequences:

>Translated_385_residues
MILMVIELLSVFIALLACFYASYSDIKRGIIPNRLTFPVIGLGLLLNGARALMESDPWIFIYTAIFTAGIFALGYILWRM
VAWAGGDVKLFTAVTSLLPFQPSLVSYSFLGTAFPVTASYPFPLTVIINSILALLPFLLVYVFFIIYTSRRHLMDEFMEP
LRQYRTSMVLALVITSAVTLTFLITDFLPFQIIVLSLILVYLLTMVISRLPPRIKAVIVSVIIVYSLYKNFELTVSGVVI
LWVSITVIQLIRKLLTSITREALQDTMGVDELKEGMILASTLYRKGDEYYFDDSSLLDRFRTAARTGDVSALTYRGEPVV
SAMAAGLREEEIETLRDLVSRGKIKDEFRIRRGMPFAPAIFIGLLVSLLIGDLAMILFRLFDIIF
>Mature_385_residues
MILMVIELLSVFIALLACFYASYSDIKRGIIPNRLTFPVIGLGLLLNGARALMESDPWIFIYTAIFTAGIFALGYILWRM
VAWAGGDVKLFTAVTSLLPFQPSLVSYSFLGTAFPVTASYPFPLTVIINSILALLPFLLVYVFFIIYTSRRHLMDEFMEP
LRQYRTSMVLALVITSAVTLTFLITDFLPFQIIVLSLILVYLLTMVISRLPPRIKAVIVSVIIVYSLYKNFELTVSGVVI
LWVSITVIQLIRKLLTSITREALQDTMGVDELKEGMILASTLYRKGDEYYFDDSSLLDRFRTAARTGDVSALTYRGEPVV
SAMAAGLREEEIETLRDLVSRGKIKDEFRIRRGMPFAPAIFIGLLVSLLIGDLAMILFRLFDIIF

Specific function: Unknown

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To M.jannaschii MJ0835.2

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y421_METTH (O26521)

Other databases:

- EMBL:   AE000666
- PIR:   H69154
- RefSeq:   NP_275564.1
- STRING:   O26521
- GeneID:   1470382
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH421
- NMPDR:   fig|187420.1.peg.419
- eggNOG:   arNOG07641
- OMA:   WDILGET
- ProtClustDB:   CLSK2750293
- BioCyc:   MTHE187420:MTH421-MONOMER
- InterPro:   IPR009639
- InterPro:   IPR000045

Pfam domain/function: PF06819 Arc_PepC; PF01478 Peptidase_A24

EC number: NA

Molecular weight: Translated: 43350; Mature: 43350

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf96f4e0)-; HASH(0xf90174c)-; HASH(0xfc141e4)-; HASH(0xfc3c42c)-; HASH(0xf78b7fc)-; HASH(0xfb76abc)-; HASH(0xfc405a8)-; HASH(0xf0b18f4)-; HASH(0xf14bcc8)-; HASH(0xfb7b934)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9371463